Science and Exploration

NASA Spaceline Current Awareness List #1,020  14 October 2022 (Space Life Science Research Results)

By Keith Cowing
Press Release
NASA
October 14, 2022
Filed under , , , , , ,
NASA Spaceline Current Awareness List #1,020  14 October 2022 (Space Life Science Research Results)
Space Biology
NASA

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

In case you missed it: Viktor Stolc, PhD, associate editor of the journal Sleep Epidemiology, is preparing a special issue solicitation for NASA-funded PIs who have published in sleep research. For more information, go to https://www.journals.elsevier.com/sleep-epidemiology/forthcoming-special-issues/what-time-is-it-for-sleep-in-space.

Papers deriving from NASA support:

1

Keller N, Whittle RS, McHenry N, Johnston A, Duncan C, Ploutz-Snyder L, De La Torre GG, Sheffield-Moore M, Chamitoff G, Diaz-Artiles A.

Virtual Reality exergames: A promising countermeasure to improve motivation and restorative effects during long duration spaceflight missions.

Front Physiol. 2022 Oct 11;13:932425.

https://doi.org/10.3389/fphys.2022.932425

PI: L. Ploutz-Snyder

Note: From the abstract: “Long duration spaceflight missions will require novel exercise systems to protect astronaut crew from the detrimental effects of microgravity exposure. The SPRINT protocol is a novel and promising exercise prescription that combines aerobic and resistive training using a flywheel device, and it was successfully employed in a 70-day bed-rest study as well as onboard the International Space Station. Our team created a VR simulation to further augment the SPRINT protocol when using a flywheel ergometer training device (the Multi-Mode Exercise Device or M-MED). The simulation aspired to maximal realism in a virtual river setting while providing real-time biometric feedback on heart rate performance to subjects. In this pilot study, five healthy, male, physically-active subjects aged 35 ± 9.0 years old underwent 2 weeks of SPRINT protocol, either with or without the VR simulation.” This article is part of Research Topic “Space Countermeasures and Medicine – Implementation into Earth medicine and Rehabilitation” (https://www.frontiersin.org/research-topics/29370/space-countermeasures-and-medicine—implementation-into-earth-medicine-and-rehabilitation#overview). The Research Topic also includes articles from previous Current Awareness Lists #997 https://doi.org/10.3389/fphys.2022.897694, #1,004 https://doi.org/10.3389/fphys.2022.921862, #1,009 https://doi.org/10.3389/fphys.2022.921434, #1,012 https://doi.org/10.3389/fphys.2022.928313, #1,014 https://doi.org/10.3389/fphys.2022.943443, #1,015 https://doi.org/10.3389/fphys.2022.952723 and #1,018 https://doi.org/10.3389/fphys.2022.921368. This article may be obtained online without charge.

Journal Impact Factor: 4.755

Funding: PI reports indirect link to Integrated Resistance and Aerobic Training Study (Sprint) study.

2

Nguyen CN, Urquieta E.

Contemporary review of dermatologic conditions in space flight and future implications for long-duration exploration missions.

Life Sci Space Res. 2022 Oct 13. Review. Online ahead of print.

https://doi.org/10.1016/j.lssr.2022.10.004

Note: From the abstract: “Future planned exploration missions to outer space will almost surely require the longest periods of continuous space exposure by the human body yet. As the most external organ, the skin seems the most vulnerable to injury. Therefore, discussion of the dermatological implications of such extended-duration missions is critical.”

Journal Impact Factor: 2.730

Funding: “Translational Research Institute for Space Health through NASA NNX16AO69A.”

3

Kothiyal P, Eley G, Ilangovan H, Hoadley KA, Elgart SR, Mao XW, Eslami P.

A multi-omics longitudinal study of the murine retinal response to chronic low-dose irradiation and simulated microgravity.

Sci Rep. 2022 Oct 7;12:16825.

https://pubmed.ncbi.nlm.nih.gov/36207342

PI: X.W. Mao

Note: Hindlimb unloading study. GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.

Journal Impact Factor: 4.996

Funding: “The data used in this study has been generated as part of the work supported by NASA NRA NNX13AL97G (X.W.M.) and NASA Human Research Program Grant No. 80NSSC18K0310 (X.W.M.).”

4

Turner RT, Nesser KL, Philbrick KA, Wong CP, Olson DA, Branscum AJ, Iwaniec UT.

Leptin and environmental temperature as determinants of bone marrow adiposity in female mice.

Front Endocrinol. 2022 Oct 6;13:

959743.

https://doi.org/10.3389/fendo.2022.959743

PI: R.T. Turner

Note: This article is part of Research Topic “Bone Marrow Adiposity: Contributions to Bone, Aging, and Beyond” (https://www.frontiersin.org/research-topics/20353/bone-marrow-adiposity-contributions-to-bone-aging-and-beyond#overview). This article may be obtained online without charge.

Journal Impact Factor: 6.055

Funding: “This work was supported by National Institutes of Health (AR060913) and National Aeronautics and Space Administration (80NSSC19K0430).”

5

Heldmann JL, Marinova MM, Lim DSS, Wilson D, Carrato P, Kennedy K, Esbeck A, Colaprete TA, Elphic RC, Captain J, Zacny K, Stolov L, Mellerowicz B, Palmowski J, Bramson AM, Putzig N, Morgan G, Sizemore H, Coyan J.

Mission architecture using the SpaceX Starship vehicle to enable a sustained human presence on Mars.

New Space. 2022 Sep;10(3):259-73.

https://pubmed.ncbi.nlm.nih.gov/36199953

Journal Impact Factor: 0.80

Funding: “Portions of this work were funded by a grant to PI J.L. Heldmann through NASA’s SSERVI (Solar System Exploration Research Virtual Institute) for the RESOURCE project.”

___________________________________________________

Other papers of interest:

1

Wakayama S, Soejima M, Kikuchi Y, Hayashi E, Ushigome N, Hasegawa A, Mochida K, Suzuki T, Yamazaki C, Shimazu T, Sano H, Umehara M, Matsunari H, Ogura A, Nagashima H, Wakayama T.

Development of a new device for manipulating frozen mouse 2-cell embryos on the International Space Station.

PLoS One. 2022 Oct 7;17(10):e0270781.

https://pubmed.ncbi.nlm.nih.gov/36206235

Note: From the abstract: “Here, we describe the development of a new device that allows astronauts to thaw and culture frozen mouse 2-cell embryos on the ISS without direct contact with the embryos.” This article may be obtained online without charge.

2

Fall DA, Lee AG, Bershad EM, Kramer LA, Mader TH, Clark JB, Hirzallah MI.

Optic nerve sheath diameter and spaceflight: Defining shortcomings and future directions.

npj Microgravity. 2022 Oct 6;8:42. Review.

https://pubmed.ncbi.nlm.nih.gov/36202836

Note: This article may be obtained online without charge.

3

Chen X, Yang J, Lv H, Che J, Wang J, Zhang B, Shang P.

The potential benefits of melatonin in the prevention and treatment of bone loss in response to microgravity.

Acta Astronaut. 2022 Oct 13. Online ahead of print.

https://doi.org/10.1016/j.actaastro.2022.10.020

Note: From the abstract: “We present the main risk factors for bone loss in response to microgravity, including circadian misalignment, oxidative stress and increased iron levels.”

4

Hirayama J, Hattori A, Takahashi A, Furusawa Y, Tabuchi Y, Shibata M, Nagamatsu A, Yano S, Maruyama Y, Matsubara H, Sekiguchi T, Suzuki N.

Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure.

J Pineal Res. 2022 Oct 6. Review. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/36203395

Note: This article may be obtained online without charge.

5

Vinken M.

Hepatology in space: Effects of spaceflight and simulated microgravity on the liver.

Liver International. 2022 Oct 2. Review. Online ahead of print.

https://doi.org/10.1111/liv.15444

Note: This article may be obtained online without charge.

6

Sayapin SN.

Creation of local artificial gravity for gravitational hemorehabilitation of cosmonauts in prolonged weightlessness.

Biomedical Engineering. 2022 Sep 22;56:198-203.

https://doi.org/10.1007/s10527-022-10200-8

Note: From the abstract: “This study addresses the problem of the adverse impact of prolonged weightlessness on cosmonauts’ bodies, in particular on blood. The problem can be solved by creating artificial gravity onboard space stations. Two main areas are defined: installation of a full-size short-radius centrifuge onboard space stations and rotation of a space station or one of its modules. However, in the short term, both approaches are difficult to implement. Here we propose applying a local artificial gravity effect not to the entire body, but only to its liquid tissue–blood–for the purpose of gravitational hemorehabilitation of cosmonauts in prolonged weightlessness.”

7

Chen F, Jiang N, Zhang YW, Xie MZ, Liu XM.

Protective effect of Gastrodia elata blume ameliorates simulated weightlessness-induced cognitive impairment in mice.

Life Sci Space Res. 2022 Oct 10. Online ahead of print.

https://doi.org/10.1016/j.lssr.2022.10.001

Note: From the abstract: “During the long-term orbital flight, exposure to microgravity negatively affects the astronauts’ development of cognition, characterized by learning and memory decline. Gastrodia elataBlume (GEB) has a significant protective effect on cognitive impairment and has been used in Asia for centuries as a functional product. A previous study demonstrated that GEB could improve memory loss in mice caused by circadian rhythm disorders. However, the effects of GEB on cognitive dysfunction caused by weightless environments have not been investigated. In this study, mice received daily treatment with GEB (0.5, 1 g·kg−1 d−1, i.g) and Huperzine A(Hup, 0.1 mg·kg−1d−1 i.g) orally until the end of the behavioral test (New object recognition test (NORT)).”

8

Cortesão M, Holland G, Schütze T, Laue M, Moeller R, Meyer V.

Colony growth and biofilm formation of Aspergillus niger under simulated microgravity.

Front Microbiol. 2022 Sep 23;13:975763.

https://pubmed.ncbi.nlm.nih.gov/36212831

Note: A clinostat was used in this study. This article may be obtained online without charge.

9

Carbajales-Dale M, Murphy TW.

The environmental and moral implications of human space travel.

Sci Total Environ. 2022 Oct 6:159222.

https://doi.org/10.1016/j.scitotenv.2022.159222

Note: From the abstract: “Humans have long dreamed of traveling to space. In response to the recent increase in commercial space flight, this paper evaluates environmental impacts of human space travel, both past and present, to shed light on the large environmental footprint of such activities. This environmental impact also has a moral component, since most of the global population will never be able to participate in such activities, yet still must bear the cost. Ironically, instead of a space future acting as a relief valve on Earth’s resources, few activities exact a heavier burden on our planet’s resources than the space pursuit, for the number of people it serves.”

10

Hao Y, Lu L, Liu A, Lin X, Xiao L, Kong X, Li K, Liang F, Xiong J, Qu L, Li Y, Li J.

Integrating bioinformatic strategies in spatial life science research.

Brief Bioinform. 2022 Oct 5.

https://pubmed.ncbi.nlm.nih.gov/36198665

Note: From the abstract: “As space exploration programs progress, manned space missions will become more frequent and farther away from Earth, putting a greater emphasis on astronaut health. Through the collaborative efforts of researchers from various countries, the effect of the space environment factors on living systems is gradually being uncovered. Although a large number of interconnected research findings have been produced, their connection seems to be confused, and many unknown effects are left to be discovered. Simultaneously, several valuable data resources have emerged, accumulating data measuring biological effects in space that can be used to further investigate the unknown biological adaptations. In this review, the previous findings and their correlations are sorted out to facilitate the understanding of biological adaptations to space and the design of countermeasures. The biological effect measurement methods/data types are also organized to provide references for experimental design and data analysis. To aid deeper exploration of the data resources, we summarized common characteristics of the data generated from longitudinal experiments, outlined challenges or caveats in data analysis and provided corresponding solutions by recommending bioinformatics strategies and available models/tools.” This article may be obtained online without charge.

11

Borchmann S, Selenz C, Lohmann M, Ludwig H, Gassa A, Brägelmann J, Lohneis P, Meder L, Mattlener J, Breid S, Nill M, Fassunke J, Wisdom AJ, Compes A, Gathof B, Alakus H, Kirsch D, Hekmat K, Büttner R, Reinhardt HC, Hallek M, Ullrich RT.

Tripartite antigen-agnostic combination immunotherapy cures established poorly immunogenic tumors.

J Immunother Cancer. 2022 Oct;10(10):e004781.

https://pubmed.ncbi.nlm.nih.gov/36223955

Note: This article may be obtained online without charge.

12

Gutknecht AP, Gonzalez-Figueres M, Brioche T, Maurelli O, Perrey S, Favier FB.

Maximizing anaerobic performance with repeated-sprint training in hypoxia: In search of an optimal altitude based on pulse oxygen saturation monitoring.

Front Physiol. 2022 Oct 12;13:1010086.

https://doi.org/10.3389/fphys.2022.1010086

Note: This article is part of Research Topic “Long-term effects of hypoxic conditioning on sports performance, health and well-being” (https://www.frontiersin.org/research-topics/34247/long-term-effects-of-hypoxic-conditioning-on-sports-performance-health-and-well-being#overview). This article may be obtained online without charge.

13

Marcos-Lorenzo D, Frett T, Gil-Martinez A, Speer M, Swanenburg J, Green DA.

Effect of trunk exercise upon lumbar IVD height and vertebral compliance when performed supine with 1 g at the CoM compared to upright in 1 g.

BMC Sports Sci Med Rehabil. 2022 Oct 7;14:177.

https://pubmed.ncbi.nlm.nih.gov/36207739

Note: From the abstract: “Spinal unloading in microgravity is associated with stature increments, back pain, intervertebral disc (IVD) swelling and impaired spinal kinematics. The aim of this study was to determine the effect of lateral stabilization, trunk rotation and isometric abdominal exercise upon lumbar IVD height, and both passive and active vertebral compliance when performed supine on a short-arm human centrifuge (SAHC)-a candidate microgravity countermeasure-with 1 g at the CoM, compared to that generated with equivalent upright exercise in 1 g.” This article may be obtained online without charge.

14

Rabineau J, Issertine M, Hoffmann F, Gerlach D, Caiani EG, Haut B, van de Borne P, Tank J, Migeotte P-F.

Cardiovascular deconditioning and impact of artificial gravity during 60-day head-down bed rest—Insights from 4D flow cardiac MRI.

Front Physiol. 2022 Oct 7;13:944587.

https://doi.org/10.3389/fphys.2022.944587

Note: Head-down bedrest study. This article is part of Research Topic “Rising Stars in Environmental, Aviation and Space Physiology: 2022” (https://www.frontiersin.org/research-topics/29535/rising-stars-in-environmental-aviation-and-space-physiology-2022#articles). The Research Topic also includes articles from previous Current Awareness Lists #993 https://doi.org/10.3389/fphys.2022.846229, #1,004 https://doi.org/10.3389/fphys.2022.862793, #1,010 https://doi.org/10.3389/fphys.2022.899830, and #1,015 https://doi.org/10.3389/fphys.2022.933450 and https://doi.org/10.3389/fphys.2022.902983. This article may be obtained online without charge.

15

Idol RA, Bhattacharya S, Huang G, Song Z, Huttenlocher A, Keller NP, Dinauer MC.

Neutrophil and macrophage NADPH oxidase 2 differentially control responses to inflammation and to Aspergillus fumigatus in mice.

J Immunol. 2022 Oct 3. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/36192110

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