Science and Exploration

NASA Spaceline Current Awareness List #1,014  26 August  2022 (Space Life Science Research Results)

By Keith Cowing
Press Release
August 26, 2022
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NASA Spaceline Current Awareness List #1,014  26 August  2022 (Space Life Science Research Results)
NASA Astronaut Kate Rubins sequenced DNA in space for the first time ever for the Biomolecule Sequencer investigation, using the MinION sequencing device. Credits: NASA

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Madrigal P, Singh NK, Wood JM, Gaudioso E, Hernández-Del-Olmo F, Mason CE, Venkateswaran K, Beheshti A.

Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome.

Microbiome. 2022 Aug 24;10:134.

PIs: N.K. Singh, C.E. Mason, K. Venkateswaran, A. Beheshti

Note: ISS results. GeneLab is available at This article may be obtained online without charge.

Journal Impact Factor: 16.837

Funding: “AB was supported and funded by NASA grant 16-ROSBFP_GL-0005: NNH16Z‑ TT001N-FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883) and The Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404). This work was partially supported by the ESA Space Omics Topical Team, funded by the ESA grant/contract 4000131202/20/NL/ PG/pt ‘Space Omics: Towards an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments’. CEM was supported by NASA grants (NNX16AO69A, NNX14AH50G, NNX17AB26G), the NIH (R01AI151059, U01DA053941) and Igor Tulchinsky and the WorldQuant Foundation. This research was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV, which also funded the post-doctoral fellowships for NKS.”


Ong J, Tavakkoli A, Zaman N, Kamran SA, Waisberg E, Gautam N, Lee AG.

Terrestrial health applications of visual assessment technology and machine learning in spaceflight associated neuro-ocular syndrome.

npj Microgravity. 2022 Aug 25;8:37.

PI: A. Tavakkoli

Note: From the abstract: “The neuro-ocular effects of long-duration spaceflight have been termed Spaceflight Associated Neuro-Ocular Syndrome (SANS) and are a potential challenge for future, human space exploration. The underlying pathogenesis of SANS remains ill-defined, but several emerging translational applications of terrestrial head-mounted, visual assessment technology and machine learning frameworks are being studied for potential use in SANS. To develop such technology requires close consideration of the spaceflight environment which is limited in medical resources and imaging modalities. This austere environment necessitates the utilization of low mass, low footprint technology to build a visual assessment system that is comprehensive, accessible, and efficient. In this paper, we discuss the unique considerations for developing this technology for SANS and translational applications on Earth.” This article may be obtained online without charge.

Journal Impact Factor: 4.97

Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) under NASA Grant 80NSSC20K1831 titled: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”


Laiakis EC, Pinheiro M, Nguyen T, Nguyen H, Beheshti A, Dutta SM, Russell WK, Emmett MR, Britten RA.

Quantitative proteomic analytic approaches to identify metabolic changes in the medial prefrontal cortex of rats exposed to space radiation.

Front Physiol. 2022 Aug 26;


PI: R.A. Britten

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.755

Funding: “This work was funded by NASA grant support NNX11AC56G and NNX14AE73G (P.I. RB). The Mass Spectrometry Facility at UTMB is supported in part by Cancer Prevention Research Institute of Texas (CPRIT) grant number RP190682.”


Vroom MM, Troncoso-Garcia A, Duscher AA, Foster JS.

Modeled microgravity alters apoptotic gene expression and caspase activity in the squid-vibrio symbiosis.

BMC Microbiol. 2022 Aug 18;22:202.

PI: J.S. Foster

Note: A high aspect ratio vessel was used in this study. This article may be obtained online without charge.

Journal Impact Factor: 4.465

Funding: “This project was funded by the National Aeronautics and Space Administration 80NSSC18K1465 awarded to JSF. MMV was supported by a Dissertation Improvement Fellowship from the NASA Florida Space Grant Consortium. This work was also supported in part by USDA Hatch grant FLA-MCS-006063.”


Stainforth R, Vuong N, Adam N, Kuo B, Wilkins RC, Yauk C, Beheshti A, Chauhan V.

Benchmark dose modeling of transcriptional data: A systematic approach to identify best practices for study designs used in radiation research.

Int J Radiat Biol. 2022 Aug 22;1-13.

Journal Impact Factor: 3.352

Funding: A. Beheshti is affiliated with NASA Ames Research Center.


Kluis L, Patel R, Thompson WK, Lewandowski B, Diaz-Artiles A.

The impact of stance during heel raises on the hybrid ultimate lifting kit (HULK) device: A future microgravity exercise machine.

Front Physiol. 2022 Aug 23;13:943443.

Note: This article is part of Research Topic “Space Countermeasures and Medicine – Implementation into Earth medicine and Rehabilitation” (—implementation-into-earth-medicine-and-rehabilitation#overview). The Research Topic also includes articles from previous Current Awareness Lists #997, #1,004, #1,009, and #1,012 This article may be obtained online without charge.

Journal Impact Factor: 4.755

Funding: “This research has been partially funded by Texas A&M Triads for Transformation (T3). The data used in this analysis were collected as part of a directed biomechanical modeling project funded by the NASA Human Research Program.”


Hao J, High R, Siu KC.

Gender-specific visual perturbation effects on muscle activation during incline treadmill walking: A virtual reality study.

Ergonomics. 2022 Aug 21;1-12. Online ahead of print.

Journal Impact Factor: 2.561

Funding: “This study was supported by the NASA Nebraska Space Grant & EPSCoR (NNX15AK50A).”


Grant LK, Czeisler CA, Lockley SW, Rahman SA.

Time-of-day and meal size effects on clinical lipid markers.

J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1373-e9.

Journal Impact Factor: 6.134

Funding: “This work was supported by the National Space Biomedical Research Institute (Lockley: HPF01301) through NASA NCC 9–58 and by the National Center for Research Resources through grants to Brigham and Women’s Hospital General Clinical Research Center (NCRR M01 RR02635) and the Harvard Clinical and Translational Science Center (NCRR UL1 RR025758).”


Other papers of interest:


Yoshida K, Hada M, Kizu A, Kitada K, Eguchi-Kasai K, Kokubo T, Teramura T, Yano S, Suzuki HH, Watanabe H, Kondoh G, Nagamatsu A, Saganti P, Cucinotta FA, Morita T.

Comparison of biological measurement and physical estimates of space radiation in the International Space Station.

Heliyon. 2022 Aug 17;e10266. Online ahead of print.

Note: ISS results. This article may be obtained online without charge.


Harris M, Duda PI, Kelman I, Glick N.

Addressing disaster and health risks for sustainable outer space.

Integr Environ Assess Manag. 2022 Aug 16. Online ahead of print.

Note: From the abstract: “Any future outer space exploration and exploitation should more fully consider disaster and health risks as part of aiming for sustainability. The advent of the so-called ‘New Space’ race, age, or era characterized by democratization, commercialization, militarization, and overlapping outer space activities such as tourism presents challenges for disaster-related and health-related risks in and for outer space. Such challenges have been extensively researched for Earth, but less so for space. This article presents an overview of key aspects for addressing disaster and health risks in outer space within a wider sustainability framing.” This article may be obtained online without charge.


Rappaport MB, Corbally CJ.

Neuroplasticity as a foundation for decision-making in space.

NeuroSci. 2022 Aug 9;3(3):457-75.

Note: From the abstract: “This is an exploratory review of two very recent, intersecting segments of space science: neuroplasticity in space, and decision-making in space.” This article is part of Special Issue “Beyond the Conductivity—The Impact of Neuroplasticity in Health and Disease” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.


Sarli SL, Watts JK.

Harnessing nucleic acid technologies for human health on Earth and in space.

Life Sci Space Res. 2022 Aug 22. Online ahead of print.


Tran QD, Tran V, Toh LS, Williams PM, Tran NN, Hessel V.

Space medicines for space health.

ACS Med Chem Lett. 2022;13(8):1231-47.

Note: From the abstract: “Scientists from around the world are studying the effects of microgravity and cosmic radiation via the ‘off-Earth’ International Space Station (ISS) laboratory platform. The ISS has helped scientists make discoveries that go beyond the basic understanding of Earth. Over 300 medical experiments have been performed to date, with the goal of extending the knowledge gained for the benefit of humanity. This paper gives an overview of these numerous space medical findings, critically identifies challenges and gaps, and puts the achievements into perspective toward long-term space traveling and also adding benefits to our home planet.” This article may be obtained online without charge.


Mustapha F, Sengupta K, Puech PH.

May the force be with your (immune) cells: An introduction to traction force microscopy in immunology.

Front Immunol. 2022 Jul 28;13:898558.

Note: This article is part of Research Topic “The Cytoskeleton in T Cell Migration and Activation” ( This article may be obtained online without charge.


Yuste RA, Muenkel M, Axarlis K, Gómez Benito MJ, Reuss A, Blacker G, Tal MC, Kraiczy P, Bastounis EE.

Borrelia burgdorferi modulates the physical forces and immunity signaling in endothelial cells.

iScience. 2022 Jul 19;25(8):104793.

Note: This article may be obtained online without charge.


Guglielmo M, Marta B.

Stem cells and the microenvironment: Reciprocity with asymmetry in regenerative medicine.

Acta Biotheoretica. 2022 Aug 13;70:24.


Patel Z, Schroeder JA, Bunch PM, Evans JK, Steber CR, Johnson AG, Farris JC, Hughes RT.

Discordance between oncology clinician-perceived and radiologist-intended meaning of the postradiotherapy positron emission tomography/computed tomography freeform report for head and neck cancer.

JAMA Otolaryngol Head Neck Surg. 2022 Aug 18. Online ahead of print.


Yonezawa H, Yamamoto N, Hayashi K, Takeuchi A, Miwa S, Igarashi K, Morinaga S, Asano Y, Saito S, Tada K, Nojima T, Tsuchiya H.

Do liquid nitrogen-treated tumor-bearing nerve grafts have the capacity to regenerate, and do they pose a risk of local recurrence? A study in rats.

Clin Orthop Relat Res. 2022 Aug 19. Online ahead of print.


Yoshihara T, Dobashi S, Takaragawa M, Naito H.

Effect of losartan treatment on Smad signaling and recovery from hindlimb unloading-induced soleus muscle atrophy in female rats.

Eur J Pharmacol. 2022 Aug 18;175223.

Note: Hindlimb unloading study.


Zambolin F, Giuriato G, Laginestra FG, Ottaviani MM, Favaretto T, Calabria E, Duro-Ocana P, Bagley L, Faisal A, Peçanha T, McPhee JS, Venturelli M.

Effects of nociceptive and mechanosensitive afferents sensitization on central and peripheral hemodynamics following exercise-induced muscle damage.

J Appl Physiol (1985). 2022 Aug 18. Online ahead of print.


Wang L, Yu Y, Ni S, Li D, Liu J, Xie D, Chu HY, Ren Q, Zhong C, Zhang N, Li N, Sun M, Zhang ZK, Zhuo Z, Zhang H, Zhang S, Li M, Xia W, Zhang Z, Chen L, Shang P, Pan X, Lu A, Zhang BT, Zhang G.

Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice.

Theranostics. 2022;12(13):5645-74.

Note: This article may be obtained online without charge.


Heusel-Gillig L, Santucci V, Hall CD.

Development and validation of the modified motion sensitivity test.

Otol Neurotol. 2022 Sep 1;43(8):944-9.

Note: From the abstract: “The aim of this study was to develop and validate an outcome measure for individuals with motion-provoked dizziness.”


Mao Y, Pan L, Li W, Xiao S, Qi R, Zhao L, Wang J, Cai Y.

Stroboscopic lighting with intensity synchronized to rotation velocity alleviates motion sickness gastrointestinal symptoms and motor disorders in rats.

Front Integr Neurosci. 2022 Jul 28;16:941947.

Note: This article may be obtained online without charge.


Reuten AJC, Smeets JBJ, Martens MH, Bos JE.

Self-motion perception without sensory motion.

Exp Brain Res. 2022 Aug 20.

Note: This article may be obtained online without charge.

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