NASA Spaceline Current Awareness List #1,017 16 September 2022 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Hupfeld KE, McGregor HR, Hass CJ, Pasternak O, Seidler RD.
Sensory system-specific associations between brain structure and balance.
Neurobiol Aging. 2022 Nov;119:102-16.
https://pubmed.ncbi.nlm.nih.gov/36030560
Note: From the abstract: “Nearly 75% of older adults in the US report balance problems. Although it is known that aging results in widespread brain atrophy, less is known about how brain structure relates to balance in aging. We collected T1
– and diffusion-weighted MRI scans and measured postural sway of 36 young (18-34 years) and 22 older (66-84 years) adults during eyes open, eyes closed, eyes open-foam, and eyes closed-foam conditions. We calculated summary measures indicating visual, proprioceptive, and vestibular contributions to balance.”
Journal Impact Factor: 4.755
Funding: “During completion of this work, KH was supported by a National Science Foundation Graduate Research Fellowship under Grant no. DGE-1315138 and DGE-1842473 , National Institute of Neurological Disorders and Stroke training grant T32-NS082128 , and National Institute on Aging fellowship 1F99AG068440 . HM was supported by a Natural Sciences and Engineering Research Coun- cil of Canada postdoctoral fellowship and a NASA Human Research Program augmentation grant. RS was supported by a grant from the National Institute on Aging U01AG061389 . A portion of this work was performed in the McKnight Brain Institute at the Na- tional High Magnetic Field Laboratory’s Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) Facility, which is supported by National Science Foundation Cooperative Agreement No. DMR-1644779 and the State of Florida.”
2
Clément G, Rittweger J, Nitsche A, Doering W, Frings-Meuthen P, Hand O, Frett T, Noppe A, Paulke F, Lecheler L, Jordan J, Stern C, Mulder E.
Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA [Artificial Gravity Bed Rest Study with the European Space Agency] bed rest study.
Front Physiol. 2022 Sep 8;13:976926.
https://doi.org/10.3389/fphys.2022.976926
PI: G. Clément
Note: Head-down tilt bedrest study. This article may be obtained online without charge.
Journal Impact Factor: 4.755
Funding: “The study was funded by the German Aerospace Center, the European Space Agency (Contract Number 4000113871/15/NL/PG) and the National Aeronautics and Space Administration (Contract Number 80JSC018P0078), and performed at the: envihab research facility of the DLR Institute of Aerospace Medicine.”
3
Clément GR, Crucian BE, Downs M, Krieger S, Laurie SS, Lee SMC, Macias BR, Mulder E, Rivas E, Roma PG, Rosenberg MJ, Sibonga JD, Smith SM, Spector ER, Whiting SE, Wood SJ, Zwart SR.
International standard measures during the AGBRESA bed rest study.
Acta Astronaut. 2022 Nov;200:163-75.
https://doi.org/10.1016/j.actaastro.2022.08.016
PI: G. Clément
Note: Head-down tilt bedrest study.
Journal Impact Factor: 2.954
Funding: “This work was supported by the National Aeronautics and Space Administration.”
4
Hendrickse PW, Wüst RCI, Ganse B, Giakoumaki I, Rittweger J, Bosutti A, Degens H.
Capillary rarefaction during bed rest is proportionally less than fibre atrophy and loss of oxidative capacity.
J Cachexia Sarcopenia Muscle. 2022 Sep 13. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36102002
Note: Head-down tilt bedrest study.
Journal Impact Factor: 12.063
Funding: “We acknowledge the UK Space Agency (ST/S0001735/1 and ST/T00066X/1), the European Space Agency (ESA; 16-16ESA AGBR-0013, contract number 4000113871/15/NL/PG), the National Aeronautics and Space Administration (NASA; contract number 80JSC018P0078), the German Research Foundation (DFG; grant number GA 2420/1-1), the German Aerospace Center (DLR; grant number 50WB1928) and the Italian Space Agency (MIAG project ASI n.2021-13-U.0) for funding.”
5
Chakrabortty SK, Khodor YL, Kitchen RR, Miller DL, Babcock KM, Manning KS, Lang SP, Tadigotla V, Yu W, Bershad E, Skog J, Zanello S.
Exosome based analysis for Space Associated Neuro-Ocular Syndrome and health risks in space exploration.
npj Microgravity. 2022 Sep 14;8:40.
https://pubmed.ncbi.nlm.nih.gov/36104352
PI: S. Zanello
Note: From the abstract: “Molecular profiling to characterize the effects of environmental exposures is important from the human health and performance as well as the occupational medicine perspective in space exploration. We have developed a novel exosome-based platform that allows profiling of biological processes in the body from a variety of body fluids. The technology is suitable for diagnostic applications as well as studying the pathophysiology of the Space Associated Neuro-Ocular Syndrome in astronauts and monitoring patients with chronically impaired cerebrospinal fluid drainage or elevated intracranial pressure. In this proof-of-concept, we demonstrate that: (a) exosomes from different biofluids contain a specific population of RNA transcripts; (b) urine collection hardware aboard the ISS is compatible with exosome gene expression technology; (c) cDNA libraries from exosomal RNA can be stored in dry form and at room temperature, representing an interesting option for the creation of longitudinal molecular catalogs that can be stored as a repository for retrospective analysis.”
Journal Impact Factor: 4.97
Funding: “This research was supported by Grant NNX16AH78G from the Human Research Program (HRP), U.S. National Aeronautics and Space Administration (NASA) to S.Z. Additional support to S.Z. was provided by the 2018 Innovation Charge Account cycle supported by the Johnson Space Center Chief Technology Office (JSC CTO).”
6
Huff JL, Poignant F, Rahmanian S, Khan N, Blakely EA, Britten RA, Chang P, Fornace AJ, Hada M, Kronenberg A, Norman RB, Patel ZS, Shay JW, Weil MM, Simonsen LC, Slaba TC.
Galactic cosmic ray simulation at the NASA Space Radiation Laboratory–Progress, challenges and recommendations on mixed-field effects.
Life Sci Space Res. 2022 Sep 10. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.09.001
PIs: E.A. Blakely, M. Hada, A. Kronenberg, C. Limoli/A.J. Fornace/ M.M. Weil/R.A. Britten/J.W. Shay/NSCOR
Note: From the abstract: “This report includes a summary of the GCRsim [galactic cosmic ray simulator] workshop and a description of the current status of the GCRsim. This information is important for future advancements and applications in space radiobiology.”
Journal Impact Factor: 2.730
Funding: “This work was supported by the Human Research Program of the Space Operations Mission Directorate of the National Aeronautics and Space Administration (NASA) [JLH, TCS, RBN, LCS] and by the Human Health and Performance contract NNJ15HK11B [ZSP]; the NASA Langley Cooperative Agreement 80LARC17C0004 [NK FP, SR]; NASA grants 80JSC02IT0017, NNJ16HP22I and supported by the U.S. Department of Energy Office of Science under Contract No. DE-AC02-05CH11231 [EAB]; NASA grants NNX14AE73G, NNX15AI22G, NNX16AC40G [RAB]; NNX15AI21G [AJF]; NNJ16HP231 [AK]; NNX16AR97G [MH]: NNX15AK13G [MMW]; NNX16AE08G, NNX15AI21G [JWS, distinguished Southland Financial Corporation chair in Geriatrics Research] and the Harold Simmons NCI Designated Comprehensive Cancer Center Support Grant CA142543 [JWS].”
7
Yarbrough D, Gerecht S.
Engineering smooth muscle to understand extracellular matrix remodeling and vascular disease.
Bioengineering. 2022 Sep 7;9(9):449.
https://doi.org/10.3390/bioengineering9090449
PI: S. Gerecht
Note: This article is part of Special Issue “Cell–ECM Interactions for Tissue Engineering and Tissue Regeneration” (https://www.mdpi.com/journal/bioengineering/special_issues/Cell_ECM_Interactions). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 5.046
Funding: “Danielle Yarbrough is a 2022 recipient of the NSF Graduate Research Fellowship Program. Studies of smooth muscle engineering in our lab are partially funded by RAD0102 from the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A.”
8
Borlongan MC, Rosi S.
Stem cell therapy for sequestration of traumatic brain injury-induced inflammation.
Int J Mol Sci. 2022 Sep 7;23(18):10286.
https://www.mdpi.com/1422-0067/23/18/10286
PI: S. Rosi/VNSCOR
Note: This article is part of Special Issue “Molecular Research on Neurodegenerative Diseases 3.0” (https://www.mdpi.com/journal/ijms/special_issues/neurodegenerative_dis3). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 6.208
Funding: “This work was supported by National Institutes of Health grants R01CA133216, R01CA213441 and R01AG056770 (S.R.) and NASA grants NNX14AC94G (S.R.) and 80NSSC19K1581 (S.R.).”
9
Schwertz H, Middleton EA.
Autophagy and its consequences for platelet biology.
Thromb Res. 2022 Aug 28. Online ahead of print.
https://doi.org/10.1016/j.thromres.2022.08.019
PI: H. Schwertz
Journal Impact Factor: 10.079
Funding: “The preparation of this manuscript was supported by National Institutes of Health (1K08HL153953-01 to EAM), and National Aeronautics and Space Administration (NASA, Space Biology 80NSSC22K0255 to HS).”
10
Schwertz H, Rowley JW, Portier I, Middleton EA, Tolley ND, Campbell RA, Eustes AS, Chen K, Rondina MT.
Human platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5.
Autophagy. 2022;18(7):1534-50.
https://doi.org/10.1080/15548627.2021.1990669
PI: H. Schwertz
Note: From the publisher’s website: “Article first published online 18 November 2021.”
Journal Impact Factor: 16.016
Funding: PI reports NASA Space Biology grant 80NSSC22K0255 funding.
11
Lynch OF, Calvi LM.
Immune dysfunction, cytokine disruption, and stromal changes in Myelodysplastic Syndrome: A review.
Cells. 2022;11(3):580.
https://doi.org/10.3390/cells11030580
PI: K. O’Banion
Note: This article is part of Special Issue “The Impact of Immune Activation on Hematopoiesis” (https://www.mdpi.com/journal/cells/special_issues/immune_act). This article may be obtained online without charge.
Journal Impact Factor: 7.666
Funding: “This research was funded by the Evans MDS Discovery Research Grant from the Edward P. Evans Foundation, the Taub Foundation Grants Program for MDS Research from the Henry and Marilyn Taub Foundation, the National Aeronautics and the Space Administration grant 80NSSC21K0542 and the SKAWA Foundation, all to L.M.C.”
12
Titone MK, Goel N, Ng TH, MacMullen LE, Alloy LB.
Impulsivity and sleep and circadian rhythm disturbance predict next-day mood symptoms in a sample at high risk for or with recent-onset bipolar spectrum disorder: An ecological momentary assessment study.
J Affect Disord. 2022 Feb 1;298:17-25.
https://pubmed.ncbi.nlm.nih.gov/34728283
PI: N. Goel
Journal Impact Factor: 6.533
Funding: “This work was supported by MH077908 and MH102310 to Lauren B. Alloy. Writing of this manuscript also was supported by: 1) the Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, Department of Veterans Affairs to Madison Titone, and 2) National Aeronautics and Space Administration (NASA) grants NNX14AN49G and 80NSSC20K0243 and R01DK117488 to Namni Goel.”
13
Pramanik A, Mayer J, Sinha SS, Sharma PC, Patibandla S, Gao Y, Corby LR, Bates JT, Bierdeman MA, Tandon R, Seshadri R, Ray PC.
Human ACE2 peptide-attached plasmonic-magnetic heterostructure for magnetic separation, surface enhanced Raman spectroscopy identification, and inhibition of different variants of SARS-CoV-2 infections.
ACS Appl Bio Mater. 2022 Sep 2. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36053723
PI: R. Tandon
Journal Impact Factor: 3.95
Funding: “P.C.R. acknowledges NSF-RAPID Grant No. DMR-2030439 and NSF-PREM Grant No. DMR-1826886 for their generous funding. We also acknowledge NIH-NIMHD Grant No. 1U54MD015929-01for bioimaging core facility. R.T. is supported by a NASA Award (80NSSC19K1603) and COVID-19 funds from the University of Mississippi Medical Center.”
___________________________________________________
Other papers of interest:
1
Rampoldi A, Forghani P, Li D, Hwang H, Armand LC, Fite J, Boland G, Maxwell J, Maher K, Xu C.
Space microgravity improves proliferation of human iPSC-derived cardiomyocytes.
Stem Cell Reports. 2022 Aug 27;S2213-6711(22)00416-7. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36084640
Note: ISS results. This article may be obtained online without charge.
2
Al Zaman MA, Islam MR, Maruf HMAR, Nizam QMR.
Effectiveness of Kevlar and water-soaked hygienic wipes in a combined radiation shield for manned long term space missions.
Radiat Phys Chem. 2022 Nov;201:110483.
https://doi.org/10.1016/j.radphyschem.2022.110483
Note: From the abstract: “Exposure to Galactic cosmic rays (GCR) and solar particle events (SPE) in long term space missions, astronauts will experience both immediate and delayed impacts. To address space radiation active and passive shielding approaches are available and deploying a suitable coupling of these two shields can be a good solution. This paper presents a combined radiation shield comprising an active toroidal shield with an additional 10 cm layer of a passive shield made of Kevlar or Water-soaked hygienic wipes (WSHW).”
3
Herranz R, da Silveira W, Bezdan D, Giacomello S, Szewczyk N.
Building the Space Omics Topical Team to boost European space researchers’ role in the international consortia redefining spaceflight-generated datasets.
iScience. 2022 Sep 16;25(9):104868.
https://pubmed.ncbi.nlm.nih.gov/36060057
Note: From the abstract: “In a broadening and more competitive space exploration landscape, playing at scale is necessary to obtain results. European researchers share their lessons learned on growing a research program where omics techniques can feed new knowledge, both fundamental and practical, for space exploration. Sending people to new space destinations will require interdisciplinary research centered around omics and personalized medicine, with added constraints of low-gravity and high-radiation environments.” This article may be obtained online without charge.
4
Niu D, Zhang M, Mujumdar AS, Cao P.
Recent progress on quality improvement and detection technologies of special foods used for activities in space and aviation: A review.
Crit Rev Food Sci Nutr. 2022 Sep 5;1-13. Review. Online ahead of print
https://pubmed.ncbi.nlm.nih.gov/36062820
Note: From the abstract: “This paper focuses on the development and evolution, quality improvement and research progress in the rapidly emerging area of new detection technologies of special foods for use in space and to some extent aviation.”
5
Sucosky P, Kalaiarasan VV, Quasebarth GB, Strack P, Shar JA.
Atherogenic potential of microgravity hemodynamics in the carotid bifurcation: A numerical investigation.
npj Microgravity. 2022 Sep 9;8:39.
https://pubmed.ncbi.nlm.nih.gov/36085153
Note: From the abstract: “Long-duration spaceflight poses multiple hazards to human health, including physiological changes associated with microgravity. The hemodynamic adaptations occurring upon entry into weightlessness have been associated with retrograde stagnant flow conditions and thromboembolic events in the venous vasculature but the impact of microgravity on cerebral arterial hemodynamics and function remains poorly understood. The objective of this study was to quantify the effects of microgravity on hemodynamics and wall shear stress (WSS) characteristics in 16 carotid bifurcation geometries reconstructed from ultrasonography images using computational fluid dynamics modeling.” This article may be obtained online without charge.
6
Zong B, Wang Y, Wang J, Zhang P, Kan G, Li M, Feng J, Wang Y, Chen X, Jin R, Ge Q.
Effects of long-term simulated microgravity on liver metabolism in rhesus macaques.
Faseb J. 2022 Sep 7;36(10):e22536.
https://pubmed.ncbi.nlm.nih.gov/36070186
Note: Head-down bed rest study.
7
Zecca F, Nkansah KJ, Travers G, Araujo SV, Green DA.
Reliability of bioreactance-derived hemodynamic monitoring during simulated sustained gravitational transitions induced by short-arm human centrifugation.
Med Eng Phys. 2022 Sep;107:103868.
https://pubmed.ncbi.nlm.nih.gov/36068042
Note: Short-arm human centrifuge results.
8
Zhong Z, Dong H, Wu Y, Zhou S, Li H, Huang P, Tian H, Li X, Xiao H, Yang T, Xiong K, Zhang G, Tang Z, Li Y, Fan X, Yuan C, Ning J, Li Y, Xie J, Li P.
Remote ischemic preconditioning enhances aerobic performance by accelerating regional oxygenation and improving cardiac function during acute hypobaric hypoxia exposure.
Front Physiol. 2022 Sep 9;13:950086.
https://doi.org/10.3389/fphys.2022.950086
Note: This article may be obtained online without charge.
9
Singh VK, Seed TM.
Armed Forces Radiobiology Research Institute/Uniformed Services University of the Health Sciences perspective on space radiation countermeasure discovery.
Life Sci Space Res. 2022 Sep 14. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.09.004
Note: From the abstract: “The Armed Forces Radiobiology Research Institute/Uniformed Services University of the Health Sciences has a long history of researching and developing MCMs specifically designed to support terrestrial-based military missions involving a radiation-threat component. The development of MCMs for both low and high doses of radiation are major aims of current research, and as such can provide lessons learned for the development of countermeasures applicable to future space missions and its extraterrestrial radiation environment.”
10
Arbeille P, Guillon L, Zuj K, Besnard S, Clot C.
A 3D volume capture for ultrasound assessment of various organs and vessels by novice operators.
Acta Astronaut. 2022 Dec 22;201:75-82.
https://doi.org/10.1016/j.actaastro.2022.09.013
Note: From the abstract: “The quality of ultrasound images is dependent on operator skill level. Therefore, an automated system is required for situations, such as spaceflight, where a trained sonographer is not present. The current study compared an automated 3D volume capture method of ultrasound assessment (triggered by novices) with respect to teleoperation by sonographer expert teleoperated assessment (T-echo).”
11
Kanda GN, Tsuzuki T, Terada M, Sakai N, Motozawa N, Masuda T, Nishida M, Watanabe CT, Higashi T, Horiguchi SA, Kudo T, Kamei M, Sunagawa GA, Matsukuma K, Sakurada T, Ozawa Y, Takahashi M, Takahashi K, Natsume T.
Robotic search for optimal cell culture in regenerative medicine.
eLife. 2022 Jun 28;11:e77007.
https://pubmed.ncbi.nlm.nih.gov/35762203
Note: This article may be obtained online without charge.
12
Moiseev SA, Gorodnichev RM.
Motor synergy structure variability in different intensity locomotions.
Human Physiology. 2022 Sep 8;48:370-80.
