NASA Spaceline Current Awareness List #1,016 9 September 2022 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Biancotti JC, Carpo N, Zamudio J, Vergnes L, Espinosa-Jeffrey A.
Profiling the secretome of space traveler human neural stem cells.
J Stem Cell Res Dev Ther. 2022 Jun 10;8:094.
http://dx.doi.org/10.24966/SRDT-2060/100094
PI: A. Espinosa-Jeffrey
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 1.07
Funding: “We thank NASA Space Biology for Grant NNX15AB43G. The IDDRC Cell Culture Core is supported by NIH/NICHD grant number U54HD087101-05.”
2
Allen LA, Kalani AH, Estante F, Rosengren AJ, Stodieck L, Klaus D, Zea L.
Simulated micro-, lunar, and Martian gravities on Earth—effects on Escherichia coli growth, phenotype, and sensitivity to antibiotics.
Life. 2022 Sep 8;12(9):1399.
PI: L. Zea
Note: A clinostat was used in this study. This article is part of Special Issue “Gravitational Microbiology Research and Applications” (https://www.mdpi.com/journal/life/special_issues/gravitational_microbiology). The Special Issue also includes articles from previous Current Awareness Lists #984 https://doi.org/10.3390/life12010047; and #1,006 https://doi.org/10.3390/life12060774 and https://doi.org/10.3390/life12050660; and #1,011 https://doi.org/10.3390/life12081168. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.251
Funding: “This material is based upon work supported by the National Aeronautics and Space Administration under Grant No. 80NSSC18K1468 to L.Z.”
3
Mhatre SD, Iyer J, Petereit J, Dolling-Boreham RM, Tyryshkina A, Paul AM, Gilbert R, Jensen M, Woolsey RJ, Anand S, Sowa MB, Quilici DR, Costes SV, Girirajan S, Bhattacharya S.
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster.
Cell Rep. 2022 Sep 6;40(10):111279.
PIs: S. Bhattacharya, A.M. Paul, NASA Postdoctoral Program Fellowship
Note: From the abstract: “Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in Drosophila aboard the International Space Station in response to spaceflight microgravity (SFμg) and artificially simulated Earth gravity (SF1g) via inflight centrifugation as a countermeasure.” GeneLab is available at
https://genelab.nasa.gov. This article may be obtained online without charge.
Journal Impact Factor: 9.995
Funding: “We would like to thank the ISS Research Integration Office at NASA JSC for funding to S.B. for the validation of the MVP platform (NASA-OZ [2017–2018]). The Nevada Proteomics and Bioinformatics Centers are supported by a grant from the National Institute of General Medical Sciences (GM103440). Bioinformatics is also supported by 5 U54 GM104944. We would like to thank Redwire (previously Techshot, Inc.) for supporting the mission and developing the hardware used.”
4
Wang M, Danz K, Ly V, Rojas-Pierce M.
Microgravity enhances the phenotype of Arabidopsis zigzag-1 and reduces the Wortmannin-induced vacuole fusion in root cells.
npj Microgravity. 2022 Sep 6;8:38.
PI: M. Rojas-Pierce
Note: From the abstract: “The spaceflight environment of the International Space Station poses a multitude of stresses on plant growth including reduced gravity. Plants exposed to microgravity and other conditions on the ISS display root skewing, changes in gene expression and protein abundance that may result in changes in cell wall composition, antioxidant accumulation and modification of growth anisotropy. Systematic studies that address the effects of microgravity on cellular organelles are lacking but altered numbers and sizes of vacuoles have been detected in previous flights. The prominent size of plant vacuoles makes them ideal models to study organelle dynamics in space. Here, we used Arabidopsis zigzag-1 (zig-1) as a sensitized genotype to study the effect of microgravity on plant vacuole fusion.” This article may be obtained online without charge.
Journal Impact Factor: 4.97
Funding: “Special thanks to Dr. Ye Zhang from Kennedy Space Center, Gerard Newsham, Donald Houze, Susan Manning-Roach and Anne Marie Campbell form MEI Technologies for help with the SVT, EVT, and Flight assays. Special thanks to astronaut Thomas Pesquet for conducting the BRIC-PDFU actuation during flight. This work was supported by a grant from the National Aeronautics and Space Administration (80NSSC19K0145 to M.R.P).”
5
Liu Q, Jimenez M, Inda ME, Riaz A, Zirtiloglu T, Chandrakasan AP, Lu TK, Traverso G, Nadeau P, Yazicigil RT.
A threshold-based bioluminescence detector with a CMOS-integrated photodiode array in 65 nm for a multi-diagnostic ingestible capsule.
IEEE J Solid-State Circuits. 2022:1-14.
PI: M. Jimenez
Note: From the abstract: “This article presents a highly miniaturized ingestible electronic capsule for biochemical detection via onboard genetically engineered biosensor bacteria. The core integrated circuit (IC) is a threshold-based bioluminescence detector with a CMOS-integrated photodiode array in a 65-nm technology that utilizes a dual-duty-cycling front end to achieve low power consumption. The implemented IC achieved 59-nW active power consumption, 25-fA/count resolution, and a 59-fA minimum detectable signal (MDS) using a calibrated optical source. The IC was then integrated with other system components into a battery-powered wireless ingestible capsule measuring just 6.5 mm thick × 12 mm diameter. We demonstrated successful detection of low-intensity bioluminescent signals from bioengineered bacterial sensors when exposed to the intestinal inflammation biomarker tetrathionate in vitro. Together, the IC and mm-scale smart pill systems demonstrate high sensitivity with low-power multiplexed measurement capability suitable for noninvasive disease diagnosis and monitoring in the gastrointestinal (GI) tract.” This article may be obtained online without charge.
Journal Impact Factor: 4.755
Funding: “Translational Research Institute of Space Health (Grant Number: NNX16AO69A); 10.13039/100000875-Pew Charitable Trusts (Grant Number: 00030623).”
6
Hoffman JA, Hecht MH, Rapp D, Hartvigsen JJ, SooHoo JG, Aboobaker AM, McClean JB, Liu AM, Hinterman ED, Nasr M, Hariharan S, Horn KJ, Meyen FE, Okkels H, Steen P, Elangovan S, Graves CR, Khopkar P, Madsen MB, Voecks GE, Smith PH, Skafte TL, Araghi KR, Eisenman DJ.
Mars Oxygen ISRU experiment (MOXIE)-Preparing for human Mars exploration.
Sci Adv. 2022 Sep 2;8(35):eabp8636.
Note: From the abstract: “MOXIE [Mars Oxygen In Situ Resource Utilization (ISRU) Experiment] is the first demonstration of ISRU on another planet, producing oxygen by solid oxide electrolysis of carbon dioxide in the martian atmosphere. A scaled-up MOXIE would contribute to sustainable human exploration of Mars by producing on-site the tens of tons of oxygen required for a rocket to transport astronauts off the surface of Mars, instead of having to launch hundreds of tons of material from Earth’s surface to transport the required oxygen to Mars. MOXIE has produced oxygen seven times between landing in February 2021 and the end of 2021 and will continue to demonstrate oxygen production during night and day throughout all martian seasons. This paper reviews what MOXIE has accomplished and the implications for larger-scale oxygen-producing systems.” This article may be obtained online without charge.
Journal Impact Factor: 14.957
Funding: “Portions of this research were carried out at MIT under a contract with the National Aeronautics and Space Administration (NNH17CH01C) and at the Jet Propulsion Laboratory, California Institute of Technology, under NASA contract 80NM0018D0004.”
7
Kilcullen M, Bisbey TM, Rosen M, Salas E.
Does team orientation matter? A state‐of‐the‐science review, meta‐analysis, and multilevel framework.
J Organ Behav. 2022 Mar 22. Review.
PIs: S. Burke, E. Salas
Journal Impact Factor: 10.079
Funding: “This work was partially supported by NASA grants NNX16AB08G and NNX16AP96G and the US Army Research Institute (ARI) for the Behavioral and Social Sciences and was accomplished under Cooperative Agreement Number W911NF‐19‐2‐0173.”
___________________________________________________
Other papers of interest:
1
Zamarioli A, Adam G, Maupin KA, Childress PJ, Brinker A, Ximenez JPB, Chakraborty N, Gautam A, Hammamieh R, Kacena MA.
Systemic effects of BMP2 treatment of fractures on non-injured skeletal sites during spaceflight.
Front Endocrinol (Lausanne). 2022 Aug 15;13:910901.
https://pubmed.ncbi.nlm.nih.gov/36046782
Note: From the abstract: “Unloading associated with spaceflight results in bone loss and increased fracture risk. Bone morphogenetic protein 2 (BMP2) is known to enhance bone formation, in part, through molecular pathways associated with mechanical loading; however, the effects of BMP2 during spaceflight remain unclear. Here, we investigated the systemic effects of BMP2 on mice sustaining a femoral fracture followed by housing in spaceflight (International Space Station or ISS) or on Earth. We hypothesized that in spaceflight, the systemic effects of BMP2 on weight-bearing bones would be blunted compared to that observed on Earth.” This article is part of Research Topic “Impaired Bone Healing due to Bone Disuse and Osteometabolic Disorders” (https://www.frontiersin.org/research-topics/26720/impaired-bone-healing-due-to-bone-disuse-and-osteometabolic-disorders#overview). This article may be obtained online without charge.
2
Lishnevskii AE, Ivanova OA, Inozemtsev KO, Hirn A, Apathy I, Zabori B, Csoke A, Deme S, Pazmandi T, Szanto P, Kartashov DA, Tolochek RV, Kartsev IS, Shurshakov VA.
Monitoring radiation loads and quality factors of ionizing space radiation in the ISS service module with the use of research equipment “Tritel”.
Aviakosm Ekolog Med. 2022;56(4):89-94. Russian.
https://www.elibrary.ru/item.asp?id=49365997
Note: ISS results. From the abstract: “This article reports results of measuring the absorbed doses and quality coefficients of ionizing cosmic radiation in the service module of the International Space Station (ISS), from June through October 2020, with the Tritel dosimeter as part of the Matryoshka-R space experiment.”
3
Mitrikas VG.
Effects of radiation doses on the Russian cosmonauts of the main ISS missions.
Aviakosm Ekolog Med. 2022;56(4):21-6. Russian.
https://www.elibrary.ru/item.asp?id=49365987
Note: ISS results.
4
Boppana A, Priddy ST, Stirling L, Anderson AP.
Challenges in quantifying heel-lift during spacesuit gait.
Aerosp Med Hum Perform. 2022 Aug 1;93(8):643-8.
https://pubmed.ncbi.nlm.nih.gov/36050859
Note: From the abstract: “Data was originally collected by Fineman et al. in 2018 to assess lower body relative coordination in the spacesuit. Inertial measurement units (IMUs) were mounted on the spacesuit lower legs (SLLs) and spacesuit operator’s shank as three operators walked on a level walkway in three spacesuit padding conditions. Discrete wavelet transforms were used to identify foot-flat phase and heel-off for each step. Differences in heel-off timepoints were calculated in each step as a potential indicator of heel-lift, with spacesuit-delayed heel-off suggesting heel-lift. Average drift rates were estimated prior to and after applying zero-velocity (ZVUs) and zero-position updates (ZPUs).”
5
Heinicke C, Verseux C.
The MaMBA facility as a testbed for bioregenerative life support systems.
Life Sci Space Res. 2022 Sep 6. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.08.009
Note: From the abstract: “The Moon and Mars Base Analog (MaMBA) is a concept for an extraterrestrial habitat developed at the Center of Applied Space Technology and Microgravity (ZARM) in Bremen, Germany. The long-term goal of the associated project is to create a technologically functioning prototype for a base on the Moon and on Mars. One key aspect of developing such a prototype base is the integration of a bioregenerative life support system (BLSS) and its testing under realistic conditions. A long-duration mission to Mars, in particular, will require BLSS with a reliability that can hardly be reached without extensive testing, starting well in advance of the mission.”
6
Mu X, He W, Rivera VAM, De Alba RAD, Newman DJ, Zhang YS.
Small tissue chips with big opportunities for space medicine.
Life Sci Space Res. 2022 Sep 8. Review. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.09.002
Note: From the article: “In this review, we describe the technical fundamentals of tissue chips and their promising utility in space medicine. In particular, tissue chips are characterized by small footprints, tissue-level anatomy, and long-term maintenance of the tissue functions, thus highly promising for studying long-term space travel-related biological effects. We also review promising examples of tissue chips for space medicine, including drug development and fundamental biomedicine research, such as cancer biology.”
7
Kudriavtseva NS, Sorokin AE.
Preliminary multi-criteria analysis of the structure of a physical-chemical life support system for a remote space mission vehicle.
Aviakosm Ekolog Med. 2022;56(4):95-101. Russian.
https://www.elibrary.ru/item.asp?id=49365998
Note: From the abstract: “Preliminary structural analysis of a physical-chemical life support system (LSS) was made for a 1000-day mission of 4 crew members from Earth’s orbit to Mars orbit and back using the next 5 criteria: robustness, total equivalent mass, insertion mass and volume, and combined expenses on R&D and reliability testing.”
8
Xu Q, Wang M, Wang H, Liu B, You X, Ji M.
Cognitive style and flight experience influence on confirmation bias in lost procedures.
Aerosp Med Hum Perform. 2022 Aug;93(8):618-26.
https://pubmed.ncbi.nlm.nih.gov/36050854
Note: From the abstract: “Accident analysis and empirical research have shown that the decision-making process of pilots after becoming lost is adversely affected by confirmation bias; this constitutes a serious threat to aviation safety. However, the underlying mechanism of confirmation bias in the context of lost procedures are still unclear. This study used scenario-based map-reading tasks to conduct two experiments to explore the mechanism of confirmation bias in the lost procedures. In Experiment 1, 34 undergraduate students and 28 flying cadets were enrolled in a formal experiment to examine the effects of verbal-imagery cognitive style, experience level, and their interaction on confirmation bias. In Experiment 2, we further explored the influence of strategy as a core component of experience on confirmation bias with 26 flying cadets.”
9
Ilyin LA, Vasin MV, Ushakov IB.
Tolerance of drug B-190 (indralin), its effect on pilot’s professional activities and resistance to extreme flight factors.
Aviakosm Ekolog Med. 2022;56(4):27-34. Russian.
https://www.elibrary.ru/item.asp?id=49365988
10Rozhkov SV, Sharlo KA, Shenkman BS, Mirzoev ТМ.
Contribution of mTORC1 and GSK-3 to the regulation of ribosome biogenesis in rat postural muscle under simulated microgravity.
Aviakosm Ekolog Med. 2022;56(4):44-52. Russian.
https://www.elibrary.ru/item.asp?id=49365990
Note: Hindlimb unloading results.
11Bychkova TM, Nikitenko OV, Utina DM, Ivanov АА.Effect of long-term fractionated γ-irradiation on mice lifespan.
Aviakosm Ekolog Med. 2022;56(4):77-82. Russian.
https://www.elibrary.ru/item.asp?id=49365995
12
Nisar S, Masoodi T, Prabhu KS, Kuttikrishnan S, Zarif L, Khatoon S, Ali S, Uddin S, Akil AA, Singh M, Macha MA, Bhat AA.
Natural products as chemo-radiation therapy sensitizers in cancers.
Biomed Pharmacother. 2022 Oct;154:113610. Review.
https://pubmed.ncbi.nlm.nih.gov/36030591
13
Peng X, Liu Y, He W, Hoppe ED, Zhou L, Xin F, Haswell ES, Pickard BG, Genin GM, Lu TJ.
Acoustic radiation force on a long cylinder, and potential sound transduction by tomato trichomes.
Biophys J. 2022 Aug 30;S0006-3495(22)00707-X. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36045574
14
Yasnetsov VV, Kaurova DE.
Administration in extreme conditions of medicines based on nicotinic acid and its derivatives.
Aviakosm Ekolog Med. 2022;56(4):35-43. Review. Russian.
https://elibrary.ru/item.asp?id=49365989
15
Yu JJ, Non AL, Heinrich EC, Gu W, Alcock J, Moya EA, Lawrence ES, Tift MS, O’Brien KA, Storz JF, Signore AV, Khudyakov JI, Milsom WK, Wilson SM, Beall CM, Villafuerte FC, Stobdan T, Julian CG, Moore LG, Fuster MM, Stokes JA, Milner R, West JB, Zhang J, Shyy JY, Childebayeva A, Vázquez-Medina JP, Pham LV, Mesarwi OA, Hall JE, Cheviron ZA, Sieker J, Blood AB, Yuan JX, Scott GR, Rana BK, Ponganis PJ, Malhotra A, Powell FL, Simonson TS.
Time domains of hypoxia responses and -omics insights.
Front Physiol. 2022 Aug 8;13:885295. Review.
https://pubmed.ncbi.nlm.nih.gov/36035495
Note This article is part of Research Topic “Time Domains of Hypoxia Adaptation: Evolutionary Insights and Applications, Volume II” (https://www.frontiersin.org/research-topics/17159/time-domains-of-hypoxia-adaptation-evolutionary-insights-and-applications-volume-ii#overview). This article may be obtained online without charge.
16
Weng M, Guo M, Li T, Zhou C, Sun C, Yue Y, Liao Q, Cai S, Lu X, Zhou D, Miao C.
Anemia tolerance versus blood transfusion on long-term outcomes after colorectal cancer surgery: A retrospective propensity-score-matched analysis.
Front Oncol. 2022 Aug 15;12:940428.
https://pubmed.ncbi.nlm.nih.gov/36046042
Note: This article is part of Research Topic “Perioperative Management and Cancer Outcome” (https://www.frontiersin.org/research-topics/36490/perioperative-management-and-cancer-outcome#overview). This article may be obtained online without charge.
17
Ayaz H, Baker WB, Blaney G, Boas DA, Bortfeld H, Brady K, Brake J, Brigadoi S, Buckley EM, Carp SA, Cooper RJ, Cowdrick KR, Culver JP, Dan I, Dehghani H, Devor A, Durduran T, Eggebrecht AT, Emberson LL, Fang Q, Fantini S, Franceschini MA, Fischer JB, Gervain J, Hirsch J, Hong KS, Horstmeyer R, Kainerstorfer JM, Ko TS, Licht DJ, Liebert A, Luke R, Lynch JM, Mesquida J, Mesquita RC, Naseer N, Novi SL, Orihuela-Espina F, O’Sullivan TD, Peterka DS, Pifferi A, Pollonini L, Sassaroli A, Sato JR, Scholkmann F, Spinelli L, Srinivasan VJ, St Lawrence K, Tachtsidis I, Tong Y, Torricelli A, Urner T, Wabnitz H, Wolf M, Wolf U, Xu S, Yang C, Yodh AG, Yücel MA, Zhou W.
Optical imaging and spectroscopy for the study of the human brain: Status report.
Neurophotonics. 2022 Aug 30;9(Suppl 2):S24001.
https://pubmed.ncbi.nlm.nih.gov/36052058
Note: This article may be obtained online without charge.
18
Belova SP, Tyganova SA, Shenkman BS.
Changes in mechanical properties and myosin phenotype of the postural and locomotor muscles after 21-days of limited mobility.
Aviakosm Ekolog Med. 2022;56(4)70-6:Russian.
https://elibrary.ru/item.asp?id=49365994
19
Kochergin AY, Markin AA, Zhuravleva OA, Vostrikova LV, Zabolotskaya IV, Kuzichkin DS, Zhuravleva TV, Smirnova TA, Vorontsov AL.
Effects of 21-days of head-down bed rest on the hemostasis system of a healthy human.
Aviakosm Ekolog Med. 2022;56(4):59-63. Russian.
https://www.elibrary.ru/item.asp?id=49365992
Note: Head-down bed rest study.
20
Lafontant A, Mahanna Gabrielli E, Bergonzi K, Forti RM, Ko TS, Shah RM, Arkles JS, Licht DJ, Yodh AG, Kofke WA, White BR, Baker WB.
Comparison of optical measurements of critical closing pressure acquired before and during induced ventricular arrhythmia in adults.
Neurophotonics. 2022 Aug 25;9(3):035004.
https://pubmed.ncbi.nlm.nih.gov/36039170
Note: This article may be obtained online without charge.
21
Ratushny AY, Buravkova LB.
Differentiation potential of the mesenchymal stromal cells during replicative senescence.
Aviakosm Ekolog Med. 2022;56(4):Russian.
https://elibrary.ru/item.asp?id=49365993
Note: From the abstract: “Mesenchymal stromal/stem cells (MSCs) are capable of multilinear differentiation and are involved in tissue homeostasis, including the remodeling and repair processes. With age, these cells can increasingly activate senescence (cell aging) that alters cell functions and their microenvironment, which can be the reason for age-related pathologies. One of the features of senescent MSCs is thought to be a decline of multipotency that may limit their reparative functions in tissues. This paper presents a study of the MSCs osteogenic and adipogenic potential during replicative senescence.”
22Schastlivtseva DV, Kotrovskaya TI, Koloteva MI, Glebova ТМ.
Dynamics of the brain biopotentials in volunteers for modeled head-to-pelvis g-loads (+GZ) on a short-arm human centrifuge.
Aviakosm Ekolog Med. 2022;56(4):53-8. Russian.
https://www.elibrary.ru/item.asp?id=49365991
Note: Short-arm human centrifuge results.
