Release of CASIS Request for Information-3D Microphysiological Systems for Organs-On-Chips Research

The Center for the Advancement of Science in Space (CASIS) is pleased to release this Request For Information (RFI) to gather information from subject matter experts and entities with experience and/or research and development programs in tissue engineering or microphysiological systems related to tissues-on-a-chip, organs-on-chips, or 3D organotypic tissue constructs that recapitulate the microarchitecture and functions of living organs using human cells.

This RFI represents an opportunity to bring new tools to biology, medicine, pharmacology, physiology, and toxicology for research applications on the ISS National Lab to benefit human disease research, tissue engineering and regenerative medicine on Earth. CASIS plans to develop a sponsored research program that will provide opportunities for research on the ISS National Lab seeking to use microphysiological systems in microgravity to create and/or interrogate 3D, in-vitro models for bone and cartilage, skeletal muscle, brain, gastrointestinal tract, lung, liver, microvasculature, skin, and other tissues.

This RFI seeks responses from experts and entities to identify the appropriate in-vitro models and platform technologies for fundamental discovery or translational research in microgravity where outcomes may be extrapolated to understanding whole organism response.

The RFI can be accessed through NSPIRES at:  http://nspires.nasaprs.com/external/solicitations/summary.do?method=init&solId={90AF503E-2814-2780-5EB3-0C484AD0ED9C}&path=open

Responses are due September 8, 2015.