Status Report

NASA Spaceline Current Awareness List #999 13 May 2022 (Space Life Science Research Results)

By SpaceRef Editor
May 13, 2022
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
Hupfeld KE, Richmond SB, McGregor HR, Schwartz DL, Luther MN, Beltran NE, Kofman IS, De Dios YE, Riascos RF, Wood SJ, Bloomberg JJ, Mulavara AP, Silbert LC, Iliff JJ, Seidler RD, Piantino J.
Longitudinal [magnetic resonance imaging] MRI-visible perivascular space (PVS) changes with long-duration spaceflight.
Sci Rep. 2022 May 5;12:7238.
PI: R.D. Seidler
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 4.380
Funding: “This work was supported by grants from the National Aeronautics and Space Administration (NASA NNX11AR02G) and the National Space Biomedical Research Institute (#NCC 9-58) to RS, AM, SW, and JB. During completion of this work, KH was supported by a National Science Foundation Graduate Research Fellowship under Grant no. DGE-1315138 and DGE-1842473, National Institute of Neurological Disorders and Stroke training grant T32-NS082128, and National Institute on Aging fellowship 1F99AG068440. DS was supported by the National Institute on Aging under Grant nos. R01AG056712 and P30AG008017. LS was supported by the National Institute on Aging under Grant no. P30AG066518. JP was supported by the National Heart Lung and Blood Institute under Grant no. K23HL150217-01. The authors also wish to thank all of the astronauts who volunteered their time, without whom this project would not have been possible.”
Lee AG, Mader TH, Gibson CR, Tarver W, Brunstetter T.
Lower body negative pressure as a potential countermeasure for spaceflight-associated neuro-ocular syndrome.
JAMA Ophthalmol. 2022 May 5. Online ahead of print.
Note: This article is a Response to an Original Investigation article by Hearon et al. that appeared in Current Awareness List #979
Journal Impact Factor: 7.4
Funding: W. Tarver is affiliated with NASA Johnson Space Center.
DiGiacomo J, McKay C, Davila A.
ThermoBase: A database of the phylogeny and physiology of thermophilic and hyperthermophilic organisms.
PLoS One. 2022 May 10;17(5):e0268253.
Note: From the abstract: “Thermophiles and hyperthermophiles are those organisms which grow at high temperature (> 40°C). The unusual properties of these organisms have received interest in multiple fields of biological research, and have found applications in biotechnology, especially in industrial processes. However, there are few listings of thermophilic and hyperthermophilic organisms and their relevant environmental and physiological data. Such repositories can be used to standardize definitions of thermophile and hyperthermophile limits and tolerances and would mitigate the need for extracting organism data from diverse literature sources across multiple, sometimes loosely related, research fields.” This article may be obtained online without charge.
Journal Impact Factor: 3.240
Funding: “This work was supported by the NASA Internal Scientist Funding Model (Habitable Environments and Biosignatures Project).”
Other papers of interest:
Berkovich YA, Buryak AA, Ochkov OA, Smolyanina SO, Lapach SN.
Minimization of the equivalent system mass of a vitamin greenhouse with LED lighting for various scenarios of space missions.
Acta Astronautica. 2022 May 7. Online ahead of print.
Note: From the abstract: “To improve the habitat of the manned spacecraft (MS) crews with fresh vitamin greens, relatively small and economical space greenhouses (SG) with LED-based lamps (LED) can be used. In order to reduce the costs of onboard resources when growing plants in SG, the method of adaptive search optimization of the lighting parameters of plants during their growth was used.”
Kuang S, Singh NM, Wu Y, Shen Y, Ren W, Tu L, Yong KT, Song P.
Role of microfluidics in accelerating new space missions.
Biomicrofluidics. 2022 Apr 21;16(2):021503. Review.
Note: From the abstract: “In this review, we focus on recent advances in space microfluidic technologies and their impact on the state-of-the-art space missions.”
Oronsky B, Caroen S, Abrouk N, Reid TR.
RRx-001 and the right stuff: Protection and treatment in outer space.
Life Sci Space Res. 2022 May 12. Online ahead of print.
Note: From the abstract: “From antibiotics to aspirin to antimalarials and to anticancer agents, about half of the world’s best-selling drugs are derived from nature. However, accelerating climatic disruption, habitat destruction, pollution, and biodiversity loss all negatively impact the potential of natural sources to continue to serve as repositories of novel pharmaceuticals. On that basis, the final frontier for drug development is perhaps not the rainforests, coral reefs, and other natural habitats but rather the aerospace industry with its virtually unlimited and inexhaustible man-made ‘library’ of potentially bioactive compounds.” This article may be obtained online without charge.
Zatsepilin AV, Khomenko MN, Filatov VN, Chistov SD, Simukhin VV, Kislyakov YY.
Psychophysiological aspects of executing supermaneuver flights.
Aviakosm Ekolog Med. 2022;56(2):39-45. Russian.
Note: From the abstract: “The authors propose methods of psychophysiological training substantiated by the results of analysis of pilots’ entries in a questionnaire addressing some psychophysiological aspects of flying supermaneuver aircrafts.”
Bruno V, Sarasso P, Fossataro C, Ronga I, Neppi-Modona M, Garbarini F.
The rubber hand illusion in microgravity and water immersion.
npj Microgravity. 2022 May 6;8:15.
Note: Parabolic flight and water immersion results. This article may be obtained online without charge.
Burmistrov VI, Ivanov IV, Matkevich EI, Praskurichiy ЕА.
Analysis of the significance of factors contributing to the pilotless vehicle accident rate.
Aviakosm Ekolog Med. 2022;56(2):73-84. Russian.
Note: From the abstract: “Analysis of the air accident rates of MQ-1 Predators and MQ-9 Reapers from the Drone Crash Database for the period from 2001 through 2021 (12 countries, 174 accidents total) disclosed major factors, including human, for accidents.”
Ivanov IV, Milanin АА, Zhelty OP, Stas YV.
Medico-psychological correction of emotional stress with hyperventilation: Assessment of clinical effects and indications for application to pilots and combatants.
Aviakosm Ekolog Med. 2022;56(2):54-63. Russian.
Pisarenko YE, Chulaevsky АО, Rybnikova MN.
Up-to-date approach to improvement of the system of professional psychological selection of military test-pilots.
Aviakosm Ekolog Med. 2022;56(2):46-53. Russian.
Ryumin OO, Voitenko АМ.
Important managerial qualities of the interplanetary crew commander: Structure, assessment, development.
Aviakosm Ekolog Med. 2022;56(2):5-10. Russian.
Soldatov SK, Dragan SP, Bogomolov AV, Pirozhkov MV, Skryabin SY, Gorodenko OV, Sinelnikov IA.
Hygienic aspects of the noise generated by aerodrome facilities.
Aviakosm Ekolog Med. 2022;56(2):85-89. Russian.
Note: From the abstract: “This article discusses the assessment of acoustic working conditions of the engineering and technical staff (ITS) serving modern aviation complexes.”
Budhwani KI, Patel ZH, Guenter RE, Charania AA.
A hitchhiker’s guide to cancer models.
Trends Biotechnol. 2022 May 7;S0167-7799(22)00101-9. Review. Online ahead of print.
Note: From the abstract: “Cancer is a complex and uniquely personal disease. More than 1.7 million people in the United States are diagnosed with cancer every year. As the burden of cancer grows, so does the need for new, more effective therapeutics and for predictive tools to identify optimal, personalized treatment options for every patient. Cancer models that recapitulate various aspects of the disease are fundamental to making advances along the continuum of cancer treatment from benchside discoveries to bedside delivery. In this review, we use a thought experiment as a vehicle to arrive at four broad categories of cancer models and explore the strengths, weaknesses, opportunities, and threats for each category in advancing our understanding of the disease and improving treatment strategies.”
Boldt K, Joumaa V, Turnbull J, Fedak PWM, Herzog W.
A high-whey-protein diet does not enhance mechanical and structural remodeling of cardiac muscle in response to aerobic exercise in rats.
Phys Act Nutr. 2022 Mar 31;26(1):28-38.
Note: This article may be obtained online without charge.
Vilchinskaya NA, Rozhkov SV, Komarova MY, Dmitrieva RI, Shenkman BS.
Effect of modeled gravitational unloading on soleus muscle satellite cells.
Aviakosm Ekolog Med. 2022;56(2):20-9. Russian.
Note: Hindlimb unloading study.
Zhao D, Wang X, Cheng B, Yin M, Hou Z, Li X, Liu K, Tie C, Yin M.
Degradation-kinetics-controllable and tissue-regeneration-matchable photocross-linked alginate hydrogels for bone repair.
ACS Appl Mater Interfaces. 2022 May 4. Online ahead of print.
Kundapur V, Mayer M, Auer RN, Alexander A, Weibe S, Pushie MJ, Cranmer-Sargison G.
Is mini beam ready for human trials? Results of randomized study of treating De-Novo brain tumors in canines using linear accelerator generated mini beams.
Radiat Res. 2022 May. Online ahead of print.
Lebedeva-Gueorgievskaya KB, Perevezentsev AA, Kuznetsova OS, Kudrin VS, Mitrofanova OV, Masanova AA, Shtemberg AS.
Molecular, neurophysiological, and integrative effects of the combined exposure to tail-suspension and ionizing radiation in rats.
Aviakosm Ekolog Med. 2022;56(2):30-8. Russian.
Filatov VN, Shishov АА, Dvornikov MV, Shishkin AN, Ryzhov DI, Nikiforov DA.
Hypobaric chamber as a method of psychophysiological training for risky occupations associated with exposure to high-level hypoxia.
Aviakosm Ekolog Med. 2022;56(2):64-72. Russian.
McCann HM, Lake BPM, Hoffman KS, Davola ME, Mossman KL, Rullo AF.
Covalent immune proximity-induction strategy using SuFEx-engineered bifunctional viral peptides.
ACS Chem Biol. 2022 May 6. Online ahead of print.
Note: From the abstract: “Covalent antibody recruiting molecules (cARMs) constitute a proximity-inducing chemical strategy to modulate the recognition and elimination of cancer cells by the immune system. Recognition is achieved through synthetic bifunctional molecules that use covalency to stably bridge endogenous hapten-specific antibodies like anti-dinitrophenyl (anti-DNP), with tumor antigens on cancer cell surfaces. To recruit these antibodies, cARMs are equipped with the native hapten-binding molecule. The majority of cancer-killing immune machinery, however, recognizes epitopes on protein ligands and not small molecule haptens (e.g., Fc receptors, pathogen-specific antibodies). To access this broader class of immune machinery for recruitment, we developed a covalent immune proximity-inducing strategy.” This article may be obtained online without charge.
de Jong FJM, Wingelaar TT, Brinkman P, van Ooij P-JAM, Maitland-van der Zee A-H, Hollmann MW, van Hulst RA.
Pulmonary oxygen toxicity through exhaled breath markers after hyperbaric oxygen treatment table 6.
Front Physiol. 2022 May 10;13:899568.
Note: This article may be obtained online without charge.
Baldassarre G, Zuccarelli L, Manferdelli G, Manfredini V, Marzorati M, Pilotto A, Porcelli S, Rasica L, Šimunič B, Pišot R, Narici M, Grassi B.
Decrease in work rate in order to keep a constant heart rate: Biomarker of exercise intolerance following a 10-day bed rest.
J Appl Physiol (1985). 2022 May 5. Online ahead of print.
Note: Bedrest study. This article may be obtained online without charge.
Tamma G, Di Mise A, Ranieri M, Centrone M, Venneri M, D’Agostino M, Ferrulli A, Šimunič B, Narici M, Pisot R, Valenti G.
Early biomarkers of altered renal function and orthostatic intolerance during 10-day bedrest.
Front Physiol. 2022 Apr 20;13:858867.
Note: Bedrest study. This article may be obtained online without charge.
Irmak T, Kotian V, Happee R, de Winkel KN, Pool DM.
Amplitude and temporal dynamics of motion sickness.
Front Syst Neurosci. 2022 May 9;16:866503.
Note: This article may be obtained online without charge.
Matyushev TV, Dvornikov MV, Ryzhenkov SP, Maksimova ID, Rybina AS, Malyshev AD, Noskov RG.
Theoretical evaluation of the human decompression tolerance inside a depresserized hermetic cabin.
Aviakosm Ekolog Med. 2022;56(2):90-7. Russian.
Vlasova DD, Sadova AA, Galina VS, Guermanov NS, Rykova MP, Antropova EN, Kutko OV, Shulguina SM, Orlova KD, Shmarov VA, Lysenko EA, Ponomarev SA.
Effect of 21-day dry immesrion on expression of inborn immunity genes associated with the Toll-like receptors’ signaling pathways.
Aviakosm Ekolog Med. 2022;56(2):11-9. Russian.
Note: Dry immersion results.
Xiang J, Zhou L, Xie Y, Zhu Y, Xiao L, Chen Y, Zhou W, Chen D, Wang M, Cai L, Guo L.
Mesh-like electrospun membrane loaded with atorvastatin facilitates cutaneous wound healing by promoting the paracrine function of mesenchymal stem cells.
Stem Cell Res Ther. 2022 May 7;13:190.
Note: This article may be obtained online without charge.

SpaceRef staff editor.