NASA Spaceline Current Awareness List #999 13 May 2022 (Space Life Science Research Results)

 

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

 

Papers deriving from NASA support:

 

1

Hupfeld KE, Richmond SB, McGregor HR, Schwartz DL, Luther MN, Beltran NE, Kofman IS, De Dios YE, Riascos RF, Wood SJ, Bloomberg JJ, Mulavara AP, Silbert LC, Iliff JJ, Seidler RD, Piantino J.

Sci Rep. 2022 May 5;12:7238.

PI: R.D. Seidler

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.380

Funding: “This work was supported by grants from the National Aeronautics and Space Administration (NASA NNX11AR02G) and the National Space Biomedical Research Institute (#NCC 9-58) to RS, AM, SW, and JB. During completion of this work, KH was supported by a National Science Foundation Graduate Research Fellowship under Grant no. DGE-1315138 and DGE-1842473, National Institute of Neurological Disorders and Stroke training grant T32-NS082128, and National Institute on Aging fellowship 1F99AG068440. DS was supported by the National Institute on Aging under Grant nos. R01AG056712 and P30AG008017. LS was supported by the National Institute on Aging under Grant no. P30AG066518. JP was supported by the National Heart Lung and Blood Institute under Grant no. K23HL150217-01. The authors also wish to thank all of the astronauts who volunteered their time, without whom this project would not have been possible.”

 

2

Lee AG, Mader TH, Gibson CR, Tarver W, Brunstetter T.

JAMA Ophthalmol. 2022 May 5. Online ahead of print.

Note: This article is a Response to an Original Investigation article by Hearon et al. that appeared in Current Awareness List #979 https://pubmed.ncbi.nlm.nih.gov/34882176.

Journal Impact Factor: 7.4

Funding: W. Tarver is affiliated with NASA Johnson Space Center.

 

3

DiGiacomo J, McKay C, Davila A.

PLoS One. 2022 May 10;17(5):e0268253.

Note: From the abstract: “Thermophiles and hyperthermophiles are those organisms which grow at high temperature (> 40°C). The unusual properties of these organisms have received interest in multiple fields of biological research, and have found applications in biotechnology, especially in industrial processes. However, there are few listings of thermophilic and hyperthermophilic organisms and their relevant environmental and physiological data. Such repositories can be used to standardize definitions of thermophile and hyperthermophile limits and tolerances and would mitigate the need for extracting organism data from diverse literature sources across multiple, sometimes loosely related, research fields.” This article may be obtained online without charge.

Journal Impact Factor: 3.240

Funding: “This work was supported by the NASA Internal Scientist Funding Model (Habitable Environments and Biosignatures Project).”

 

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Other papers of interest:

 

1

Berkovich YA, Buryak AA, Ochkov OA, Smolyanina SO, Lapach SN.

Acta Astronautica. 2022 May 7. Online ahead of print.

Note: From the abstract: “To improve the habitat of the manned spacecraft (MS) crews with fresh vitamin greens, relatively small and economical space greenhouses (SG) with LED-based lamps (LED) can be used. In order to reduce the costs of onboard resources when growing plants in SG, the method of adaptive search optimization of the lighting parameters of plants during their growth was used.”

 

2

Kuang S, Singh NM, Wu Y, Shen Y, Ren W, Tu L, Yong KT, Song P.

Biomicrofluidics. 2022 Apr 21;16(2):021503. Review.

Note: From the abstract: “In this review, we focus on recent advances in space microfluidic technologies and their impact on the state-of-the-art space missions.”

 

3

Oronsky B, Caroen S, Abrouk N, Reid TR.

Life Sci Space Res. 2022 May 12. Online ahead of print.

Note: From the abstract: “From antibiotics to aspirin to antimalarials and to anticancer agents, about half of the world’s best-selling drugs are derived from nature. However, accelerating climatic disruption, habitat destruction, pollution, and biodiversity loss all negatively impact the potential of natural sources to continue to serve as repositories of novel pharmaceuticals. On that basis, the final frontier for drug development is perhaps not the rainforests, coral reefs, and other natural habitats but rather the aerospace industry with its virtually unlimited and inexhaustible man-made ‘library’ of potentially bioactive compounds.” This article may be obtained online without charge.

 

4

Zatsepilin AV, Khomenko MN, Filatov VN, Chistov SD, Simukhin VV, Kislyakov YY.

Aviakosm Ekolog Med. 2022;56(2):39-45. Russian.

Note: From the abstract: “The authors propose methods of psychophysiological training substantiated by the results of analysis of pilots’ entries in a questionnaire addressing some psychophysiological aspects of flying supermaneuver aircrafts.”

 

5

Bruno V, Sarasso P, Fossataro C, Ronga I, Neppi-Modona M, Garbarini F.

npj Microgravity. 2022 May 6;8:15.

Note: Parabolic flight and water immersion results. This article may be obtained online without charge.

 

6

Aviakosm Ekolog Med. 2022;56(2):73-84. Russian.

Note: From the abstract: “Analysis of the air accident rates of MQ-1 Predators and MQ-9 Reapers from the Drone Crash Database for the period from 2001 through 2021 (12 countries, 174 accidents total) disclosed major factors, including human, for accidents.”

 

7

Aviakosm Ekolog Med. 2022;56(2):54-63. Russian.

 

8

Aviakosm Ekolog Med. 2022;56(2):46-53. Russian.

 

9

Aviakosm Ekolog Med. 2022;56(2):5-10. Russian.

 

10

Soldatov SK, Dragan SP, Bogomolov AV, Pirozhkov MV, Skryabin SY, Gorodenko OV, Sinelnikov IA.

Aviakosm Ekolog Med. 2022;56(2):85-89. Russian.

Note: From the abstract: “This article discusses the assessment of acoustic working conditions of the engineering and technical staff (ITS) serving modern aviation complexes.”

 

11

Budhwani KI, Patel ZH, Guenter RE, Charania AA.

Trends Biotechnol. 2022 May 7;S0167-7799(22)00101-9. Review. Online ahead of print.

Note: From the abstract: “Cancer is a complex and uniquely personal disease. More than 1.7 million people in the United States are diagnosed with cancer every year. As the burden of cancer grows, so does the need for new, more effective therapeutics and for predictive tools to identify optimal, personalized treatment options for every patient. Cancer models that recapitulate various aspects of the disease are fundamental to making advances along the continuum of cancer treatment from benchside discoveries to bedside delivery. In this review, we use a thought experiment as a vehicle to arrive at four broad categories of cancer models and explore the strengths, weaknesses, opportunities, and threats for each category in advancing our understanding of the disease and improving treatment strategies.”

 

12

Boldt K, Joumaa V, Turnbull J, Fedak PWM, Herzog W.

Phys Act Nutr. 2022 Mar 31;26(1):28-38.

Note: This article may be obtained online without charge.

 

13

Vilchinskaya NA, Rozhkov SV, Komarova MY, Dmitrieva RI, Shenkman BS.

Aviakosm Ekolog Med. 2022;56(2):20-9. Russian.

Note: Hindlimb unloading study.

 

14

Zhao D, Wang X, Cheng B, Yin M, Hou Z, Li X, Liu K, Tie C, Yin M.

ACS Appl Mater Interfaces. 2022 May 4. Online ahead of print.

 

15

Kundapur V, Mayer M, Auer RN, Alexander A, Weibe S, Pushie MJ, Cranmer-Sargison G.

Radiat Res. 2022 May. Online ahead of print.

 

16

Lebedeva-Gueorgievskaya KB, Perevezentsev AA, Kuznetsova OS, Kudrin VS, Mitrofanova OV, Masanova AA, Shtemberg AS.

Aviakosm Ekolog Med. 2022;56(2):30-8. Russian.

 

17

Aviakosm Ekolog Med. 2022;56(2):64-72. Russian.

 

18

McCann HM, Lake BPM, Hoffman KS, Davola ME, Mossman KL, Rullo AF.

ACS Chem Biol. 2022 May 6. Online ahead of print.

Note: From the abstract: “Covalent antibody recruiting molecules (cARMs) constitute a proximity-inducing chemical strategy to modulate the recognition and elimination of cancer cells by the immune system. Recognition is achieved through synthetic bifunctional molecules that use covalency to stably bridge endogenous hapten-specific antibodies like anti-dinitrophenyl (anti-DNP), with tumor antigens on cancer cell surfaces. To recruit these antibodies, cARMs are equipped with the native hapten-binding molecule. The majority of cancer-killing immune machinery, however, recognizes epitopes on protein ligands and not small molecule haptens (e.g., Fc receptors, pathogen-specific antibodies). To access this broader class of immune machinery for recruitment, we developed a covalent immune proximity-inducing strategy.” This article may be obtained online without charge.

 

19

de Jong FJM, Wingelaar TT, Brinkman P, van Ooij P-JAM, Maitland-van der Zee A-H, Hollmann MW, van Hulst RA.

Front Physiol. 2022 May 10;13:899568.

Note: This article may be obtained online without charge.

 

20

Baldassarre G, Zuccarelli L, Manferdelli G, Manfredini V, Marzorati M, Pilotto A, Porcelli S, Rasica L, Šimunič B, Pišot R, Narici M, Grassi B.

J Appl Physiol (1985). 2022 May 5. Online ahead of print.

Note: Bedrest study. This article may be obtained online without charge.

 

21

Tamma G, Di Mise A, Ranieri M, Centrone M, Venneri M, D’Agostino M, Ferrulli A, Šimunič B, Narici M, Pisot R, Valenti G.

Front Physiol. 2022 Apr 20;13:858867.

Note: Bedrest study. This article may be obtained online without charge.

 

22

Irmak T, Kotian V, Happee R, de Winkel KN, Pool DM.

Amplitude and temporal dynamics of motion sickness.

Front Syst Neurosci. 2022 May 9;16:866503.

Note: This article may be obtained online without charge.

 

23

Matyushev TV, Dvornikov MV, Ryzhenkov SP, Maksimova ID, Rybina AS, Malyshev AD, Noskov RG.

Aviakosm Ekolog Med. 2022;56(2):90-7. Russian.

 

24

Vlasova DD, Sadova AA, Galina VS, Guermanov NS, Rykova MP, Antropova EN, Kutko OV, Shulguina SM, Orlova KD, Shmarov VA, Lysenko EA, Ponomarev SA.

Aviakosm Ekolog Med. 2022;56(2):11-9. Russian.

Note: Dry immersion results.

 

25

Xiang J, Zhou L, Xie Y, Zhu Y, Xiao L, Chen Y, Zhou W, Chen D, Wang M, Cai L, Guo L.

Stem Cell Res Ther. 2022 May 7;13:190.

Note: This article may be obtained online without charge.