Status Report

NASA Spaceline Current Awareness List #997 29 April 2022 (Space Life Science Research Results)

By SpaceRef Editor
April 29, 2022
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
Mehta SK, Szpara ML, Rooney BV, Diak DM, Shipley MM, Renner DW, Krieger SS, Nelman-Gonzalez MA, Zwart SR, Smith SM, Crucian BE.
Dermatitis during spaceflight associated with HSV-1 reactivation.
Viruses. 2022 Apr 11;14(4):789.
PIs: S.K. Mehta, S.R. Zwart, S.M. Smith, B.E. Crucian
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 5.048
Funding: “This research was funded by the NASA Human Research Program, Human Health and Countermeasures Element, via a directed study to Brian E. Crucian, and by National Institutes of Health R01 AI132692 (to M.L.S.).”
Greene KA, Tooze JA, Lenchik L, Weaver AA.
Change in lumbar muscle size and composition on MRI with long-duration spaceflight.
Ann Biomed Eng. 2022 Apr 22.
PI: A.A. Weaver
Note: The spaceflight information is not evident in the available abstract.
Journal Impact Factor: 3.934
Funding: “The authors thank Charlie Warren, Meredith Rossi, and Saroochi Agarwal from NASA’s Lifetime Surveillance of Astronaut Health and Life Sciences Data Archive for preparing the imaging dataset and in-flight exercise data used in this study. Funding was provided by the NASA Human Research Program (NNX16AP89G). Dr. Ashley Weaver is supported by a NIH/NIA Career Development Award (K25 AG058804) and Katelyn Greene is supported by a NIH/NIA Predoctoral Fellowship (F31 AG069414).”
Ong J, Tavakkoli A, Strangman G, Zaman N, Kamran SA, Zhang Q, Ivkovic V, Lee AG.
Neuro-ophthalmic imaging and visual assessment technology for spaceflight associated neuro-ocular syndrome (SANS).
Surv Ophthalmol. 2022 Apr 21;S0039-6257(22)00048-0. Review. Online ahead of print.
PIs: A. Tavakkoli, G. Strangman
Note: From the abstract: “Spaceflight associated neuro-ocular syndrome (SANS) refers to a unique collection of neuro-ophthalmic clinical and imaging findings observed in astronauts after long duration spaceflight. Current in-flight and post-flight imaging modalities (e.g., optical coherence tomography, orbital ultrasound, and funduscopy) have played an instrumental role in the understanding and monitoring of SANS development; however, the precise etiology for this neuro-ophthalmic phenomenon is still not completely understood. SANS may be a potential barrier to future deep space missions, and therefore it is critical to further elucidate the underlying pathophysiology for effective countermeasures. The complexity and unique limitations of spaceflight require careful consideration and integration of leading technology to advance our knowledge of this extraterrestrial syndrome. We describe the current neuro-ophthalmic imaging modalities and hypotheses that have improved our current understanding of SANS, discuss newer developments in SANS imaging (including non-invasive near-infrared spectroscopy), and summarize emerging research in the development of an aspirational future head-mounted virtual reality display with multimodal visual assessment technology for the detection of neuro-ocular findings in SANS.”
Journal Impact Factor: 6.048
Funding: “The research detailed in this article was funded by National Aeronautics and Space
Administration (NASA) grants [80NSSC20K1831] and [NCC958SMST02801].”
Tesei D, Jewczynko A, Lynch AM, Urbaniak C.
Understanding the complexities and changes of the astronaut microbiome for successful long-duration space missions.
Life (Basel). 2022 Mar 28;12(4):495. Review.
PI: C. Urbaniak, NASA Postdoctoral Program Fellowship
Note: From the abstract: “Here, we review various conditions that are caused by long-term space exploration and discuss the role of the microbiome in promoting or ameliorating these conditions, as well as space-related factors that impact microbiome composition.” This article is part of Special Issue “The Effect of Space Travel on the Microbiome and Physiology of Astronauts” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.817
Funding: “C.U. was supported by a NASA 2020 Space Biology (NNH18ZTT001N-FG2) grant (80NSSC21K0320).”
Harris K, Laws JM, Elias DA, Green A, Goswami N, Jordan J, Kamine TH, Mazzolai L, Petersen LG, Winnard AJ, Weber T.
Search for venous endothelial biomarkers heralding venous thromboembolism in space: A qualitative systematic review of terrestrial studies.
Front Physiol. 2022 Apr 27;13:885183.
PI: L.G. Petersen
Note: From the abstract: “A qualitative systematic review focused on endothelial disruption/dysfunction was conducted following the guidelines produced by the Space Biomedicine Systematic Review Group, which are based on Cochrane review guidelines. We aimed to assess the venous endothelial biochemical and imaging markers that may predict increased risk of VTE during spaceflight by surveying the existing knowledge base surrounding these markers in analogous populations to astronauts on the ground.” This article may be obtained online without charge.
Journal Impact Factor: 4.566
Funding: “The European Space Agency provided funding to cover the open access cost of this publication. Publication costs were covered specifically from the ESA-sponsored Topical Team on “Pathophysiology, risk and clinical presentation of venous thromboembolism (VTE) and its evaluation of its prevention, diagnosis, mitigation and management strategies in spaceflight” (Grant number 4000131108/20/NL/PG/pt) and NASA Grant number 80NSSC19K0020, PI.”
Britten RA, Sanford LD, Guo M-L, Krishnan B, Emmett MR, Laiakis EC.
A Sankofian appraisal on how to maximize translatability of rodent space radiation/CNS studies to astronauts.
THREE. 2022 Apr 25.
PIs: RA Britten, LD Sanford, MR Emmett, C Limoli
Note: This article may be obtained online without charge.
Journal Impact Factor: Not applicable to this publication
Funding: “RAB: NNJ06HD89G, NNX11AC56G, NNX14AE73G, NNX15AI22G, NNX16AC40G, 80NSSC19K1582; LS: 80NSSC19K1582; KB: NNX15AI22G, AARG-17-533363, R21AG059223, R01AG063945; ME: NNX15AD65G, NASA/Texas Space Grant Consortium Fellowship.”
Schmidbaur H, Kawaguchi A, Clarence T, Fu X, Hoang OP, Zimmermann B, Ritschard EA, Weissenbacher A, Foster JS, Nyholm SV, Bates PA, Albertin CB, Tanaka E, Simakov O.
Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization.
Nat Commun. 2022 Apr 21;13(1):2172.
PI: J.S. Foster
Note: This article may be obtained online without charge.
Journal Impact Factor: 14.919
Funding: “H.S., O.P.H., E.R., and O.S. were supported by the Austrian Science Fund (FWF) grant P30686-B29. O.S. was supported by Whitman Center Early Career Fellowship (Frank R. Lillie Quasi-Endowment Fund, L. & A. Colwin Summer Research Fellowship, Bell Research Award in Tissue Engineering). H.S. was supported by the short-term grant abroad (KWA) of the University of Vienna. H.S. and O.S. were supported by the University of Chicago/ Vienna Strategic Partnership Programme Mobility Grant. A.K. was supported by the JSPS Postdoctoral Fellowship for Overseas Researchers program from Japan. C.B.A. was supported by the Hibbitt Early Career Fellowship. Eggs and paralarvae of E. scolopes were generated in part by support by the NASA Space Biology 80NSSC18K1465 awarded to J.S.F. S.V.N. was supported by the National Science Foundation IOS-1557914. This work was supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC0001003), the UK Medical Research Council (FC001003), and the Wellcome Trust (FC001003).”
Handbook of Space Pharmaceuticals.
Pathak, Y, Araújo dos Santos M, Zea L, editors.
Cham, Switerland: Springer, 2022. 978-3-31-950909-9.
PI: L. Zea
Note: Chapters include: Introduction to Pharmaceuticals; Understanding the Routes of Administration; Physicochemical Basic Principles for Solid Dosage Forms; Physicochemical Basic Principles for Liquid Dosage Forms; Solid Dosage Forms: Formulation and Characterization; Pharmaceutical Liquid Dosage Forms in Space: Looking Toward the Future by Learning from the Past; Nano Drug Delivery Systems for Space Applications; Basic Principles of Biopharmaceutics and Pharmacokinetics During Spaceflight; Medications in Microgravity: History, Facts, and Future Trends; Evaluation of Physical and Chemical Changes in Pharmaceuticals Flown on Space Missions; Implications of Microgravity on Microemulsions and Nanoemulsions; Three-Dimensional Printing (3DP) for Space Pharmaceuticals; Neuro-ocular Effects of Spaceflight; Effects of Spaceflight on the Vestibular System; Endocrine Effects of Space Flight; Effects of Space Flight on Bone and Skeletal Tissue; Effects of Spaceflight on the Immune System; Space Motion Sickness; Effects of Space Radiation on Mammalian Cells; Pharmacogenomics in Spaceflight; Therapeutic Applications of Biophotonics in Space; Sleep in Space Environment; Physicochemical Stability of Space Medicines; Functional and Neuromuscular Aspects of Spaceflight; Effects of Spaceflight on the Nervous System; Health and Hygiene of Skin, Hair, Nails, and Teeth in the Space Environment: Daily Challenges; Mitigating Radiation Effects on Humans During Space Travel: Recent Developments; Structural Brain Changes Associated with Space; Impact of Space Pharmaceuticals on Cardiovascular System; Space Experiments Using C. elegans as a Model Organism; Rodents as a Model for Research in Space; Fish as a Model for Research in Space; Yeast in Space; Fungal Experiments in Space; Nutraceutical and Nutrients Development for Space Travel; Utility of Drug Delivery Systems in Space Travel; Ground-Based Simulators of Microgravity for Pharmaceutical Research; Vaccines in Space; Harnessing the Space Environment for the Discovery and Development of New Medicines; Future of Drug Development in Space: Unmanned Satellites and Vehicles; Protein Crystallization in Space and Its Contribution to Drug Development; Nutraceuticals for Reducing Radiation Effects During Space Travel; Nutritional and Alternative Approaches to Treatment in Space; Homeopathy as a Therapeutic Option in Space; Ayurvedic and Herbal Nutritional Supplements for Space Travellers; Plant Behavior and Metabolic Response to the Space Environment as an Alternative Food and Therapeutic Source; Melatonin: A Promising Drug to Ameliorate Main Human Space Exploration Risks.
Funding: “Luis Zea was in part supported by the National Aeronautics and Space Administration Grants No. 80NSSC17K0036, 80NSSC18K1468, and 80NSSC19K0708, as well as by BioServe Space Technologies and Universidad del Valle de Guatemala.”
A chapter written by K. Marshall-Goebel ( that appeared in Current Awareness List #996 and the following are chapters included in Handbook of Space Pharmaceuticals.
Hammond TG, Birdsall HH.
Endocrine Effects of Space Flight.
In: Handbook of Space Pharmaceuticals. Cham, Switzerland: Springer, 2022. p. 313-49.
PI: T.G. Hammond
Note: The spaceflight information is not evident in the available abstract.
Funding: “This work was supported by National Aeronautics and Space Association Grants NNX13AN32G and NNX12AM93G and the Department of Veterans Affairs.”
Hammond TG, Birdsall HH.
Vaccines in Space.
In: Handbook of Space Pharmaceuticals. Cham, Switzerland: Springer, 2022. p. 805-21.
PI: T.G. Hammond
Funding: “This work was supported by National Aeronautics and Space Association Grants NNX13AN32G and NNX12AM93G and the Department of Veterans Affairs.”
Hammond TG, Birdsall HH.
Yeast in Space.
In: Handbook of Space Pharmaceuticals. Cham, Switzerland: Springer, 2022. p. 717-32.
PI: T.G. Hammond
Funding: “This work was supported by National Aeronautics and Space Association Grants NNX13AN32G and NNX12AM93G and the Department of Veterans Affairs.”
Nielsen S, Schauer R.
Fungal Experiments in Space.
In: Handbook of Space Pharmaceuticals. Cham, Switzerland: Springer, 2022. p. 733-46.
PI: S. Nielsen
Funding: “NASA NNX12AH29G and NNX15AB37G (SN), 80NSSC17K0036 (RS).”
Other papers of interest:
Popova JA, Suvorov AV, Zaripov RN, Dyachenko AI.
Exposure of inspiratory negative pressure breathing on cosmonauts during spaceflight.
Acta Astronaut. 2022 Apr 26. Online ahead of print.
Note: ISS results. From the abstract: “The aim of our study was to investigate the effects of inspiratory negative pressure breathing (NPBin) via impedance threshold device on breathing pattern and body fluid distribution in cosmonauts during spaceflight.”
Moulder JE, Cohen EP, Medhora M, Fish BL.
Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights.
Life Sci Space Res. 2022 Apr 21. Online ahead of print.
Note: From the abstract: “Angiotensin converting enzyme (ACE) inhibitors are effective countermeasures to chronic radiation injuries in rodent models, and there is evidence for similar effects in humans. In rodent models ACE inhibitors are effective mitigators of radiation injury to kidney, lung, central nervous system (CNS) and skin, even when started weeks after irradiation. In humans, the best data for their efficacy as radiation countermeasures comes from retrospective studies of injuries in radiotherapy patients. We propose that ACE inhibitors, at doses approved for human use for other indications, could be used to reduce the risk of chronic radiation injuries from deep-space exploration.” This article may be obtained online without charge.
Cucinotta FA.
Flying without a net: Space radiation cancer risk predictions without a gamma-ray basis.
Int J Mol Sci. 2022 Apr 13;23(8):4324.
Note: This article is part of Special Issue “Radiation Damage in Biomolecules and Cells 2.0” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Chung C, Brown PD, Wefel JS.
Lessons learned from proton vs photon radiation therapy for glioblastoma signal-finding trial.
Neuro Oncol. 2022 Apr 23;noac028. Online ahead of print.
Note: This article is a Reply to a Letter to the Editor regarding the original article titled, “A Prospective Phase II Randomized Trial of Proton Radiotherapy vs Intensity-modulated Radiotherapy for Patients with Newly Diagnosed Glioblastoma” by Brown et al. To view the original article go to
Leung W, Teater M, Durmaz C, Meydan C, Chivu AG, Chadburn A, Rice EJ, Muley A, Camarillo JM, Arivalagan J, Li Z, Flowers CR, Kelleher NL, Danko CG, Imielinski M, Dave SS, Armstrong SA, Mason CE, Melnick AM.
SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis.
Cancer Discov. 2022 Apr 20;candisc.1514.2021. Online ahead of print.
Note: From the abstract: “SETD2 is the sole histone methyltransferase responsible for H3K36me3, with roles in splicing, transcription initiation and DNA damage response. Homozygous disruption of SETD2 yields a tumor suppressor effect in various cancers. However, SETD2 mutation is typically heterozygous in DLBCL. Here we show that heterozygous SETD2 deficiency results in GC hyperplasia, increased competitive fitness, with reduced DNA damage checkpoint activity and apoptosis, resulting in accelerated lymphomagenesis.”
Jansson PM, Lynggaard CD, Carlander AF, Jensen SB, Follin B, Hoeeg C, Kousholt BS, Larsen RT, Grønhøj C, Jakobsen KK, Rimborg S, Fischer-Nielsen A, Menon JML, von Buchwald C.
Mesenchymal stromal/stem cell therapy for radiation-induced salivary gland hypofunction in animal models: A protocol for a systematic review and meta-analysis.
Syst Rev. 2022 Apr 18;11(1):72.
Note: This article may be obtained online without charge.
Jefford M, Howell D, Li Q, Lisy K, Maher J, Alfano CM, Rynderman M, Emery J.
Improved models of care for cancer survivors.
Lancet. 2022 Apr 16;399(10334):1551-60. Review.
Note: This article may be obtained online without charge.
Penoncello GP, Gagneur JD, Vora SA, Yu NY, Fatyga M, Mrugala MM, Bendok BR, Rong Y.
Comprehensive commissioning and clinical implementation of GammaTiles STaRT for intracranial brain cancer.
Adv Radiat Oncol. 2022 Jul 1;7(4):100910.
Note: This article may be obtained online without charge.
Rusanov VB, Pastushkova LK, Larina IM, Orlov OI.
Possibilities of proteomics profiling in predicting dysfunction of the cardiovascular system.
Front Physiol. 2022 Apr 25;13:897694.
Note: This article is part of Research Topic “Space Countermeasures and Medicine – Implementation into Earth medicine and Rehabilitation” (–-implementation-into-earth-medicine-and-rehabilitation#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Trifonov MI, Panasevich EA.
Longitudinal study of intraindividual variability in integral parameters of the structure function of multichannel EEG.
Hum Physiol. 2022 Apr 19;48(2):134-44.
Note: From the abstract: “The aim of the work was to assess the stability (intraindividual variability) of two integral parameters of the human EEG, which characterize its spatial and temporal order in a resting state with the eyes closed or open or while performing several types of tasks.”
Asano Y, Yamamoto N, Demura S, Hayashi K, Takeuchi A, Kato S, Miwa S, Igarashi K, Higuchi T, Yonezawa H, Araki Y, Morinaga S, Saito S, Sone T, Kasahara K, Tsuchiya H.
The therapeutic effect and clinical outcome of immune checkpoint inhibitors on bone metastasis in advanced non-small-cell lung cancer.
Front Oncol. 2022 Apr 1;12:871675.
Note: This article is part of Research Topic “Combinational Immunotherapy of Cancer: Novel Targets, Mechanisms, and Strategies” ( Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Boz V, Zanchi C, Levantino L, Riccio G, Tommasini A.
Druggable monogenic immune defects hidden in diverse medical specialties: Focus on overlap syndromes.
World J Clin Pediatr. 2022 Mar 9;11(2):136-50. Review.
Note: From the abstract: “In the last two decades two new paradigms changed our way of perceiving primary immunodeficiencies: An increasing number of immune defects are more associated with inflammatory or autoimmune features rather than with infections. Some primary immune defects are due to hyperactive pathways that can be targeted by specific inhibitors, providing innovative precision treatments that can change the natural history of diseases. In this article we review some of these ‘druggable’ inborn errors of immunity and describe how they can be suspected and diagnosed in diverse pediatric and adult medicine specialties.” This article may be obtained online without charge.
Gornostaeva AN, Ratushnyi AY, Buravkova LB.
Susceptibility of healthy volunteers adaptive immune cells to MSC-mediated immunomodulation in long-term dry immersion experiment.
Hum Physiol. 2022 Apr 19;48(2):152-60.
Note: Dry immersion results.
Shoshina II, Zelenskaya IS, Karpinskaya VY, Tomilovskaya ES.
Contrast sensitivity of visual system in 5-day dry immersion with a course of high-frequency electromyostimulation.
Hum Physiol. 2022 Apr 19;48(2):145-51.
Note: Dry immersion results.
Wang P, Clark NM, Nolan TM, Song G, Bartz PM, Liao CY, Montes-Serey C, Katz E, Polko JK, Kieber JJ, Kliebenstein DJ, Bassham DC, Walley JW, Yin Y, Hongqing G.
Integrated omics reveal novel functions and underlying mechanisms of the receptor kinase FERONIA in Arabidopsis thaliana.
Plant Cell. 2022 Apr 18;koac111. Online ahead of print.
Note: This article may be obtained online without charge.
Chelnokov AA, Roshchina LV, Gladchenko DA, Pivovarova EA, Piskunov IV, Gorodnichev RM.
The effect of transcutaneous electrical spinal cord stimulation on the functional activity of spinal inhibition in the system of synergistic muscles of the lower leg in humans.
Hum Physiol. 2022 Apr 19;48(2):121-33.
Gonzalez S, Stegall P, Cain SM, Siu HC, Stirling L.
Assessment of a powered ankle exoskeleton on human stability and balance.
Appl Ergon. 2022 Sep;103:103768.
Kaneko N, Sasaki A, Yokoyama H, Masugi Y, Nakazawa K.
Effects of action observation and motor imagery of walking on the corticospinal and spinal motoneuron excitability and motor imagery ability in healthy participants.
PLoS One. 2022 Apr 18;17(4):e0266000.
Note: This article may be obtained online without charge.
Mezentseva LV, Dudnik EN, Nikenina EV.
Comparative analysis of microcirculatory reactions to hypoxic effects in male and female subjects.
Hum Physiol. 2022 Apr 19;48(2):170-5.
Note: From the abstract: “In this study, we conducted a comparative analysis of the responses to hypoxia of microcirculation (MCR) parameters of the temporal areas of the head in male and female subjects.”
Köhler A, Zoll FM, Ploner T, Hammer A, Joannidis M, Tilg H, Finkenstedt A, Hartig F.
Oxygenation performance of different non-invasive devices for treatment of decompression illness and carbon monoxide poisoning.
Front Physiol. 2022 Apr 26;13:885898.
Note: This article may be obtained online without charge.
Xu T, Jin T, Lu X, Pan Z, Tan Z, Zheng C, Liu Y, Hu X, Ba L, Ren H, Chen J, Zhu C, Ge M, Huang P.
A signature of circadian rhythm genes in driving anaplastic thyroid carcinoma malignant progression.
Cell Signal. 2022 Apr 14;110332. Online ahead of print.

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