Status Report

NASA Spaceline Current Awareness List #995 15 April 2022 (Space Life Science Research Results)

By SpaceRef Editor
April 15, 2022
Filed under , , ,
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
Barisano G, Sepehrband F, Collins HR, Jillings S, Jeurissen B, Taylor JA, Schoenmaekers C, De Laet C, Rukavishnikov I, Nosikova I, Litvinova L, Rumshiskaya A, Annen J, Sijbers J, Laureys S, Van Ombergen A, Petrovichev V, Sinitsyn V, Pechenkova E, Grishin A, Zu Eulenburg P, Law M, Sunaert S, Parizel PM, Tomilovskaya E, Roberts DR, Wuyts FL.
The effect of prolonged spaceflight on cerebrospinal fluid and perivascular spaces of astronauts and cosmonauts.
Proc Natl Acad Sci USA. 2022 Apr 11;119(17):e2120439119.
Note: ISS results. To view a full press release of this article on the SpaceRef website go to This article may be obtained online without charge.
Journal Impact Factor: 11.205
Funding: “We thank Wafa Taiym and Sara Mason (Lifetime Surveillance of Astronaut Health Program, NASA Johnson Space Center) for providing imaging and clinical data and Lucia Ichino for her critical evaluation of the manuscript. This study was funded by Russian Academy of Sciences Grant 63.1 (to E.T., I.R., and I.N.), NASA Grant 20-EPSCoR2020-0069 (to D.R.R.), ESA Grant ISLRA-2009-1062 (to F.L.W.), the Belgian Science Policy Prodex (to F.L.W., S.J., and C.D.L.), FWO Flanders (to C.S.), and the National Institute of Mental Health of the NIH Grant RF1MH123223 (to F.S.).”
Cecil AJ, Payne JE, Hawtrey LT, King B, Willing GA, Williams SJ.
Nonlinear agglomeration of bimodal colloids under microgravity.
Gravit Space Res. 2022 Apr 7;10(1):1-9.
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “NASA EPSCoR (NNX14AN28A) ‘Influence of gravity on electrokinetic and electrochemical colloidal self-assembly for future materials’ ZIN-Technologies.”
Zwart SR, Auñón-Chancellor SM, Heer M, Melin MM, Smith SM.
Albumin, oral contraceptives, and venous thromboembolism risk in astronauts.
J Appl Physiol (1985). 2022 Apr 7. Online ahead of print.
PI: S.M. Smith
Note: From the article: “The data presented herein are from ISS astronauts who participated in the Nutritional Status Assessment project, the Space Biochemical Profile study, or the Standard Measures project—studies that generated a broad array of biochemistry data from blood and urine collections.”
Journal Impact Factor: 3.531
Funding: “The data here were funded by the NASA Human Research Program’s Human Health and Countermeasures Element, and by the German Federal Ministry for Economics and Technology/DLR Forschung unter Weltraumbedingungen Grant 50WB0931 & 50WB1231 (to M.H.).”
Boyan BD, Berger MB, Nelson FR, Donahue HJ, Schwartz Z.
The biological basis for surface-dependent regulation of osteogenesis and implant osseointegration.
J Am Acad Orthop Surg. 2022 Apr 5. Online ahead of print.
PI: H.J. Donahue
Journal Impact Factor: 3.02
Funding: “National Institutes of Health R01 AM 072500-20 (B.D.B.; Z.S.); AB Dental (Z.S.); Medtronic Spine (B.D.B.; Z.S.); Institut Straumann AG (B.D.B.; Z.S.); R01 AR068132-20 (H.J.D.); NASA grant 80NSSC18K1473 (H.J.D.); and National Space Biological Research Institute NSBRI/NASA MA02802 (H.J.D.).”
Estrada UML, Meeks G, Salazar-Marioni S, Scalzo F, Farooqui M, Vivanco-Suarez J, Gutierrez SO, Sheth SA, Giancardo L.
Quantification of infarct core signal using [computed tomography] CT imaging in acute ischemic stroke.
Neuroimage Clin. 2022;34:102998.
PI: L. Giancardo
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.881
Funding: “This work has been supported by NIH grant R01NS121154. LG is supported in part by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A, NIH grants UL1TR003167, and a Cancer Prevention and Research Institute of Texas grant (RP 170668).”
Mairani A, Mein S, Blakely EA, Debus J, Durante M, Ferrari A, Fuchs H, Georg D, Grosshans DR, Guan F, Haberer T, Harrabi SB, Horst F, Inaniwa T, Karger CP, Mohan R, Paganetti H, Parodi K, Sala PR, Schuy C, Tessonnier T, Titt U, Weber U.
Roadmap: Helium ion therapy.
Phys Med Biol. 2022 Apr 8. Online ahead of print.
PI: E.A. Blakely
Note: From the abstract: “Helium ion beam therapy for the treatment of cancer was one of several developed and studied particle modalities in the 1950’s, leading to clinical trials beginning in 1975 at the Lawrence Berkeley National Laboratory. The trial shutdown was followed by decades of research and clinical silence on the topic while proton and carbon ion therapy made debuts at research facilities and academic hospitals worldwide. The lack of progression in understanding of principle facets of helium ion beam therapy in terms of physics, biological and clinical findings persist today, mainly attributable to its highly limited availability. Despite this major setback, there has been an increasing focus on evaluating and establishing clinical and research programs using helium ion beams, with both therapy and imaging initiatives to supplement the clinical palette of radiotherapy in the treatment of aggressive disease and sensitive clinical cases.” This article may be obtained online without charge.
Journal Impact Factor: 3.609
Funding: “This work was supported by the NASA Grant NNJ16HP22I, and under contract DEAC02- 05CH11231 with the US Department of Energy Office of Science.”
Schreckenghost D, Holden K, Greene M, Milam T, Hamblin C.
Effect of automating procedural work on situation awareness and workload.
Hum Factors. 2022 Jan 28;187208211060978.
PI: D. Schreckenghost
Note: From the abstract: “In future deep space exploration missions, crew will have to work more autonomously from Earth. Greater crew autonomy will increase dependence on automated systems. This study investigates the performance effects of different strategies to automate procedural work for space exploration operations.”
Journal Impact Factor: 2.888
Funding: PI reports NASA grant 80NSSC19K0667 funding.
Other papers of interest:
Nakano M, Furuichi T, Sokabe M, Iida H, Yano S, Tatsumi H.
Entanglement of Arabidopsis seedlings to a mesh substrate under microgravity conditions in KIBO on the ISS.
Plants (Basel). 2022 Mar 31;11(7):956.
Note: ISS results. This article is part of Special Issue “Plant Responses to Gravity, Microgravity, and Space Environment” ( The Special Issue also includes an article from previous Current Awareness List #988 Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Horst F, Boscolo D, Durante M, Luoni F, Schuy C, Weber U.
Thick shielding against galactic cosmic radiation: A Monte Carlo study with focus on the role of secondary neutrons.
Life Sci Space Res. 2022 Apr 9. Online ahead of print.
Note: From the abstract: “The exposure to galactic cosmic radiation (GCR) is a major health concern for astronauts. Crewed missions with durations of several years are foreseen in future space exploration projects such as permanent habitats on the Moon and flights to Mars. This aim requires elaborate space radiation shielding concepts and a proper understanding of the underlying radiation physics and radiobiology as well as their interplay.”
Sekulic S, Jovanovic A, Zivanovic Z, Simic S, Kesic S, Petkovic B, Capo I, van Loon JJWA.
Which precocial rodent species is more suitable as the experimental model of microgravity influence on prenatal musculoskeletal development on International Space Station?
Life Sci Space Res. 2022 May;33:48-57. Review.
Note: From the abstract: “The aim of this paper is to identify which precocial rodent species is more appropriate as an experimental model to investigate influence of microgravity on prenatal musculoskeletal development using existing habitats for rodents on the ISS.” This article may be obtained online without charge.
Goldsmith M, Crooks SD, Condon SF, Willie BM, Komarova SV.
Bone strength and composition in spacefaring rodents: Systematic review and meta-analysis.
npj Microgravity. 2022 Apr 13;8:10.
Note: From the abstract: “To synthesize the available data to assess how much and how consistently bone strength and composition parameters are affected by spaceflight, we systematically identified studies reporting bone health in spacefaring animals from Medline, Embase, Web of Science, BIOSIS, and NASA Technical reports. Previously, we reported the effect of spaceflight on bone architecture and turnover in rodents and primates. For this study, we selected 28 articles reporting bone strength and composition in 60 rats and 60 mice from 17 space missions ranging from 7 to 33 days in duration.” This article may be obtained online without charge.
Bacci S, Bani D.
The epidermis in microgravity and unloading conditions and their effects on wound healing.
Front Bioeng Biotechnol. 2022 Mar 22;10:666434. Mini Review.
Note: From the abstract: “This mini-review is focused on the effects of microgravity and unloading conditions on the epidermis and its keratinocytes.” This article and the article below (Xue et al.) are part of Research Topic “Wound Management and Healing in Space” ( The Research Topic also includes articles from previous Current Awareness Lists #958, #972, and #973 and Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Xue L, Deng T, Guo R, Peng L, Guo J, Tang F, Lin J, Jiang S, Lu H, Liu X, Deng L.
A composite hydrogel containing mesoporous silica nanoparticles loaded with Artemisia argyi extract for improving chronic wound healing.
Front Bioeng Biotechnol. 2022 Mar 25;10:825339.
Note: This article and the article above (Bacci et al.) are part of Research Topic “Wound Management and Healing in Space” ( This article may be obtained online without charge.
Masini MA, Bonetto V, Manfredi M, Pastò A, Barberis E, Timo S, Vanella VV, Robotti E, Masetto F, Andreoli F, Fiore A, Tavella S, Sica A, Donadelli M, Marengo E.
Prolonged exposure to simulated microgravity promotes stemness impairing morphological, metabolic and migratory profile of pancreatic cancer cells: A comprehensive proteomic, lipidomic and transcriptomic analysis.
Cell Mol Life Sci. 2022 Apr 7;79(5):226.
Note: A random positioning machine was used in this study. This article may be obtained online without charge.
Ewing LE, Biju PG, Pathak R, Melnyk S, Hauer-Jensen M, Koturbash I.
Methods for induction and assessment of intestinal permeability in rodent models of radiation injury.
Methods Cell Biol. 2022;168:235-47.
Kim H, Kamm RD, Vunjak-Novakovic G, Wu JC.
Progress in multicellular human cardiac organoids for clinical applications.
Cell Stem Cell. 2022 Apr 7;29(4):503-14. Review.
Note: From the abstract: “Advances in self-organizing cardiac organoids to recapitulate human cardiogenesis have provided a powerful tool for unveiling human cardiac development, studying cardiovascular diseases, testing drugs, and transplantation. Here, we highlight the recent remarkable progress on multicellular cardiac organoids and review the current status for their practical applications.”
Yeang C, Karwatowska-Prokopczuk E, Su F, Dinh B, Xia S, Witztum JL, Tsimikas S.
Effect of pelacarsen on lipoprotein(a) cholesterol and corrected low-density lipoprotein cholesterol.
J Am Coll Cardiol. 2022 Mar 22;79(11):1035-46.
Note: From the abstract: “The authors evaluated subjects with a history of cardiovascular disease and elevated Lp(a) randomized to 5 groups of cumulative monthly doses of 20-80 mg pelacarsen vs placebo. Direct Lp(a)-C was measured on isolated Lp(a) using LPA4-magnetic beads directed to apolipoprotein(a). LDL-C was reported as: 1) LDL-C as reported by the clinical laboratory; 2) LDL-Ccorr = laboratory-reported LDL-C – direct Lp(a)-C; and 3) LDL-CcorrDahlén = laboratory LDL-C – [Lp(a) mass × 0.30] estimated by the Dahlén formula.” This article may be obtained online without charge.
Ellingson BM, Gerstner ER, Lassman AB, Chung C, Colman H, Cole PE, Leung D, Allen JE, Ahluwalia MS, Boxerman J, Brown M, Goldin J, Nduom E, Hassan I, Gilbert MR, Mellinghoff IK, Weller M, Chang S, Arons D, Meehan C, Selig W, Tanner K, Yung WKA, van den Bent M, Wen PY, Cloughesy TF.
Hypothetical generalized framework for a new imaging endpoint of therapeutic activity in early phase clinical trials in brain tumors.
Neuro Oncol. 2022 Apr 5;noac086. Online ahead of print.
Bai H, Si L, Jiang A, Belgur C, Zhai Y, Plebani R, Oh CY, Rodas M, Patil A, Nurani A, Gilpin SE, Powers RK, Goyal G, Prantil-Baun R, Ingber DE.
Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip.
Nat Commun. 2022 Apr 8;13:1928.
Note: From the abstract: “Mechanical breathing motions have a fundamental function in lung development and disease, but little is known about how they contribute to host innate immunity. Here we use a human lung alveolus chip that experiences cyclic breathing-like deformations to investigate whether physical forces influence innate immune responses to viral infection.” This article may be obtained online without charge.
Le QV, Lee J, Byun J, Shim G, Oh YK.
DNA-based artificial dendritic cells for in situ cytotoxic T cell stimulation and immunotherapy.
Bioact Mater. 2022 Sep;15:160-72.
Note: This article may be obtained online without charge.
Wang T, Zhang H, Qiu W, Han Y, Liu H, Li Z.
Biomimetic nanoparticles directly remodel immunosuppressive microenvironment for boosting glioblastoma immunotherapy.
Bioact Mater. 2022 Oct;16:418-32.
Note: This article may be obtained online without charge.
Zheng H, Guo B, Qiu X, Xia Y, Qu Y, Cheng L, Meng F, Zhong Z.
Polymersome-mediated cytosolic delivery of cyclic dinucleotide [stimulator of interferon genes] STING agonist enhances tumor immunotherapy.
Bioact Mater. 2022 Oct;16:1-11.
Note: This article may be obtained online without charge.
Wen M, Yu N, Wu S, Huang M, Qiu P, Ren Q, Zhu M, Chen Z.
On-demand assembly of polymeric nanoparticles for longer-blood-circulation and disassembly in tumor for boosting sonodynamic therapy.
Bioact Mater. 2022 Dec;18:242-53.
Note: From the abstract: “Sonodynamic therapy (SDT) is one of the promising strategies for tumor therapy, but its application is usually hindered by fast clearance in blood-circulation, abnormal tumor microenvironment, and inefficient generation of reactive oxygen species. To solve these problems, we proposed an on-demand assembly-disassembly strategy, where the assembly is favorable for longer-blood-circulation and then the disassembly in tumor is favorable for boosting SDT.” This article may be obtained online without charge.
Ballambat RP, Zuber M, Khader SMA, Ayachit A, Ahmad KAB, Vedula RR, Kamath SG, Shuaib IL.
Influence of postural changes on haemodynamics in internal carotid artery bifurcation aneurysm using numerical methods.
Vis Comput Ind Biomed Art. 2022 Apr 8;5:11.
Note: Head-down tilt test results. This article may be obtained online without charge.
Kim JS, Newman-Toker DE, Kerber KA, Jahn K, Bertholon P, Waterston J, Lee H, Bisdorff A, Strupp M.
Vascular vertigo and dizziness: Diagnostic criteria.
J Vestib Res. 2022 Mar 31. Online ahead of print.
Herdman D, Norton S, Murdin L, Frost K, Pavlou M, Moss-Morris R.
The INVEST trial: A randomised feasibility trial of psychologically informed vestibular rehabilitation versus current gold standard physiotherapy for people with Persistent Postural Perceptual Dizziness.
J Neurol. 2022 Apr 10;1-11.
Note: This article may be obtained online without charge.
Hetman M, Slomnicki L, Hodges E, Ohri SS, Whittemore SR.
Role of circadian rhythms in pathogenesis of acute [central nervous system] CNS injuries: Insights from experimental studies.
Exp Neurol. 2022 Apr 9:114080. Review. Online ahead of print.
Palombo C, Kozakova M, Morizzo C, Losso L, Pagani M, Salvi P, Parker KH, Hughes AD.
Carotid reservoir pressure decrease after prolonged head down tilt bed rest in young healthy subjects is associated with reduction in left ventricular ejection time and diastolic length.
Front Physiol. 2022 Mar 25;13:866045.
Note: Head-down tilt bed rest study. This article is part of Research Topic “Methods and Applications in Vascular Physiology” ( This article may be obtained online without charge.
Schröder A, Alefeld A, Forneck A, Spanier G, Deschner J, Proff P, Kirschneck C.
Impact of melatonin on periodontal ligament fibroblasts during mechanical strain.
Eur J Orthod. 2022 Apr 9;cjac013. Online ahead of print.
Note: From the abstract: “The endogenous hormone melatonin regulates the circadian rhythm and impacts on bone metabolism. As patient compliance to wear removable orthodontic appliances is generally higher at night, when melatonin release is increased, a boosting effect on tooth movement would be favorable for therapy, whereas an inhibiting effect would indicate daytime wear to be more therapy-effective. We hypothesize that melatonin has either a stimulating or impeding effect on the expression profile of periodontal ligament fibroblasts (PDLF) during simulated orthodontic compressive and tensile strain, which would suggest either an accelerating or inhibiting impact on orthodontic tooth movement in vivo.”

SpaceRef staff editor.