Status Report

NASA Spaceline Current Awareness List #994 8 April 2022 (Space Life Science Research Results)

By SpaceRef Editor
April 8, 2022
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
Mhatre SD, Iyer J, Puukila S, Paul AM, Tahimic CGT, Rubinstein L, Lowe M, Alwood JS, Sowa MB, Bhattacharya S, Globus RK, Ronca AE.
Neuro-consequences of the spaceflight environment.
Neurosci Biobehav Rev. 2022 Jan;132:908-35. Review.
PI: A.E. Ronca
Note: From the introduction: “This review summarizes the current literature on the neural consequences of spaceflight, describes potential mechanisms contributing to the structural and physiological alterations in the CNS, and discusses potential countermeasures effective in mitigating these effects.”
Journal Impact Factor: 8.989
Funding: “Funding was provided by the National Aeronautics and Space Administration (NASA)Human Research Program (HRP)Human Factors Behavioral Performance Element Grant 18-18FLAG_2-0028.”
Wostyn P, Gibson CR, Mader TH.
Optic disc edema in astronauts from a choroidal point of view.
Aerosp Med Hum Perform. 2022 Apr;93(4):396-8.
Note: From the abstract: “Optic disc edema has been well documented in astronauts both during and after long-duration spaceflight and is hypothesized to largely result from increased pressure within the orbital subarachnoid space brought about by a generalized rise in intracranial pressure or from sequestration of cerebrospinal fluid within the orbital subarachnoid space with locally elevated optic nerve sheath pressure. In addition, a recent prospective study documented substantial spaceflight-associated peripapillary choroidal thickening, which may be a contributing factor in spaceflight-associated neuro-ocular syndrome. In the present article, based on the above, we offer a new perspective on the pathogenesis of microgravity-induced optic disc edema from a choroidal point of view.”
Journal Impact Factor: 0.889
Funding: C.R. Gibson is affiliated with NASA Space Medicine Operations Division, Houston, TX.
Bishawi M, Lee FH, Abraham DM, Glass C, Blocker SJ, Cox DJ, Brown ZD, Rockman HA, Mao L, Slaba TC, Dewhirst MW, Truskey GA, Bowles DE.
Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.
iScience. 2022 Apr 15;25(4):104086.
PI: D.E. Bowles
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “…This work is supported by NASA research grant NNX16AK20G to DEB, Translational Research Institute though NASA cooperative agreement NNX16AK20G to DEB, National Institutes of Health 100000002grants NIH-NHLBI 1R38HL143612-01 to M.B., 1K08HL125905-01 to D.M. A, and HL056687 and HL075443 to H.A.R. …”
Goldford JE, George AB, Flamholz AI, Segrè D.
Protein cost minimization promotes the emergence of coenzyme redundancy.
Proc Natl Acad Sci USA. 2022 Apr 5;119(14):e2110787119.
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.733
Funding: “GBMF4513/Gordon and Betty Moore Foundation (Gordon E. and Betty I. Moore Foundation); 80NSSC17K0295/NASA/NASA/United States; 80NSSC17K0296/NASA/NASA/United States; 1724150/NSF | BIO | Division of Emerging Frontiers (EF).”
Kaplonek P, Cizmeci D, Fischinger S, Collier AR, Suscovich T, Linde C, Broge T, Mann C, Amanat F, Dayal D, Rhee J, de St Aubin M, Nilles EJ, Musk ER, Menon AS, Saphire EO, Krammer F, Lauffenburger DA, Barouch DH, Alter G.
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions.
Sci Transl Med. 2022 Mar 29;eabm2311. Online ahead of print.
PI: A.S. Menon
Note: This article may be obtained online without charge.
Journal Impact Factor: 17.956
Funding: “We acknowledge the Reproductive Scientist Development Program from the Eunice Kennedy Shriver National Institute of Child Health & Human Development and Burroughs Wellcome Fund HD000849 (A.Y.C.) and the support from the Ragon Institute of MGH, MIT, and Harvard (G.A). This work was also supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (D.D., E.R.M and A.S.M), the Massachusetts Consortium on Pathogen Readiness (MassCPR) (G.A.), and the National Institutes of Health (3R37AI080289-11S1, R01AI146785, U19AI42790-01, U19AI135995-02, U19AI42790-01, 1U01CA260476 – 01, CIVIC75N93019C00052) (G.A.). SpaceX provided in-kind contributions in support of the research such as logistical coordination and access to facilities (E.R.M.).”
Other papers of interest:
Glukhikh DO, Naumov IA, Schoenmaekers C, Kornilova LN, Wuyts FL.
The role of different afferent systems in the modulation of the otolith-ocular reflex after long-term space flights.
Front Physiol. 2022 Mar 14;13:743855.
Note: ISS results. This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior” ( The Research Topic also includes articles from previous Current Awareness Lists #956; #967; #969; #973; #975,, and; #976; #977; #979; #982; #985; #987; #988; #991; and #992 This article may be obtained online without charge.
Hagio S, Ishihara A, Terada M, Tanabe H, Kibushi B, Higashibata A, Yamada S, Furukawa S, Mukai C, Ishioka N, Kouzaki M.
Muscle synergies of multi-directional postural control in astronauts on Earth after a long-term stay in space.
J Neurophysiol. 2022 Mar 30. Online ahead of print.
Note: The spaceflight information is not evident in the available abstract.
Wildman JL, Fedele D, Wilder A, Curtis MT, DiazGranados D.
Team self-maintenance during long-duration space exploration: A conceptual framework.
Hum Factors. 2022 Mar 30;187208221076185. Online ahead of print.
Note: From the abstract: “Based on themes drawn from nine subject matter expert interviews combined with an extensive literature review on related concepts, we developed an integrative conceptual framework of the key inputs, processes, and outputs involved in TSM within LDSE contexts.”
Corbett MA, Newman DG.
Student drowsiness during simulated solo flight.
Aerosp Med Hum Perform. 2022 Apr;93(4):354-61.
Groner O, Frenkel-Nir Y, Erlich-Shoham Y, Shoval G, Gordon B.
Medically disqualifying conditions among aircrew candidates.
Aerosp Med Hum Perform. 2022 Apr;93(4):384-9.
Rempe MJ, Basiarz E, Rasmussen I, Belenky G, Lamp A.
Pilot in-flight sleep during long-range and ultra-long range commercial airline flights.
Aerosp Med Hum Perform. 2022 Apr;93(4):368-75.
Kurazumi T, Ogawa Y, Takko C, Kato T, Konishi T, Iwasaki KI.
Short-term volume loading effects on estimated intracranial pressure in human volunteers.
Aerosp Med Hum Perform. 2022 Apr;93(4):347-53.
Note: From the abstract: “Short-term fluid loading is used as part of post-spaceflight medical procedures and clinical treatment in hospitals. Hypervolemia with hemodilution induced by rapid fluid infusion reportedly impaired dynamic cerebral autoregulation. However, the effects on intracranial pressure (ICP) remain unknown. Therefore, we estimated ICP noninvasively (nICP) to examine whether rapid fluid infusion would raise ICP.”
Mitchell SJ, Bennett MH, Moon RE.
Decompression sickness and arterial gas embolism.
N Engl J Med. 2022 Mar 31;386(13):1254-64. Review.
Mori S, Kosaki K, Matsui M, Takahashi K, Yoshioka M, Tarumi T, Sugawara J, Shibata A, Kuro OM, Saito C, Yamagata K, Oka K, Maeda S.
Sedentary behavior is associated with reduced cardiovagal baroreflex sensitivity in healthy adults.
Hypertens Res. 2022 Apr 4.
Piening BD, Dowdell AK, Zhang M, Loza BL, Walls D, Gao H, Mohebnasab M, Li YR, Elftmann E, Wei E, Gandla D, Lad H, Chaib H, Sweitzer NK, Deng M, Pereira AC, Cadeiras M, Shaked A, Snyder MP, Keating BJ.
Whole transcriptome profiling of prospective endomyocardial biopsies reveals prognostic and diagnostic signatures of cardiac allograft rejection.
J Heart Lung Transplant. 2022 Feb 3;S1053-2498(22)01394-8. Online ahead of print.
Davidson T, Zhang H, Dong H, Grams MP, Park SS, Yan Y.
Overcoming immunotherapy resistance with radiation therapy and dual immune checkpoint blockade.
Adv Radiat Oncol. 2022 Jul 1;7(4):100931.
Note: This article may be obtained online without charge.
Van Averbeke V, Berkell M, Mysara M, Rodriguez-Ruiz JP, Xavier BB, De Winter FHR, Jongers B, Jairam RK, Hotterbeekx A, Goossens H, Cohen ES, Malhotra-Kumar S, Kumar-Singh S.
Host immunity influences the composition of murine gut microbiota.
Front Immunol. 2022 Mar 15;13:828016.
Note: This article may be obtained online without charge.
Xin Y, Ji H, Cho E, Roh KB, You J, Park D, Jung E.
Immune-enhancing effect of water-soluble beta-glucan derived from enzymatic hydrolysis of yeast glucan.
Biochem Biophys Rep. 2022 Jul;30:101256.
Note: This article may be obtained online without charge.
Mann AO, Hanna BS, Muñoz-Rojas AR, Sandrock I, Prinz I, Benoist C, Mathis D.
IL-17A-producing γδT cells promote muscle regeneration in a microbiota-dependent manner.
J Exp Med. 2022 May 2;219(5):e20211504.
Watkins B, Schuster HM, Gerwin L, Schoser B, Kröger S.
The effect of methocarbamol and mexiletine on murine muscle spindle function.
Muscle Nerve. 2022 Apr 3. Online ahead of print.
Note: This article may be obtained online without charge.
Man J, Graham T, Squires-Donelly G, Laslett AL.
The effects of microgravity on bone structure and function.
npj Microgravity. 2022 Apr 5;8(1):9. Review.
Note: From the abstract: “This review introduces a plethora of on-ground research that elucidate the intricate process of bone loss, utilizing technology that simulates microgravity. Observations from these studies are largely congruent to data obtained from spaceflight experiments, while offering more insights behind the molecular mechanisms leading to microgravity-induced bone loss. These insights are discussed herein, as well as how that knowledge has contributed to studies of current therapeutic agents. This review also points out discrepancies in existing data, highlighting knowledge gaps in our current understanding. Further dissection of the exact mechanisms of microgravity-induced bone loss will enable the development of more effective preventative and therapeutic measures to protect against bone loss, both in space and possibly on ground.” This article may be obtained online without charge.
Ke P, Zheng C, Liu F, Wu L, Tang Y, Wu Y, Lv D, Chen H, Qian L, Wu X, Zeng K.
Relationship between circadian genes and memory impairment caused by sleep deprivation.
PeerJ. 2022 Mar 21;10:e13165.
Note: This article may be obtained online without charge.
Cheng Y, Zhang Y, Chen F, Chen Z, Xue T, Zhang Q, Xu M.
Virtual reality for the measurement of [subjective visual vertical] SVV and [subjective visual horizontal] SVH during static head tilt in healthy adults: A novel vestibular test.
Acta Otolaryngol. 2022 Apr 6;1-7. Online ahead of print.
Note: Head tilt results.
Fell CA, Brooks-Richards TL, Woodruff M, Allenby MC.
Soft pneumatic actuators for mimicking multi-axial femoropopliteal artery mechanobiology.
Biofabrication. 2022 Apr 4. Online ahead of print.
Mohan AT, Abdelrahman AM, Anding WJ, Lowndes BR, Blocker RC, Hallbeck MS, Bakri K, Moran SL, Mardini S.
Microsurgical skills training course and impact on trainee confidence and workload.
J Plast Reconstr Aesthet Surg. 2022 Feb 19;S1748-6815(22)00075-4. Online ahead of print.
Note: NASA Task Load Index assessment.

SpaceRef staff editor.