Status Report

NASA Spaceline Current Awareness List #993 1 April 2022 (Space Life Science Research Results)

By SpaceRef Editor
April 1, 2022
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
Manian V, Orozco-Sandoval J, Diaz-Martinez V, Janwa H, Agrinsoni C.
Detection of target genes for drug repurposing to treat skeletal muscle atrophy in mice flown in spaceflight.
Genes (Basel). 2022 Mar 8;13(3):473.
PI: H. Janwa
Note: ISS, BIONM1 biosatellite, and STS-18 shuttle results. From the abstract: “This article investigates multi-modal gene disease and disease drug networks via link prediction algorithms to select drugs for repurposing to treat skeletal muscle atrophy. Key target genes that cause muscle atrophy in the left and right extensor digitorum longus muscle tissue, gastrocnemius, quadriceps, and the left and right soleus muscles are detected using graph theoretic network analysis, by mining the transcriptomic datasets collected from mice flown in spaceflight made available by GeneLab.” This article is part of Topic “Complex Systems and Artificial Intelligence” ( GeneLab is available at This article may be obtained online without charge.
Journal Impact Factor: 4.096
Funding: “This research was funded by NASA EPSCoR, grant 80NSSC20M0132. The APC is funded by 80NSSC20M0132.”
Torres-Espin A, Keller A, Johnson GTA, Fields AJ, Krug R, Ferguson AR, Hargens AR, O’Neill CW, Lotz JC, Bailey JF.
Using hierarchical unsupervised learning to integrate and reduce multi-level and multi-paraspinal muscle MRI data in relation to low back pain.
Eur Spine J. 2022 Mar 25. Online ahead of print.
PI: A.R. Hargens
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 3.134
Funding: “We thank NASA ISS crew members who participated in these studies supported by NASA grants (NNX10AM18G). We also thank participants to the study funded by NIH (NIHR01AR63705 and U19 AR076737).”
Antonsen EL, Myers JG, Boley L, Arellano J, Kerstman E, Kadwa B, Buckland DM, Van Baalen M.
Estimating medical risk in human spaceflight.
npj Microgravity. 2022 Mar 31;8:8.
Note: From the abstract: “NASA and commercial spaceflight companies will soon be retuning humans to the Moon and then eventually sending them on to Mars. These distant planetary destinations will pose new risks—in particular for the health of the astronaut crews. The bulk of the evidence characterizing human health and performance in spaceflight has come from missions in Low Earth Orbit. As missions last longer and travel farther from Earth, medical risk is expected to contribute an increasing proportion of total mission risk. To date, there have been no reliable estimates of how much. The Integrated Medical Model (IMM) is a Probabilistic Risk Assessment (PRA) Monte-Carlo simulation tool developed by NASA for medical risk assessment. This paper uses the IMM to provide an evidence-based, quantified medical risk estimate comparison across different spaceflight mission durations.” This article may be obtained online without charge.
Journal Impact Factor: 4.415
Funding: “The authors would like to thank R. D. Reed for technical editing and review. The Integrated Medical Model (IMM) was developed through funding from the Human Research Program by the Exploration Medical Capabilities Element at Johnson Space Center. In 2017 IMM transitioned to operations and is now operated and maintained by the Crew Health and Safety Program at NASA Johnson Space Center.”
Urquieta E, Wu J, Hury J, Donoviel D.
Establishment of an open biomedical database for commercial spaceflight.
Nat Med. 2022 Mar 22. Online ahead of print.
Note: This article is a correspondence to an editorial titled “Open Science in Space” that appeared in Current Awareness List #969
Journal Impact Factor: 53.44
Funding: “All authors were supported by the Translational Research Institute for Space Health through NASA NNX16AO69A.”
Hinterman E, Moccia A, Baber S, Maffia F, Sciarretta S, Smith T, Stamler N, Nowak H, Lukic J, Sumini V, Zhan Z, Schneiderman T, Lordos G, Seaman E, Babakhanova S, Kusters J, Bernelli-Zazzera F, Maggiore P, Mainini L, Hoffman J.
MarsGarden: Designing an ecosystem for a sustainable multiplanetary future.
Acta Astronaut. 2022 Mar 26. Online ahead of print.
Note: From the abstract: “Exploration of space has always held a certain fascination for humankind. Stepping foot on the Moon may have been the achievement of the century, and sending humans to Mars will be even more challenging and exciting. To achieve self-sufficiency off the Earth, humans will need a steady supply of food while also maintaining adequate mental health. We propose here a closed-loop ecosystem that accomplishes both while being feasible to transport, construct, and maintain on Mars.”
Journal Impact Factor: 2.413
Funding: “This work was supported by the Space Architecture for Extra-planetary Exploration (SAEXE) Project under the Alta Scuola Politecnica Program of Politecnico di Torino and Politecnico di Milano, and by the 2019 Breakthrough, Innovative and Game-changing (BIG) Idea Challenge under the NASA Game Changing Development (GCD) Program, which awarded second place to the Biosphere Engineered Architecture for Viable Extraterrestrial Residence (BEAVER) project team.”
Harper JD, Lingeman JE, Sweet RM, Metzler IS, Sunaryo P, Williams JC, Jr., Maxwell AD, Thiel J, Cunitz BW, Dunmire B, Bailey MR, Sorensen MD.
Fragmentation of stones by burst wave lithotripsy in the first 19 humans.
J Urol. 2022 Mar 21;101097ju0000000000002446. Online ahead of print.
PI: M.R. Bailey
Note: From the abstract: “We report stone comminution in the first 19 human subjects by burst wave lithotripsy (BWL), which is the transcutaneous application of focused, cyclic ultrasound pulses.” The press release for this article is available on the UW Medicine Newsroom website at
Journal Impact Factor: 7.450
Funding: PI reports NASA/NSBRI funding.
Dominguez-Martinez I, Joaquin-Ovalle F, Ferrer-Acosta Y, Griebenow KH.
Folate-decorated cross-linked cytochrome c nanoparticles for active targeting of non-small cell lung carcinoma (NSCLC).
Pharmaceutics. 2022 Feb 24;14(3):490.
Note: This article is part of Special Issue “Targeted Nanotherapy in Cancer Disease” ( This article may be obtained online without charge.
Journal Impact Factor: 6.321
Funding: “This research was funded by the National Institute on Minority Health and Health Disparities (NIMHD) and the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health under award number U54MD007587. I.D.-M. acknowledges the National Aeronautics and Space Administration Cooperative Agreement no. 80NSSC20M0052 (Puerto Rico Space Grant Consortium).”
Didier KD, Hammer SM, Alexander AM, Rollins KS, Barstow TJ.
The acute effects of passive heating on endothelial function, muscle microvascular oxygen delivery, and expression of serum HSP90α.
Microvasc Res. 2022 July;142:104356.
PI: K.D. Didier
Journal Impact Factor: 3.514
Funding: “This work is supported by the Translation Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A for KDD and National Institutes of Health awards: T32HL07111 to SMH and AR56950 to AMA.”
Park SY, Pekas EJ, Anderson CP, Kambis TN, Mishra PK, Schieber MN, Wooden TK, Thompson JR, Kim KS, Pipinos 2nd.
Impaired microcirculatory function, mitochondrial respiration, and oxygen utilization in skeletal muscle of claudicating patients with peripheral artery disease.
Am J Physiol Heart Circ Physiol. 2022 Mar 25. Online ahead of print.
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.733
Funding: “P20GM109090/National Institutes of Health COBRE; NNX15AI09H/NASA/NASA/United States; R01 AG034995/AG/NIA NIH HHS/United States; R01 AG049868/AG/NIA NIH HHS/United States.”
Kandel P, Semerci F, Mishra R, Choi W, Bajic A, Baluya D, Ma L, Chen K, Cao AC, Phongmekhin T, Matinyan N, Jiménez-Panizo A, Chamakuri S, Raji IO, Chang L, Fuentes-Prior P, MacKenzie KR, Benn CL, Estébanez-Perpiñá E, Venken K, Moore DD, Young DW, Maletic-Savatic M.
Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis.
Proc Natl Acad Sci USA. 2022 Mar 29;119(13):e2023784119.
PI: M. Maletic-Savatic
Note: A commentary to this article titled, “Oleic acid regulates hippocampal neurogenesis as a TLX ligand” by Y. Shi, R.M. Evans, and F.H. Gage, is available at The press release for this article is available on the Baylor College of Medicine website at This article may be obtained online without charge.
Journal Impact Factor: 4.733
Funding: This work led to NASA/TRISH TRAD grant.
Miller SR, Abresch HE, Baroch JJ, Fishman Miller CK, Garber AI, Oman AR, Ulrich NJ.
Genomic and functional variation of the Chlorophyll d-producing cyanobacterium Acaryochloris marina.
Microorganisms. 2022 Mar 6;10(3):569.
Note: This article is part of Special Issue “Phototrophic Bacteria” ( This article may be obtained online without charge.
Journal Impact Factor: 4.128
Funding: “This work was supported by award NNA15BB04A from the National Aeronautics and Space Administration to S.R.M.”
Rhodes CG, Loaiza JR, Romero LM, Gutiérrez Alvarado JM, Delgado G, Rojas Salas O, Ramírez Rojas M, Aguilar-Avendaño C, Maynes E, Valerín Cordero JA, Soto Mora A, Rigg CA, Zardkoohi A, Prado M, Friberg MD, Bergmann LR, Marín Rodríguez R, Hamer GL, Chaves LF.
Anopheles albimanus (Diptera: Culicidae) ensemble distribution modeling: Applications for malaria elimination.
Insects. 2022 Feb 22;13(3):221.
Note: This article is part of Collection “Vector-Borne Diseases in a Changing World” ( This article may be obtained online without charge.
Journal Impact Factor: 2.769
Funding: “This research was funded by Costa Rica’s Ministry of Health. Additional support came from the Canada Foundation for Innovation, WestGrid and Compute Canada. We would also like to thank the support of NASA and Goddard Space Flight Center (GSFC) Applied Science Programs. L.R.B. acknowledges funding from the Canada Research Chairs Program. C.G.R. acknowledges funding from a Texas A&M University diversity fellowship.”
Raines R, McKnight I, White H, Legg K, Lee C, Li W, Lee PHU, Shim JW.
Drug-targeted genomes: Mutability of ion channels and [G-protein-coupled receptors] GPCRs.
Biomedicines. 2022 Mar 3;10(3):594.
Note: This article is part of Special Issue “Advances in Cardiovascular Pharmacology: The Era of Targeted-Therapies in Cardiology” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 6.081
Funding: “This work has been supported by the state of West Virginia’s startup fund to Marshall University faculty members. This work is also supported by the NASA WV Research Enhancement Award (to J.W.S.), NASA WV student fellowship (to I.M.), as well as the Marshall University Genomics Core for providing access to shared instrumentation. The Genomics Core is supported by funding from the WV-INBRE grant (NIH P20GM103434), the COBRE ACCORD grant (P20GM121299) and the West Virginia Clinical and Translational Science Institute (WV-CTSI) grant (2U54GM104942). Wei Li is supported by the Marshall University Institute Fund and the National Institutes of Health award (R15HL145573).”
Akarapipad P, Kaarj K, Breshears LE, Sosnowski K, Baker J, Nguyen BT, Eades C, Uhrlaub JL, Quirk G, Nikolich-Žugich J, Worobey M, Yoon JY.
Smartphone-based sensitive detection of SARS-CoV-2 from saline gargle samples via flow profile analysis on a paper microfluidic chip.
Biosens Bioelectron. 2022 July 1;207:114192.
Note: From the abstract: “Respiratory viruses, especially coronaviruses, have resulted in worldwide pandemics in the past couple of decades. Saliva-based paper microfluidic assays represent an opportunity for noninvasive and rapid screening, yet both the sample matrix and test method come with unique challenges. In this work, we demonstrated the rapid and sensitive detection of SARS-CoV-2 from saliva samples, which could be simpler and more comfortable for patients than existing methods.” This article may be obtained online without charge.
Journal Impact Factor: 10.618
Funding: “This project was funded by The University of Arizona’s Test All Test Smart program. L.E.B. acknowledges the University of Arizona NASA Space Grant Fellowship. P.A. acknowledges the Royal Thai Government Scholarship from the Ministry of Higher Education, Science, Research and Innovation, Thailand. K.K. acknowledges the scholarship from the Development and Promotion of Science and Technology Talents Project (DPST) of Thailand. K.S. acknowledges the Computational and Mathematical Modeling of Biomedical Systems Training Grant from the National Institute of General Medical Sciences (NIGMS), grant number GM132008. J.B. acknowledges W. L. Gore & Associates, Inc. for the undergraduate research fellowship.”
Other papers of interest:
Zeng D, Cui J, Yin Y, Xiong Y, Yu W, Zhao H, Guan S, Cheng D, Sun Y, Lu W.
The memory of rice response to spaceflight stress: From the perspective of metabolomics and proteomics.
Int J Mol Sci. 2022 Mar 21;23(6):3390.
Note: China’s ShiJian-10 retractable satellite results. This article is part of Special Issue “ROS and Abiotic Stress in Plants 2.0” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Kim HW, Park BH, Park H, Baek BC, Choi IG, Rhee MS.
Low-shear modeled microgravity affects metabolic networks of Escherichia coli O157:H7 EDL933: Further insights into space-microbiology consequences.
Food Res Int. 2022 Apr;154:111013.
Note: From the abstract: “Escherichia coli O157:H7 EDL933 exposed to low-shear modeled microgravity (LSMMG) and normal gravity (NG) was used for a transcriptomic analysis.” This article may be obtained online without charge.
Grimm D, Schulz H, Krüger M, Cortés-Sánchez JL, Egli M, Kraus A, Sahana J, Corydon TJ, Hemmersbach R, Wise PM, Infanger M, Wehland M.
The fight against cancer by microgravity: The multicellular spheroid as a metastasis model.
Int J Mol Sci. 2022 Mar 12;23(6):3073. Review.
Note: From the article: “This review focuses on cellular and tissue studies under altered gravity conditions.” This article may be obtained online without charge.
Mapstone LJ, Leite MN, Purton S, Crawford IA, Dartnell L.
Cyanobacteria and microalgae in supporting human habitation on Mars.
Biotechnol Adv. 2022 Mar 19;107946. Review. Online ahead of print.
Note: From the abstract: “Establishing the first human presence on Mars will be the most technically challenging undertaking yet in the exploration beyond our planet. The remoteness of Mars from Earth, the inhospitable surface conditions including low atmospheric pressure and cold temperatures, and the need for basic resources including water, pose a formidable challenge to this endeavor. The intersection of multiple disciplines will be required to provide solutions for temporary and eventually permanent Martian habitation. This review considers the role cyanobacteria and eukaryotic microalgae (collectively referred to here as “microalgae”) may have in supporting missions to the red planet.”
Wallner B, Schenk B, Paal P, Falk M, Strapazzon G, Martini WZ, Brugger H, Fries D.
Hypothermia induced impairment of platelets: Assessment with multiplate vs. ROTEM—An in vitro study.
Front Physiol. 2022 Mar 29;13:852182.
Note: This article may be obtained online without charge.
Hochman-Mendez C, Mesquita FCP, Morrissey J, da Costa EC, Hulsmann J, Tang-Quan K, Xi Y, Lee P-F, Sampaio LC, Taylor DA.
Restoring anatomical complexity of a left ventricle wall as a step toward bioengineering a human heart with human induced pluripotent stem cell-derived cardiac cells.
Acta Biomater. 2022 Mar 15;141:48-58.
Note: This article may be obtained online without charge.
Shamraeva MA, Pekov SI, Bormotov DS, Levin RE, Larina IM, Nikolaev EN, Popov IA.
The lightweight spherical samplers for simplified collection, storage, and ambient ionization of drugs from saliva and blood.
Acta Astronaut. 2022 Mar 24. Online ahead of print.
Lazarides AL, Flamant EM, Cullen MM, Ferlauto HR, Cochrane N, Gao J, Jung SH, Visgauss JD, Brigman BE, Eward WC.
Investigating readmission rates for patients undergoing oncologic resection and endoprosthetic reconstruction for primary sarcomas and tumors involving bone.
J Surg Oncol. 2022 Mar 23. Online ahead of print.
Zhang Y, Du G, Zhan Y, Guo K, Zheng Y, Tang L, Jianzhong G, Liang J.
Muscle atrophy evaluation via radiomics analysis using ultrasound images: A cohort data study.
IEEE Trans Biomed Eng. 2022 Mar 24. Online ahead of print.
Habib K, Fallah B, Edgell H.
Effect of upright posture on endothelial function in women and men.
Front Physiol. 2022 Mar 24;13:846229.
Note: This article is part of Research Topic “Rising Stars in Environmental, Aviation and Space Physiology: 2022” ( Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

SpaceRef staff editor.