NASA Spaceline Current Awareness List #989 4 March 2022 (Space Life Science Research Results)

 

Papers deriving from NASA support:

 

1

Bijlani S, Parker C, Singh NK, Sierra MA, Foox J, Wang CCC, Mason CE, Venkateswaran K.

J Fungi (Basel). 2022 Feb 8;8(2):165.

PIs: C.C.C. Wang, K. Venkateswaran

Note: ISS results. This article is part of Special Issue “New Trends in Yeast Genomics” (https://www.mdpi.com/journal/jof/special_issues/Yeast_sensors). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 5.816

Funding: “The research described in this manuscript was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV, and NASA’s 2018 Space Biology (ROSBio) NNH18ZTT001N-FG App B: Flight and Ground Space Biology Research Grant 80NSSC19K1501 awarded to C.C.C.W. We also thank WorldQuant Foundation for their support, as well as the Starr Cancer Consortium: (I13-0052), the National Institutes of Health (R01AI151059, U01DA053941, R35GM138152), the Bill and Melinda Gates Foundation (OPP1151054), and the Alfred P. Sloan Foundation (G-2015-13964).”

 

2

Hummerick ME, Khodadad CLM, Dixit AR, Spencer LE, Maldonado-Vasquez GJ, Gooden JL, Spern CJ, Fischer JA, Dufour N, Wheeler RM, Romeyn MW, Smith TM, Massa GD, Zhang Y.

Life (Basel). 2021 Oct 9;11(10):1060.

Note: ISS results. This article, the article directly below (Steinberg et al.), and an article below in the “Other” section (Clark et al.) are part of Special Issue “Space Life Sciences” (https://www.mdpi.com/journal/life/special_issues/space_bio). The Special Issue also includes articles from previous Current Awareness Lists #917 https://doi.org/10.3390/life10090196;

#920 https://doi.org/10.3390/life10100235; #933 https://doi.org/10.3390/life11010033 and https://doi.org/10.3390/life11020109; #936 https://doi.org/10.3390/life11020112; #944 https://doi.org/10.3390/life11040283; #945 https://doi.org/10.3390/life11020109; #953 https://doi.org/10.3390/life11060492 and https://doi.org/10.3390/life11050449; #965 https://doi.org/10.3390/life11080829, https://doi.org/10.3390/life11080770, and https://doi.org/10.3390/life11080741; and #969 https://doi.org/10.3390/life11090960. This article may be obtained online without charge.

Journal Impact Factor: 3.817

Funding: “This research was funded by NASA Space Biology program.”

 

3

Steinberg LM, Martino AJ, House CH.

Life (Basel). 2021 Dec 10;11(12):1374.

Note: From the abstract: “Future crewed space travel will require efficient recycling of nutrients from organic waste back into food production. Microbial systems are a low-energy, efficient means of nutrient recycling, but their use in a life support system requires predictability and reproducibility in community formation and reactor performance. To assess the reproducibility of microbial community formation in fixed-film reactors, we inoculated replicate anaerobic reactors from two methanogenic inocula: a lab-scale fixed-film, plug-flow anaerobic reactor and an acidic transitional fen. Reactors were operated under identical conditions, and we assessed reactor performance and used 16s rDNA amplicon sequencing to determine microbial community formation.” This article, the article directly above (Hummerick et al.), and an article below in the “Other” section (Clark et al.) are part of Special Issue “Space Life Sciences” (https://www.mdpi.com/journal/life/special_issues/space_bio). This article may be obtained online without charge.

Journal Impact Factor: 3.817

Funding: “This research was funded by NASA’s Office of Education’s Space Grant program through the Ralph Steckler/Space Grant Space Colonization Research and Technology Development Opportunity, grant number 09-STECKLER09-0022. We also acknowledge support from NSF grant #EF-1724099 and the NASA Pennsylvania Space Grant Consortium (NASA grant #NNX15AK06H).”

 

4

Ly V, Velichala SR, Hargens AR.

Life (Basel). 2022 Feb 11;12(2):268. Review.

PI: A.R. Hargens

Note: From the introduction: “The purpose of this review is to summarize the current understanding of physiological changes induced by space travel and to explore potential countermeasures against maladaptive responses to spaceflight.” This article is part of Special Issue “Space Flight Factors and Cytoskeleton Organization” (https://www.mdpi.com/journal/life/special_issues/Space_flight). The Special Issue also includes an article from previous Current Awareness List #984 https://doi.org/10.3390/life12010100. This article may be obtained online without charge.

Journal Impact Factor: 3.817

Funding: “This research was funded by NASA Grant 80NSSC19K0409.”

 

5

Yura Y, Walsh K.

Shinzo. 2022 Feb;54(2):268-78.

PI: K. Walsh

Journal Impact Factor: Not available for this journal

Funding: “This work was funded by NIH grants AG073249, AG072095, HL139819, HL141256, and HL152174 and NASA grant 80NSSC21K0549 to KW.”

 

6

Zhang Y, Richards JT, Feiveson AH, Richards SE, Neelam S, Dreschel TW, Plante I, Hada M, Wu H, Massa GD, Douglas GL, Levine HG.

Life (Basel). 2022 Jan 19;12(2):144.

PI: Y. Zhang

Note: This is article is part of Special Issue “Space Radiobiology” (https://www.mdpi.com/journal/life/special_issues/space_radiobiology). The Special Issue also includes articles from previous Current Awareness Lists #968 https://doi.org/10.3390/life11080849, and #977 https://doi.org/10.3390/life11111112 and https://doi.org/10.3390/life11111190. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 3.817

Funding: “This research was funded by the NASA Space Biology Program (GCR1 and single beam experiments in 2017) and Human Research Program (GCR2 and SPE experiments during 2018–2021).”

 

7

Feuerecker M, Strewe C, Aumayr M, Heitland T, Limper U, Crucian B, Baatout S, Choukér A.

Biomedicines. 2022 Feb 15;10(2):448.

Note: This article and two articles below in the “Other” section (Lau et al. and Radstake et al.) are part of Topic “Translation from Microgravity Research to Earth Application” (https://www.mdpi.com/topics/microgravity_research). The Topic also includes articles from previous Current Awareness Lists #970 https://doi.org/10.3390/ijms22189997 and https://doi.org/10.3390/biomedicines9091205; #976 https://doi.org/10.3390/ijms222111759; and #984 https://doi.org/10.3390/biomedicines10010059. Additional articles will be forthcoming and may be found in the link to the Topic. This article may be obtained online without charge.

Journal Impact Factor: 6.081

Funding: B. Crucian is affiliated with NASA Johnson Space Center.

 

8

Finch E, Lowe R, Fischinger S, de St Aubin M, Siddiqui SM, Dayal D, Loesche MA, Rhee J, Beger S, Hu Y, Gluck MJ, Mormann B, Hasdianda A, Musk ER, Alter G, Menon AS, Nilles EJ, Kucharski AJ.

PLoS Biol. 2022 Feb 10;20(2):e3001531.

PI: A.S. Menon

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “…AM was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement (https://www.nasa.gov/hrp/tri; NNX16AO69A). …”

 

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Other papers of interest:

 

1

Drug Metab Pers Ther. 2022 Feb 24. Online ahead of print.

Note: ISS results.

 

2

Kharin SA, Deshevaya EA, Fialkina SV, Guridov АА, Polianskaya AB, Dymova АА, Osipova PD, Poddubko SV.

Aviakosm Ekolog Med. 2022;56(1):76-85. Russian.

Note: ISS results.

 

3

Lau P, Vico L, Rittweger J.

Biomedicines. 2022 Feb 1;10(2):342. Review.

Note: From the introduction: “In this review, we discuss the cellular events associated with the process of osteogenic cell differentiation, namely bone formation and resorption, with a brief consideration of other interconnected tissues. In the second part, we discuss musculoskeletal crosstalk and its dissociation under the conditions of modified gravity. In addition, we also highlight the big knowledge gap in space medicine as of now and identify how the translation from microgravity research to applications in space may be possible in the future.” This article, an article above in the “NASA” section (Feuerecker et al.), and the article below (Radstake et al.) are part of Topic “Translation from Microgravity Research to Earth Application” (https://www.mdpi.com/topics/microgravity_research). This article may be obtained online without charge.

 

4

Radstake WE, Baselet B, Baatout S, Verslegers M.

Biomedicines. 2022 Feb 2;10(2):364. Review.

Note: From the abstract: “Traveling to space puts astronauts at risk of developing serious health problems. Of particular interest is the skin, which is vitally important in protecting the body from harmful environmental factors. Although data obtained from long-duration spaceflight studies are inconsistent, there have been indications of increased skin sensitivity and signs of dermal atrophy in astronauts. To better understand the effects of spaceflight stressors including microgravity, ionizing radiation and psychological stress on the skin, researchers have turned to in vitro and in vivo simulation models mimicking certain aspects of the spaceflight environment. In this review, we provide an overview of these simulation models and highlight studies that have improved our understanding on the effect of simulation spaceflight stressors on skin function.” This article, an article above in the “NASA” section (Feuerecker et al.), and the article above (Lau et al.) are part of Topic “Translation from Microgravity Research to Earth Application” (https://www.mdpi.com/topics/microgravity_research). This article may be obtained online without charge.

 

5

Turk J Ophthalmol. 2022 Feb 23;52(1):57-63. Review.

Note: From the abstract: “Long-term exposure to microgravity and space radiation leads to physiological and pathological changes in human biology. Pathological neuro-ocular changes are collected under the name spaceflight-associated neuro-ocular syndrome. This review examines studies on the effects of microgravity and space radiation on the ocular structures and their results. In addition, we discuss treatment methods and hypotheses to reduce the effects of microgravity and space radiation on biological structures.” This article may be obtained online without charge.

 

6

Yang JW, Song QY, Zhang MX, Ai JL, Wang F, Kan GH, Wu B, Zhu SQ.

Int J Ophthalmol. 2022 Feb 18;15(2):336-41. Review.

Note: From the abstract: “With the continuing progress in space exploration, a new and perplexing condition related to spaceflight ocular syndrome has emerged in the past four decades. National Aeronautics and Space Administration (NASA) has named this condition ‘spaceflight-associated neuro-ocular syndrome’ (SANS). This article gives an overview of the current research about SANS and traditional Chinese medicine (TCM) by analyzing the existing publications on PubMed and CNKI and reports from NASA about SANS, summarizing the potential pathogenesis of SANS and physical interventions for treating SANS, and discussing the feasibility of treating SANS with TCM.” This article may be obtained online without charge.

 

7

Clark KB.

Life (Basel). 2022 Feb 4;12(2):236. Review.

Note: This article and two articles above in the NASA section (Hummerick et al. and Steinberg et al.) are part of Special Issue “Space Life Sciences” (https://www.mdpi.com/journal/life/special_issues/space_bio). This article may be obtained online without charge.

 

8

Jin X, Ai W, Zhang Y, Dong W.

Life Sci Space Res. 2022 May;33:13-20.

Note: From the abstract: ” Controlled Ecological Life Support System (CELSS) is a closed artificial ecosystem which can regenerate oxygen, food, water and other substances for crew survival in long-term space missions. Solid organic waste is a vital resource pool for material reuse and recycling in CELSS. In this study, solid wastes including wheat straw and food waste were disposed via aerobic composting under functional microbial agent inoculation. Compared to tests with a commercial microbial agent addition and without exogenous microorganisms, system performance was promoted by the self-developed microbial agent significantly which exhibited the highest composting temperature (67.4 ± 1.5 °C) and longest thermophilic period (7 days).”

 

9

Aviakosm Ekolog Med. 2022;56(1):68-75. Russian.

Note: A random positioning machine was used in this study.

 

10

Rozanov IA, Kuznetsova PG, Savinkina AO, Shved DM, Ryumin OO, Tomilovskaya ES, Gushchin VI.

Aviakosm Ekolog Med. 2022;56(1):55-61. Russian.

Note: Dry immersion results.

 

11

Zhao Y, Zhong G, Du R, Zhao D, Li J, Li Y, Xing W, Jin X, Zhang W, Sun W, Liu C, Liu Z, Yuan X, Kan G, Han X, Li Q, Chang YZ, Li Y, Ling S.

Front Cell Dev Biol. 2022 Feb 2;9:796902.

Note: Hindlimb unloading study. This article is part of Research Topic “The Regulating Mechanisms of Development, Growth, and Metabolism: From Ground to Space” (https://www.frontiersin.org/research-topics/22183/the-regulating-mechanisms-of-development-growth-and-metabolism-from-ground-to-space#articles). The Research Topic also includes articles from previous Current Awareness Lists #975 https://doi.org/10.3389/fcell.2021.739944, #981 https://doi.org/10.3389/fcell.2021.797167, and #985 https://doi.org/10.3389/fcell.2021.797060. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

12

Gavrishin AI, Ivanov IV.

Aviakosm Ekolog Med. 2022;56(1):14-25. Russian.

 

13

Aviakosm Ekolog Med. 2022;56(1):47-54. Russian.

 

14

Ilyin VK, Komissarova DV, Usanova NA, Morozova YA, Starkova LV, Khizhnyak SV.

Aviakosm Ekolog Med. 2022;56(1):62-7. Russian.

Note: From the abstract: “Archival journals of isolation experiments conducted in the State Research Center of the Russian Federation – IBMP RAS during the period from 1980 to 1990 are analyzed.”

 

15

Aviakosm Ekolog Med. 2022;56(1):5-14. Russian.

Note: From the abstract: “This review is devoted to the analysis of information on the causes of calcium homeostasis disorders, including those associated with the accumulation of macroergic phosphates, in various types of functional muscle unloading.”

 

16

Aviakosm Ekolog Med. 2022;56(1):26-31. Russian.

 

17

George D, Pallu S, Bourzac C, Wazzani R, Allena R, Rémond Y, Portier H.

Life (Basel). 2022 Feb 3;12(2):233.

Note: This article is part of Research Topic “Impact of Physical Exercises on Bone Activities” (https://www.mdpi.com/journal/life/special_issues/physical_exercises_bone). This article may be obtained online without charge.

 

18

Kurian AG, Singh RK, Lee JH, Kim HW.

ACS Appl Bio Mater. 2022 Feb 22. Online ahead of print.

 

19

Liu C, Gao X, Li Y, Sun W, Xu Y, Tan Y, Du R, Zhong G, Zhao D, Liu Z, Jin X, Zhao Y, Wang Y, Yuan X, Pan J, Yuan G, Li Y, Xing W, Kan G, Wang Y, Li Q, Han X, Li J, Ling S, Li Y.

Bone Res. 2022 Feb 24;10:18.

Note: This article may be obtained online without charge.

 

20

Tailhan JL, Kurtz T, Godio-Raboutet Y, Rossi P, Thollon L.

J Mech Behav Biomed Mater. 2022 May;128:105132.

 

21

Siddiqui HB, Dogru S, Lashkarinia SS, Pekkan K.

J Cardiovasc Dev Dis. 2022 Feb 21;9(2):64. Review.

Note: This article is part of Special Issue “Comparative Developmental Cardiovascular Biomechanics and Bioengineering” (https://www.mdpi.com/journal/jcdd/special_issues/Comparative_Developmental). The Special Issue also includes an article from previous Current Awareness List #937 https://doi.org/10.3390/jcdd8020014. This article may be obtained online without charge.

 

22

Sohrabi M, Ebrahimzadeh Torkamani M, Ali Nedaie H.

Phys Med. 2022 Mar 1;95:167-75.

 

23

Mayr NA, Snider JW, Regine WF, Mohiuddin M, Hippe DS, Peñagarícano J, Mohiuddin M, Kudrimoti MR, Zhang H, Limoli CL, Le QT, Simone CB, 2^nd.

Adv Radiat Oncol. 2022 Mar 1;7(2):100866.

Note: This article may be obtained online without charge.

 

24

Okumura M, Du J, Kageyama SI, Yamashita R, Hakozaki Y, Motegi A, Hojo H, Nakamura M, Hirano Y, Okuma Y, Okuma HS, Tsuchihara K, Akimoto T.

Br J Cancer. 2022 Feb 19. Online ahead of print.

Note: This article may be obtained online without charge.

 

25

Zhang X, Hou L, Li F, Zhang W, Wu C, Xiang L, Li J, Zhou L, Wang X, Xiang Y, Xiao Y, Li SC, Chen L, Ran Q, Li Z.

Theranostics. 2022 Jan 16;12(4):1621-38.

Note: This article may be obtained online without charge.

 

26

Lawther AJ, Phillips AJK, Chung NC, Chang A, Ziegler AI, Debs S, Sloan EK, Walker AK.

Brain Behav Immun Health. 2022 May;21:100428.

Note: This article may be obtained online without charge.

 

27

Curthoys IS, Smith PF, de Miguel AR.

J Clin Med. 2022 Feb 21;11(4):1132. Review.

Note: This article is part of Special Issue “Recent Advances in Diagnosis and Treatment of Vestibular Disorders” (https://www.mdpi.com/journal/jcm/special_issues/Vestibular_Disorders).  Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.