NASA Spaceline Current Awareness List #988 25 February 2022 (Space Life Science Research Results)

 

Papers deriving from NASA support:

 

1

Martirosyan A, Falke S, McCombs D, Cox M, Radka CD, Knop J, Betzel C, DeLucas LJ.

npj Microgravity. 2022 Feb 17;8:4.

PI: L.J. DeLucas

Note: ISS results. From the introduction: “Proteins are vital and important macromolecules without which our bodies and other living organisms would be unable to repair, regulate, or protect against unwanted infectious organisms. Determination of the atomic three-dimensional structure of proteins provides critical information that allows scientists to understand how they function and interact. X-ray crystallography is the most efficient method to determine protein structures, although the technique requires growth of protein crystals of sufficient quality.” This article may be obtained online without charge.

Journal Impact Factor: 4.415

Funding: “The authors would like to thank all the people that have been involved in the SpaceX SPX10 and SPX15 mission. The authors would like to thank all the crewmembers of ISS expedition 50 and 52. Also, the authors would like to thank all the participants (i.a., Zin Technologies) of the projects Biophysics 1 and 4. This research has been supported by the NASA (Grant No. 80NSSC18K0013), by Deutsche Luft und Raumfahrt Agentur (DLR) supporting the project via grant 50WB1422, by the Cluster of Excellence ‘Advanced Imaging of Matter’ of the Deutsche Forschungsgemeinschaft (DFG)—EXC 2056—project ID 390715994, and by DFG project BE1443/29-1.”

 

2

Finseth T, Dorneich MC, Keren N, Franke WD, Vardeman SB.

Appl. Sci. 2022 Feb 22;12(5):2289.

PI: M.C. Dorneich

Note: This article is part of Special Issue “Applied Cognitive Sciences” (https://www.mdpi.com/journal/applsci/special_issues/Cognitive_Sciences). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 2.679

Funding: “This research was funded by National Aeronautics and Space Administration, grant number 80NSSC18K1572.”

 

3

Böcker J, Schmitz M-T, Mittag U, Jordan J, Rittweger J.

Front Physiol. 2022 Feb 22;12:74387.

Note: Bed rest study. This article is part of Research Topic “Investigation of the Inter-individual Variability of Physiological Responses to Changes in Activity Levels-, Gravity Loading-, Nutritional Status, Pharmaceuticals and Exposure to Radiation” (https://www.frontiersin.org/research-topics/14100/investigation-of-the-inter-individual-variability-of-physiological-responses-to-changes-in-activity#articles). The Research Topic also includes articles from previous Current Awareness Lists #921 https://doi.org/10.3389/fphys.2020.573581, #937 https://doi.org/10.3389/fphys.2021.614619, #952 https://doi.org/10.3389/fphys.2021.685473, #959 https://doi.org/10.3389/fphys.2021.676501, #979 https://doi.org/10.3389/fphys.2021.777611, #986 https://doi.org/10.3389/fphys.2022.810055, and #987 https://doi.org/10.3389/fphys.2022.832214. This article may be obtained online without charge.

Journal Impact Factor: 4.566

Funding: “The writing of this manuscript was funded by internal funding (Cost unit 2475030). However, the bed rest studies were funded as follows: AGBRESA by DLR, ESA (Contract No. 4000113871/15/NL/PG), and NASA (Contract No. 80JSC018P0078); BBR by ESA (Contract No. 14431/02/NL/SH2); participation at LTBR was funded by DLR (50 WB 0156); MEP by ESA and DLR (50WB1121); NUC by Microgravity Application Program of ESA and Space Directorate of the German Aerospace Center (DLR); Planhab by European Union Programme FP7 (Grant No. 284438), ESA (Contract No. 40001043721/11/NL/KML), and the Slovene Research Agency (Contract No. L3-3654); RSL by ESA (contract number 4000113871-15-NL); and Valdoltra by the Italian Space Agency (ASI), the Slovene Ministry of Defence, and the Gosta Fraenckel foundation for medical research.”

 

4

Hill JR, Caldwell BS.

Front Physiol. 2022 Jan 26;13:779873.

Note: This article is part of Research Topic “Wearable Technology for Human Performance” (https://www.frontiersin.org/research-topics/20640/wearable-technology-for-human-performance#articles). This article may be obtained online without charge.

Journal Impact Factor: 4.566

Funding: “This work was supported by the Planetary Science and Technology Through Analog Research (PSTAR) Program (NNH14ZDA001N-PSTAR) grant ‘Biologic Analog Science Associated with Lava Terrains’ (BASALT) (14-PSTAR14_2-0007) to D. Lim and additional support from NASA SSERVI ‘Field Investigations to Enable Solar System Science and Exploration’ (FINESSE) grant to J. Heldmann, and the NASA Indiana Space Grant Consortium training grant (NNX15AI07H) to BC. BC was the institutional PI for these grants (FINESSE: NNX14AF37A; BASALT: NNX15AM05A; and INSGC: NNX15AI07H).”

 

5

Park SY, Wooden TK, Pekas EJ, Anderson CP, Yadav SK, Slivka DR, Layec G.

J Appl Physiol (1985). 2022 Feb 17. Online ahead of print.

Journal Impact Factor: 3.495

Funding: “P20GM109090/HHS | National Institutes of Health (NIH); NNX15AI09H/NASA/NASA/United States; 80NSSC20M0112/NASA Nebraska Space Grant; N/A/NASA Nebraska Space Grant Fellowship; 5444/The Sherwood Foundation.”

 

_______________________________________________________

 

 

Other papers of interest:

 

1

Domnin PA, Parfenov VA, Kononikhin AS, Petrov SV, Shevlyagina NV, Arkhipova AY, Koudan EV, Nezhurina EK, Brzhozovskiy AG, Bugrova AE, Moysenovich AM, Levin AA, Karalkin PA, Pereira F, Zhukhovitsky VG, Lobakova ES, Mironov VA, Nikolaev EN, Khesuani YD, Ermolaeva SA.

Int J Mol Sci. 2022 Feb 6;23(3):1837.

Note: ISS results. This article and an article below in this section (Fedeli et al.) are part of Special Issue “Microgravity and Space Medicine 2.0” (https://www.mdpi.com/journal/ijms/special_issues/microgravity_2). The Special Issue also includes articles from previous Current Awareness Lists #953 https://doi.org/10.3390/ijms22094901, https://doi.org/10.3390/ijms22115428, and https://doi.org/10.3390/ijms22126299; #976 https://doi.org/10.3390/ijms222111911; #979 https://doi.org/10.3390/ijms222312841; and #983 https://doi.org/10.3390/ijms23010136. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

2

Doroshin A, Jillings S, Jeurissen B, Tomilovskaya E, Pechenkova E, Nosikova I, Rumshiskaya A, Litvinova L, Rukavishnikov I, De Laet C, Schoenmaekers C, Sijbers J, Laureys S, Petrovichev V, Van Ombergen A, Annen J, Sunaert S, Parizel PM, Sinitsyn V, zu Eulenburg P, Osipowicz K, Wuyts FL.

Front Neural Circuits, 2022 Feb 18;16:815838.

Note: ISS results. From the abstract: “In this study, we present findings of brain structural changes associated with long-duration spaceflight based on diffusion magnetic resonance imaging (dMRI) data. Twelve cosmonauts who spent an average of six months aboard the International Space Station (ISS) were scanned in an MRI scanner preflight, ten days after flight, and at a follow-up time point seven months after flight.” This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior” (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). The Research Topic also includes articles from previous Current Awareness Lists #956 https://doi.org/10.3389/fncir.2021.659557; #967 https://doi.org/10.3389/fphys.2021.654906; #969 https://doi.org/10.3389/fphys.2021.746509; #973 https://doi.org/10.3389/fncir.2021.723504; #975 https://doi.org/10.3389/fncir.2021.757817, https://doi.org/10.3389/fncir.2021.760313, and https://doi.org/10.3389/fphys.2021.750414; #976 https://doi.org/10.3389/fphys.2021.770502; #977 https://doi.org/10.3389/fphys.2021.782860; #979 https://doi.org/10.3389/fncir.2021.750176; #982 https://doi.org/10.3389/fphys.2021.795321; #985 https://doi.org/10.3389/fphys.2022.806357; and #987 https://doi.org/10.3389/fphys.2021.751016. To view the SpaceRef press release go to: http://spaceref.com/space-medicine/human-brains-get-rewired-to-adapt-to-long-term-space-missions-study-finds.html. This article may be obtained online without charge.

 

3

Gronwald BJ, Kijak K, Jezierska K, Gronwald HA, Kosko K, Matuszczak M, Bielawska-Victorini HB, Podraza W, Orzechowski L, Lietz-Kijak D.

Int J Environ Res Public Health. 2022 Jan 26;19(3):1367.

Note: Analog space mission results. This article is part of Special Issue “Correlation between Food and Oral Health: Prevention, Diagnosis and Management of Linked Pathologies” (https://www.mdpi.com/journal/ijerph/special_issues/Food_Oral_Health). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

4

Kato S, Murakami M, Saika R, Soga K, Wakabayashi K, Hashimoto H, Yano S, Matsumoto S, Kasahara H, Kamada M, Shimazu T, Hashimoto T, Hoson T.

Plants (Basel). 2022 Feb 8;11(3):465.

Note: ISS results. This article is part of Special Issue “Plant Responses to Gravity, Microgravity, and Space Environment” (https://www.mdpi.com/journal/plants/special_issues/Gravity_and_Plants). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

5

Fedeli V, Cucina A, Dinicola S, Fabrizi G, Catizone A, Gesualdi L, Ceccarelli S, Harrath AH, Alwasel SH, Ricci G, Pedata P, Bizzarri M, Monti N.

Int J Mol Sci. 2022 Feb 16;23(4):2163.

Note: A random positioning machine was used in this study. This article and an article above in this section (Domnin et al.) are part of Special Issue “Microgravity and Space Medicine 2.0” (https://www.mdpi.com/journal/ijms/special_issues/microgravity_2). This article may be obtained online without charge.

 

6

Liang R, Wang L, Sun S, Zheng C, Yang J, Ming D.

Life Sci Space Res. 2022 May;33:21-32.

Note: The method of simulated microgravity is not evident in the available abstract.

 

7

Dello Russo C, Bandiera T, Monici M, Surdo L, Yip VLM, Wotring V, Morbidelli L.

Br J Pharmacol. 2022 Feb 15. Review. Online ahead of print.

Note: Bed rest study review. From the abstract: “As human spaceflight continues with extended mission durations, the demand of effective and safe drugs is going to increase. To date, the medications used during missions (for space motion sickness, sleep disturbances, allergies, pain and sinus congestion) are administered under the assumption that they act similarly as on Earth. During spaceflights however fluid shifts, muscle and bone loss, immune system dysregulation and changes in the gastrointestinal tract and metabolism are documented. These alterations may change the pharmacokinetics (PK) and pharmacodynamics. The information gained from bed rest studies and from in-flight observations is partial and demonstrates variability in drug PK. The objectives of this review are to report: i) the impact of the space environmental stressors on human physiology in relation to PK; ii) the state-of-the-art on experimental data in space and/or in ground-based models; iii) the validation of ground-based models for PK studies; and iv) the identification of possible research gaps.”

 

8

Jordan J, Limper U, Tank J.

Neurol Sci. 2022 Feb 23. Review. Online ahead of print.

Note: From the abstract: “The harsh environmental conditions during space travel, particularly weightlessness, impose a major burden on the human body including the cardiovascular system. Given its importance in adjusting the cardiovascular system to environmental challenges, the autonomic nervous system has been in the focus of scientists and clinicians involved in human spaceflight. This review provides an overview on human autonomic research under real and simulated space conditions with a focus on orthostatic intolerance.”

 

9

Sawyers L, Anderson C, Boyd MJ, Hessel V, Wotring V, Williams PM, Toh LS.

Res Social Adm Pharm. 2022 Feb 12;S1551-7411(22)00034-1. Online ahead of print.

Note: From the abstract: “Human physiology undergoes extensive changes in space potentially leading to alterations in the way a medication functions. Understanding the efficacy behind Pharmacological Countermeasures (PCMs) and deliverable pharmacy services is imperative for the future presence of humans in space. However, while the pharmacist plays an integral role for human health terrestrially, pharmacist input has been minimal for human health in the space sector. Here, we explore the pharmacist’s potential role in larger medical teams for future missions.”

 

10

Sanzone G, Field S, Lee D, Liu J, Ju P, Wang M, Navabpour P, Sun H, Yin J, Lievens P.

ACS Appl Mater Interfaces. 2022 Feb 18. Online ahead of print.

Note: From the abstract: “Inside a spacecraft, the temperature and humidity, suitable for the human crew onboard, also creates an ideal breeding environment for the proliferation of bacteria and fungi; this can present a hazard to human health and create issues for the safe running of equipment. To address this issue, wear-resistant antimicrobial thin films prepared by magnetron sputtering were developed, with the aim to coat key internal components within spacecrafts.”

 

11

Liu HY, Zhao CH, Zhang H, Wang W, Liu QJ.

Comput Methods Biomech Biomed Engin. 2022 Feb 16;1-10. Online ahead of print.

Note: From the abstract: “Osteoporosis occurs in astronauts after long-term spaceflight owing to the lack of gravity. The mechanical microenvironment of osteocytes in load-bearing bone are changed during resistance exercise, which prevents massive bone loss in the human body. A cylindrical fluid-structure coupling finite element model for osteons with a two-stage pore structure (i.e., Haversian canal, lacunar-canalicular system) was established with the software COMSOL. In the Earth’s gravity field and in microgravity, considering the effects of pulsating pressure of arterioles, a comparative study was performed on the changes in hydrodynamic microenvironment of osteocytes during human body high-intensity exercise at different frequencies (defined as causing bone to produce 3000 με) and the body is at rest.”

 

12

Schmitz J, Ahlbäck A, DuCanto J, Kerkhoff S, Komorowski M, Löw V, Russomano T, Starck C, Thierry S, Warnecke T, Hinkelbein J.

J Clin Med. 2022 Jan 27;11(3):646.

Note: From the article: “We conducted a randomized parallel group trial (RCT) comparing two new methods for CPR in a free-floating underwater setting. Both methods require the operator to stabilize the patient on his/her thighs and deliver chest compressions using both arms in the first method (Schmitz–Hinkelbein method), or using one elbow in the Cologne method.” This article is part of the Special Issue “Cardiopulmonary Resuscitation: Clinical Updates and Perspectives” (https://www.mdpi.com/journal/jcm/special_issues/cardiopulmonary_resuscitation). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

13

Turton HA, Pickworth J, Paterson GG, Lawrie A, Baillie JK, Thompson AAR.

Front Physiol. 2022 Feb 16;13:825819.

Note: This article is part of Research Topic “Stroke and Infarction at High Altitude” (https://www.frontiersin.org/research-topics/22829/stroke-and-infarction-at-high-altitude#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

14

Duran AT, Romero E, Diaz KM.

Curr Cardiol Rep. 2022 Feb 19. Review. Online ahead of print.

 

15

Park H, Ryu J, Jung S, Park H, Oh H, Kook M.

Materials (Basel). 2022 Jan 21;15(3):827.

Note: This article is part of the Special Issue “Synthesis and Characterization of Hybrid Scaffolds in Bone Tissue Regeneration” (https://www.mdpi.com/journal/materials/special_issues/Synthesis_BoneRegeneration). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

16

Sharlo K, Lvova I, Turtikova O, Tyganov S, Kalashnikov V, Shenkman B.

Arch Biochem Biophys. 2022 Mar 30;718:109150.

Note: Hindlimb unloading study.

 

17

Wu YF, Lapp S, Dvoretskiy S, Garcia G, Kim M, Tannehill A, Daniels L, Boppart MD.

J Appl Physiol (1985). 2022 Feb 17. Online ahead of print.

 

18

Xu Z, Fu T, Guo Q, Zhou D, Sun W, Zhou Z, Chen X, Zhang J, Liu L, Xiao L, Yin Y, Jia Y, Pang E, Chen Y, Pan X, Fang L, Zhu MS, Fei W, Lu B, Gan Z.

Nat Commun. 2022 Feb 16;13:894.

Note: This article may be obtained online without charge.

 

19

Wang L, You X, Zhang L, Zhang C, Zou W.

Bone Res. 2022 Feb 18;10:16. Review.

Note: This article may be obtained online without charge.

 

20

Xu M, Du J, Cui J, Zhang S, Zhang S, Deng M, Zhang W, Li H, Yu Z.

Front Bioeng Biotechnol. 2022 Jan 28;10:818572.

Note: Hindlimb unloading study. This article is part of Research Topic “Progress on Musculoskeletal Disorders and Stem Cell Therapies” (https://www.frontiersin.org/research-topics/25012/progress-on-musculoskeletal-disorders-and-stem-cell-therapies#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

21

Tu W, Feng Y, Lai Q, Wang J, Yuan W, Yang J, Jiang S, Wu A, Cheng S, Shao J, Li J, Jiang Z, Tang H, Shi Y, Zhang S.

Radiat Res. 2022 Feb 16. Online ahead of print.

 

22

Wang L, Zhang D, Song Y, Zhang H.

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Feb;36(2):149-52. Review. Chinese.

 

23

Travers G, Kippelen P, Trangmar SJ, González-Alonso J.

Cells. 2022 Jan 24;11(3):383. Review.

Note: This article is part of the Special Issue “Brain-Body Interactions in the Maintenance of Homeostasis: An Honorary Issue in Memory of Prof. Claude Bernard” (https://www.mdpi.com/journal/cells/special_issues/Honorary_Issue_Claude_Bernard) Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

24

Invernizzi PL, Signorini G, Scurati R, Michielon G, Benedini S, Bosio A, Staiano W.

Int J Environ Res Public Health. 2022 Jan 21;19(3):1175.

Note: NASA Task Load Index assessment. This article may be obtained online without charge.