Status Report

NASA Spaceline Current Awareness List #986 11 February 2022 (Space Life Science Research Results)

By SpaceRef Editor
February 11, 2022
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Bretl KN, Clark TK.
Quantitative analysis of short-radius artificial gravity parameters to mitigate spaceflight-relevant physiological deconditioning.
Acta Astronaut. 2022 Feb 2. Online ahead of print.
Note: Bedrest studies. From the abstract: “Using artificial gravity (AG) as a physiological countermeasure for astronauts during spaceflight has been discussed and researched for decades; however, today there still exists a lack of optimized AG design. The enclosed work critically analyzes the existing literature of bedrest studies (a ground-based analog of microgravity) to provide insight into the benefit of using AG to counteract physiological deconditioning. Physiological data were extracted from 20+ publications that studied the benefit of AG centrifugation during bedrest of 4–60 days in length. Both AG parameters (i.e., loading level, duration of exposure, presence of exercise, etc.) and the physiological measures investigated varied between studies. To aggregate dissimilar measures, we combined outcomes within each physiological subsystem. Multiple linear regression models were used to analyze each subsystem across studies and determine which AG parameters produced the most effective mitigation of bedrest-induced physiological deconditioning.”
Journal Impact Factor: 2.413
Funding: “This work was supported by a NASA Space Technology Research Fellowship, Grant Number 80NSSCK0085.”
Kramer LA, Hasan KM, Gabr RE, Macias BR, Marshall-Goebel K, Laurie SS, Hargens AR.
Cerebrovascular effects of lower body negative pressure at 3T MRI: Implications for long-duration space travel.
J Magn Reson Imaging. 2022 Feb 4. Online ahead of print.
PI: K. Marshall-Goebel
Note: From the article: “Subjects were placed inside a custom-built MRI compatible semi-airtight acrylic chamber sealed at the iliac crest by a compliant waistband that effectively isolated the lower body from atmospheric conditions. A commercial vacuum was attached and positioned outside the magnet room where motor speed was modulated to generate 25 mmHg LBNP (LBMP25) within the chamber for approximately 60 minutes.”
Journal Impact Factor: 3.954
Funding: “The authors acknowledge funding from the NASA Human Research Program directed study.”
Ong J, Zaman N, Kamran SA, Waisberg E, Tavakkoli A, Lee AG, Webster M.
A multi-modal visual assessment system for monitoring Spaceflight Associated Neuro-Ocular Syndrome (SANS) during long duration spaceflight.
J Vis. 2022 Feb 1;22(3):6.
PI: A. Tavakkoli
Note: From the abstract: “Spaceflight Associated Neuro-Ocular Syndrome (SANS) refers to a unique collection of neuro-ophthalmic clinical and imaging findings that are observed in astronauts during long duration spaceflight. These findings include optic disc edema, posterior globe flattening, retinal nerve layer fiber thickening, optic nerve sheath distension, and hyperopic shift. SANS currently serves as a large barrier to deep space exploration; however, the exact pathophysiology is still being investigated. While in-flight imaging exists on the International Space Station, there are limitations to constant monitoring. To efficiently document the subtle changes that occur in SANS, NASA has funded the development of a head-mounted display, multi-modal visual assessment system; this novel device integrates visual acuity, visual field, contrast sensitivity, and metamorphopsia data (indirect indications) with known terrestrial neuro-ophthalmic imaging (direct indications) from astronauts and terrestrial analogs.”
Journal Impact Factor: 2.240
Funding: “This research was funded by NASA Grant 80NSSC20K1831 titled: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”
Penninckx S, Pariset E, Cekanaviciute E, Costes SV.
Quantification of radiation-induced DNA double strand break repair foci to evaluate and predict biological responses to ionizing radiation.
NAR Cancer. 2021 Dec 22;3(4):zcab046.
PI: S.V. Costes
Journal Impact Factor: Not available for this journal
Funding: “National Aeronautics and Space Administration award #NNJ16HP24I to S.V.C. (Principal Investigator – PI).”
Kent BA, Rahman SA, St Hilaire MA, Grant LK, Rüger M, Czeisler CA, Lockley SW.
Circadian lipid and hepatic protein rhythms shift with a phase response curve different than melatonin.
Nat Commun. 2022 Feb 3;13:681.
PIs: M.A. St Hilaire, S.W. Lockley
Note: This article may be obtained online without charge.
Journal Impact Factor: 14.919
Funding: “S.A.R., M.S.H., L.K.G., C.A.C. and S.W.L. were supported by NASA NNX14AK53G, M.S.H. by NINR R21NR018974 and NASA 80NSSC20K0576, and C.A.C. by NIA P01 AG009975. S.A.R., M.R., C.A.C., and S.W.L. were supported, in part, by the National Space Biomedical Research Institute through NASA NCC 9–58.”
Hilditch CJ, Wong LR, Bathurst NG, Feick NH, Pradhan S, Santamaria A, Shattuck NL, Flynn-Evans EE.
Rise and shine: The use of polychromatic short-wavelength-enriched light to mitigate sleep inertia at night following awakening from slow-wave sleep.
J Sleep Res. 2022 Jan 31;e13558. Online ahead of print.
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.981
Funding: “This work was supported in part by the Naval Medical Research Center’s Naval Advanced Medical Development Program (MIPR N3239820WXHN007), and the NASA Airspace Operations and Safety Program, System-Wide Safety.”
McFarland AJ, Ray PR, Bhai S, Levine BD, Price TJ.
RNA sequencing on muscle biopsy from a 5-week bed rest study reveals the effect of exercise and potential interactions with dorsal root ganglion neurons.
Physiol. Rep. 2022 Feb 8;10(3):e15176.
PI: B.D. Levine
Note: Bed rest study. This article may be obtained online without charge.
Journal Impact Factor: 2.261
Funding: “This study was supported by the National Institutes of Health Grant NS065926, National Space Biomedical Research Institute through National Aeronautics and Space Administration NCC 9-58, American Heart Association postdoctoral fellowship Grant No. 0525077Y, and the Clinical Translational Research Center (formerly General Clinical Research Center) Grant No. RR-00804.”
Giovannini I, Boothby TC, Cesari M, Goldstein B, Guidetti R, Rebecchi L.
Production of reactive oxygen species and involvement of bioprotectants during anhydrobiosis in the tardigrade Paramacrobiotus spatialis.
Sci Rep. 2022 Feb 4;12:1938.
PI: T.C. Boothby
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.380
Funding: This work has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant agreement No. 734434 and FAR 2015 of the Department of Life Sciences, UNIMORE. B.G. was supported by NSF Grants IOS 1557432 and IOS 2028860. T.C.B. was supported by NASA Grant 80NSSC20K0283 and an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Grant # 2P20GM103432.”
Other papers of interest:
Saveko A, Brykov V, Kitov V, Shpakov A, Tomilovskaya E.
Adaptation in gait to Lunar and Martian gravity unloading during long-term isolation in the ground-based space station model.
Front Hum Neurosci. 2022 Jan 12;15:742664.
Note: Body weight unloading study. The h/p/cosmos airwalk system was used in this study. This article may be obtained online without charge.
Yao Z, Feng J, Liu H.
Bioweathering improvement of lunar soil simulant improves the cultivated wheat’s seedling length.
Acta Astronaut. 2022 Apr;193:1-8.
Note: From the abstract: “Crewed base is the future trend of lunar exploration. Bioregenerative life support system (BLSS) is necessary for crewed lunar bases, with plant cultivation as the core functional unit. Since transport from the Earth to the Moon is expensive, BLSS should make full use of in situ resources. Lunar soil is the most abundant in situ resource on lunar surface and has little biological toxicity, which could be used as the substrate of plant cultivation in BLSS.”
Wuest SL, Cerretti G, Wadsworth JL, Follonier C, Rattenbacher-Kiser KF, Bradley T, Egli M, Ille F.
Cytosolic calcium and membrane potential in articular chondrocytes during parabolic flight.
Acta Astronaut. 2022 Apr;193:287-302.
Note: Parabolic flight results. This article may be obtained online without charge.
Kjærgaard A, Leon GR, Chterev K.
Team effectiveness and person-environment adaptation in an analog lunar habitat.
Aerosp Med Hum Perform. 2022 Feb;93(2):70-8.
Note: From the abstract: “Maintaining psychologically adaptive relationships among team members operating in an isolated, confined, and extreme (ICE) environment for an extended period continues to be a challenge, with relevance for long-duration missions to the Moon and beyond.”
Tobita K, Mekjavic IB, McDonnell AC.
Individual variation exists within the psychological response to hypoxic bed rest: A retrospective analysis.
Front Physiol. 2022 Feb 10;13:810055.
Note: Bed rest study analysis. This article is part of Research Topic “Investigation of the Inter-individual Variability of Physiological Responses to Changes in Activity Levels-, Gravity Loading-, Nutritional Status, Pharmaceuticals and Exposure to Radiation” ( The Research Topic also includes articles from previous Current Awareness Lists #921, #937, #952, #959, and #979 This article may be obtained online without charge.
Trinity JD, Drummond MJ, Fermoyle CC, McKenzie AI, Supiano MA, Richardson RS.
Cardiovasomobility: An integrative understanding of how disuse impacts cardiovascular and skeletal muscle health.
J Appl Physiol (1985). 2022 Feb 3. Review. Online ahead of print.
Li C, Zhang Z, Wang G, Rong C, Zhu W, Lu X, Liu Y, Zhang H.
Accuracies of bone resection, implant position, and limb alignment in robotic-arm-assisted total knee arthroplasty: A prospective single-centre study.
J Orthop Surg Res. 2022 Jan 29;17:61.
Note: From the abstract: “This study assessed the accuracy of robotic-arm-assisted total knee arthroplasty (RATKA) for bone resection, component size prediction, implant placement, and limb alignment.” This article may be obtained online without charge.
Yu S, Tang Q, Chen G, Lu X, Yin Y, Xie M, Long Y, Zheng W, Guo F, Shao L, Shi A, Chen L.
Circadian rhythm modulates endochondral bone formation via MTR1/AMPKβ1/BMAL1 signaling axis.
Cell Death Differ. 2022 Jan 29. Online ahead of print.
Guerrieri P, Jacob NK, Maxim PG, Sawant A, Van Nest SJ, Mohindra P, Dominello MM, Burmeister JW, Joiner MC.
Three discipline collaborative radiation therapy (3DCRT) special debate: FLASH radiotherapy needs ongoing basic and animal research before implementing it to a large clinical scale.
J Appl Clin Med Phys. 2022 Feb 1;e13547. Online ahead of print.
He D, Zhao Z, Fu B, Li X, Zhao L, Chen Y, Liu L, Liu R, Li J.
Exosomes participate in the radiotherapy resistance of cancers.
Radiat Res. 2022 Feb 7. Online ahead of print.
Salem AM, Jackson IL, Gibbs A, Poirier Y, Newman D, Zodda A, Vujaskovic Z, Kaytor MD, Serebrenik AA, Gobburu J, Gopalakrishnan M.
Interspecies comparison and radiation effect on pharmacokinetics of BIO 300, a nanosuspension of genistein, after different routes of administration in mice and non-human primates.
Radiat Res. 2022 Feb 4. Online ahead of print.
Barcellos-Hoff MH.
The radiobiology of TGFβ.
Semin Cancer Biol. 2022 Feb 2;S1044-579X(22)00022-0. Online ahead of print.
Note: From the abstract: “Ionizing radiation is a pillar of cancer therapy that is deployed in more than half of all malignancies. The therapeutic effect of radiation is attributed to induction of DNA damage that kills cancers cells, but radiation also affects signaling that alters the composition of the tumor microenvironment by activating transforming growth factor β (TGFβ). TGFβ is a ubiquitously expressed cytokine that acts as biological lynchpin to orchestrate phenotypes, the stroma and immunity in normal tissue; these activities are subverted in cancer to promote malignancy of cancer cells, a permissive tumor microenvironment and immune evasion.”
Ross E, Kinney M, Fogt N.
Coincidence anticipation timing responses with head tracking and eye tracking.
Aerosp Med Hum Perform. 2022 Feb;93(2):79-88.
Note: From the abstract: “Head tracking movements are common in interceptive tasks. The benefits of these movements are unclear. The purpose of this study was to compare coincidence anticipation timing (CAT) responses for a simulated approaching object when the eyes were used in tracking the object and when the head was used in tracking the object.”
Dart TS, Morse BG.
Variations on Ernsting’s post-decompression hypoxia prevention model.
Aerosp Med Hum Perform. 2022 Feb;93(2):99-105.
Bery A, Bagchi U, Bergen AA, Felder-Schmittbuhl MP.
Circadian clocks, retinogenesis and ocular health in vertebrates: New molecular insights.
Dev Biol. 2022 Feb 3;S0012-1606(22)00015-X. Review. Online ahead of print.
Miyake T, Doi M.
[Roles of the circadian clock mechanism in the regulation of daily rhythms of body temperature].
Brain Nerve. 2022 Feb;74(2):159-66. Review. Japanese.
Mohandas R, Douma LG, Scindia Y, Gumz ML.
Circadian rhythms and renal pathophysiology.
J Clin Invest. 2022 Feb 1;132(3):e148277. Review.
Note: This article may be obtained online without charge.
Chapleau RR, Regn DD, de Castro MJ.
Surveying the genomic landscape supporting the development of precision military aerospace medicine.
Aerosp Med Hum Perform. 2022 Feb;93(2):89-93.
Note: From the abstract: “Precision medicine is an approach to healthcare that is modifying clinical management by leveraging technological advances in genomics that assess a patient’s genetic information to identify unique predispositions. While the civilian sector is integrating genomics widely to personalize diagnosis and treatment, the military medical environment has reacted more slowly. The operational requirements of military service encourage a tailored approach for focusing military precision medicine on occupation-specific conditions. Here, we present a survey of the genomic landscape related to military aerospace medicine.”
Yu H, Yu T, Wang J, Wei F, Gong H, Dong H, He X, Wang Z, Yang J.
Validation of a three-dimensional printed dry lab pancreaticojejunostomy model in surgical assessment: A cross-sectional study.
BMJ Open. 2022 Feb 1;12(2):e052295.
Note: NASA Task Load Index assessment. This article may be obtained online without charge.

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