NASA Spaceline Current Awareness List #986 11 February 2022 (Space Life Science Research Results)

 

Papers deriving from NASA support:

 

1

Bretl KN, Clark TK.

Acta Astronaut. 2022 Feb 2. Online ahead of print.

Note: Bedrest studies. From the abstract: “Using artificial gravity (AG) as a physiological countermeasure for astronauts during spaceflight has been discussed and researched for decades; however, today there still exists a lack of optimized AG design. The enclosed work critically analyzes the existing literature of bedrest studies (a ground-based analog of microgravity) to provide insight into the benefit of using AG to counteract physiological deconditioning. Physiological data were extracted from 20+ publications that studied the benefit of AG centrifugation during bedrest of 4–60 days in length. Both AG parameters (i.e., loading level, duration of exposure, presence of exercise, etc.) and the physiological measures investigated varied between studies. To aggregate dissimilar measures, we combined outcomes within each physiological subsystem. Multiple linear regression models were used to analyze each subsystem across studies and determine which AG parameters produced the most effective mitigation of bedrest-induced physiological deconditioning.”

Journal Impact Factor: 2.413

Funding: “This work was supported by a NASA Space Technology Research Fellowship, Grant Number 80NSSCK0085.”

 

2

Kramer LA, Hasan KM, Gabr RE, Macias BR, Marshall-Goebel K, Laurie SS, Hargens AR.

J Magn Reson Imaging. 2022 Feb 4. Online ahead of print.

PI: K. Marshall-Goebel

Note: From the article: “Subjects were placed inside a custom-built MRI compatible semi-airtight acrylic chamber sealed at the iliac crest by a compliant waistband that effectively isolated the lower body from atmospheric conditions. A commercial vacuum was attached and positioned outside the magnet room where motor speed was modulated to generate 25 mmHg LBNP (LBMP₂₅) within the chamber for approximately 60 minutes.”

Journal Impact Factor: 3.954

Funding: “The authors acknowledge funding from the NASA Human Research Program directed study.”

 

3

Ong J, Zaman N, Kamran SA, Waisberg E, Tavakkoli A, Lee AG, Webster M.

J Vis. 2022 Feb 1;22(3):6.

PI: A. Tavakkoli

Note: From the abstract: “Spaceflight Associated Neuro-Ocular Syndrome (SANS) refers to a unique collection of neuro-ophthalmic clinical and imaging findings that are observed in astronauts during long duration spaceflight. These findings include optic disc edema, posterior globe flattening, retinal nerve layer fiber thickening, optic nerve sheath distension, and hyperopic shift. SANS currently serves as a large barrier to deep space exploration; however, the exact pathophysiology is still being investigated. While in-flight imaging exists on the International Space Station, there are limitations to constant monitoring. To efficiently document the subtle changes that occur in SANS, NASA has funded the development of a head-mounted display, multi-modal visual assessment system; this novel device integrates visual acuity, visual field, contrast sensitivity, and metamorphopsia data (indirect indications) with known terrestrial neuro-ophthalmic imaging (direct indications) from astronauts and terrestrial analogs.”

Journal Impact Factor: 2.240

Funding: “This research was funded by NASA Grant 80NSSC20K1831 titled: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”

 

4

Penninckx S, Pariset E, Cekanaviciute E, Costes SV.

NAR Cancer. 2021 Dec 22;3(4):zcab046.

PI: S.V. Costes

Journal Impact Factor: Not available for this journal

Funding: “National Aeronautics and Space Administration award #NNJ16HP24I to S.V.C. (Principal Investigator – PI).”

 

5

Kent BA, Rahman SA, St Hilaire MA, Grant LK, Rüger M, Czeisler CA, Lockley SW.

Nat Commun. 2022 Feb 3;13:681.

PIs: M.A. St Hilaire, S.W. Lockley

Note: This article may be obtained online without charge.

Journal Impact Factor: 14.919

Funding: “S.A.R., M.S.H., L.K.G., C.A.C. and S.W.L. were supported by NASA NNX14AK53G, M.S.H. by NINR R21NR018974 and NASA 80NSSC20K0576, and C.A.C. by NIA P01 AG009975. S.A.R., M.R., C.A.C., and S.W.L. were supported, in part, by the National Space Biomedical Research Institute through NASA NCC 9–58.”

 

6

Hilditch CJ, Wong LR, Bathurst NG, Feick NH, Pradhan S, Santamaria A, Shattuck NL, Flynn-Evans EE.

J Sleep Res. 2022 Jan 31;e13558. Online ahead of print.

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.981

Funding: “This work was supported in part by the Naval Medical Research Center’s Naval Advanced Medical Development Program (MIPR N3239820WXHN007), and the NASA Airspace Operations and Safety Program, System-Wide Safety.”

 

7

McFarland AJ, Ray PR, Bhai S, Levine BD, Price TJ.

Physiol. Rep. 2022 Feb 8;10(3):e15176.

PI: B.D. Levine

Note: Bed rest study. This article may be obtained online without charge.

Journal Impact Factor: 2.261

Funding: “This study was supported by the National Institutes of Health Grant NS065926, National Space Biomedical Research Institute through National Aeronautics and Space Administration NCC 9-58, American Heart Association postdoctoral fellowship Grant No. 0525077Y, and the Clinical Translational Research Center (formerly General Clinical Research Center) Grant No. RR-00804.”

 

8

Giovannini I, Boothby TC, Cesari M, Goldstein B, Guidetti R, Rebecchi L.

Sci Rep. 2022 Feb 4;12:1938.

PI: T.C. Boothby

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.380

Funding: “This work has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant agreement No. 734434 and FAR 2015 of the Department of Life Sciences, UNIMORE. B.G. was supported by NSF Grants IOS 1557432 and IOS 2028860. T.C.B. was supported by NASA Grant 80NSSC20K0283 and an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Grant # 2P20GM103432.”

 

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Other papers of interest:

 

1

Saveko A, Brykov V, Kitov V, Shpakov A, Tomilovskaya E.

Front Hum Neurosci. 2022 Jan 12;15:742664.

Note: Body weight unloading study. The h/p/cosmos airwalk system was used in this study. This article may be obtained online without charge.

 

2

Yao Z, Feng J, Liu H.

Acta Astronaut. 2022 Apr;193:1-8.

Note: From the abstract: “Crewed base is the future trend of lunar exploration. Bioregenerative life support system (BLSS) is necessary for crewed lunar bases, with plant cultivation as the core functional unit. Since transport from the Earth to the Moon is expensive, BLSS should make full use of in situ resources. Lunar soil is the most abundant in situ resource on lunar surface and has little biological toxicity, which could be used as the substrate of plant cultivation in BLSS.”

 

3

Wuest SL, Cerretti G, Wadsworth JL, Follonier C, Rattenbacher-Kiser KF, Bradley T, Egli M, Ille F.

Acta Astronaut. 2022 Apr;193:287-302.

Note: Parabolic flight results. This article may be obtained online without charge.

 

4

Kjærgaard A, Leon GR, Chterev K.

Aerosp Med Hum Perform. 2022 Feb;93(2):70-8.

Note: From the abstract: “Maintaining psychologically adaptive relationships among team members operating in an isolated, confined, and extreme (ICE) environment for an extended period continues to be a challenge, with relevance for long-duration missions to the Moon and beyond.”

 

5

Tobita K, Mekjavic IB, McDonnell AC.

Individual variation exists within the psychological response to hypoxic bed rest: A retrospective analysis.

Front Physiol. 2022 Feb 10;13:810055.

Note: Bed rest study analysis. This article is part of Research Topic “Investigation of the Inter-individual Variability of Physiological Responses to Changes in Activity Levels-, Gravity Loading-, Nutritional Status, Pharmaceuticals and Exposure to Radiation” (https://www.frontiersin.org/research-topics/14100/investigation-of-the-inter-individual-variability-of-physiological-responses-to-changes-in-activity#articles). The Research Topic also includes articles from previous Current Awareness Lists #921 https://doi.org/10.3389/fphys.2020.573581, #937 https://doi.org/10.3389/fphys.2021.614619, #952 https://doi.org/10.3389/fphys.2021.685473, #959 https://doi.org/10.3389/fphys.2021.676501, and #979 https://doi.org/10.3389/fphys.2021.777611. This article may be obtained online without charge.

 

6

Trinity JD, Drummond MJ, Fermoyle CC, McKenzie AI, Supiano MA, Richardson RS.

J Appl Physiol (1985). 2022 Feb 3. Review. Online ahead of print.

 

7

Li C, Zhang Z, Wang G, Rong C, Zhu W, Lu X, Liu Y, Zhang H.

J Orthop Surg Res. 2022 Jan 29;17:61.

Note: From the abstract: “This study assessed the accuracy of robotic-arm-assisted total knee arthroplasty (RATKA) for bone resection, component size prediction, implant placement, and limb alignment.” This article may be obtained online without charge.

 

8

Yu S, Tang Q, Chen G, Lu X, Yin Y, Xie M, Long Y, Zheng W, Guo F, Shao L, Shi A, Chen L.

Cell Death Differ. 2022 Jan 29. Online ahead of print.

 

9

Guerrieri P, Jacob NK, Maxim PG, Sawant A, Van Nest SJ, Mohindra P, Dominello MM, Burmeister JW, Joiner MC.

J Appl Clin Med Phys. 2022 Feb 1;e13547. Online ahead of print.

 

10

He D, Zhao Z, Fu B, Li X, Zhao L, Chen Y, Liu L, Liu R, Li J.

Radiat Res. 2022 Feb 7. Online ahead of print.

 

11

Salem AM, Jackson IL, Gibbs A, Poirier Y, Newman D, Zodda A, Vujaskovic Z, Kaytor MD, Serebrenik AA, Gobburu J, Gopalakrishnan M.

Radiat Res. 2022 Feb 4. Online ahead of print.

 

12

Barcellos-Hoff MH.

Semin Cancer Biol. 2022 Feb 2;S1044-579X(22)00022-0. Online ahead of print.

Note: From the abstract: “Ionizing radiation is a pillar of cancer therapy that is deployed in more than half of all malignancies. The therapeutic effect of radiation is attributed to induction of DNA damage that kills cancers cells, but radiation also affects signaling that alters the composition of the tumor microenvironment by activating transforming growth factor β (TGFβ). TGFβ is a ubiquitously expressed cytokine that acts as biological lynchpin to orchestrate phenotypes, the stroma and immunity in normal tissue; these activities are subverted in cancer to promote malignancy of cancer cells, a permissive tumor microenvironment and immune evasion.”

 

13

Ross E, Kinney M, Fogt N.

Aerosp Med Hum Perform. 2022 Feb;93(2):79-88.

Note: From the abstract: “Head tracking movements are common in interceptive tasks. The benefits of these movements are unclear. The purpose of this study was to compare coincidence anticipation timing (CAT) responses for a simulated approaching object when the eyes were used in tracking the object and when the head was used in tracking the object.”

 

14

Dart TS, Morse BG.

Aerosp Med Hum Perform. 2022 Feb;93(2):99-105.

 

15

Bery A, Bagchi U, Bergen AA, Felder-Schmittbuhl MP.

Dev Biol. 2022 Feb 3;S0012-1606(22)00015-X. Review. Online ahead of print.

 

16

Miyake T, Doi M.

Brain Nerve. 2022 Feb;74(2):159-66. Review. Japanese.

 

17

Mohandas R, Douma LG, Scindia Y, Gumz ML.

J Clin Invest. 2022 Feb 1;132(3):e148277. Review.

Note: This article may be obtained online without charge.

 

18

Chapleau RR, Regn DD, de Castro MJ.

Aerosp Med Hum Perform. 2022 Feb;93(2):89-93.

Note: From the abstract: “Precision medicine is an approach to healthcare that is modifying clinical management by leveraging technological advances in genomics that assess a patient’s genetic information to identify unique predispositions. While the civilian sector is integrating genomics widely to personalize diagnosis and treatment, the military medical environment has reacted more slowly. The operational requirements of military service encourage a tailored approach for focusing military precision medicine on occupation-specific conditions. Here, we present a survey of the genomic landscape related to military aerospace medicine.”

 

19

Yu H, Yu T, Wang J, Wei F, Gong H, Dong H, He X, Wang Z, Yang J.

BMJ Open. 2022 Feb 1;12(2):e052295.

Note: NASA Task Load Index assessment. This article may be obtained online without charge.