NASA Spaceline Current Awareness List #985 4 February 2022 (Space Life Science Research Results)

 

Papers deriving from NASA support:

 

1

Goodenow-Messman DA, Gokoglu SA, Kassemi M, Myers JG Jr.

npj Microgravity. 2022 Jan 28;8(1):2.

PI: J.G. Myers, Project Scientist, Cross-Cutting Computational Modeling Project (CCMP)

Note: ISS and shuttle results. This article may be obtained online without charge.

Journal Impact Factor: 4.415

Funding: “The funding for this study is supplied internally through NASA’s Human research program. Many thanks go to Dr. DeVon Griffin and Ms. Kelly Gilkey of the NASA Glenn Research Center and Dr. Steve Platts of the Johnson Space Center for their support of this project. We would also like to thank the astronauts who, over the years, provided 24-h urine specimens to make this study possible and to epidemiologists and data scientists at the NASA LSAH for performing the data mining required to fulfill this study. We also thank the NASA GRC L IT support, Lee Lam, Lee Monai, Diana Drury, and Brian Birk, for their help and support over the years, specifically with the intricacies of implementing MATLAB and JESS.”

 

2

Okada A, Matsumoto T, Ohshima H, Isomura T, Koga T, Yasui T, Kohri K, LeBlanc A, Spector E, Jones J, Shackelford L, Sibonga J.

Bisphosphonate use may reduce the risk of urolithiasis in astronauts on long-term spaceflights.

JBMR Plus. 2022 Jan;6(1):e10550. Available online 6 September 2021.

PI: A. LeBlanc

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 6.741

Funding: “This project was supported by the Human Research Program at the National Aeronautic Space Administration and the Japan Aerospace Exploration Agency. The authors especially thank the astronauts who participated in this research project.”

 

3

Wang Y, Tang J, Vimal VP, Lackner JR, DiZio P, Hong P.

Front Physiol. 2022 Jan 28;13:806357.

PI: V.P. Vimal, TRISH Postdoctoral Program Fellowship

Note: The multi-axis rotation system device (MARS) was used in this study. This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior” (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). The Research Topic also includes articles from previous Current Awareness Lists #956 https://doi.org/10.3389/fncir.2021.659557; #967 https://doi.org/10.3389/fphys.2021.654906; #969 https://doi.org/10.3389/fphys.2021.746509; #973 https://doi.org/10.3389/fncir.2021.723504; #975 https://doi.org/10.3389/fncir.2021.757817, https://doi.org/10.3389/fncir.2021.760313, and https://doi.org/10.3389/fphys.2021.750414; #976 https://doi.org/10.3389/fphys.2021.770502; #977 https://doi.org/10.3389/fphys.2021.782860; #979 https://doi.org/10.3389/fncir.2021.750176; and #982 https://doi.org/10.3389/fphys.2021.795321. This article may be obtained online without charge.

Journal Impact Factor: 4.566

Funding: “VV was supported by the Translational Research Institute for Space Health through NASA NNX16AO69A. The MARS device was provided by the Air Force Office of Scientific Research AFOSR FA9550-12-1-0395. The computing was supported by the NSF OAC 1920147.”

 

4

Nemec-Bakk AS, Sridharan V, Landes RD, Singh P, Cao M, Dominic P, Seawright JW, Chancellor JC, Boerma M.

Life Sci Space Res (Amst). 2022 Feb;32:105-12.

PI: M. Boerma

Journal Impact Factor: 2.082

Funding: “This work was supported by the National Space Biomedical Research Institute [RE03701 through NCC 9-58], the National Aeronautics and Space Administration [80NSSC17K0425 and 80NSSC19K0437], and the National Institutes of General Medical Sciences [P20 GM109005]. The authors wish to thank the BNL support group, the NSRL physicists, the UAMS Experimental Pathology Core, and the animal care staff at UAMS and BNL for their excellent technical support.”

 

5

Shuryak I, Slaba TC, Plante I, Poignant F, Blattnig SR, Brenner DJ.

Sci Rep. 2022 Jan 27;12(1):1453.

PI: D.J. Brenner

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.380

Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) grant NNX16AR81A (DJB and IS), and by the Health and Human Performance Contract (HHPC) number NNJ15HK11 (IP).”

 

6

Clément G, Beaton KH, Reschke MF, Wood SJ.

Sci Rep. 2022 Jan 26;12(1):1430.

PI: S.J. Wood

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.380

Funding: “This work was funded by the National Institute of Health (Wood), the National Space Biomedical Research Institute (Reschke), the National Aeronautics and Space Administration (Reschke), and the Centre National d’Etudes Spatiales (Clément).” PI Wood reports additional funding under NSBRI project “Sensorimotor adaptation following exposure to ambiguous inertial motion cues.”

 

7

Karlebach G, Aronow B, Baylin SB, Butler D, Foox J, Levy S, Meydan C, Mozsary C, Saravia-Butler AM, Taylor DM, Wurtele E, Mason CE, Beheshti A, Robinson PN.

Genomics. 2022 Mar;114(2):110270.

PI: A. Beheshti

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.736

Funding: “…A.B. was supported by supplemental funds for COVID-19 research from Translational Research Institute of Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404). …”

 

8

Park J, Foox J, Hether T, Danko DC, Warren S, Kim Y, Reeves J, Butler DJ, Mozsary C, Rosiene J, Shaiber A, Afshin EE, MacKay M, Rendeiro AF, Bram Y, Chandar V, Geiger H, Craney A, Velu P, Melnick AM, Hajirasouliha I, Beheshti A, Taylor D, Saravia-Butler A, Singh U, Wurtele ES, Schisler J, Fennessey S, Corvelo A, Zody MC, Germer S, Salvatore S, Levy S, Wu S, Tatonetti NP, Shapira S, Salvatore M, Westblade LF, Cushing M, Rennert H, Kriegel AJ, Elemento O, Imielinski M, Rice CM, Borczuk AC, Meydan C, Schwartz RE, Mason CE.

Cell Reports Med. 2022 Jan;100522. Online ahead of print.

PI: A. Beheshti

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was supported by the NCI (R01CA234614) and NIAID (2R01AI107301) and NIDDK (R01DK121072 and 1RO3DK117252) to Department of Medicine, Weill Cornell Medicine (R.E.S.). R.E.S. is supported as an Irma Hirschl Trust Research Award Scholar. A.B. is supported by supplemental funds for COVID-19 research from Translational Research Institute for Space Health (TRISH) through NASA Cooperative Agreement NNX16AO69A (T-0404) and further funding was provided by KBR, Inc.”

 

9

Siddiqui SM, Bowman KA, Zhu AL, Fischinger S, Beger S, Maron JS, Bartsch YC, Atyeo C, Gorman MJ, Yanis A, Hultquist JF, Lorenzo-Redondo R, Ozer EA, Simons LM, Talj R, Rankin DA, Chapman L, Meade K, Steinhart J, Mullane S, Siebert S, Streeck H, Sabeti P, Halasa N, Musk ER, Barouch DH, Menon AS, Nilles EJ, Lauffenburger DA, Alter G.

mBio. 2022 Jan 25;13(1):e02141-21. Online ahead of print.

PI: A.S. Menon

Note: This article may be obtained online without charge.

Journal Impact Factor: 7.867

Funding: “We acknowledge support from the Ragon Institute of MGH, MIT, and Harvard and the Massachusetts Consortium on Pathogen Readiness (MassCPR), the NIH (U01CA260476, 3R37AI080289-11S1, 1R01AI146785-01A1, 75N93019C00052, 75N93019C00071, and R01AI152158), the U.S. Food and Drug Association (HHSF223201810172C), and the National Center for Advancing Translational Sciences (UL1TR000445). We thank the Vanderbilt University Dance Marathon Fund, Samana Cay MGH Research Scholars program, Nancy Zimmerman, Mark and Lisa Schwartz, and Terry and Susan Ragon for their support. We thank Bing Chen for protein antigen production efforts. S.M.S. was partially supported by the U.S. Food and Drug Administration (HHSF223201810172C). E.J.N. is supported by the CDC (U01 GH002238). D.A.L. was partially supported by the National Institute for Allergy and Infectious Disease (U19 AI135995). D.A.R. is supported by the National Institutes of Health (TL1TR002244). This work was also supported by the Translational Research Institute through NASA NNX16AO69A. …”

 

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Other papers of interest:

 

1

Kamine TH, Smith BW, Fernandez GL.

Aerosp Med Hum Perform. 2022 Feb;93(2):123-7.

Note: NASA Task Load Index assessment. From the abstract: “As NASA and private spaceflight companies push forward with plans for missions to cis-lunar and interplanetary space, the risk of surgical emergency increases. At latencies above 500 ms, telesurgery is not likely to be successful, so near-real-time telementoring is a more viable option. We examined the effect of a 700-ms time delay on the performance of first year surgical residents on a simulated task requiring significant feedback from a mentor in a pilot study.”

 

2

Wu XT, Yang X, Tian R, Li Y-H, Wang C-Y, Fan Y-B, Sun L-W.

FASEB J. 2022 Feb;36(2):e22114. Review.

Note: From the abstract: “Decades of spaceflight studies have provided abundant evidence that individual cells in vitro are capable of sensing space microgravity and responding with cellular changes both structurally and functionally. However, how microgravity is perceived, transmitted, and converted to biochemical signals by single cells remains unrevealed. Here in this review, over 40 cellular biology studies of real space fights were summarized.” This article may be obtained online without charge.

 

3

Du J, Zeng L, Yu Z, Chen S, Chen X, Zhang Y, Yang H.

Microsyst Nanoeng. 2022 Jan 14;8:11.

Note: A magnetic levitation microsystem was used in this study. This article may be obtained online without charge.

 

4

Ma C, Xiong Y, Han P, Zhang X, Cao Y, Wang B, Zhao H, Duan E, Zhang JV, Lei X.

Front Cell Dev Biol. 2022 Jan 10;9:797060.

Note: A random position machine was used in this study. This article is part of Research Topic “The Regulating Mechanisms of Development, Growth, and Metabolism: From Ground to Space” (https://www.frontiersin.org/research-topics/22183/the-regulating-mechanisms-of-development-growth-and-metabolism-from-ground-to-space#articles). The Research Topic also includes articles from previous Current Awareness Lists #975 https://doi.org/10.3389/fcell.2021.739944 and #981 https://doi.org/10.3389/fcell.2021.797167. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

5

Yuzawa R, Koike H, Manabe I, Oishi Y.

Sci Rep. 2022 Jan 26;12(1):1377.

Note: A 3D clinostat was used in this study. From the abstract: “Muscle wasting is a major problem leading to reduced quality of life and higher risks of mortality and various diseases. Muscle atrophy is caused by multiple conditions in which protein degradation exceeds its synthesis, including disuse, malnutrition, and microgravity. While Vitamin D receptor (VDR) is well known to regulate calcium and phosphate metabolism to maintain bone, recent studies have shown that VDR also plays roles in skeletal muscle development and homeostasis.” This article may be obtained online without charge.

 

6

Reindl J, Kundrat P, Girst S, Sammer M, Schwarz B, Dollinger G.

Sci Rep. 2022 Jan 25;12:1305.

Note: From the abstract: “The human body is constantly exposed to ionizing radiation of different qualities. Especially the exposure to high-LET (linear energy transfer) particles increases due to new tumor therapy methods using e.g. carbon ions. Furthermore, upon radiation accidents, a mixture of radiation of different quality is adding up to human radiation exposure. Finally, long-term space missions such as the mission to mars pose great challenges to the dose assessment an astronaut was exposed to.” This article may be obtained online without charge.

 

7

Chopra K, Jeffries O, Tallent J, Heffernan S, Kilduff L, Gray A, Waldron M.

Aerosp Med Hum Perform. 2022 Jan;93(1):13-21.

 

8

Li H, Cao T, Ding W, Liang L, Fan GC, Qu L, Peng T.

J Cardiovasc Transl Res. 2022 Jan 28. Online ahead of print.

Note: Hindlimb unloading study.

 

9

Noonan AM, Oxland TR, Brown SHM.

Eur Spine J. 2022 Jan 28 Online ahead of print.

 

10

Sato H, Nagano T, Satoh W, Kumasaka K, Shindoh C, Miura M.

Pflugers Arch. 2022 Jan 23. Online ahead of print.

 

11

Zhu H, Monavari M, Zheng K, Distler T, Ouyang L, Heid S, Jin Z, He J, Li D, Boccaccini AR.

Small. 2022 Feb 1;e2104996. Online ahead of print.

 

12

Fujino S, Sun J, Nakayama S, Horikoshi Y, Kinugasa Y, Ishida M, Sakai C, Ike T, Doi S, Masaki T, Tashiro S.

Radiat Res. 2022 Jan 28. Online ahead of print.

 

13

Orekhova NYA, Modorov MV.

Int J Radiat Biol. 2022 Jan 24;1-17. Online ahead of print.

 

14

Li J, Geng J, Lin T, Cai M, Sun Y.

J Orthop Translat. 2022 Mar;33:1-12.

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

15

Divjak M, Sedej G, Murks N, Gerževič M, Marusic U, Pišot R, Šimunič B, Holobar A.

Inter-person differences in isometric coactivations of triceps surae and tibialis anterior decrease in young, but not in older adults after 14 days of bed rest.

Front Physiol. 2022 Jan 28;12:809243.

Note: Bed rest study. This article is part of Research Topic “Neuromechanics in Movement and Disease with Physiological and Pathophysiological Implications: From fundamental Experiments to Bio-inspired Technologies” (https://www.frontiersin.org/research-topics/18381/neuromechanics-in-movement-and-disease-with-physiological-and-pathophysiological-implications-from-f#articles). This article may be obtained online without charge.

 

16

Jin X, Ai W, Dong W.

Life Sci Space Res (Amst). 2022 Feb;32:1-7.

 

17

Wang W, Yu Y, Li X, Xu J, Ren P, Deng Y, Lv X.

Appl Microbiol Biotechnol. 2022 Jan 29. Online ahead of print.

Note: From the abstract: “Understanding the effects of long-term exposure to space environment is paramount to maintaining the safety, health of astronauts. The physical dosimeters currently used on the space station cannot be used to assess the physiological effects of radiation. Moreover, some developed biological methods are time-consuming and passive and cannot be used for active and real-time detection of the physiological effects of radiation in space environment. Here, the SOS promoter: recA-eGFP genetic engineering bacteria was constructed and characterized, and DNA damage effects of some chemical reagents and radiation were evaluated.”

 

18

Liu Y, Zhu T, Li J, Bao Y, Cheng B, Chen S, Du J, Hu S.

Biomacromolecules. 2022 Jan 23. Online ahead of print.

Note: From the abstract: “Intractable skin defects, which involve excessive inflammation and bacterial infections, caused by burns, trauma, and diabetes are a major challenge for clinicians. Compared with traditional skin transplantation, tissue-engineered skin has the advantages of a wide range of sources, prominent biological activity, and no damage to the donor area during the operation. Therefore, an effective wound-healing mat with antibacterial, anti-inflammatory, and microvascularization bioactivities is urgent to be developed. In this study, we have synthesized a poly(ester-urethane)urea/silk fibroin/magnolol nanofibrous composite mat (PSM) through electrospinning and post-hydrogen bond cross-linking.”

 

19

Mascharak S, Talbott HE, Januszyk M, Griffin M, Chen K, Davitt MF, Demeter J, Henn D, Bonham CA, Foster DS, Mooney N, Cheng R, Jackson PK, Wan DC, Gurtner GC, Longaker MT.

Cell Stem Cell. 2022 Jan 24;S1934-5909(21)00525-7. Online ahead of print.

Note: From the abstract: “Regeneration is the holy grail of tissue repair, but skin injury typically yields fibrotic, non-functional scars. Developing pro-regenerative therapies requires rigorous understanding of the molecular progression from injury to fibrosis or regeneration. Here, we report the divergent molecular events driving skin wound cells toward scarring or regenerative fates.”