NASA Spaceline Current Awareness List #983. 21 January 2022 (Space Life Science Research Results)

 

Papers deriving from NASA support:

 

1

Lombardino J, Bijlani S, Singh NK, Wood JM, Barker R, Gilroy S, Wang CCC, Venkateswaran K.

Microbiol Spectr. 2022 Jan 12;e0199421. Online ahead of print.

PI: K. Venkateswaran

Note: ISS results.

Journal Impact Factor: 7.171

Funding: “Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. We thank researchers associated with Biotechnology and Planetary Protection group at JPL for their facility support. Government sponsorship acknowledged. This research was funded by 2012 Space Biology NNH12ZTT001N grant number 19-12829-26 under task order NNN13D111T awarded to K.V.”

 

2

Morsi A, Massa GD, Morrow RC, Wheeler RM, Mitchell CA.

Life Sci Space Res. 2022 Feb;32:71-8.

PI: G.D. Massa

Note: Ground-based analog study.

Journal Impact Factor: 7.171

Funding: “This research was co-funded by the Human Research Program and Space Biology (MTL#1075) in the ILSRA 2015 NRA call and NASA Grant NNX15AN78G to Purdue University.”

 

3

Shymanovich T, Vandenbrink JP, Herranz R, Medina FJ, Kiss JZ.

Plant Physiol Biochem. 2022 Jan 15;171:191-200.

PI: J.Z. Kiss

Note: ISS results.

Journal Impact Factor: 4.270

Funding: “This work was supported by the National Aeronautics and Space Administration [grant 80NSSC17K0546 to John Z. Kiss] and by the Spanish Plan Estatal de Investigaci´on Científica y Desarrollo Tecnol´ogico [Grant RTI2018-099309-B-I00, co-funded by EU-ERDF, to F. Javier Medina].”

 

4

Trudel G, Shahin N, Ramsay T, Laneuville O, Louati H.

Nat Med. 2022 Jan 14.

Note: ISS results.

Journal Impact Factor: 53.44

Funding: “We thank all 14 participants, who generously consented to the collection of these specimens in addition to their other mission duties, as well as the NASA Increment Science Coordinators at JSC and Reta Warren at the JSC Clinical Laboratory for the care of the blood samples…”

 

5

Aronne G, Muthert LWF, Izzo LG, Romano LE, Iovane M, Capozzi F, Manzano A, Ciska M, Herranz R, Medina FJ, Kiss JZ, van Loon JJWA.

Life Sci Space Res. 2022 Feb;32:8-16.

PI: J.Z. Kiss

Note: A random positioning machine and large diameter centrifuge were used in this study.

Journal Impact Factor: 2.082

Funding: “Authors acknowledge Andrea Buonanno’s contribution to create all parts of the ROOTROPS device in CATIA V5. We would also like to thank Mr. Alan Dowson from ESA-ESTEC TEC-MMG LIS Lab for his support in preparation and during this study. This work was supported by the ESA-HRE CORA contract #4000127705/19/NL/PG/pt. Financial support was also provided by ESA-TEC contract #4000116223/16/NL/KML/hh to Jack J.W.A. van Loon, by Spanish Agencia Estatal de Investigaci´on (grant RTI2018–099309-B-I00, co-funded by EU-ERDF) to F. Javier Medina, and by NASA (grant 80NSSC17K0546) to John Z. Kiss.”

 

6

Izzo LG, Romano LE, Muthert LWF, Iovane M, Capozzi F, Manzano A, Ciska M, Herranz R, Medina FJ, Kiss JZ, van Loon JJWA, Aronne G.

Environ Exp Bot. 2022 Jan;193:104700.

PI: J.Z. Kiss

Note: A random positioning machine and large diameter centrifuge were used in this study.

Journal Impact Factor: 5.545

Funding: “Authors acknowledge Andrea Buonanno’s contribution to create all parts of the ROOTROPS device in CATIA V5. We would also like to thank Mr. Alan Dowson from ESA-ESTEC TEC- MMG LIS Lab for his support in preparation and during this study. This work was supported by the ESA-HRE CORA contract #4000127705/19/NL/PG/pt. Financial support was also provided by ESA-TEC contract #4000116223/16/NL/KML/hh to Jack J.W.A. van Loon, by Spanish Agencia Estatal de Investigación (Grant RTI2018-099309-B-I00, co-funded by EU– ERDF) to F. Javier Medina, and by NASA (Grant 80NSSC17K0546) to John Z. Kiss.”

 

7

Braveboy-Wagner J, Sharoni Y, Lelkes PI.

Int J Mol Sci. 2022 Jan;23(1):136.

PI: P.I. Lelkes

Note: A random positioning machine was used in this study. This article may be obtained online without charge.

Journal Impact Factor: 5.924

Funding: “This study was supported, in part, by NASA Grant/Contract 80NSSC18K1480 (P.I.L., P.I.) and a Dissertation Completion Grant from the Temple Graduate School (JBW). Y.S. acknowledges funding by Lycored Ltd., Beer Sheva, Israel (grant number 89964661). Publication of this article was funded in part by the Temple University Libraries Open Access Publishing Fund.”

 

8

Cromwell RL, Huff JL, Simonsen LC, Patel ZS.

New Space. 2021 Dec 1;9(4):204-16.

Note: Various Earth-based analogs used to simulate the unique physiological and behavioral effects associated with spaceflight are reviewed in this article. This article may be obtained online without charge.

Journal Impact Factor: 1.4

Funding: “This review was supported by the Translational Research Institute for Space Health (TRISH) at the Baylor College of Medicine (R.L.C.; Z.S.P.—The Red Risk School); through the NASA Human Health and Performance Contract #NNJ15HK11B (Z.S.P.); and NASA directly ( J.L.H. and L.C.S.).”

 

9

Kumar K, Datta K, Fornace AJ Jr, Suman S.

Heliyon. 2022 Jan;8(1):e08691.

PI: A.J. Fornace Jr

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.1

Funding: “This work was supported by National Aeronautics and Space Administration (NASA) grant NNX09AU95G and institutional funds.”

 

10

Loucas BD, Shuryak I, Kunkel SR, Cornforth MN.

Radiat Res. 2022 Jan 14. Online ahead of print.

PIs: B.D. Loucas, M.N. Cornforth

Journal Impact Factor: 2.841

Funding: “Financial support from the following sources is gratefully acknowledged: National Aeronautics and Space Administration, Human Research Program (NASA/HRP) 80NSSC18K0864 (BDL); 80NSSC21K0679 (MNC); National Institute of Allergy and Infectious Diseases (NIAID) 2U19AI067773 (IS).”

 

11

Wang C, Sani ES, Gao W.

Adv Funct Mater. 2021 Dec 26;2111022. Review. Online ahead of print.

PI: W. Gao

Journal Impact Factor: 18.808

Funding: “This project was supported by the National Institutes of Health grant R01HL155815, Office of Naval Research grants N00014‐21‐1‐2483 and N00014‐21‐1‐2845, the Translational Research Institute for Space Health through NASA NNX16AO69A, and Rothenberg Innovation Initiative (RI2) and Rosen Center for Bioengineering at California Institute of Technology.”

 

12

Jahng JWS, Wu JC.

Mol Ther. 2022 Jan 5;30(1):6-7.

PI: J.W.S. Jahng, TRISH Postdoctoral Fellowship Program

Journal Impact Factor: 11.454

Funding: “The current work is supported by National Institute of Health (NIH) grants R01 HL126527, R01 HL130020, and R01 HL146990 (J.C.W.), and the Translational Research Institute for Space Health (TRISH) through Cooperative Agreement NNX16AO69A (J.W.S.J).”

 

13

Huang Y, Harris BS, Minami SA, Jung S, Shah PS, Nandi S, McDonald KA, Faller R.

Biophys J. 2022 Jan 4;121(1):79-90.

PI: K.A. McDonald

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.033

Funding: “Y.H. and R.F. were partially supported by the National Science Foundation under grant CBET 1911267. S.A.M. and S.J. were partially supported by a COVID-19 Research Accelerator Funding Track award by the UC Davis Office of Research (https://covid19research.ucdavis.edu/tags/craft). B.S.H. was partially supported by the Laboratory Directed Research and Development program of Lawrence Livermore National Laboratory, under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344. K.A.M. and S.N. were partially supported by NASA Space Technology Research (award NNX17AJ31G) and by the Translational Research Institute through NASA (grant NNX16AO69A).”

 

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Other papers of interest:

 

1

Reizis E, Cai D, Serpas L, Gleason EJ, Martin K, Foley KD, Copeland DS, Kraves S, Alvarez Saavedra E.

Gravit Space Res. 2021 Dec 30;9(1):159-63.

Note: ISS results. This article may be obtained online without charge.

 

2

Blottner D, Trautmann G, Furlan S, Gambara G, Block K, Gutsmann M, Sun LW, Worley PF, Gorza L, Scano M, Lorenzon P, Vida I, Volpe P, Salanova M.

Int J Mol Sci. 2021 Dec 22;23(1):75.

Note: BION-M1 biosatellite mission and hindlimb unloading results. This article is part of Special Issue “Cellular and Molecular Signaling Meet the Space Environment” (https://www.mdpi.com/journal/ijms/special_issues/Cellular_molecular_signaling_space). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

3

Xie J, Wang L, Zheng H.

Int J Mol Sci. 2021 Dec 22;23(1):63.

Note: Chinese spacelab Tiangong-2 mission results. This article is part of Special Issue “Biotic and Abiotic Stress Effects on Plant Structure and Physiology” (https://www.mdpi.com/journal/ijms/special_issues/Plant_Structure_Physiology). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

4

Tang H, Rising HH, Majji M, Brown RD.

Nutrients. 2021 Dec 31;14(1):194. Review.

Note: This article is part of Section “Nutrition and Public Health” (https://www.mdpi.com/journal/nutrients/sections/Nutrition_Public_Health). This article may be obtained online without charge.

 

5

Gaines D, Nestorova GG.

Life Sci Space Res. 2022 Feb;32:54-62.

 

6

Lu S-Y, Guo S, Chai S-B, Yang J-Q, Yue Y, Li H, Yan H-F, Zhang T, Sun P-M, Sun H-W, Zhou J-L, Yang J-W, Li Z-P, Cui Y.

Life Sci Space Res. 2022 Feb;32:26-37.

Note: The method of simulated microgravity is not evident in the available abstract.

 

7

Rusanov VB, Pastushkova LK, Chernikova AG, Kashirina DN, Goncharova AG, Nosovsky AM, Kussmaul AR, Yakhya YD, Popova OV, Brzhozovskiy AG, Orlov OI, Larina IM.

Life Sci Space Res. 2022 Feb;32:17-25.

Note: SIRIUS analog mission results.

 

8

Watkins P, Hughes J, Gamage TV, Knoerzer K, Ferlazzo ML, Banati RB.

Life Sci Space Res. 2022 Feb;32:79-95. Review.

Note: From the abstract: “In this review, we provide a summary of the existing knowledge about current space food products, the impact of radiation and storage on food composition, the identification of radiolytic biomarkers and identify gaps in our knowledge that are specific in relation to the effect of the cosmic radiation on food in space.”

 

9

Wuest SL, Cerretti G, Wadsworth JL, Follonier C, Rattenbacher-Kiser KF, Bradley T, Egli M, Ille F.

Acta Astronaut. 2022 Jan 17. Online ahead of print.

Note: Parabolic flight results.

 

10

Weber B, Proske U.

Life Sci Space Res. 2022 Feb;32:63-9. Review.

Note: From the abstract: “This is a review of the current state of knowledge of the effects of weightlessness on human proprioception. Two aspects have been highlighted: the sense of limb position and performance in sensorimotor tasks.”

 

11

Dai TX, Son HN, Chi HNQ, Huy HNQ, Minh NT, Tram NTT, Huyen NTT, Quan TM, Chung DC, Nhung TH, Minh TT, Diem TH, Mai NTP, Long LT.

Curr Issues Mol Biol. 2021 Dec 10;43(3):2210-9.

Note: A 3D clinostat was used in this study. This article is part of Section “Biochemistry, Molecular and Cellular Biology” (https://www.mdpi.com/journal/cimb/sections/BMCB). This article may be obtained online without charge.

 

12

Schulz H, Strauch SM, Richter P, Wehland M, Krüger M, Sahana J, Corydon TJ, Wise P, Baran R, Lebert M, Grimm D.

Expert Rev Proteomics. 2022 Jan 17. Review. Online ahead of print.

Note: From the abstract: “We summarize the findings over the recent 3 years on µg-induced changes in the proteome of protists, plants, rodent and human cells. Considering the thematic orientation of microgravity-related publications in that time frame, we focus on medicine-associated findings such as the µg-induced antibiotic resistance of bacteria, the myocardial consequences of µg-induced calpain activation and the role of MMP13 in osteoarthritis. All these point to the fact that µg is an extreme stressor that could not be evolutionarily addressed on Earth.”

 

13

Tran KN, Choi J-I.

Life Sci Space Res. 2022 Feb;32:96-104.

Note: Hindlimb unloading study.

 

14

Anasuya B, Deepak KK, Jaryal AK.

Int J Yoga. 2021 Sep-Dec;14(3):188-97.

Note: Head-down tilt test study. This article may be obtained online without charge.

 

15

Shankhwar V, Singh D, Deepak KK.

Life Sci Space Res. 2022 Feb;32:45-53.

Note: Head-down tilt test study. This article may be obtained online without charge.

 

16

Bjursten H, Oudin Åström D, Nozohoor S, Ahmad K, Tang M, Bjurbom M, Hansson EC, Jeppsson A, Joost Holdflod Møller C, Jormalainen M, Juvonen T, Mennander A, Olsen PS, Olsson C, Ahlsson A, Oudin A, Pan E, Raivio P, Wickbom A, Sjögren J, Geirsson A, Gudbjartsson T, Zindovic I.

Interact Cardiovasc Thorac Surg. 2022 Jan 6;34(1):105-10. Available online 27 August 2021.

Note: From the abstract: “Acute type A aortic dissection (ATAAD) is a rare but severe condition, routinely treated with emergent cardiac surgery. Many surgeons have the notion that patients with ATAAD tend to come in clusters, but no studies have examined these observations. This investigation was undertaken to study the potential association between the lunar cycle and the incidence of ATAAD.” This article may be obtained online without charge.

 

17

Brocca L, Rossi M, Canepari M, Bottinelli R, Pellegrino MA.

Int J Mol Sci. 2021 Dec 23;23(1):148.

Note: Hindlimb unloading study. This article is part of Special Issue “Skeletal Muscle Molecular Signalling in Various Models of Disuse and Unloading” (https://www.mdpi.com/journal/ijms/special_issues/Skeletal_Muscle_Molecular_Signalling). The Special Issue also includes an article from Current Awareness List #972 https://doi.org/10.3390/ijms221910444. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

18

Logeson ZS, MacLennan RJ, Abad GB, Methven JM, Gradl MR, Pinto MD, Pinto RS, Stock MS.

PLoS One. 2022 Jan 11;17(1):e0262553.

Note: This article may be obtained online without charge.

 

19

Sato I, Yamamoto S, Kakimoto M, Fujii M, Honma K, Kumazaki S, Matsui M, Nakayama H, Kirihara S, Ran S, Hirohata S, Watanabe S.

J Electromyogr Kinesiol. 2022 Feb;62:102627.

 

20

Thompson JM, West DWD, Doering TM, Budiono BP, Lessard SJ, Koch LG, Britton SL, Byrne NM, Brown MA, Ashton KJ, Coffey VG.

PLoS One. 2022 Jan 13;17(1):e0261723.

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

21

Cherkashina NI, Pavlenko VI, Mikhailov MM, Lapin AN, Yuriev SA, Bondarenko NI, Sidelnikov RV.

Acta Astronaut. 2022 Jan 15. Online ahead of print.

 

22

Panek A, Miszczyk J.

Radiat Res. 2021 Dec 27. Online ahead of print.

 

23

Zaharieva EK, Sasatani M, Kamiya K.

Radiat Res. 2021 Dec 27. Online ahead of print.

 

24

Qian Y, Jiang S, Jing X, Shi Y, Qin H, Xin B, Chi L, Wu B.

Front Psychol. 2021 Dec 22;12:732362.

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

 

25

Neurobiol Sleep Circadian Rhythms. 2022 May;12:100073. Available online 28 December 2021.

 

26

Kahle ER, Han B, Chandrasekaran P, Phillips ER, Mulcahey MK, Lu XL, Marcolongo MS, Han L.

ACS Nano. 2022 Jan 11. Online ahead of print.

 

27

Gupta A, Edwards Iii HM, Rodriguez AR, McKindles RJ, Stirling LA.

Appl Ergon. 2022 Apr;100:103648.

Note: From the abstract: “Inhibitory control, the ability to inhibit impulsive responses and irrelevant stimuli, enables high level functioning and activities of daily living. The Simon task probes inhibition using interfering stimuli, i.e., cues spatially presented on the opposite side of the indicated response; incongruent response times (RT) are slower than congruent RTs. Operational applicability of the Simon task beyond finger/hand manipulations and visual/auditory cues is unclear, but important to consider as new technologies provide tactile cues and require motor responses from the lower extremity (e.g., exoskeletons). In this study, twenty participants completed the Simon task under four conditions, each combination of two cue (visual/tactile) and response (upper/lower-extremity) modalities.”

 

28

Lak A, Asefi M.

Acta Astronaut. 2022 Mar;192:351-67.

Note: From the abstract: “Deployable lunar structures have been and are being developed as an appropriate solution to the volumetric limitations of cargo mission flights. A deployable lunar habitat consisting of linear and planar elements connected through simple movable joints is introduced. This new structure is made of some linear units consisting of two types of scissor-like elements (SLE): 1) a modified polar scissor-like element and 2) a closed-loop of angulated scissor-like elements. After conducting theoretical research on lunar habitats, the evaluation criteria of transformable lunar structures are derived and then many new concepts are evaluated. The design considerations of such structures are discussed, and a proper form for these habitat types is selected. An experimental study is run to assess the best deployment strategy for the whole structure. By introducing the dimensional properties of the lunar habitats through physical and digital modeling process per crewmember, the derived alternatives from the previous stage are analyzed and the best transformation strategy that meets the aforementioned considerations is developed.”

 

29

Vinogradova OL, Tomilovskaya ES, Kozlovskaya IB.

Hum Physiol. 2022 Jan 14;47:716-34. Review.

Note: From the abstract: “The review considers the current ideas about the role of the gravitational factor in activities of the sensorimotor and cardiovascular systems, as well as new basic problems and questions of space medicine and physiology.”