NASA Spaceline Current Awareness List #979 17 December 2021 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm . Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Papers deriving from NASA support:
1
Nickerson CA, Medina-Colorado AA, Barrila J, Poste G, Ott CM.
A vision for spaceflight microbiology to enable human health and habitat sustainability.
Nature Microbiology. 2021 Dec 13. Online ahead of print.
PIs: C.A. Nickerson, C.M. Ott
Note: From the acknowledgments: “Many of the topics discussed here were the focus of a Nature conference, The Microbiology of Human Spaceflight, held at the NASA Johnson Space Center in June, 2019; we thank the participants of that conference for their ideas and discussions (https://www.nasa.gov/feature/the-microbiology-of-human-spaceflight-conference-proceedings ).”
Journal Impact Factor: 17.745
Funding: “C.A.N., J.B. and C.M.O. were funded by NASA grants NNX15AL06G, NNX17AC79G, 80NSSC18K1478 (includes NASA PECASE funding to J.B.) and 80NSSC20K0016.”
2
Cunningham K, Hinton TG, Luxton JJ, Bordman A, Okuda K, Taylor LE, Hayes J, Gerke HC, Chinn SM, Anderson D, Laudenslager ML, Takase T, Nemoto Y, Ishiniwa H, Beasley JC, Bailey SM.
Evaluation of DNA damage and stress in wildlife chronically exposed to low-dose, low-dose rate radiation from the Fukushima Dai-ichi Nuclear Power Plant accident.
Environ Int. 2021 Oct;155:106675.
PI: S.M. Bailey
Note: This article may be obtained online without charge.
Journal Impact Factor: 9.621
Funding: “Funding for this project was provided by the Colorado State University – Fukushima University Exchange Program; University of Georgia, as well as the U.S. Department of Energy under Award No. DE-EM0004391 to the University of Georgia Research Foundation; the University of Georgia Office of Global Engagement Asia-Georgia Internship Connection Scholarship/Freeman Asia Grant; NIH T-35 Veterinary Student Summer Scholar and NIH T-32 Veterinary Predoctoral Scholar fellowships (CVMBS, Colorado State University); NASA (80NSSC19K0434); and the Research Council of Norway through its Centres of Excellence funding scheme, project number 223268/F50.”
3
Hearon CM Jr, Dias KA, Babu G, Marshall JET, Leidner J, Peters K, Silva E, MacNamara JP, Campain J, Levine BD.
Effect of nightly lower body negative pressure on choroid engorgement in a model of spaceflight-associated neuro-ocular syndrome: A randomized crossover trial.
JAMA Ophthalmol. 2021 Dec 9. Online ahead of print.
Note: Head-down tilt bedrest study.
Journal Impact Factor: 7.4
Funding: “This study was supported by NASA (grants 80NSSC19K0300 and 80NSSC19K0300-P00001).”
4
Cycil LM, Hausrath EM, Ming DW, Adcock CT, Raymond J, Remias D, Ruemmele WP.
Investigating the growth of algae under low atmospheric pressures for potential food and oxygen production on Mars.
Front Microbiol. 2021 Nov 12;12:733244.
Note: This article is part of Research Topic “Bioregenerative Life-Support Systems for Crewed Missions to the Moon and Mars” (https://www.frontiersin.org/research-topics/16705/bioregenerative-life-support-systems-for-crewed-missions-to-the-moon-and-mars#articles ). The Research Topic also includes articles from previous Current Awareness Lists #960 https://doi.org/10.3389/fspas.2021.699688 , https://pubmed.ncbi.nlm.nih.gov/34276632 , https://doi.org/10.3389/fspas.2021.700370 , https://doi.org/10.3389/fspas.2021.711550 ,https://doi.org/10.3389/fmicb.2021.700010 , https://doi.org/10.3389/fspas.2021.700579 , https://doi.org/10.3389/fspas.2021.699097 ; #961 https://doi.org/10.3389/fspas.2021.665649 ; #962 https://doi.org/10.3389/fspas.2021.700270 ; #964 https://doi.org/10.3389/fmicb.2021.709746 ; and #975 https://doi.org/10.3389/fmicb.2021.700810 . This article may be obtained online without charge.
Journal Impact Factor: 5.640
Funding: “This research was financially supported by the National Aeronautics and Space Administration (NASA) with NASA EPSCoR (grant #80NSSC19M0171) and a sub-award from the Nevada NASA EPSCoR Research Infrastructure Development Seed (grant # 80NSSC19M0056). DR acknowledges funding from the Austrian Science Fund (FWF): P29959.”
5
Nastasi N, Renninger N, Bope A, Cochran SJ, Greaves J, Haines SR, Balasubrahmaniam N, Stuart K, Panescu J, Bibby K, Hull NM, Dannemiller KC.
Persistence of viable MS2 and Phi6 bacteriophages on carpet and dust.
Indoor Air. 2021 Dec 9. Online ahead of print.
PI: K.C. Dannemiller
Note: From the abstract: “Resuspension of dust from flooring is a major source of human exposure to microbial contaminants, but the persistence of viruses on dust and carpet and the contribution to human exposure are often unknown. The goal of this work is to determine viability of MS2 and Phi6 bacteriophages on cut carpet, looped carpet, and house dust both over time and after cleaning.”
Journal Impact Factor: 5.770
Funding: “The Ohio State University; 1942501/NSF; G-2018-1124/Alfred P. Sloan Foundation; 80NSSC19K0429/NASA/NASA/United States.”
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Other papers of interest:
1
Uruno A, Saigusa D, Suzuki T, Yumoto A, Nakamura T, Matsukawa N, Yamazaki T, Saito R, Taguchi K, Suzuki M, Suzuki N, Otsuki A, Katsuoka F, Hishinuma E, Okada R, Koshiba S, Tomioka Y, Shimizu R, Shirakawa M, Kensler TW, Shiba D, Yamamoto M.
Nrf2 plays a critical role in the metabolic response during and after spaceflight.
Commun Biol. 2021 Dec 9;4(1):1381.
Note: ISS results. This article may be obtained online without charge.
2
Wise PM, Neviani P, Riwaldt S, Corydon TJ, Wehland M, Braun M, Krüger M, Infanger M, Grimm D.
Changes in exosomal miRNA composition in thyroid cancer cells after prolonged exposure to real microgravity in space.
Int J Mol Sci. 2021 Dec;22(23):12841.
Note: ISS results. This article may be obtained online without charge.
3
Jamšek M, Kunavar T, Blohm G, Nozaki D, Papaxanthis C, White O, Babič J.
Effects of simulated microgravity and hypergravity conditions on arm movements in normogravity.
Frontiers in Neural Circuits. 2021 Dec 14;15:750176.
Note: Parabolic flight results. This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior” (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles ). The Research Topic also includes articles from previous Current Awareness Lists #956 https://doi.org/10.3389/fncir.2021.659557 ; #967 https://doi.org/10.3389/fphys.2021.654906 ; #969 https://doi.org/10.3389/fphys.2021.746509 ; #973 https://doi.org/10.3389/fncir.2021.723504 ; #975 https://doi.org/10.3389/fncir.2021.757817 , https://doi.org/10.3389/fncir.2021.760313 , and https://doi.org/10.3389/fphys.2021.750414 ; #976 https://doi.org/10.3389/fphys.2021.770502 ; and #977 https://doi.org/10.3389/fphys.2021.782860 . Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
4
Markin AA, Zhuravleva OA, Kuzichkin DS, Vostrikova LV, Zabolotskaya IV, Loginov VI, Smirnova TA.
Investigating the metabolic reactions of subjects with four-month isolation in a hermetic volume under stress conditions.
Human Physiology. 2021 Dec 10;47(5):542-50.
Note: SIRIUS-19 analog mission results.
5
Dolan CP, Imholt F, Yang TJ, Bokhari R, Gregory J, Yan M, Qureshi O, Zimmel K, Sherman KM, Falck A, Yu L, Leininger E, Brunauer R, Suva LJ, Gaddy D, Dawson LA, Muneoka K.
Mouse digit tip regeneration is mechanical load dependent.
J Bone Miner Res. 2021 Nov 16. Online ahead of print.
Note: Hindlimb unloading study.
6
Takahashi I, Matsuzaki T, Kuroki H, Hoso M.
Physiological reloading recovers histologically disuse atrophy of the articular cartilage and bone by hindlimb suspension in rat knee joint.
Cartilage. 2021 Dec 10:19476035211063857. Online ahead of print.
Note: Hindlimb unloading study.
7
Krivonogova EV, Krivonogova OV, Poskotinova LV.
Individual-typological features of the reactivity of EEG rhythms, cardiovascular system and lactoferrin level in the conditions of general air cooling of a person.
Human Physiology. 2021 Dec 10;47(5):533-41.
8
Prins PJ, Buxton JD, McClure TS, D’Agostino DP, Ault DL, Welton GL, Jones DW, Atwell AD, Slack MA, Slack ML, Williams CE, Blanchflower ME, Kannel KK, Faulkner MN, Szmaciasz HL, Croll SM, Stanforth LM, Harris TD, Gwaltney HC, Koutnik AP.
Ketone bodies impact on hypoxic CO2 retention protocol during exercise.
Front Physiol. 2021 Dec 13;12:780755.
Note: This article may be obtained online without charge.
9
Macaeva E, Tabury K, Michaux A, Janssen A, Averbeck N, Moreels M, De Vos WH, Baatout S, Quintens R.
High-LET carbon and iron ions elicit a prolonged and amplified p53 signaling and inflammatory response compared to low-LET x-rays in human peripheral blood mononuclear cells.
Front Oncol. 2021 Nov 23;11:768493.
Note: This article is part of Research Topic “Multifaceted Approaches Combining Low or High LET Radiation and Pharmacological Interventions in Cancer and Radioprotection: From Bench to Bedside” (https://www.frontiersin.org/research-topics/18218/multifaceted-approaches-combining-low-or-high-let-radiation-and-pharmacological-interventions-in-can#articles ). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
10
Ticllacuri V, Mio R.
Design and simulation of a soft robotic device for muscle rehabilitation and blood flow stimulation therapy.
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:1588-92.
11
Rota Graziosi E, François S, Pateux J, Gauthier M, Butigieg X, Oger M, Drouet M, Riccobono D, Jullien N.
Muscle regeneration after high-dose radiation exposure: Therapeutic potential of Hedgehog pathway modulation?
Int J Radiat Biol. 2021 Dec 8:1-27. Online ahead of print.
12
Sporkova A, Ghosh S, Al-Hasani J, Hecker M.
Lin11-Isl1-Mec3 domain proteins as mechanotransducers in endothelial and vascular smooth muscle cells.
Front Physiol. 2021 Nov 19;12:769321. Review.
Note: This article is part of Research Topic “Cardiovascular Mechanobiology” (https://www.frontiersin.org/research-topics/17731/cardiovascular-mechanobiology#articles ). This article may be obtained online without charge.
13
Alonso MG, Yawny A, Bertolino G.
A tool for solving bone growth related problems using finite elements adaptive meshes.
J Mech Behav Biomed Mater. 2021 Nov 13;104946. Online ahead of print.
14
Priddy C, Li J.
The role of the Nrf2/Keap1 signaling cascade in mechanobiology and bone health.
Bone Rep. 2021 Dec;15:101149. Review.
Note: This article may be obtained online without charge.
15
Reis J, Ramos A.
In sickness and in health: The oxygen reactive species and the bone.
Front Bioeng Biotechnol. 2021 Nov 23;9:745911. Review.
Note: This article is part of Research Topic “Biomechanics and Oxidative Stress” (https://www.frontiersin.org/research-topics/16588/biomechanics-and-oxidative-stress#articles ). This article may be obtained online without charge.
16
Singh P, Eley J, Mahmood N, Bhandary B, Dukic T, Tu KJ, Polf J, Lamichhane N, Mahmood J, Vujaskovic Z, Shukla HD.
Therapeutic efficacy of variable biological effectiveness of proton therapy in U-CH2 and MUG-Chor1 human chordoma cell death.
Cancers (Basel). 2021 Dec 4;13(23):6115.
Note: This article is part of Section “Cancer Therapy” (https://www.mdpi.com/journal/cancers/sections/Cancer_Therapy ). This article may be obtained online without charge.
17
Iddar A, El Mzibri M, Moutaouakkil A.
Effects of the Cobalt-60 gamma radiation on Pichia pastoris glyceraldehyde-3-phosphate dehydrogenase.
Int J Radiat Biol. 2021 Dec 6;1-9. Online ahead of print.
18
Li TJ, Lee TY, Lo Y, Lee LY, Li IC, Chen CC, Chang FC.
Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo.
BMC Complement Med Ther. 2021 Dec 5;21(1):295.
Note: Hindlimb unloading study. This article may be obtained online without charge.
19
Royal JT, Eiken O, Keramidas ME, McDonnell AC, Mekjavic IB.
Heterogeneity of hematological response to hypoxia and short-term or medium-term bed rest.
Front Physiol. 2021 Dec 14;12:777611.
Note: Bed rest study. This article is part of Research Topic “Investigation of the Inter-individual Variability of Physiological Responses to Changes in Activity Levels-, Gravity Loading-, Nutritional Status, Pharmaceuticals and Exposure to Radiation” (https://www.frontiersin.org/research-topics/14100/investigation-of-the-inter-individual-variability-of-physiological-responses-to-changes-in-activity#articles ). The Research Topic also includes articles from previous Current Awareness Lists #921 https://doi.org/10.3389/fphys.2020.573581 , #937 https://doi.org/10.3389/fphys.2021.614619 , #952 https://doi.org/10.3389/fphys.2021.685473 , and #959 https://doi.org/10.3389/fphys.2021.676501 . Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
20
Dida M, Cian C, Barraud PA, Guerraz M, Laboissière R.
Idiosyncratic multisensory reweighting as the common cause for motion sickness susceptibility and adaptation to postural perturbation.
PLoS One. 2021 Dec 9;16(12):e0260863.
Note: This article may be obtained online without charge.
21
Sugawara T, Wada Y, Ito T, Sakai H.
Bilateral asymmetry in ocular counter-rolling reflex is associated with individual motion sickness susceptibility.
Front Neurol. 2021 Nov 19;12:759764.
Note: This article may be obtained online without charge.
22
Tu MY, Chu H, Lai CY, Chiang KT, Huang CC, Chin HC, Wen YH, Chen CL.
Effect of standardized yelling on subjective perception and autonomic nervous system activity in motion sickness.
Int J Environ Res Public Health. 2021 Dec 6;18(23):12854.
Note: This article may be obtained online without charge.
23
Luis NM, Schnorrer F.
Mechanobiology of muscle and myofibril morphogenesis.
Cells Dev. 2021 Dec 1;203760. Online ahead of print.
Note: This article may be obtained online without charge.
24
Bari V, De Maria B, Cairo B, Gelpi F, Lambert E, Esler M, Baumert M, Porta A.
Assessing correlation between heart rate variability markers based on Laguerre expansion and direct measures of sympathetic activity during incremental head-up tilt.
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:5411-4.
Note: Head-up tilt test study.
25
Freeborn TJ, Critcher S, Hooper GL.
Short-term segmental bioimpedance alterations during 6° head-down tilt.
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:6974-7.
Note: Head-down tilt test study.
26
Hassan D, Wehler D, Krones R, Khalaf K, Ahammer H, Jelinek HF.
Determination of heart rate changes using simulated head up tilt test for syncope patient assessment.
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:4273-6.
Note: Head-up tilt test study.
27
Riberholt CG, Gluud C, Jakobsen JC, Ovesen C, Mehlsen J, Møller K.
Statistical analysis plan: Early mobilization by head-up tilt with stepping versus standard care after severe traumatic brain injury.
Contemp Clin Trials Commun. 2021 Dec;24:100856.
Note: Head-up tilt test study. This article may be obtained online without charge.
28
Langeard A, Mathon C, Ould-Slimane M, Decker L, Bessot N, Gauthier A, Chastan N.
Kinematics or kinetics: Optimum measurement of the vertical variations of the center of mass during gait initiation.
Sensors (Basel). 2021 Dec;21(23):7954.
Note: This article is part of Special Issue “Sensor Technology for Fall Prevention” (https://www.mdpi.com/journal/sensors/special_issues/ST_FP ). This article may be obtained online without charge.
29
Wheeler DR, Oldani S, Montagna L, Vinci V.
Space medicine: A spot for future plastic surgeons?
Plast Reconstr Surg. 2021 Dec 6. Viewpoint. Online ahead of print.
Note: From the abstract: “With longer Mars missions already in planning and the inevitable commercialization of space travel in the not-too-distant future, the health of a growing number of astronauts and civilians before, during, and after space flight is an interesting and challenging future consideration. Due to microgravity and increased radiation in space, many of the terrestrial laws of medicine do not hold true, with minor to major changes seen across most of the body’s systems. Some of these are cardiovascular deconditioning, muscle and bone loss, and ophthalmological and immunological alterations.”
