NASA Spaceline Current Awareness List #978 10 December 2021 (Space Life Science Research Results)

 

Papers deriving from NASA support:

 

1

Waters SM, Ledford S, Wacker A, Verma S, Serda B, McKaig J, Varelas J, N. PM, Venkateswaran K, Smith DJ.

International Journal of Astrobiology. 2021 Dec;20(6):435-44.

PIs: D.J. Smith, S. Waters, NASA Postdoctoral Program

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 1.673

Funding: “This work was funded by the NASA Postdoctoral Fellowship Program (S.M.W.), NASA Space Biology and NASA Planetary Protection research grants (D.J.S. and K.V.), the Blue Marble Institute Training Program (P.N. and S.V.) and the Space Life Sciences Training Program (B.M.S., J.M., A.W., & S.M.L.). The research described in this publication was carried out in part at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA (K.V.). Government sponsorship is acknowledged. NASA Planetary Protection research grant.”

 

2

Glaros Z, Carvalho RE, Flynn-Evans EE.

Hum Factors. 2021 Dec 5:187208211056756. Online ahead of print.

Note: The NASA Task Load Index was used in this study.

Journal Impact Factor: 2.888

Funding: “The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the NASA Engineering Safety Center (NESC).”

 

3

Miller KH, Sutton E, Pantalos G.

Surg Innov. 2021 Dec 4:15533506211053210. Online ahead of print.

PI: G. Pantalos

Note: From the introduction: “This project was designed to create and evaluate the efficacy of visual/audio presentation in providing just-intime and/or refresher training of surgical tasks for nonsurgeons, and to consider the impact of non-surgeons performing a procedure during exploration space flight.”

Journal Impact Factor: 1.458

Funding: “This work is supported by grant T0110 from the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A and by the NASA Flight Opportunities program as Payloads T0049-P and T0155-S. No additional financial support was received in support of this publication.”

 

4

Juran CM, Zvirblyte J, Cheng-Campbell M, Blaber EA, Almeida EAC.

Stem Cell Res. 2021 Oct;56:102513. Available online 26 August 2021.

PIs: E.A. Blaber, E.A.C. Almeida, C.M. Juran, NASA Postdoctoral Program Fellowship

Note: GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.

Journal Impact Factor: 2.020

Funding: “We thank NASA GeneLab Sequencing Group at NASA Ames Research Center (Moffett Field, CA), including V. Boyko and Dr. A. Seravia-Butler (NASA ARC) for technical assistance in scRNA-seq sample processing for sequencing and single cell sequence data QC and validation. We also thank Dr. Nancy Searby (NASA HQ), for the initial design and prototype iterations of the two-motor mechanical loading systems used in our studies (Searby, 2002). This work was supported by NASA Space Biology grants NNH14ZTT001N-0063 to Dr. E. Almeida, NNH14ZTT001N-0062 to Dr. E. Blaber, and a NASA Space Biology Postdoctoral Fellowship to Dr. C. Juran.”

 

5

Martin SA, Riordan RT, Wang R, Yu Z, Aguirre-Burk AM, Wong CP, Olson DA, Branscum AJ, Turner RT, Iwaniec UT, Perez VI.

Exp Gerontol. 2021 Oct 15;154:111516. Available online 10 August 2021.

PI: R.T. Turner

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.032

Funding: “This work was supported by grants from the American Federation for Aging Research, the Collins Medical Trust, the National Institute of Food and Agriculture-Agricultural Experimental Station Multi-state W4002 and Oregon Agricultural Experiment Station (OR00735) and the National Aeronautics and Space Administration (80NSSC19K0430 and NNX15AL15G).”

 

6

Gumulya Y, Zea L, Kaksonen AH.

Minerals Engineering. 2022 Jan;176:107288. Review.

PI: L. Zea

Note: From the abstract: “This paper reviews in situ resources available on the Moon, Mars, and Near-Earth Asteroids (NEAs) for implementing biomining processes in space, the effects of the space environment on biomining microbes, and space-based bioreactor designs that will enable leaching of metals from regoliths.”

Journal Impact Factor: 4.765

Funding: “Y.G. and A.H.K. were funded by CSIRO Synthetic Biology Future Science Platform, CSIRO Space Technology Future Science Platform, and CSIRO Land and Water. L.Z. was supported by the National Aeronautics and Space Administration under Grant No. 80NSSC18K1468 and by University of Colorado Boulder’s Research Innovation Office (RIO) Seed Grant funding.”

 

7

Shuryak I, Sachs RK, Brenner DJ.

Sci Rep. 2021 Dec 6;11(1):23467.

PI: D.J. Brenner

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.379

Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) grant NNX16AR81A (DJB and IS) and #80JSC021T9917 (RKS), and by contract #DE-AC02-05CH11231 with the U.S. Department of Energy (RKS).”

 

8

Foox J, Nordlund J, Lalancette C, Gong T, Lacey M, Lent S, Langhorst BW, Ponnaluri VKC, Williams L, Padmanabhan KR, Cavalcante R, Lundmark A, Butler D, Mozsary C, Gurvitch J, Greally JM, Suzuki M, Menor M, Nasu M, Alonso A, Sheridan C, Scherer A, Bruinsma S, Golda G, Muszynska A, Łabaj PP, Campbell MA, Wos F, Raine A, Liljedahl U, Axelsson T, Wang C, Chen Z, Yang Z, Li J, Yang X, Wang H, Melnick A, Guo S, Blume A, Franke V, Ibanez de Caceres I, Rodriguez-Antolin C, Rosas R, Davis JW, Ishii J, Megherbi DB, Xiao W, Liao W, Xu J, Hong H, Ning B, Tong W, Akalin A, Wang Y, Deng Y, Mason CE.

Genome Biol. 2021 Dec 6;22(1):332.

PI: C.E. Mason

Note: This article may be obtained online without charge.

Journal Impact Factor: 13.583

Funding: “The authors wish to thank Justin Zook for contributions to study design and advice for bioinformatics analysis. J.N, A.L, U.L, T.A, and A.R are supported by grants from the Swedish Research Council (2017-00630 / 2019-01976). I.I.C, R.R, and C.R.A are supported by ISCIII, project number PI18/00050. This project received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 824110-EASI-Genomics. T.G and Y.P.D are supported by NIH Grants 5P30GM114737, P20GM103466, U54 MD007584, and 2U54MD007601. The genomic work carried out at the Loma Linda University Center for Genomics was funded in part by the National Institutes of Health (NIH) grant S10OD019960 (CW). This project is partially supported by AHA grant 18IPA34170301 (CW). We would also like to thank the Epigenomics Core Facility at Weill Cornell Medicine, the Starr Cancer Consortium (I13-0052), World-Quant, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, NNX17AB26G), the NIH (R01MH117406, R01CA249054, R01AI151059, P01CA214274, U01DA053941), and the Leukemia and Lymphoma Society (LLS) MCL7001-18, LLS 9238-16, LLS-MCL7001-18).”

 

9

Gong K, Guo G, Beckley NA, Yang X, Zhang Y, Gerber DE, Minna JD, Burma S, Zhao D, Akbay EA, Habib AA.

Nat Commun. 2021 Dec 1;12(1):7014.

PI: S. Burma

Note: From the abstract: “Inhibition of RTK [receptor tyrosine kinases] pathways in cancer triggers an adaptive response that promotes therapeutic resistance. Because the adaptive response is multifaceted, the optimal approach to blunting it remains undetermined. TNF [tumor necrosis factor] upregulation is a biologically significant response to EGFR [epidermal growth factor receptor] inhibition in NSCLC [non-small cell lung cancer]. Here, we compared a specific TNF inhibitor (etanercept) to thalidomide and prednisone, two drugs that block TNF and also other inflammatory pathways.” This article may be obtained online without charge.

Journal Impact Factor: 14.919

Funding: “This work was supported in part by funding from the Department of Veteran’s Affairs to AH (2I01BX002559-07) and from the National Institutes of Health (1R01CA244212- 01A1) to A.H. This work was also supported by NCI Lung Cancer SPORE (P50CA70907), U01CA176284, and CPRIT (RP110708 and RP160652) to J.D.M. D.E.G. is supported by a National Cancer Institute (NCI) Midcareer Investigator Award in Patient-Oriented Research, K24CA201543-01. S.B. is supported by grants from the National Institutes of Health (RO1CA197796) and the National Aeronautics and Space Administration (NNX16AD78G). E.A.A. is supported by CPRIT RR160080, NCI 2P50CA070907-22, Welch Foundation grant 1975-20190330, A Breath of Hope Lung Foundation Fellowship Award (ABOHLF 2020), NCCN Foundation Young Investigator Award (NCCN 2021), and Forbeck Foundation Grant. D.Z. was supported by NIH grant R01 CA194578, Research reported in this publication was supported in part by the Harold C. Simmons Comprehensive Cancer Center’s Biomarker Research Core, which are supported by NCI Cancer Center Support Grant 1P30 CA142543–03. We acknowledge NIH shared instrumentation grant 1S10OD023552-01 that funded the MRI equipment.”

 

10

Hendrickson R, Urbaniak C, Minich JJ, Aronson HS, Martino C, Stepanauskas R, Knight R, Venkateswaran K.

Microbiome. 2021 Dec 4;9(1):238.

Note: From the introduction: “…the objective of this study was to perform an in-depth analysis of the SAF facility microbial community composition over the course of 6 months, using 16S rRNA gene-targeted amplicon sequencing to understand spatial and temporal relationship of the spore-forming members and bacterial diversity.” This article may be obtained online without charge.

Journal Impact Factor: 14.65

Funding: “The research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004). This research was supported by the JPL Mars Program Office project. Additional funding sources included NSF grants OIA-1826734 and OCE-1335810 and NASA grant 18-EXO18-0048 to RS.”

 

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Other papers of interest:

 

1

Gravano S, Lacquaniti F, Zago M.

npj Microgravity. 2021 Dec 3;7(1):50.

Note: ISS results. From the abstract: “Here, a group of astronauts grasped an imaginary ball, threw it against the ceiling or the front wall, and caught it after the bounce, during pre-flight, in-flight, and post-flight experiments. They varied the throwing speed across trials and imagined that the ball moved under Earth’s gravity or weightlessness.” This article may be obtained online without charge.

 

2

Gong X, Liu M, Li N, Wu P, Zhao D, Gu Z, Wang Y.

Space Med Med Eng. 2021;2021(3):189-93. Chinese.

Note: From the abstract: “To verify the influence of 5 day repeated body-position change on the hyper-gravity endurance six young healthy male subjects were trained with repeated position change training 1 time per day for 5 days. During the training, the subject’s heartbeat and blood pressure were monitored.”

 

3

Polyakov AV, Svistunov AA, Kondratenko SN, Kovachevich IV, Repenkova LG, Savelyeva MI, Shikh EV, Badriddinova LY.

Drug Metab Pers Ther. 2021 Nov 29. Online ahead of print.

Note: From the article: “The data obtained allow recommending the studied drugs for rational pharmacotherapy in the possible development of cardiovascular disease in manned spaceflight.“

 

4

He H, Liu H, Guo Y.

Space Med Med Eng. 2021;2021(3):266-71. Chinese. Review.

Note: From the abstract: “The physiological adaptive changes of the human body to the weightlessness environment during spaceflight can affect the physical health of astronauts, such as space motion sickness, cardiovascular system disorders, bone and muscle degeneration, and immune function decline. Using the theory of ‘holistic concept, syndrome differentiation, and treatment’ of traditional Chinese medicine, it was concluded that the total pathogenesis of weightlessness effect was deficiency of liver, spleen and kidney, which was mainly yin deficiency, and there were symptoms such as qi and blood disorder, qi deficiency and blood stasis.”

 

5

Liu M, Zhang W, Gong X, Shi D, Zhou W, Wu P, Zou L, Li Y, Li N, Huang W.

Space Med Med Eng. 2021;2021(3):194-200. Chinese.

 

6

Kim H, Shin Y, Kim D-H.

Front Cell Dev Biol. 2021 Dec 8;9:740009. Review.

Note: This article is part of Research Topic “Space Mechanobiology and Medicine” (https://www.frontiersin.org/research-topics/17450/space-mechanobiology-and-medicine#articles). The Research Topic also includes articles from previous Current Awareness Lists #963 https://doi.org/10.3389/fcell.2021.672098, https://doi.org/10.3389/fcell.2021.689662, and https://doi.org/10.3389/fcell.2021.707470; #971 https://doi.org/10.3389/fcell.2021.732370; and #977 https://doi.org/10.3389/fcell.2021.750775. This article may be obtained online without charge.

 

7

Yu S, Yuan P, Xu Y.

Space Med Med Eng. 2021;2021(3):272-82. Chinese.

Note: Head-down tilt bedrest study.

 

8

Li X, Jiao Z, Chang Y, Guo H, Bao J, Sun C.

Space Med Med Eng. 2021;2021(3):201-7. Chinese.

 

9

Dalecki M, Steinberg F, Beurskens R.

Hum Factors. 2021 Dec 3:187208211051804. Online ahead of print.

Note: From the abstract: “An unstable tracking and a choice reaction task was performed for one minute under ST [single-task] and DT [dual-task] conditions in 5 m water submersion and on dry land in 43 participants. Tracking and choice reaction time performance for both tasks were analyzed in blocks of 10 seconds.”

 

10

Kaksonen AH, Deng X, Morris C, Khaleque HN, Zea L, Gumulya Y.

Microorganisms. 2021 Nov 23;9(12):2416.

Note: A clinostat was used in this study. This article is part of Special Issue “Astrobiology and Microorganisms: Life to the Extreme, on Earth and Beyond Mechanobiology” (https://www.mdpi.com/journal/microorganisms/special_issues/astrobiology_microorganisms). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

11

Robson DJ, Cappelletti C.

Acta Astronautica. 2022 Feb;191:394-403.

Note: From the abstract: “This paper outlines some of the challenges and opportunities facing the space biomedical community and how CubeSats may (and indeed already are) supporting this research area.”

 

12

Wubshet NH, Arreguin-Martinez E, Nail M, Annamalai H, Koerner R, Rousseva M, Tom T, Gillespie RB, Liu AP.

Rev Sci Instrum. 2021 Nov 1;92(11):114101.

Note: A random positioning machine was used in this study.

 

13

Brickey WJ, Thompson MA, Sheng Z, Li Z, Owzar K, Ting JPY.

Radiat Res. 2021 Dec 2. Online ahead of print.

 

14

P SR, Kashyap B, Dekker H, Mikkonen JJ, Palander A, Bravenboer N, Kullaa AM.

Int J Radiat Biol. 2021 Dec 2:1-29. Review. Online ahead of print.

 

15

Verma N, Tiku AB.

Int J Radiat Biol. 2021 Dec 2:1-29. Online ahead of print.

Note: From the abstract: “Radiation induced bystander effect (RIBE) is considered as an important consequence of radiation exposures. Based on the type of effect induced, it has important implications in radiation therapy. mTOR (mammalian Target of Rapamycin) pathway, a key regulator of cell survival in response to various stressors, plays an important role in radiation induced damages. Besides cell survival, over-expression of mTOR promotes resistance to radiation. However, the role of mTOR signalling in induction/modulation of RIBE is still unclear. The main objective of this study was to evaluate the role of mTOR pathway in RIBE and to understand its relationship with radiation response of target cells.”

 

16

Hobson CM, Falvo MR, Superfine R.

APL Bioeng. 2021 Dec;5(4):041508. Review.

Note: This article may be obtained online without charge.

 

17

Keshavarz B, Golding JF.

Curr Opin Neurol. 2021 Nov 26. Review. Online ahead of print.

 

18

Krutki P, Mrówczyński W, Celichowski J, Bączyk M.

J Appl Physiol (1985). 2021 Dec 2. Online ahead of print.

Note: From the abstract: “Whole-body vibration (WBV) is often applied as an alternative method for strength training or to prevent muscle force decrease. Previous studies indicated that WBV induced: 1) changes in the contractile parameters predominantly of fast motor units, 2) higher motoneuron excitability, and 3) higher motoneuron firing rates at lower stimulus intensities compared with the control. In this study, we evaluated the influence of WBV on Ia monosynaptic input from muscle spindles because the tonic vibration reflex is responsible for the enhancement of muscle activity observed after WBV.”

 

19

Kjeld T, Isbrand AB, Linnet K, Zerahn B, Højberg J, Hansen EG, Gormsen LC, Bejder J, Krag T, Vissing J, Bøtker HE, Arendrup HC.

Note: This article is part of Research Topic “Physiology and Physiopathology of Breath-Holding Activity” (https://www.frontiersin.org/research-topics/17771/physiology-and-physiopathology-of-breath-holding-activity#articles). This article may be obtained online without charge.