NASA Spaceline Current Awareness List #977 3 December 2021 (Space Life Science Research Results)

 

In case you missed it: The astrobiology web website features an article titled, “Researchers Put Space Garden Microbes Under the Microscope,” discussing how NASA scientists are carefully monitoring the microbiome of the International Space Station with two goals in mind—to map and keep track of microbes present through time, and to discover any patterns of microbial growth that could potentially affect the crew’s health and safety—in order to determine whether or not the station itself creates conditions that spur microbial growth. Further reading is available at http://astrobiology.com/2021/12/researchers-put-space-garden-microbes-under-the-microscope.html.

 

Papers deriving from NASA support:

 

1

Haveman NJ, Schuerger AC.

Astrobiology. 2021 Nov 18. Online ahead of print.

PI: N.J. Haveman, NASA Space Biology Postdoctoral Fellowship

Note: ISS results. From the abstract: “In this study, we show how the MinION sequencing platform can be used to diagnose the opportunistic pathogen, Fusarium oxysporum sensu lato; a fungal infection on Zinnia hybrida (zinnia) plants that were grown on the International Space Station (ISS) in 2015–2016.”

Journal Impact Factor: 4.335

Funding: “This study was supported in part by NASA Space Biology Postdoctoral Fellowship (80NSSC19K0520) awarded to N.J.S.”

 

2

Koller DP, Kasanin V, Flynn-Evans EE, Sullivan JP, Dijk DJ, Czeisler CA, Barger LK.

npj Microgravity. 2021 Nov 18;7(1):48.

Note: From the abstract: “This study extends previous findings by analyzing how spaceflight affects characteristics of sleep spindles and slow waves, two sleep oscillations associated with sleep quality and quantity, in four astronauts before, during and after two Space Shuttle missions.” This article may be obtained online without charge.

Journal Impact Factor: 4.415

Funding: “We thank the Space Shuttle crew members who participated in this study; Dr. Leopold Summerer and ESA’s Advanced Concepts Team for their help in initiating and running this study; Dr. R. Hughes for his role in the original study; NASA’s LSDA, LSAH, and IRB teams, as well as Inês Antunes, ESA’s Human Research Science Coordinator, for their continuous support. Dr. Flynn-Evans was supported by the NASA Human Research Program. Drs. Barger and Czeisler and Mr. Sullivan were supported in part by R01OH011773.”

 

3

Bretl KN, Clark TK.

J Vestib Res. 2021 Nov 14. Online ahead of print.

Note: From the abstract: “Eleven subjects were exposed to the CC illusion for up to 50 25-minute acclimation sessions. The metric of acclimation rate was calculated as the slope of each subject’s linear increase in spin rate across sessions. As potential predictors of acclimation rate, we gathered age, gender, demographics, and activity history, and measured subjects’ vestibular perceptual thresholds in the yaw, pitch, and roll rotation axes.”

Journal Impact Factor: 2.435

Funding: “The funding for this research was provided via a NASA Space Technology Research Fellowship, Grant Number 80NSSCK0085.”

 

4

Kiffer FC, Luitel K, Tran FH, Patel RA, Guzman CS, Soler I, Xiao R, Shay JW, Yun S, Eisch AJ.

Behav Brain Res. 2022 Feb 15;419:113677.

PIs: J.W. Shay, S. Yun, A.J. Eisch, F.C. Kiffer, TRISH Postdoctoral Program Fellowship

Journal Impact Factor: 3.332

Funding: “This work was supported by NASA grants 80NSSC17K0060 (Eisch), 80NSSC21K0814 (Yun), NNX16AE08G (Shay); by the Translational Research Institute for Space Health through NASA cooperative agreement NNX16AO69A (Kiffer); NIH MH107945 (Eisch and Yun); the University of Pennsylvania McCabe Fund (Yun); the NARSAD Brain & Behavior Research Foundation award for Young Investigators (Yun); the Children’s Hospital of Philadelphia Department of Anesthesiology and Critical Care Development Fund (Eisch).”

 

5

De Martino E, Hides J, Elliott JM, Hoggarth MA, Zange J, Lindsay K, Debuse D, Winnard A, Beard D, Cook JA, Salomoni SE, Weber T, Scott J, Hodges PW, Caplan N.

Spine J. 2021 Nov 20;S1529-9430(21)01028-7. Online ahead of print.

Note: Head-down tilt bedrest study. This article may be obtained online without charge.

Journal Impact Factor: 4.166

Funding: “The AGBRESA study was funded by the German Aerospace Center, the European Space Agency (contract number: 4000113871/15/NL/PG), and the National Aeronautics and Space Administration (contract number: 80JSC018P0078). The study was performed at the “:envihab” research facility of the DLR Institute of Aerospace Medicine. Funding for this ESA-selected project (ESA-HSO-U-LE-0629) was received from the STFC/UK Space Agency (ST/R005753/1).”

 

6

Yamazaki EM, Antler CA, Casale CE, MacMullen LE, Ecker AJ, Goel N.

Front Physiol. 2021 Nov 29;12:782860.

PI: N. Goel

Note: This article and an article below in the “Other” section (Guillon et al.) are part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior” (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). The Research Topic also includes articles from previous Current Awareness Lists #956 https://doi.org/10.3389/fncir.2021.659557; #967 https://doi.org/10.3389/fphys.2021.654906; #969 https://doi.org/10.3389/fphys.2021.746509; #973 https://doi.org/10.3389/fncir.2021.723504; #975 https://doi.org/10.3389/fncir.2021.757817, https://doi.org/10.3389/fncir.2021.760313, and https://doi.org/10.3389/fphys.2021.750414; and #976 https://doi.org/10.3389/fphys.2021.770502. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

Journal Impact Factor: 4.566

Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) [grant numbers NNX14AN49G and 80NSSC20K0243 (to NG)]. This work was also partially supported from National Institutes of Health [grant number NIH R01DK117488 (to NG)].”

 

7

Plante I, Poignant F, Slaba T.

Life (Basel). 2021 Oct 20;11(11):1112.

Note: From the abstract: “To understand the biological effects of radiation, it is important to determine how ionizing radiation deposits energy in micrometric targets. The energy deposited in a target located in an irradiated tissue is a function of several factors such as the radiation type and the irradiated volume size. We simulated the energy deposited by energetic ions in spherical targets of 1, 2, 4, and 8 µm radii encompassed in irradiated parallelepiped volumes of various sizes using the stochastic radiation track structure code Relativistic Ion Tracks (RITRACKS).” This article and an article below in the “Other” section (Calvaruso et al.) are part of Special Issue “Space Radiobiology” (https://www.mdpi.com/journal/life/special_issues/space_radiobiology). The Special Issue also includes an article from previous Current Awareness List #968 https://doi.org/10.3390/life11080849. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 3.817

Funding: “This work was supported by NASA Human Health and Performance (HHPC) contract number NNJ15HK11B (I.P.) and by the NASA Langley Cooperative Agreement 80LARC17C0004 (F.P.). This work is supported by the Human Research Program under the Human Exploration and Operations Mission Directorate at NASA (T.S.).”

 

8

Roberts DR, Collins HR, Al Kasab S.

JAMA Ophthalmol. 2021 Nov 24. Online ahead of print.

PI: D.R. Roberts

Note: This article is a comment on an article from previous Current Awareness List #951 https://pubmed.ncbi.nlm.nih.gov/34014272.

Journal Impact Factor: 7.4

Funding: “Dr. Roberts reported grants from NASA during the conduct of the study.”

 

9

Marshall-Goebel K, Kramer LA, Macias BR.

JAMA Ophthalmol. 2021 Nov 24. Online ahead of print.

PIs: K. Marshall-Goebel, L.A. Kramer, B.R. Macias

Note: This article is the reply to the comment article above on an article from previous Current Awareness List #951 https://pubmed.ncbi.nlm.nih.gov/34014272.

Journal Impact Factor: 7.4

Funding: “Drs. Marshall-Goebel, Kramer, and Macias reported grants from NASA during the conduct of the study.”

 

_______________________________________________________

 

 

Other papers of interest:

 

1

Bull Exp Biol Med. 2021 Nov;172(1):81-4.

Note: The method of simulated hypogravity is not evident in the available abstract. This article may be obtained online without charge.

 

2

Basirun C, Ferlazzo ML, Howell NR, Liu GJ, Middleton RJ, Martinac B, Narayanan SA, Poole K, Gentile C, Chou J.

Front Cell Dev Biol. 2021 Oct 29;9:750775. Mini review.

Note: From the abstract: “This mini review aims to identify the impact of microgravity and radiation on the cardiovascular system. Being able to understand the effect that comes with deep space explorations, including that of microgravity and space radiation, may also allow us to get a deeper understanding of the heart and ultimately our own basic physiological processes.” This article and an article below (Rosenstein et al.) are part of Research Topic “Space Mechanobiology and Medicine” (https://www.frontiersin.org/research-topics/17450/space-mechanobiology-and-medicine#articles). The Research Topic also includes articles from previous Current Awareness List #963 https://doi.org/10.3389/fcell.2021.672098, https://doi.org/10.3389/fcell.2021.689662, and https://doi.org/10.3389/fcell.2021.707470; and #971 https://doi.org/10.3389/fcell.2021.732370. This article may be obtained online without charge.

 

3

Rosenstein AH, Walker VK.

Front Cell Dev Biol. 2021 Nov 29;9:702849.

Note: This article and the article above (Basirun et al.) are part of Research Topic “Space Mechanobiology and Medicine” (https://www.frontiersin.org/research-topics/17450/space-mechanobiology-and-medicine#articles). You may also view a write-up promoting this article on the astrobiology web website at http://astrobiology.com/2021/12/cells-replication-of-dna-is-more-error-prone-in-microgravity.html. This article may be obtained online without charge.

 

4

Mohanta TK, Mishra AK, Mohanta YK, Al-Harrasi A.

Front Plant Sci. 2021 Oct 27;12:771985. Review.

Note: From the abstract: “This review aims to elucidate the detailed molecular mechanisms and genetic mutations found in plants used in recent space crop projects and how these can be applied in space breeding programs in the future.” This article is part of the Research Topic “Enviromics in Plant Breeding” (https://www.frontiersin.org/research-topics/17196/enviromics-in-plant-breeding#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

5

Strigari L, Strolin S, Morganti AG, Bartoloni A.

Front Public Health. 2021 Nov 8;9:733337. Review.

Note: This article is part of the Research Topic “Medical Application and Radiobiology” (https://www.frontiersin.org/research-topics/14492/medical-application-and-radiobiology-research-of-particle-radiation#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

6

Calvaruso M, Militello C, Minafra L, La Regina V, Torrisi F, Pucci G, Cammarata FP, Bravatà V, Forte GI, Russo G.

Life (Basel). 2021 Nov 5;11(11):1190.

Note: From the abstract: “In our study, we aimed to characterize, at the biological and mechanical level, a Random Positioning Machine in order to simulate microgravity in an in vitro model of Triple-Negative Breast Cancer (TNBC).” This is article and an article above in the “NASA” section (Plante et al.) are part of Special Issue “Space Radiobiology” (https://www.mdpi.com/journal/life/special_issues/space_radiobiology). This article may be obtained online without charge.

 

7

Guillon L, Kermorgant M, Charvolin T, Bonneville F, Bareille M-P, Cassol E, Beck A, Beaurain M, Péran P, Lotterie J-A, Traon AP-L, Payoux P.

Front Physiol. 2021 Nov 22;12:789298.

Note: Dry immersion results. This article and an article above in the “NASA” section (Yamazaki et al.) are part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior” (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

8

Richter C, Braunstein B, Staeudle B, Attias J, Suess A, Weber T, Mileva KN, Rittweger J, Green DA, Albracht K.

Sci Rep. 2021 Nov 19;11(1):22555.

Note: From the abstract: “…this study investigated lower limb joint kinematics and gastrocnemius medialis behavior during running at 1 g, simulated Martian gravity, and simulated Lunar gravity on the vertical treadmill facility.” This article may be obtained online without charge.

 

9

Abdelfattah OM, Sayed A, Elgendy IY, Munir M, Saleh Y, Kapadia SR, Abela GS, Jneid H.

Cardiovasc Revasc Med. 2021 Nov 20;S1553-8389(21)00745-4. Online ahead of print.

 

10

Booker CN, Haga CL, Boregowda SV, Strivelli J, Phinney DG.

npj Microgravity. 2021 Nov 26;7(1):49.

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

11

Kalashnikov VE, Tyganov SA, Turtikova OV, Kalashnikova EP, Glazova MV, Mirzoev TM, Shenkman BS.

Life (Basel). 2021 Nov;11(11):1161.

Note: Hindlimb unloading study. This article is part of Section “Physiology and Pathology” (https://www.mdpi.com/journal/life/sections/Physiology_and_Pathology). This article may be obtained online without charge.

 

12

Paramonova, II, Vilchinskaya NA, Shenkman BS.

Pharmaceuticals (Basel). 2021 Nov 16;14(11):1167.

Note: Hindlimb unloading study. This article is part of Special Issue “Drug Insight: Histone Deacetylase (HDAC) Inhibitors” (https://www.mdpi.com/journal/pharmaceuticals/special_issues/HDAC_pharm). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

13

Sun L, An S, Zhang Z, Zhou Y, Yu Y, Ma Z, Fan X, Tang L, Guo J.

Int J Mol Sci. 2021 Nov 9;22(22):12112.

Note: Hindlimb unloading study. This article belongs to Section “Molecular Pathology, Diagnostics, and Therapeutics” (https://www.mdpi.com/journal/ijms/sections/Pathology_Diagnostics_Therapeutics). This article may be obtained online without charge.

 

14

Dolan CP, Imholt F, Yang TJ, Bokhari R, Gregory J, Yan M, Qureshi O, Zimmel K, Sherman K, Falck A, Yu L, Leininger E, Brunauer R, Suva LJ, Gaddy D, Dawson LA, Muneoka K.

J Bone Miner Res. 2021 Nov 16. Online ahead of print.

Note: Hindlimb unloading study.

 

15

Konosu A, Funato T, Matsuki Y, Fujita A, Sakai R, Yanagihara D.

Note: From the abstract: “Humans and animals learn the internal model of bodies and environments from their experience and stabilize posture against disturbances based on the predicted future states according to the internal model. We evaluated the mechanism of predictive control during standing, by using rats to construct a novel experimental system and comparing their behaviors with a mathematical model.” This article is part of Research Topic “The Neural Basis of Hyper-Adaptability in Humans and Animals” (https://www.frontiersin.org/research-topics/18103/the-neural-basis-of-hyper-adaptability-in-humans-and-animals#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

16

Bodnyk KA, Kim DG, Pan X, Hart RT.

J Biomech Eng. 2021 Nov 24. Online ahead of print.

Note: From the abstract: “As an alternative to drug treatments, low-magnitude mechanical stimulation (LMMS) may improve skeletal health without potential side effects from drugs. LMMS has been shown to increase bone health short term in both animal and clinical studies. Long term changes to the mechanical properties of bone from LMMS are currently unknown, so the objective of this research is to investigate the long-term effects of whole body vibration therapy on the elastic and viscoelastic properties of bone.”

 

17

Harijanto C, Lim A, Vogrin S, Duque G.

Gerontology. 2021 Nov 15;1-11. Online ahead of print.

 

18

Kohama I, Yanagawa T, Okamoto M, Ohno T, Chikuda H.

Asia Pac J Clin Oncol. 2021 Nov 23. Online ahead of print.

 

19

MacDonald EA, Quinn TA.

Biophys Rev. 2021 Sep 15;13(5):707-16. Review.

 

20

Harada T, Sugawara T, Ito T, Wada Y, Fukunaga M, Sadato N, Larroque SK, Demertzi A, Laureys S, Sakai H.

Front Neurosci. 2021 Nov 4;15:763040.

Note: This article may be obtained online without charge.

 

21

Nürnberger M, Klingner C, Witte OW, Brodoehl S.

Front Hum Neurosci. 2021 Oct 29;15:757735.

Note: This article is part of Research Topic “The Brain Under Fatigue” (https://www.frontiersin.org/research-topics/18593/the-brain-under-fatigue#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

22

Sakai H, Harada T, Larroque SK, Demertzi A, Sugawara T, Ito T, Wada Y, Fukunaga M, Sadato N, Laureys S.

Hum Brain Mapp. 2021 Nov 15. Online ahead of print.

Note: This article may be obtained online without charge.

 

23

Sudo D, Hosokawa M, Maeda Y.

J Phys Ther Sci. 2021 Nov;33(11):857-61.

Note: This article may be obtained online without charge.

 

24

Ming X, Wang W, Shahnazi K, Sun J, Zhang Q, Li P, Hong Z, Sheng Y.

Int J Radiat Biol. 2021 Nov 22:1-26. Online ahead of print.