Status Report

NASA Spaceline Current Awareness List # 968 24 September 2021 (Space Life Science Research Results)

By SpaceRef Editor
September 24, 2021
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Simpson AC, Urbaniak C, Bateh JR, Singh NK, Wood JM, Debieu M, O’Hara NB, Houbraken J, Mason CE, Venkateswaran K.
Draft genome sequences of fungi isolated from the International Space Station during the Microbial Tracking-2 experiment.
Microbiol Resour Announc. 2021 Sep 16;10(37):e0075121.
PIs: C. Jaing, C. Urbaniak, NASA Postdoctoral Program Fellowship
Note: ISS results. GeneLab is available at This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “Part of the research described was carried out at the Jet Propulsion Laboratory (JPL) of the California Institute of Technology under a contract with NASA. This research was funded by a 2014 Space Biology NNH14ZTT002N award (grant 80NSSC18K0113) to Crystal Jaing and K.V., which also partially funded postdoctoral fellowships for C.U. and J.M.W. Additionally, A.C.S. was supported by grant 80NM0018D0004, funded to K.V. We thank astronauts Colonel Jack Fischer, Colonel Mark Vande Hei, Norishige Kanai, and Alexander Gerst for collecting samples aboard the ISS, the implementation team(Fathi Karouia) at NASA Ames Research Center for coordinating this effort, and Crystal Jaing (Lawrence Livermore National Laboratory), principal investigator of the team.”
Borg AM, Baker JE.
Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond low-Earth orbit.
Synth Biol (Oxf). 2021 Sep 2;6(1):ysab023. Review.
PI: J.E. Baker
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This manuscript was funded by a grant from NASA (80NSSC19K0498), and in part by a grant from the Foundation for Heart Science.”
Kluis L, Keller N, Bai H, Iyengar N, Shepherd R, Diaz-Artiles A.
Reducing metabolic cost during planetary ambulation using robotic actuation.
Aerosp Med Hum Perform. 2021 Jul;92(7):570-8.
Note: From the abstract: “Using the OpenSim framework, we completed a biomechanical analysis of three walking conditions: unsuited, suited with the extravehicular mobility unit (EMU) spacesuit (represented as external joint torques applied to human joints), and suited with the EMU and assisted by robotic actuators capable of producing up to 10 Nm of torque. For each scenario, we calculated the inverse kinematics and inverse dynamics of the lower body joints (hip, knee, and ankle). We also determined the activation of muscles and robotic actuators (when present). Finally, from inverse dynamics and muscle activation results, the metabolic cost of one gait cycle was calculated in all three conditions.”
Journal Impact Factor: 0.889
Funding: “ORCID identifier:, Department of Aerospace Engineering, Texas A&M University, College Station, TX. We would like to acknowledge the NASA Innovative Advanced Concepts (NIAC) program (grant number 80NSSC19K0969) for supporting and funding this research.”
Mao XW, Stanbouly S, Jones T, Nelson G.
Evaluating ocular response in the retina and optic nerve head after single and fractionated high-energy protons.
Life (Basel). 2021 Aug 19;11(8):849.
PIs: X.W. Mao, G. Nelson
Note: This article belongs to Special Issue “Space Radiobiology” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 2.991
Funding: “This study was supported by NASA Human Research Program grant# 80NSSC18K0310, 80NSSC18K0785, and NASA Space Biology grant # NNX15AB41G.”
Tichy ED, Ma N, Sidibe D, Loro E, Kocan J, Chen DZ, Khurana TS, Hasty P, Mourkioti F.
Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening.
Cell Rep. 2021 May 11;35(6):109098.
PI: F. Mourkioti
Note: This article may be obtained online without charge.
Journal Impact Factor: 9.423
Funding: We thank A. Sacco for providing the human samples, M. Pasparakis for providing the NEMOfl/fl mice, and W.J. Tseng and S. Liu (PCMD Imaging Core) for assistance with the μCT experiments. We would like to thank H. Papaioannou, A. Scaramella, I. Paez, Y. Lee, and G. Wang for unbiased validation and analysis assistance. The authors were supported by startup funds from the Perelman School of Medicine, the McCabe Award, the NIH Pilot Grant (P30 AR069619), NASA (18-FG_ind_2-0022), and the NIH (R01HL146662) to F.M.”
Tichy ED, Mourkioti F.
Telomere length assessments of muscle stem cells in rodent and human skeletal muscle sections.
STAR Protocols. 2021 Dec 17;2(4):100830.
PI: F. Mourkioti
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “We thank both Jim Morgan and Alan Meeker (Johns Hopkins) for the current version of Telometer. This work was supported by the NASA (18-FG_ind_2–0022) and the NIH (R01HL146662) to F.M.”
Chai C, Chin S, Blancaflor EB.
Imaging the cytoskeleton in living plant roots.
Methods Mol Biol. 2022;2364:139-148. Available online 21 Sep 2021.
PI: E.B. Blancaflor
Funding: “This work is supported by the National Aeronautics and Space Administration (NASA grants 80NSSC19K0129 and 80NSSC18K1462) and Noble Research Institute LLC.”
Other papers of interest:
Boulanger N, Buisseret F, Dehouck V, Dierick F, White O.
Motor strategies and adiabatic invariants: The case of rhythmic motion in parabolic flights.
Phys Rev E. 2021 Aug;104(2):024403.
Note: Parabolic flight results.
Manzano A, Pereda-Loth V, de Bures A, Sáez-Vásquez J, Herranz R, Medina FJ.
Light signals counteract alterations caused by simulated microgravity in proliferating plant cells.
Am J Bot. 2021 Sep 15. Online ahead of print.
Note: A random positioning machine was used in this study. This article may be obtained online without charge.
Ohira T, Ino Y, Kimura Y, Nakai Y, Kimura A, Kurata Y, Kagawa H, Kimura M, Egashira K, Matsuda C, Ohira Y, Furukawa S, Hirano H.
Effects of microgravity exposure and fructo-oligosaccharide ingestion on the proteome of soleus and extensor digitorum longus muscles in developing mice.
npj Microgravity. 2021 Sep 17;7(1):34.
Note: ISS and hindlimb unloading results. This article may be obtained online without charge.
Su X, Guo Y, Fang T, Jiang X, Wang D, Li D, Bai P, Zhang B, Wang J, Liu C.
Effects of simulated microgravity on the physiology of Stenotrophomonas maltophilia and multiomic analysis.
Front Microbiol. 2021 Aug 27;12:701265.
Note: This article is part of Research Topic “Extremophiles: Microbial Genomics and Taxogenomics” ( The Research Topic also includes two articles from previous Current Awareness List #941 and Additional articles will be forthcoming and may be found in the link to the Research Topic. A high-aspect rotating vessel was used in this study. This article may be obtained online without charge.
Ainsbury EA, Moquet J, Sun M, Barnard S, Ellender M, Lloyd D.
The future of biological dosimetry in mass casualty radiation emergency response, personalised radiation risk estimation and space radiation protection.
Int J Radiat Biol. 2021 Sep 13;1-22. Online ahead of print.
Lautenschlaeger FS, Dumke R, Schymalla M, Hauswald H, Carl B, Stein M, Keber U, Jensen A, Engenhart-Cabillic R, Eberle F.
Comparison of carbon ion and photon reirradiation for recurrent glioblastoma.
Strahlenther Onkol. 2021 Sep 14. Online ahead of print.
Note: This article may be obtained online without charge.
Rogers CJ, Kyubwa EM, Lukaszewicz AI, Starbird MA, Nguyen M, Copeland BT, Yamada-Hanff J, Menon N.
Observation of unique circulating miRNA signatures in non-human primates exposed to total-body vs. whole thorax lung irradiation.
Radiat Res. 2021 Sep 15. Online ahead of print.
Moroni L, Tabury K, Stenuit H, Grimm D, Baatout S, Mironov V.
What can biofabrication do for space and what can space do for biofabrication?
Trends Biotechnol. 2021 Sep 17;S0167-7799(21)00195-5. Review. Online ahead of print.
Note: From the abstract: “Biofabrication in space is one of the novel promising and prospective research directions in the rapidly emerging field of space STEM. There are several advantages of biofabrication in space. Under microgravity, it is possible to engineer constructs using more fluidic channels and thus more biocompatible bioinks. Microgravity enables biofabrication of tissue and organ constructs of more complex geometries, thus facilitating novel scaffold-, label-, and nozzle-free technologies based on multi-levitation principles. However, when exposed to microgravity and cosmic radiation, biofabricated tissues could be used to study pathophysiological phenomena that will be useful on Earth and for deep space manned missions. Here, we provide leading concepts about the potential mutual benefits of the application of biofabrication technologies in space.” This article may be obtained online without charge.

SpaceRef staff editor.