NASA Spaceline Current Awareness List #967 17 September 2021 (Space Life Science Research Results)

Papers deriving from NASA support:

1

Cahill T, Cope H, Bass JJ, Overbey EG, Gilbert R, da Silveira WA, Paul AM, Mishra T, Herranz R, Reinsch SS, Costes SV, Hardiman G, Szewczyk NJ, Tahimic CGT.

Int J Mol Sci. 2021 Sep;22(17):9470.

Note: ISS and hindlimb unloading results. This article and the article below (Kumar et al.) belong to Special Issue “Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment” (https://www.mdpi.com/journal/ijms/special_issues/OSaD_space). The Special Issue also includes articles from previous Current Awareness Lists #944 https://doi.org/10.3390/ijms22063070, #947 https://doi.org/10.3390/ijms22073668, and #965 https://doi.org/10.3390/ijms22169020. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 4.556

Funding: “T.C. was supported by the NI Department for the Economy (DfE) Research Studentship. H.C. is supported by the Horizon Centre for Doctoral Training at the University of Nottingham (UKRI grant no. EP/S023305/1). R.H. is supported by the Spanish Plan Estatal de Investigación Científica y Desarrollo Tecnológico Grant RTI2018-099309-B-I00. S.S.R. is supported by the NASA Ames Space Biology Program.”

 

2

Kumar A, Tahimic CGT, Almeida EAC, Globus RK.

Int J Mol Sci. 2021 Aug 23;22(16):9088.

PIs: E.A.C. Almeida, R.K. Globus

Note: Space Shuttle Discovery STS-131 mission results. This article and the article above (Cahill et al.) belong to Special Issue “Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment” (https://www.mdpi.com/journal/ijms/special_issues/OSaD_space). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 4.556

Funding: “This work was supported by a NASA Human Research Program grant (NNH04ZUU005N/RAD 2004-0000-0110) to R.K.G. and a NASA Space Biology grant (NNH08ZTT003N) to E.A.C.A. A.K. was a recipient of a NASA Space Biology Postdoctoral Fellowship award.”

 

3

Petersen E, Pattarini JM, Mulcahy RA, Beger SB, Mitchell MR, Hu YD, Middleton KN, Frazier W, Mormann B, Esparza H, Asadi A, Musk ER, Alter G, Nilles E, Menon AS.

Aerosp Med Hum Perform. 2021 Jul 1;92(7):597-602.

PI: A.S. Menon

Note: SpaceX Crew Demo-2 mission results. This HSP [Health Stabilization Program] was implemented during the COVID-19 pandemic. From the abstract: “This article details and discusses the first commercial implementation and adaptation of the HSP prior to the Crew Demo-2 launch.”

Journal Impact Factor: 0.889

Funding: “This work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A.”

 

4

Douglas GL, Wheeler RM, Fritsche RF.

Sustainability. 2021 Aug 22;13(16):9424.

Note: From the abstract: “Here, we provide a potential approach toward sustainability with the phased addition of bioregenerative foods over the course of NASA‘s current mission plans.” This article belongs to Special Issue “Technologies for Developing Sustaining Foods for Specialized Missions” (https://www.mdpi.com/journal/sustainability/special_issues/SustainingFoods). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 3.251

Funding: “Support for this manuscript was provided by NASA Advanced Exploration Systems.”

5

Mahadevan AD, Hupfeld KE, Lee JK, De Dios YE, Kofman IS, Beltran NE, Mulder E, Bloomberg JJ, Mulavara AP, Seidler RD.

PI: R.D. Seidler

Note: Head-down-tilt bed rest study. This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior” (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). The Research Topic also includes an article from previous Current Awareness List #956 https://doi.org/10.3389/fncir.2021.659557. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 4.566

Funding: “This work was supported by grants from the National Aeronautics and Space Administration (NASA; NNX11AR02G and 80NSSC17K0021) and from the National Space Biomedical Research Institute (NSBRI; SA02802) to RS, APM, and JB. During this work, KH received support from a National Science Foundation Graduate Research Fellowship under Grant nos. DGE-1315138 and DGE-1842473, training grant NINDS T32- NS082128, and fellowship NIA F99 AG068440-01.”

6

Paul A-L, Haveman N, Califar B, Ferl RJ.

Front Plant Sci. 2021 Sep 13;12:691790.

PI: A-L. Paul

Note: This article is part of Research Topic “DNA Methylation in Plants Associated with Abiotic Stress” (https://www.frontiersin.org/research-topics/12797/dna-methylation-in-plants-associated-with-abiotic-stress#articles). This article may be obtained online without charge.

Journal Impact Factor: 5.753

Funding: “This work was supported by the National Aeronautics and Space Administration–Space Life and Physical Sciences (NNX14AT24G awarded to A-LP and RF).”

7

Smith TG, Buckey JC Jr.

Anaesthesia. 2021 Sep 8. Online ahead of print.

Note: From the abstract: “Fewer than 600 people have been to space, mostly very fit and healthy professional astronauts who have undergone careful medical screening and selection, but this is about to change. Two billionaires recently took maiden flights on their companies‘ respective suborbital spacecraft, opening the way for private citizens to fly as paying customers. How will they cope with spaceflight? What should the medical approach to passengers involve? What does this have to do with anaesthetists?”

Journal Impact Factor: 5.739

Funding: “TS is an advisor in aerospace medicine to the Medical Research Council and a Member of Council of the Aerospace Medical Association (USA). He has received research grants or in-kind support from the UK Space Agency, UK Civil Aviation Authority, Royal Air Force and NASA, and has received payments from Caeli Nova for consultancy work. JB is a former payload specialist astronaut and has received funding from NASA, the Office of Naval Research, DARPA and the US National Institutes of Health.”

 

8

Wood JM, Peres JB, Bateh J, Singh NK, Aronson HS, Hendrickson R, Mason CE, Venkateswaran K.

Microbiol Resour Announc. 2021 Sep 9;10(36):e0065321.

PI: N.K. Singh

Note: From the abstract: “Heat shock-tolerant microorganisms belonging to the orders Bacillales and Micrococcales were isolated from the Spacecraft Assembly Facility at the Jet Propulsion Laboratory, and 63 draft genome sequences were assembled and identified. Further analyses of these genomes can provide insight into methods for preventing forward contamination.” This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “Part of the research described in this publication was carried out at the Jet Propulsion Laboratory (JPL), California Institute of Technology, under a contract with NASA. This research was funded by project M2020, administered at JPL in 2018. This project also funded a postdoctoral fellowship for J.M.W. and JPL student fellowships for J.B. and J.B.P.”

 

9

Cornforth MN, Bedford JS, Bailey SM.

Cytogenet Genome Res. 2021 Sep 6;1-24. Review. Online ahead of print.

PIs: M.N. Cornforth, S.M. Bailey

Note: This article may be obtained online without charge.

Journal Impact Factor: 1.636

Funding: “Studies were supported by the National Aeronautics and Space Administration (NASA): NNX15AG747G (M.N.C) and 80NSSC19K0434 (S.M.B.).”

 

10

Sides MB, Johnston SL 3^rd, Sirek A, Lee PH, Blue RS, Antonsen EL, Basner M, Douglas GL, Epstein A, Flynn-Evans EE, Gallagher MB, Hayes J, Lee SMC, Lockley SW, Monseur B, Nelson NG, Sargsyan A, Smith SM, Stenger MB, Stepanek J, Zwart SR.

Aerosp Med Hum Perform. 2021 Aug 1;92(8):650-69.

Note: From the abstract: “Teams identified published human spaceflight research and applied translational science models to define mature products for terrestrial clinical practice.”

Journal Impact Factor: 0.889

Funding: No funding cited. S.L. Johnston 3^rd, G.L. Douglas, S.M.C. Lee, A. Sargsyan, S.M. Smith, M.B. Stenger, and S.R. Zwart are affiliated with NASA Johnson Space Center; E.E. Flynn-Evans is affiliated with NASA Ames Research Center.

 

11

Baranwal G, Creed HA, Cromer WE, Wang W, Upchurch BD, Smithhart MC, Vadlamani SS, Clark MC, Busbuso NC, Blais SN, Reyna AJ, Dongaonkar RM, Zawieja DC, Rutkowski JM.

Acta Physiol (Oxf). 2021 Aug;232(4):e13656. Available online 1 April 2021.

PI: W.E. Cromer

Journal Impact Factor: 5.542

Funding: “The authors thank the Texas A&M University College of Medicine Departments of MCM and MPIM for use of their IVIS scanners. This work was funded in part by Texas A&M University College of Medicine and Department of Medical Physiology. JMR and WEC received support from the Lipedema Foundation. DZ and WW received support in part from the National Heart, Lung And Blood Institute of the National Institutes of Health (U01 HL123420). HAC, RMD, and/or JMR were supported in part by the National Institute Of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health (R01 DK119497; DK120493). JMR also received support from the American Heart Association (17GRNT33671220).” PI reports additional funding from NASA grant 80NSSC19K0438.

 

12

Casale CE, Yamazaki EM, Brieva TE, Antler CA, Goel N.

Sleep. 2021 Sep 9;zsab228. Online ahead of print.

PI: N. Goel

Journal Impact Factor: 5.849

Funding: “This work was primarily supported by the Department of the Navy, Office of Naval Research (Award No. N00014-11-1-0361) to N.G. Other support provided by National Aeronautics and Space Administration (NASA) grant NNX14AN49G and grant 80NSSC20K0243 (to N.G.), National Institutes of Health grant NIH R01DK117488 (to N.G.) and Clinical and Translational Research Center grant UL1TR000003.”

 

13

Polutchko SK, Glime GNE, Demmig-Adams B.

Molecules. 2021 Sep;26(17):5385. Review.

PI: B. Demmig-Adams

Note: This article belongs to the Special Issue “Neuroprotective Effect of Food and Natural Bioactive Compounds” (https://www.mdpi.com/journal/molecules/special_issues/natural_bioactives). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 4.411

Funding: “This work was funded by the University of Colorado and the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A.”

 

14

Vahlensieck C, Thiel CS, Zhang Y, Huge A, Ullrich O.

Int J Mol Sci. 2021 Sep;22(17):9426.

Note: Parabolic flight and suborbital ballistic rocket flight results. From the abstract: “To pinpoint potential underlying mechanisms, we compared gene expression and three-dimensional (3D) chromosomal conformational changes in human Jurkat T cells during the short-term gravitational changes in parabolic flight and suborbital ballistic rocket flight experiments.” This article belongs to the Collection “21st Anniversary of IJMS: Advances in Biochemistry” (https://www.mdpi.com/journal/ijms/special_issues/21st_Biochem). Additional articles will be forthcoming and may be found in the link to the Collection. This article may be obtained online without charge.

Journal Impact Factor: 5.923

Funding: “The 23rd DLR Parabolic Flight Campaign and the TEXUS-54 mission were funded by the DLR Space Administration on behalf of the Federal Ministry for Economic Affairs and Energy (BMWi; grant numbers: 50WB1219 and 50WB1519). The 4th Swiss Parabolic Flight Campaign was funded by the Swiss SkyLab Foundation and the Swiss Space Office (SSO) of the State Secretariat for Education, Research and Innovation (SBFI; grant number: REF-1131-61001).” Y. Zhang is affiliated with NASA Kennedy Space Center.

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Other papers of interest:

 

1

Johannes B, Bronnikov SV, Bubeev JA, Kotrovskaya TI, Shastlivtseva DV, Piechowski S, Hoermann HJ, Jordan J.

Aerosp Med Hum Perform. 2021 Jul;92(7):541-9.

Note: ISS and Mir results.

 

2

Lee I, Barh D, Podolich O, Brenig B, Tiwari S, Azevedo V, Góes-Neto A, Reva O, Kozyrovska N, de Vera JP, Kim BS.

Microbiol Resour Announc. 2021 Sep 9;10(36):e0054921.

Note: ISS results. This article may be obtained online without charge.

3

Javad Mortazavi SM, Mortazavi SA, Sihver L.

J Allergy Clin Immunol Pract. 2021 Sep;9(9):3527.

Note: This is a comment on an article that appeared in previous Current Awareness List #918 https://doi.org/10.1016/j.jaip.2020.08.064. This article may be obtained online without charge.

4

Pollock RD, Jolley CJ, Abid N, Couper JH, Estrada-Petrocelli L, Hodkinson PD, Leonhardt S, Magor-Elliott S, Menden T, Rafferty G, Richmond G, Robbins PA, Ritchie GAD, Segal MJ, Stevenson AT, Tank HD, Smith TG.

Aerosp Med Hum Perform. 2021 Aug ;92(8):633-41.

Note: A long-arm human centrifuge was used in this study.

 

5

Tang JW, Henriques A, Loh TP.

Future Microbiol. 2021 Sep 7;16:1023-8. Commentary.

6

Winnard A, Caplan N, Bruce-Martin C, Swain P, Velho R, Meroni R, Wotring V, Damann V, Weber T, Evetts S, Laws J.

Aerosp Med Hum Perform. 2021 Aug;92(8):681-8.

7

Li Y, Huang L, Iqbal J, Deng Y.

Space: Science & Technology. 2021 Jun 17;2021:9835728.

Note: Hindlimb unloading study. Press release for this article from the SpaceRef website: “It should come as no surprise that astronauts resort to various drugs to ameliorate the symptoms caused by microgravity. Unfortunately for them, microgravity has been noted to have a significant impact on the pharmacokinetics of certain drugs, which could lead to altered efficacy and unexpected outcomes. In particular, delivering an accurate amount of a drug to the brain has become a key problem in space health. In a recent effort to shed some light onto this issue, a team of scientists from Beijing Institute of Technology, China, studied the effects that microgravity has on P-glycoprotein (P-gp), an important efflux transporter. Their results are detailed in their paper published in Space: Science and Technology, on 17 Jun 2021.” For the full press release go to http://spaceref.com/space-medicine/cardiac-atrophy-findings-may-set-course-for-preventing-harm-from-long-space-flights.html. This article may be obtained online without charge.

 

8

Fukunaga H.

Radiat Res. 2021 Sep 8. Online ahead of print.

9

Wang Q, Lee Y, Pujol-Canadell M, Perrier JR, Smilenov L, Harken A, Garty G, Brenner DJ, Ponnaiya B, Turner HC.

Cytogenet Genome Res. 2021 Sep 6;1-10. Online ahead of print.

10

Coleman K, Phillips J, Sciarini M, Stubbs B, Jackson O, Kernagis D.

Aerosp Med Hum Perform. 2021 Jul;92(7):556-62.

11

J Physiol. 2021 Sep 10. Online ahead of print.

Note: Bed rest study.

 

12

Duffield GE, Robles-Murguia M, Hou TY, McDonald KA.

Int J Mol Sci. 2021 Sep;22(17):9632.

Note: This article and the article below (Öztürk et al.) belong to the Special Issue “Molecular and Cellular Mechanisms of Synchronization within the Mammalian Circadian System” (https://www.mdpi.com/journal/ijms/special_issues/Synchronization_Circadian). This article may be obtained online without charge.

 

13

Öztürk M, Ingenwerth M, Sager M, von Gall C, Ali AAH.

Int J Mol Sci. 2021 Feb 25;22(5):2288.

Note: This article and the article above (Duffield et al.) belong to the Special Issue “Molecular and Cellular Mechanisms of Synchronization within the Mammalian Circadian System” (https://www.mdpi.com/journal/ijms/special_issues/Synchronization_Circadian). This article may be obtained online without charge.