- Press Release
- Oct 2, 2022
NASA Spaceline Current Awareness List # 966 10 September 2021 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Papers deriving from NASA support:
Yang J, Barrila J, Ott CM, King O, Bruce R, McLean RJC, Nickerson CA.
Longitudinal characterization of multispecies microbial populations recovered from spaceflight potable water.
npj Biofilms and Microbiomes. 2021 Sep 6;7(1):70.
PI: C.A. Nickerson; additional funded collaborators: J. Yang, R.J.C. McLean
Note: ISS results. From the abstract: “Using NASA-archived microbial isolates collected from the ISS potable water system over several years, we profiled five phenotypes: antibiotic resistance, metabolism, hemolysis, and biofilm structure/composition of individual or multispecies communities, which represent characteristics that could negatively impact astronaut health and life-support systems.” This article may be obtained online without charge.
Journal Impact Factor: 7.29
Funding: “This study was funded by the Alfred P. Sloan Foundation, Postdoctoral Fellowship program in partnership with the National Aeronautics and Space Administration (NASA) G-2017-9852 (JY and CAN). This work was also supported by the NASA grant 80NSSC19K1597 (JY and RJCM) and NASA grant NNX17AC79G (JY, JB, CMO, RJCM, and CAN). All ISS strains were provided by Dr. C. Mark Ott at the NASA Johnson Space Center.”
Yamanouchi S, Adachi T, Yoshida Y, Rhone J, Mao J-H, Fujiwara K, Saganti PB, Takahashi A, Hada M.
The combined effect of simulated microgravity and radiation on chromosome aberrations in human peripheral blood lymphocytes.
Biological Sciences in Space. 2021;35:15-23.
PI: M. Hada
Note: A 3D clinostat was used in this study. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This work was supported by NASA Space Biology Program (grant no. 80NSSC19K0133) (M.H., K.F., and A.T.), JAXA Front Loading Study (A.T., Y.Y., and M.H.),
Gunma University for the Promotion of Scientific Research (A.T.), Gunma University Graduate School of Medicine for the Activation of Research Activity (S.Y.), and TAMU Chancellor’s Research Initiative, Texas A&M University (P.B.S.). This work was the result of using research equipment shared in MEXT Project for Promoting Public Utilization of Advanced Research Infrastructure (Program for supporting introduction of the new sharing system) (grant no. JPMXS0430300120) (S.Y. and A.T.) and Research Projects (20B-4) with Heavy Ions at the Gunma University Heavy Ion Medical Center (GHMC) (S.Y., Y.Y., and A.T.).”
John S, Abou-Issa F, Hasenstein KH.
Space flight cultivation for radish (Raphanus sativus) in the Advanced Plant Habitat.
Gravit Space Res. 2021 Aug 22;9(1):121-32.
PI: K.H. Hasenstein
Note: From the abstract: “In preparation of a flight experiment, ground-based studies for optimizing the growth of radishes (Raphanus sativus) were conducted at the ground-based Advanced Plant Habitat (APH) unit at the Kennedy Space Center (KSC), Florida. The APH provides a large, environmentally controlled chamber that has been used to grow various plants… We report our strategies to optimize the growth substrate, watering regimen, light settings, and planting design that produces good-sized radishes, minimizes competition, and allows for easy harvesting. This information will be applicable for growth optimization of other crop plants that will be grown in the APH or other future plant growth facilities.” This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “The reported work was in preparation for a flight experiment and was supported by NASA grant 80NSSC17K0344.”
Vunjak-Novakovic G, Ronaldson-Bouchard K, Radisic M.
Organs-on-a-chip models for biological research.
Cell. 2021 Sep 2;184(18):4597-611. Review.
PI: G. Vunjak-Novakovic
Note: This article may be obtained online without charge.
Journal Impact Factor: 1.983
Funding: “This work was funded by the National Institutes of Health (UH3 EB025765, P41 EB027062, 3R01 HL076485, and CA249799), the National Science Foundation (NSF16478), the Canadian Institutes of Health Research (CIHR) (FDN-167274), the Natural Sciences and Engineering Research Council of Canada (NSERC) (RGPIN 326982-10), NSERC-CIHR (CHRP 493737-16), and NASA (NNX16AO69A). M.R. was supported by a Killam Fellowship and Canada Research Chair.”
Holloway T, Miller D, Anenberg S, Diao M, Duncan B, Fiore AM, Henze DK, Hess J, Kinney PL, Liu Y, Neu JL, O’Neill SM, Odman MT, Pierce RB, Russell AG, Tong D, West JJ, Zondlo MA.
Satellite monitoring for air quality and health.
Annu Rev Biomed Data Sci. 2021 Jul 20;4:417-47.
Journal Impact Factor: Not available for this journal
Funding: “Funding for this study was provided by the NASA Applied Sciences Program, with all authors supported by grants for the NASA Health and Air Quality Applied Sciences Team. A portion of this research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract with NASA.”
Other papers of interest:
Bogomolov VV, Polyakov AV, Kovachevich IV, Repenkova LG, Bundina MV.
[Improvement of medical supplies to help with disorders of the digestive system function during space mission.]
Aviakosm Ekolog Med. 2021;55(4):16-22. Russian.
Note: ISS and Mir results. From the abstract: “Analysis of digestive function (DF) disorders in cosmonauts-participants in 83 main missions to the Mir station and ISS showed that episodic DF problems had been abated successfully with the help of onboard medicines.”
Higashitani A, Hashizume T, Takiura M, Higashitani N, Teranishi M, Oshima R, Yano S, Kuriyama K, Higashibata A.
Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans.
npj Microgravity. 2021 Sep 1;7(1):33.
Note: ISS results. From the introduction: “Here we conducted spaceflight experiments in the International Space Station (ISS): we grew and analyzed four consecutive generations of synchronous culture of wild-type and histone deacetylase (hda)-4 mutant C. elegans.” This article may be obtained online without charge.
Mitrikas VG, Khorosheva EG.
[Long-term operation of dosimetry facility Pille onboard the ISS.]
Aviakosm Ekolog Med. 2021;55(4):86-90. Russian.
Note: ISS results. From the abstract: “Malfunctioning of the reader is likely to be the reason for low radiation doses measured by the Pille dosimeters over the more than 20 years of ISS. Rectified measurements of the average daily absorbed dose rate agreed satisfactorily with readings of the other onboard tools of radiation monitoring.”
Orešković D, Radoš M, Klarica M.
A contribution to the understanding of ocular and cerebrospinal fluid dynamics in astronauts during long-lasting spaceflight.
Croat Med J. 2021 Aug 31;62(4):420-1. Essay.
Note: From the abstract: “…we believe that the presented hypothesis of VIIP [visual impairment intracranial pressure] syndrome could be partially elucidated by our new approach to CSF [cerebrospinal fluid] physiology. Based on our CSF physiology hypothesis, another hypothesis of ICP and IOP [intraocular pressure] regulation was derived…” This article may be obtained online without charge.
Effects of aerospace environments on the cardiovascular system.
Anatol J Cardiol. 2021 Aug;25(Suppl 1):3-6.
Note: From the abstract: “There is an increasing demand for high altitude and space travel nowadays. These trips cause several physical and physiological effects on both passenger and flight crew. Therefore, it is necessary to take precautionary measures to carry out these activities safely.” This article may be obtained online without charge.
Jiang A, Foing BH, Schlacht IL, Yao X, Cheung V, Rhodes PA.
Colour schemes to reduce stress response in the hygiene area of a space station: A Delphi study.
Appl Ergon. 2022 Jan 22;98:103573. Available online 1 September 2021.
Note: ISS and Tiangong space station results. From the abstract: “This paper aims to explore colour schemes to reduce stress response in the hygiene area of a space station. We conducted a two-stage exploratory Delphi-study with 30 international experts.”
Lysova NY, Fomina EV, Kireev KS, Grishin AP.
[Effect of long-term space missions on the biomechanical characteristics of locomotion with an additional motor task.]
Aviakosm Ekolog Med. 2021;55(4):45-50. Russian.
Note: ISS results. From the abstract: “The goal of the investigation is to expand our knowledge of the gravity-dependent changes in motor control due to a prolonged stay in spaceflight conditions using the stepping-over-obstacle test.”
Makarov IA, Bogomolov VV, Voronkov YI, Alferova IV, Krivolapov VV, Khorosheva EG, Anikeev DA.
[ОCT-diagnostics of the ocular nerve edema in space flight: Analysis of the peripapillary retinal thickness.]
Aviakosm Ekolog Med. 2021;55(4):36-44. Russian.
Note: ISS results. From the abstract: “In-flight analysis of twenty eyes, ten cosmonauts were provided with fundus photos, multicolor images, HRA- and ОCТ-images made on optical coherent tomographs Spectralis I and II onboard the International space station (ISS).”
Kudryavtseva NS, Sorokin АЕ.
[Preliminary estimation of combined expenses on research and development of high-reliability physico-chemical life support systems for remote space missions with regard to common cause failures.]
Aviakosm Ekolog Med. 2021;55(4):91-8. Russian.
[Recovery of rat’s heart and respiration functioning during emergence from deep hypothermia in the process of self-heating and with an external heater.]
Aviakosm Ekolog Med. 2021;55(4):78-85. Russian.
Note: From the abstract: “The article presents modeling of the organism emergence from hypothermia preceded by cardiac arrest.”
Bukhtiyarov IV, Zibarev EV, Fomina МЕ, Mikueva VS.
[Analysis of the long-term sickness rate among airline pilots.]
Aviakosm Ekolog Med. 2021;55(4):51-9. Russian.
Note: From the abstract: “Retrospective health analysis was performed using data from 211 airline pilots and 168 flight mechanics with symptoms of chronic sensorineural hearing loss gathered from 2015 to 2020.”
Golubkova МА, Ogneva IV.
[Some aspects of the role of phosphorylation in regulation of spermatozoa motility in microgravity.]
Aviakosm Ekolog Med. 2021;55(4):5-15. Review. Russian.
Note: The results from space flights are not specified in the available English abstract. From the abstract: “The review describes mechanisms of regulating the spermatozoa motor activity.”
Takahashi N, Takami M, Chatani M.
Investigation of osteogenesis changes in medaka larvae reared in normal gravity, simulated-microgravity and hypergravity environments.
Biological Sciences in Space. 2021;35:24-31.
Note: A clinostat was used in this study. This article may be obtained online without charge.
Tsakanova G, Arakelova E, Ayvazyan V, Karalyan Z, Matevosyan L, Arakelyan A, Amirkhanyan Z, Davtyan H, Khachatryan V, Grigoryan B.
The LD50 for low-energy ultrashort-pulsed laser driven electron beam whole-body irradiation of Wistar rats.
Radiat Res. 2021 Sep 3. Online ahead of print.
Vanhoutte D, Schips TG, Vo A, Grimes KM, Baldwin TA, Brody MJ, Accornero F, Sargent MA, Molkentin JD.
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy.
Nat Commun. 2021 Jun 24;12(1):3928.
Note: Press release for this article from the SpaceRef website: “The new findings, based on studies of mouse models, represent an important milestone in a long effort to prevent or even reverse cardiac atrophy, which can lead to fatal heart failure when the body loses large amounts of weight or experiences extended periods of weightlessness in space. Detailed findings were published online June 24, 2021, in Nature Communications.” For the full press release go to http://spaceref.com/space-
medicine/cardiac-atrophy-. This article may be obtained online without charge. findings-may-set-course-for- preventing-harm-from-long- space-flights.html