NASA Spaceline Current Awareness List # 965 3 September 2021 (Space Life Science Research Results)

Papers deriving from NASA support:

1

Krieger SS, Zwart SR, Mehta S, Wu H, Simpson RJ, Smith SM, Crucian B.

Front Immunol. 2021 Aug 24;12:725748.

PIs: S.M. Smith, B. Crucian

Note: ISS results. This article is part of Research Topic “Deciphering Immune and Neuroendocrine Crosstalk in Extreme Environments” (https://www.frontiersin.org/research-topics/22110/deciphering-immune-and-neuroendocrine-crosstalk-in-extreme-environments#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

Journal Impact Factor: 7.561

Funding: “This work was funded via awards to SS and BC by the NASA Human Research Program, Human Health and Countermeasures Element.”

2

Rettig TA, Tan JC, Nishiyama NC, Chapes SK, Pecaut MJ.

Immunohorizons. 2021 Aug 25;5(8):675-86.

PIs: S.K. Chapes, M.J. Pecaut

Note: ISS results and hindlimb unloading study. From the introduction: “Five different datasets from four experiments were used in the analyses presented in this article.” This article may be obtained online without charge.

Journal Impact Factor: 2.788

Funding: “This work was supported by NNX13AN34G and NNX15AB45G from the National Aeronautics and Space Administration, GM103418 from the National Institutes of Health, the College of Veterinary Medicine at Kansas State University, and the Kansas State University Johnson Cancer Center.”

3

Smith SM, Zwart SR.

Physiology (Bethesda). 2021 Sep 1;36(5):324-30. Review.

PIs: S.M. Smith, S.R. Zwart

Note: ISS results.

Journal Impact Factor: 7.212

Funding: “The authors acknowledge the astronauts for their time, effort, and participation in the research projects described here. We also thank Kerry George for editorial assistance and the Human Health Countermeasures Element of NASA‘s Human Research Program and the Nutritional Biochemistry Laboratory Team, who have supported this research. This work was supported by the Human Health Countermeasures Element of the Human Research Program at the NASA Johnson Space Center.”

4

Shaka S, Carpo N, Tran V, Ma Y-Y, Karouia F, Espinosa-Jeffrey A.

J Stem Cell Res Dev Ther. 2021 Apr 27;7:069.

PI: A. Espinosa-Jeffrey

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 2.28

Funding: “We thank NASA Space Biology for Grant: NNX15AB43G; The IDDRC Cell Culture Core is supported by NIH/ NICHD grant number U54HD087101-05; and the Cell, Circuits, and Systems Analysis Core (NIH U54HD087101).”

5

Montesinos CA, Khalid R, Cristea O, Greenberger JS, Epperly MW, Lemon JA, Boreham DR, Popov D, Gorthi G, Ramkumar N, Jones JA.

Life (Basel). 2021 Aug 14;11(8):829. Review.

Note: This article and two articles below in the “Other Papers of Interest” section (Ellery et al. and Kermorgant et al.) are part of Special Issue “Space Life Sciences” (https://www.mdpi.com/journal/life/special_issues/space_bio). The Special Issue also includes articles from previous Current Awareness Lists #917 https://doi.org/10.3390/life10090196, #920 https://doi.org/10.3390/life10100235, #933 https://doi.org/10.3390/life11010033 and https://doi.org/10.3390/life11010042, #936 https://doi.org/10.3390/life11020112, #944 https://doi.org/10.3390/life11040283, #945 https://doi.org/10.3390/life11020109, and #953 https://pubmed.ncbi.nlm.nih.gov/34072140 and https://pubmed.ncbi.nlm.nih.gov/34067876. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 2.991

Funding: “The authors would like to acknowledge Dr. Jeffrey Sutton and Dr. Dorit Donoviel for their leadership in the Center for Space Medicine; Dr. Richard Arnold and Dr. Karen Mumy at the Department of the Navy‘s-Naval Medical Research Unit-Dayton (NAMRU-D) for their sponsorship; and Carolynn Conley, James McLeroy and the entire staff at the DoD Space Test Program at NASA/JSC for their unwavering support of countermeasures research over the years.”

6

Klein PM, Alaghband Y, Doan NL, Ru N, Drayson OGG, Baulch JE, Kramár EA, Wood MA, Soltesz I, Limoli CL.

Int J Mol Sci. 2021 Aug 21;22(16):9020.

PI: C.L. Limoli

Note: This article belongs to the Special Issue “Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment” (https://www.mdpi.com/journal/ijms/special_issues/OSaD_space). The Special Issue also includes articles from Current Awareness Lists #944 https://doi.org/10.3390/ijms22063070 and #947 https://doi.org/10.3390/ijms22073668. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 4.556

Funding: “This work was supported by NASA Specialized Center of Research grant NNX15AI22G (I.S., C.L.L.), with an associated grant augmentation award (P.M.K.). The Columbia IND Neutron Facility is funded by NIAID grant U19-AIO67773.”

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Other papers of interest:

 

1

Melnik D, Krüger M, Schulz H, Kopp S, Wehland M, Bauer J, Baselet B, Vermeesen R, Baatout S, Corydon TJ, Infanger M, Grimm D.

Int J Mol Sci. 2021 Aug 16;22(16):8777.

Note: ISS results. This article belongs to the Special Issue “Recent Advances in Thyroid Cancer Research” (https://www.mdpi.com/journal/ijms/special_issues/Advances_Thyroid). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

2

Yamagishi A, Hashimoto H, Yano H, Imai E, Tabata M, Higashide M, Okudaira K.

Astrobiology. 2021 Aug 27. Online ahead of print.

Note: ISS results. From the abstract: “The Tanpopo experiment was the first Japanese astrobiology mission on board the International Space Station. It included exposure experiments of microbes and organic compounds as well as a capture experiment of hypervelocity impacting microparticles.” This article may be obtained online without charge.

 

3

Cucinotta FA, Schimmerling W, Blakely EA, Hei TK.

Life Sci Space Res. 2021 Nov;31:59-70. Available online 3 August 2021.

Note: From the abstract: “Addressing the uncertainties in assessing health risks from cosmic ray heavy ions is a major scientific challenge recognized by many previous reports by the National Academy of Sciences (NAS) and the National Council on Radiation Protection and Measurements (NCRP) advising the National Aeronautics and Space Administration (NASA). …We discuss issues with several of the NAS recommendations with the conclusion that the recommendations could have negative impacts on crew health and safety, and violate the three principles of radiation protection (to prevent clinically significant deterministic effects, limit stochastic effects, and practice ALARA [as low as reasonably achievable])…”

4

ElGindi M, Sapudom J, Ibrahim IH, Al-Sayegh M, Chen W, Garcia-Sabaté A, Teo JCM.

Cells. 2021 Aug;10(8):1941. Review.

Note: Existing microgravity platforms including real microgravity (ISS, satellites, and parabolic flights) and simulated microgravity (2D and 3D clinostats, the Rotating Wall Vessel, also known as the Rotary Cell Culture System, and the Random Positioning Machine) are discussed in this article. From the introduction: “This review will provide a brief overview of the existing microgravity platforms and then highlight the most prominent studies in the past decade to understand the effects of gravity on the immune system.” This article may be obtained online without charge.

5

Ellery A.

Supplementing closed ecological life support systems with in-situ resources on the Moon.

Life (Basel). 2021 Aug;11(8):770. Review.

Note: This article and an article in the “NASA” section above (Montesinos et al.) and an article below (Kermorgant et al.) are part of Special Issue “Space Life Sciences” (https://www.mdpi.com/journal/life/special_issues/space_bio). This article may be obtained online without charge.

 

6

Kermorgant M, Hammoud S, Mahieu L, Geeraerts T, Beck A, Bareille MP, Soler V, Pavy-Le Traon A, Quintyn JC.

Life (Basel). 2021 Aug;11(8):741.

Note: Head-down bed rest study. This article and two articles above (Montesinos et al. and Ellery et al.) are part of Special Issue “Space Life Sciences” (https://www.mdpi.com/journal/life/special_issues/space_bio). This article may be obtained online without charge.

7

Vignati C, Mapelli M, Nusca B, Bonomi A, Salvioni E, Mattavelli I, Sciomer S, Faini A, Parati G, Agostoni P.

High Alt Med Biol. 2021 Aug 23. Online ahead of print.

Note: This article may be obtained online without charge.

 

8

Larcher I, Scheiner S.

Comput Biol Med. 2021 Sep;136:104717.

Note: This article may be obtained online without charge.

 

9

Jun SR, Boerma M, Udaondo Z, Richardson S, Thrall KD, Miousse IR, Seng J, Pathak R, Hauer-Jensen M.

Metabolites. 2021 Aug 13;11(8):540.

Note: This article is part of a Special Issue “Metabolomic Analysis of Plasma” (https://www.mdpi.com/journal/metabolites/special_issues/Metabolomic_Plasma). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

10

Front Nutr. 2021 Aug 4;8:633987. Review.

Note: This article is part of Research Topic “Muscle and Resilience in Chronic Diseases” (https://www.frontiersin.org/research-topics/9546/muscle-and-resilience-in-chronic-diseases#articles). The Research Topic also includes an article from previous Current Awareness List #824 https://doi.org/10.3389/fnut.2019.00146. This article may be obtained online without charge.

 

11

Rao R, Somvanshi P, Klerman EB, Marmar C, Doyle FJ 3^rd.

Modeling the influence of chronic sleep restriction on cortisol circadian rhythms, with implications for metabolic disorders.

Metabolites. 2021 Aug;11(8):483.

Note: This article is part of Special Issue “Circadian Disruption and Metabolic Disorder” (https://www.mdpi.com/journal/metabolites/special_issues/Circadian_Disruption). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

12

JACC Cardiovasc Imaging. 2021 Aug 18;S1936-878X(21)00509-X. Online ahead of print.