Status Report

NASA Spaceline Current Awareness List # 963 20 August 2021 (Space Life Science Research Results)

By SpaceRef Editor
August 20, 2021
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Danko D, Malli Mohan GB, Sierra MA, Rucker M, Singh NK, Regberg AB, Bell MS, O’Hara NB, Ounit R, Mason CE, Venkateswaran K.
Characterization of spacesuit associated microbial communities and their implications for NASA missions.
Front Microbiol. 2021 Jul 29;12:608478.
PI: C.E. Mason
Note: This article is part of Research Topic “Microbiology of Extreme and Human-Made Confined Environments (Spacecraft, Space Stations, Cleanrooms, and Analogous Sites)” ( The Research Topic also includes articles from previous Current Awareness Lists #896; #897; #908; #914,, and; #916; #920; #927; #935 This article may be obtained online without charge.
Journal Impact Factor: 4.235
Funding: “This research was supported by the JPL Advanced Concept Development fund awarded to KV that funded a fellowship for GM. DD was supported by the Tri-Institutional Training Program in Computational Biology and Medicine (CBM) funded by the NIH grant 1T32GM083937. We thank XSEDE and Philip Blood for their support of this project. AR and MB were supported by the Astromaterials Acquisition and Curation Office at NASA’s Johnson Space Center. EVA Swab Kit development and spacesuit testing was funded via a Johnson Space Center Independent Research and Development award for MR.” PI reports funding from grant “An Integrated Framework for Characterization of the Noncoding Genome and Epigenome in Astronauts.”
Wostyn P, Gibson CR, Mader TH.
The odyssey of the ocular and cerebrospinal fluids during a mission to Mars: The “ocular glymphatic system” under pressure.
Eye (Lond). 2021 Aug 9. Review. Online ahead of print.
Note: From the abstract: “Observations pertaining to this ocular glymphatic pathway provide critical new insights into how intracranial pressure can alter basic fluid transport in the eye. …In the present review, we integrate these new insights with findings on the intracranial and neuro-ophthalmologic effects of microgravity in one coherent conceptual framework.”
Journal Impact Factor: 3.775
Funding: C.R. Gibson is affiliated with NASA Space Medicine Operations Division (Johnson Space Center).
Lesanpezeshki L, Qadota H, Darabad MN, Kashyap K, Lacerda CMR, Szewczyk NJ, Benian GM, Vanapalli SA.
Investigating the correlation of muscle function tests and sarcomere organization in C. elegans.
Skelet Muscle. 2021 Aug 13;11(1):20.
PI: S.A. Vanapalli
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.000
Funding: “Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). This work was partially supported by funding from the Cancer Prevention and Research Institute of Texas RP160806 (S.A.V), National Aeronautics and Space Administration NNX15AL16G (S.A.V), the Biotechnology and Biological Sciences Research Council (BB/N015894/1 to N.J.S), and National Institute of General Medical Sciences (R01 GM118534 to G.M.B.).”
Pramanik A, Gao Y, Patibandla S, Mitra D, McCandless MG, Fassero LA, Gates K, Tandon R, Chandra Ray P.
The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles.
Nanoscale Adv. 2021 Mar 21;3(6):1588-96.
PI: R. Tandon
Journal Impact Factor: 4.553
Funding: “Dr. Ray thanks the National Science Foundation for generous funding via NSF-RAPID grant # DMR-2030439 and NSF-PREM grant # DMR-1826886. The authors are grateful for NIH-NIMHD grant # 1U54MD015929-01 for use of a bioimaging core facility. Dr Tandon is supported by NASA award 80NSSC19K1603 and COVID-19 funds from the University of Mississippi Medical Center.”
Other papers of interest:
Shenkman BS, Tsaturyan AK, Vikhlyantsev IM, Kozlovskaya IB, Grigoriev AI.
Molecular mechanisms of muscle tone impairment under conditions of real and simulated space flight.
Acta Naturae. 2021 Apr-Jun;13(2):85-97. Review.
Note: Dry immersion and hindlimb unloading methods are analyzed and reviewed in this article. This article may be obtained online without charge.
Demir AE, Aydın E.
Vestibular illusions and alterations in aerospace environment.
Turk Arch Otorhinolaryngol. 2021 Jun;59(2):139-49. Review.
Note: From the abstract: “The aim of this paper was to present a review about how a healthy vestibular system is negatively affected within the aerospace environment and how some vestibular disorders become exaggerated or impaired during aviation and space activities.” This article may be obtained online without charge.
Menden T, Alcaín GB, Stevenson AT, Pollock RD, Tank H, Hodkinson P, Jolley C, Smith TG, Leonhardt S, Walter M.
Dynamic lung behavior under high G acceleration monitored with electrical impedance tomography.
Physiol Meas. 2021 Aug 10. Online ahead of print.
Note: A long-arm centrifuge was used in this study.
Nishimura Y, Wang PC.
Possibility of culturing the early developing kidney cells by utilizing simulated microgravity environment.
Biochem Biophys Res Commun. 2021 Oct 8;573:9-12. Available online 7 August 2021.
Note: The method of simulated microgravity is not evident in the available abstract. This article may be obtained online without charge.
Pozhvanov G, Sharova E, Medvedev S.
Microgravity modelling by two-axial clinorotation leads to scattered organisation of cytoskeleton in Arabidopsis seedlings.
Funct Plant Biol. 2021 Aug 10. Online ahead of print.
Note: A 3D clinostat was used in this study.
Liang Y, Wang M, Liu Y, Wang C, Takahashi K, Naruse K.
Meta-analysis-assisted detection of gravity-sensitive genes in human vascular endothelial cells.
Front Cell Dev Biol. 2021 Aug 04;9:689662.
Note: This article and the following two articles (Sahana et al. and Zhang et al.) are part of Research Topic “Space Mechanobiology and Medicine” ( Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Sahana J, Corydon TJ, Wehland M, Krüger M, Kopp S, Melnik D, Kahlert S, Relja B, Infanger M, Grimm D.
Alterations of growth and focal adhesion molecules in human breast cancer cells exposed to the random positioning machine.
Front Cell Dev Biol. 2021 Jun 30;9:672098.
Note: A random positioning machine was used in this study. This article may be obtained online without charge.
Zhang S, Ueno D, Ohira T, Kato H, Izawa T, Yamanouchi S, Yoshida Y, Takahashi A, Ohira Y.
Depression of bone density at the weight-bearing joints in Wistar Hannover rats by a simulated mechanical stress associated with partial gravity environment.
Front Cell Dev Biol. 2021 Jul 26;9:707470.
Note: Hindlimb unloading study with degrees of mechanical stress. From the abstract: “The degree of mechanical stress was modified, but the ankle joint was maintained at 30°, 120°, or 160° with or without plaster fixation during 10-day hindlimb suspension.” This article may be obtained online without charge.
An FY, Yan CL, Liu YQ, Wang CX, Su Y, Shi B, Yang SH, Guo D, Jiang GF.
[Effect of Huangqi decoction on delaying renal cell apoptosis induced by 12C6+ ion irradiation in rats and its mechanism.]
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2021 May;37(3):318-23. Chinese.
Ide Y, Nakahara T, Fukada T, Nasu M.
Local irradiation of mouse tooth germ gives insight into the direct effects of irradiation on root development.
Radiat Res. 2021 Aug 13. Online ahead of print.
Hritzo B, Legesse B, Ward JM, Kaur A, Holmes-Hampton GP, Moroni M.
Investigating the multi-faceted nature of radiation-induced coagulopathies in a Göttingen minipig model of hematopoietic acute radiation syndrome.
Radiat Res. 2021 Aug;196(2):156-174. Available online 21 May 2021.
Note: This article, as well as the following articles (Guo et al. and Tsuruoka et al.) and an article from previous Current Awareness List #952, are part of the August issue.
Guo H, Zhao X, Li H, Liu K, Jiang H, Zeng X, Chang J, Ma C, Fu Z, Lv X, Wang T, Guo H, Liu K, Su H, Li Y.
GDF15 promotes cardiac fibrosis and proliferation of cardiac fibroblasts via the MAPK/ERK1/2 pathway after irradiation in rats.
Radiat Res. 2021 Aug;196(2):183-191. Available online 21 May 2021.
Tsuruoka C, Kaminishi M, Shinagawa M, Shang Y, Amasaki Y, Shimada Y, Kakinuma S.
High relative biological effectiveness of 2 MeV fast neutrons for induction of medulloblastoma in Ptch1+/- mice with radiation-specific deletion on chromosome 13.
Radiat Res. 2021 Aug;196(2):225-234. Available online 27 May 2021.
Yuan T, Han X, Liu H, Zhang J, Fan S.
Mouse parabiosis model promotes recovery of lymphocytes in irradiated mice.
Int J Radiat Biol. 2021 Aug 17:1-28. Online ahead of print.
Li Y, Xu X, Bao J, Wang W.
Effects of hyperbaric oxygen pretreatment on brain antioxidant capacity in rats with decompression sickness.
Undersea Hyperb Med. 2021 Third-Quarter;48(3):287-95.
Sohutskay DO, Buganza Tepole A, Voytik-Harbin SL.
Mechanobiological wound model for improved design and evaluation of collagen dermal replacement scaffolds.
Acta Biomater. 2021 Aug 12. Online ahead of print.

SpaceRef staff editor.