Status Report

NASA Spaceline Current Awareness List # 962 13 August 2021 (Space Life Science Research Results)

By SpaceRef Editor
August 6, 2021
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Roberts DR, Inglesby DC, Brown TR, Collins HR, Eckert MA, Asemani D.
Longitudinal change in ventricular volume is accelerated in astronauts undergoing long-duration spaceflight.
Aging Brain. 2021;1:100017.
PI: D.R. Roberts
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 4.673
Funding: “This work was supported by National Aeronautics and Space Administration (NASA), grant number NNX13AJ92G. Dr. Inglesby received support through the South Carolina NASA Established Program to Stimulate Competitive Research (EPSCoR) and the South Carolina Space Grant Consortium.”
Laurie SS, Greenwald SH, Marshall-Goebel K, Pardon LP, Gupta A, Lee SMC, Stern C, Sangi-Haghpeykar H, Macias BR, Bershad EM.
Optic disc edema and chorioretinal folds develop during strict 6° head-down tilt bed rest with or without artificial gravity.
Physiol Rep. 2021 Aug 6;9(15):e14977.
PI: E.M. Bershad
Note: Head-down tilt bed rest study. This article may be obtained online without charge.
Journal Impact Factor: 1.535
Funding: “National Aeronautics and Space Administration Human Research Program Grant #NNJ15ZSA001N-AGBR: Studying the Physiological and Anatomical Cerebral Effects of Centrifugation and Head-Down Tilt Bed Rest (SPACE-CENT) (EMB).”
Qin L, Liu L, Tu J, Yang G, Wang S, Quilichini TD, Gao P, Wang H, Peng G, Blancaflor EB, Datla R, Xiang D, Wilson KE, Wei Y.
The ARP2/3 complex, acting cooperatively with Class I formins, modulates penetration resistance in Arabidopsis against powdery mildew invasion.
Plant Cell. 2021 Jun 28;koab170. Online ahead of print.
PI: E.B. Blancaflor
Journal Impact Factor: 9.618
Funding: “This work was supported by grants from the Natural Sciences and Engineering Research Council of Canada (Discovery Grant), the Canadian Foundation for Innovation to Y.W., and the National Aeronautics and Space Administration (NASA grant number 80NSSC18K1462) to E.B.B.”
Alfano CA, Bower JL, Connaboy C, Agha NH, Baker FL, Smith KA, So CJ, Simpson RJ.
Mental health, physical symptoms and biomarkers of stress during prolonged exposure to Antarctica’s extreme environment.
Acta Astronaut. 2021 Apr;181:405-13.
PI: C.A. Alfano
Journal Impact Factor: 2.830
Funding: “This work was supported by a grant from the U.S. National Aeronautics and Space Administration (#NNX15AC13G) awarded to the first and last authors.”
Grigorev K, Foox J, Bezdan D, Butler D, Luxton JJ, Reed J, McKenna MJ, Taylor L, George KA, Meydan C, Bailey SM, Mason CE.
Haplotype diversity and sequence heterogeneity of human telomeres.
Genome Res. 2021 Jun 23;31(7):1269-79. Online ahead of print.
PIs: S.M. Bailey, C.E. Mason
Journal Impact Factor: 11.093
Funding: “We thank the Epigenomics Core Facility at Weill Cornell Medicine, the Scientific Computing Unit (SCU), Extreme Science and Engineering Discovery Environment (XSEDE) Supercomputing Resources, as well as the STARR grants I9-A9-071, I13-0052, The Vallee Foundation, The WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH51G, NNX14AB02G, NNX17AB26G), The National Institutes of Health (R01MH117406, R01NS076465, R01CA249054, R01AI151059, P01HD067244, P01CA214274), Translational Research Institute for Space Health (TRISH) (NNX16AO69A:0107, NNX16AO69A: 0061), the Leukemia and Lymphoma Society (LLS) (9238-16, Mak, MCL-982, Chen-Kiang), and the National Science Foundation (1840275).”
Somaraju AV, Griffin DJ, Olenick J, Chang C-HD, Kozlowski SWJ.
The dynamic nature of interpersonal conflict and psychological strain in extreme work settings.
J Occup Health Psychol. 2021 Aug 5. Online ahead of print.
PI: S.W.J. Kozlowski
Journal Impact Factor: 7.365
Funding: “We gratefully acknowledge the National Aeronautics and Space Administration (NASA; NNX13AM77G and NNX16AR52G, S.W.J. Kozlowski, Principal Investigator; S. Biswas & C.-H. Chang, Co-Investigators) for support of this research and to the National Defense Science and Engineering Graduate Fellowship program (NDSEG; Ajay V. Somaraju, Daniel J. Griffin) for support that in part contributed to the composition of this article.”
Other papers of interest:
Kodaira S, Naito M, Uchihori Y, Hashimoto H, Yano H, Yamagishi A.
Space radiation dosimetry at the exposure facility of the International Space Station for the Tanpopo mission.
Astrobiology. 2021 Aug 4. Online ahead of print.
Note: ISS results. From the abstract: “Three exposure panels and three references including biological and organic samples and luminescence dosimeters were launched to obtain data for different exposure durations during 3 years from May 2015 to July 2018.” This article may be obtained online without charge.
Monti E, Waldvogel J, Ritzmann R, Freyler K, Albracht K, Helm M, De Cesare N, Pavan P, Reggiani C, Gollhofer A, Narici MV.
Muscle in variable gravity: I do not know where I am, but I know what to do.”
Front Physiol. 2021 Aug 4;12:714655.
Note: Parabolic flight results. This article may be obtained online without charge.
Kermorgant M, Sadegh A, Geeraerts T, Varenne F, Liberto J, Roubelat FP, Bataille N, Bareille MP, Beck A, Godard B, Golemis A, Nasr N, Arvanitis DN, Hélissen O, Senard JM, Pavy-Le Traon A, Soler V.
Effects of venoconstrictive thigh cuffs on dry immersion-induced ophthalmological changes.
Front Physiol. 2021 Jul 14;12:692361.
Note: Dry immersion study. This article may be obtained online without charge.
Richter C, Braunstein B, Staeudle B, Attias J, Suess A, Weber T, Mileva KN, Rittweger J, Green DA, Albracht K.
Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity.
npj Microgravity. 2021 Aug 9;7(1):32.
Note: The vertical treadmill facility, a ground-based analog, was used in this study. This article may be obtained online without charge.
Möller F, Hoffmann U, Vogt T, Steinberg F.
Exercise-related effects on executive functions during a simulated underwater extravehicular activity.
Hum Factors. 2021 Aug 2;187208211032868. Online ahead of print.
Note: From the abstract: “Investigation of cognitive performance during extravehicular activities (EVAs) in a space-analog setting.”
Thorne S.
Modeling the role of gravitation in metabolic processes.
Commun Integr Biol. 2021 Jul 20;14(1):115-35.
Note: From the abstract: “…this paper is written with two goals in mind. The first goal is to summarize the extensive experimental record produced by biologists, botanists, and zoologists, identifying the strong correlation between metabolic processes and orbital periodicities. The second goal is to suggest experiments that might provide insight into how metabolic processes and gravitation might be so coupled.” This article may be obtained online without charge.
Cassatt DR, Gorovets A, Karimi-Shah B, Roberts R, Price PW, Satyamitra MM, Todd N, Wang SJ, Marzella L.
A trans-agency workshop on the pathophysiology of radiation-induced lung injury.
Radiat Res. 2021 Aug 3. Online ahead of print.
Ryšavá A, Vostálová J, Rajnochová Svobodová A.
Effect of ultraviolet radiation on the Nrf2 signalling pathway in skin cells.
Int J Radiat Biol. 2021 Jul 31;171:1-48. Review. Online ahead of print.
Mantuano P, Boccanegra B, Bianchini G, Conte E, De Bellis M, Sanarica F, Camerino GM, Pierno S, Cappellari O, Allegretti M, Aramini A, De Luca A.
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading.
Pharmacol Res. 2021 Sep;171:105798.
Note: Hind-limb unloading study.
Popov A, Lyakhovetskii V, Bazhenova E, Gorskii O, Kalinina D, Merkulyeva N, Musienko P.
The role of load-dependent sensory input in the control of balance during gait in rats.
J Exp Biol. 2021 Aug 5;224(15):jeb242138.
Note: Hind-limb unloading study. This article is part of Subject Collection “Comparative Biomechanics of Movement” ( Additional articles may be found in the link to the Subject Collection.
Tanaka S, Madokoro S, Inaoka PT, Yamazaki T.
Blood lipid profile changes in type 2 diabetic rats after tail suspension and reloading.
Lipids Health Dis. 2021 Aug 1;20(1):84.
Note: Hind-limb unloading study. This article may be obtained online without charge.
Sachdeva N, Poughon L, Gerbi O, Dussap C-G, Lasseur C, Leroy B, Wattiez R.
Ground demonstration of the use of Limnospira indica for air revitalization in a bioregenerative life-support system setup: Effect of non-nitrified urine–derived nitrogen sources.
Front Astron Space Sci. 2021 Aug 9;8:700270.
Note: This article is part of Research Topic “Bioregenerative Life-Support Systems for Crewed Missions to the Moon and Mars” ( The Research Topic also includes articles from previous Current Awareness Lists #960,,,,,,, and #961 Additional articles may be found in the link to the Research Topic. This article may be obtained online without charge.
Lewis KJ.
Osteocyte calcium signaling – A potential translator of mechanical load to mechanobiology.
Bone. 2021 Dec;153:116136. Review.
Note: This article is part of Special Issue “Bone Mechanobiology” ( The Special Issue also includes articles from previous Current Awareness Lists #952, #954, and #960 Additional articles may be found in the link to the Special Issue and others may be forthcoming.

SpaceRef staff editor.