Status Report

NASA Spaceline Current Awareness List # 958 16 July 2021 (Space Life Science Research Results)

By SpaceRef Editor
July 16, 2021
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Ponomarev S, Kalinin S, Sadova A, Rykova M, Orlova K, Crucian B.
Immunological aspects of isolation and confinement.
Front Immunol. 2021 Jun 24;12:697435. Review.
Note: Some of the experiments and research missions discussed in this article were performed at NASA Extreme Environment Mission Operations (NEEMO), NASA Human Exploration Research Analog (HERA), the Russian facility Nezemnyy Eksperimental’nyy Kompleks (NEK), the European Astronaut Centre (EAC) facility, and Concordia Research Station in Antarctica—to mention a few. From the abstract: “In this review we attempted to collect information describing changes in human immunity during isolation experiments with different conditions including short- and long-term experiments in hermetically closed chambers with artificial environment and during Antarctic winter-over.” This article may be obtained online without charge.
Journal Impact Factor: 7.561
Funding: B. Crucian is affiliated with NASA Johnson Space Center.
Ding LH, Yu Y, Edmondson EF, Weil MM, Pop LM, McCarthy M, Ullrich RL, Story MD.
Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes.
Sci Rep. 2021 Jul 7;11(1):14052.
PI: M.M. Weil/R.L. Ullrich/M.D. Story/NSCOR
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.998
Funding: “This study was funded by the NASA Specialized Center of Research on Radiation Carcinogenesis (NSCOR) programs (NNJ08ZSA003N and NNX15AK13G).”
Gibbs NM, Su SH, Lopez-Nieves S, Mann S, Alban C, Maeda HA, Masson PH.
Cadaverine regulates biotin synthesis to modulate primary root growth in Arabidopsis.
Plant J. 2021 Jul 12. Online ahead of print.
PI: P.H. Masson
Journal Impact Factor: 6.141
Funding: “This work was funded by HATCH award #WIS10338 from the College of Agriculture and Life Sciences, Fall Competition Award #MSN226688 from Office of the Vice Chancellor for Research and Graduate Education, University of Wisconsin-Madison, and grant #80NSSC19K1483 from the National Aeronautics and Space Administration. …Tecan Infinite M1000 Pro data were obtained at the University of Wisconsin-Madison Biophysics Instrumentation Facility, which was established with support from the University of Wisconsin-Madison and grants BIR-9512577 (NSF) and S10RR13790 (NIH). …Instrument acquisition and lipidomics method development was supported by National Science Foundation (EPS 0236913, MCB 1413036, DBI 0521587, DBI1228622), Kansas Technology Enterprise Corporation, K-IDeA Networks of Biomedical Research Excellence (INBRE) of National Institute of Health (P20GM103418), and Kansas State University.”
Silverman JD, Bloom RJ, Jiang S, Durand HK, Dallow E, Mukherjee S, David LA.
Measuring and mitigating PCR bias in microbiota datasets.
PLoS Comput Biol. 2021 Jul 6;17(7):e1009113. Online ahead of print.
PI: L.A. David
Note: From the abstract: “Here we present a paired modeling and experimental approach to characterize and mitigate PCR NPM-bias (PCR bias from non-primer-mismatch sources) in microbiota surveys.” This article may be obtained online without charge.
Journal Impact Factor: 4.700
Funding: “JDS was supported in part by the Duke University Medical Scientist Training Program (GM007171). JDS and LAD were supported in part by the Global Probiotics Council, a Searle Scholars Award, the Hartwell Foundation, an Alfred P. Sloan Research Fellowship, the Translational Research Institute through Cooperative Agreement NNX16AO69A, the Damon Runyon Cancer Research Foundation, the Hartwell Foundation, and NIH 1R01DK116187-01. SM would like to acknowledge the support of grants NSF IIS-1546331, NSF DMS-1418261, NSF IIS-1320357, NSF DMS-1045153, and NSF DMS1613261.”
Zhen S, van Iersel M, Bugbee B.
Why far-red photons should be included in the definition of photosynthetic photons and the measurement of horticultural fixture efficacy.
Front Plant Sci. 2021 Jun 22;12:693445.
Note: This article may be obtained online without charge.
Journal Impact Factor: 5.753
Funding: “This work was supported by the NASA-CUBES project award number NNX17AJ31G and by the USDA-NIFA-SCRI award number 2018-51181-28365 (LAMP Project).”
Other papers of interest:
de Vries H.
Editorial: Creative performance in extreme human environments: Astronauts and space.
Front Psychol. 2021 June 23;12:709676.
Note: This article is an introductory article to the Research Topic “Creative Performance in Extreme Human Environments: Astronauts and Space” ( The Research Topic also includes articles from previous Current Awareness Lists #924, #944, #950 From the abstract: “Exploration of the universe increases the need to gain insight on creative performance in extreme environments, as astronaut’s and cosmonaut’s survival may even depend on it.” This article may be obtained online without charge.
Satoh K, Alshahni MM, Umeda Y, Komori A, Tamura T, Nishiyama Y, Yamazaki T, Makimura K.
Seven years of progress in determining fungal diversity and characterization of fungi isolated from the Japanese Experiment Module KIBO, International Space Station.
Microbiol Immunol. 2021 Jul 12. Online ahead of print.
Note: ISS results. 
Zhang Z, Xue Y, Yang J, Shang P, Yuan X.
Biological effects of hypomagnetic field: Ground-based data for space exploration.
Bioelectromagnetics. 2021 Jul 10. Review. Online ahead of print.
Note: From the abstract: “The future of mankind is tied to the exploration and eventual colonization of space. Currently, people have resided in orbit at a space station. In the future, we will have opportunities to stay on the moon, Mars, or in deeper space, where astronauts are exposed to the hypomagnetic field (HMF), which refers to an extremely weak magnetic field environment compared with the geomagnetic field. However, the potential risks of HMF exposure to human health are often overlooked. Here, we summarize the literature related to the biological effects of HMF and calculate the magnitude of the effect.”
Riwaldt S, Corydon TJ, Pantalone D, Sahana J, Wise P, Wehland M, Krüger M, Melnik D, Kopp S, Infanger M, Grimm D.
Role of apoptosis in wound healing and apoptosis alterations in microgravity.
Front Bioeng Biotechnol. 2021 June 17;9:679650. Review.
Note: This article is part of the Research Topic “Wound Management and Healing in Space.” See this link for other articles in this issue: Additional articles will be forthcoming and may be found in the link to the Research Topic. From the abstract: “In this review, we provide an overview of alterations in the behavior of cutaneous cell lineages under microgravity in regard to the impact of apoptosis in wound healing. We discuss the current knowledge about wound healing in space and simulated microgravity with respect to apoptosis and available therapeutic strategies.” This article may be obtained online without charge.
Swaminathan V, Bechtel G, Tchantchaleishvili V.
Artificial tissue creation under microgravity conditions: Considerations and future applications.
Artif Organs. 2021 Jul 5. Review. Online ahead of print.
Note: A rotating wall vessel bioreactor was used in this study.
Chapleau RR, Regn DD.
Integrating the precision, sleep, and aerospace medicine fields: A systematic review of the genetic predisposition for obstructive sleep apnea in military aviation.
Sleep Breath. 2021 Jul 7. Review. Online ahead of print.
Deshetty UM, Tamatam A, Patil MM.
Menthol, a bioactive constituent of Mentha, attenuates motion sickness in mice model: Involvement of dopaminergic system.
J Food Biochem. 2021 Jul 9;e13863. Online ahead of print.
Alexander P, Vsevolod L, Natalia M, Pavel M.
Effect of hindlimb unloading on recruitment of gastrocnemius medialis muscle during treadmill locomotion in rats.
Exp Brain Res. 2021 Jul 11. Online ahead of print.
Note: Hindlimb unloading study.
Nishimura N, Iwase S, Takumi H, Yamamoto K.
Gravity-induced lower-leg swelling can be ameliorated by ingestion of α-Glucosyl Hesperidin beverage.
Front Physiol. 2021 Jun 23;12:670640.
Note: This article may be obtained online without charge.
Rabinstein AA, Braksick SA, Wijdicks EF.
Subarachnoid hemorrhage from sudden gravitational changes.
Neuroradiol J. 2021 Jul 8;19714009211030540. Online ahead of print.
Note: From the abstract: “We report the case of a diffuse non-aneurysmal subarachnoid hemorrhage due to sudden gravitational changes encountered during complex airflight maneuvers, complicated by hydrocephalus and cerebral vasospasm. This case illustrates a rare phenomenon that may again be encountered in the future with the advent and advancement of civilian spaceflight.”
Obata Y, Nakaue H, Hirasaki K, Akimitsu N, Yokoya A.
Expression of an x-ray irradiated EGFP-expressing plasmid transfected into nonirradiated human cells.
Radiat Res. 2021 Jul 8. Online ahead of print.
Taliaferro LP, Cassatt DR, Horta ZP, Satyamitra MM.
A poly-pharmacy approach to mitigate acute radiation syndrome.
Radiat Res. 2021 Jul 8. Online ahead of print.
Yang L, Friedemann T, Pan J.
Ecdysterone attenuates the development of radiation-induced oral mucositis in rats at early stage.
Radiat Res. 2021 Jul 8. Online ahead of print.

SpaceRef staff editor.