NASA Spaceline Current Awareness List # 957 9 July 2021 (Space Life Science Research Results)

Papers deriving from NASA support:

 

1

Chen Z, Stanbouly S, Nishiyama NC, Chen X, Delp MD, Qiu H, Mao XW, Wang C.

Precis Clin Med. 2021 Jun;4(2):93-108.

PI: M.D. Delp

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “The genomic work carried out at the Loma Linda University Center for Genomics was funded in part by the National Institutes of Health (NIH) (Grant No. S10OD019960) (CW), the Ardmore Institute of Health (Grant No. 2150141) (CW) and Dr. Charles A. Sims’ gift to LLU Center for Genomics. This project was partially supported by NASA Space Biology (Grant No. NNX15AE86G) (MDD and XWM), and American Heart Association (AHA) (Grant No. 18IPA34170301) (CW); and also partially supported by NIH grants HL115195- 06 (HQ)/subcontract (GSU) # SP00013920-02 (CW), and HL137962 (HQ)/subcontract (GSU) # SP00013696-01 (CW).”

2

Manian V, Orozco-Sandoval J, Diaz-Martinez V.

Genes (Basel). 2021 Jun 19;12(6):938.

Note: ISS results. This article is part of Special Section “Molecular Genetics and Genomics” (https://www.mdpi.com/journal/genes/sections/molecular_genetics). GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.

Journal Impact Factor: 4.096

Funding: “This research was funded by NASA EPSCoR, grant number 80NSSC19M0167. The APC is funded by 80NSSC19M0167.”

3

Rubinstein L, Schreurs A-S, Torres SM, Steczina S, Lowe MG, Kiffer F, Allen AR, Ronca AE, Sowa MB, Globus RK, Tahimic CGT.

npj Microgravity. 2021 Jul 6;7(1):24.

PIs: C.G.T. Tahimic, R. Globus

Note: Hindlimb unloading study. This article may be obtained online without charge.

Journal Impact Factor: 4.415

Funding: “This work was funded by a grant from the NASA Space Biology Program (R.K.G., C.G.T.T.). L.R. was supported by a fellowship from the NASA Postdoctoral Program (NPP).”

4

Pesacreta TC, Acharya A, Hasenstein KH.

Protoplasma. 2021 Jul;258(4):863-78.

PI: K.H. Hasenstein

Journal Impact Factor: 2.751

Funding: “The research was partially supported by NASA grant 80NSSC17K0344 to KHH.” (From Correction https://pubmed.ncbi.nlm.nih.gov/33651220: “The acknowledgment text was omitted from the original version in error.”)

5

Stewart JJ, Adams WW 3^rd, López-Pozo M, Doherty Garcia N, McNamara M, Escobar CM, Demmig-Adams B.

Cells. 2021 Jun 12;10(6):1481.

PI: B. Demmig-Adams

Note: This article is part of Special Issue “Photosynthesis under Biotic and Abiotic Environmental Stress.” See this link for other articles in this issue: https://www.mdpi.com/journal/cells/special_issues/Photosynthesis_Biotic_Abiotic_Environmental_Stress. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 1.983

Funding: “This work was funded by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A, the National Science Foundation award number IOS-1907338, and the University of Colorado.”

6

Zimmerman B, Kundu P, Rooney WD, Raber J.

Molecules. 2021 Jun 4;26(11):3406. Review.

PIs: J. Raber; M. Weil/J. Raber NSCOR; J. Baker

Note: This article is part of Special Issue “Nutrition and the Ageing Brain.” See this link for other articles in this issue: https://www.mdpi.com/journal/molecules/special_issues/nutrition_ageing_brain. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 3.267

Funding: “Support for B.Z. was provided by a Beckman Postdoctoral Fellowship with funding provided by the Arnold and Mabel Beckman Foundation and a Burroughs Wellcome Fund Collaborative Research Travel Grant (1018797). Support for PK was provided by NIA T32 AG055378. Support for WDR was provided by Conrad N Hilton Foundation, NIH/NINDS [R01-NS40801, R01-EB007258]. Support for WDR and BZ was provided by NIH/NIA R56AG066634. Support for JR was provided by NIH/NIA RF1 AG059088, R21 AG065914, R21AG065681, RF1AG058273, NIH/NCI R21 CA223461, NASA 80NSSC19K0498–P00001, and a grant from the Brightfocus Foundation.” J. Raber reports funding under NASA grant NNX13AD60G and M. Weil NSCOR project, grant NNX15AK13G.

 

7

Zamuruyev K, Ferreira Santos MS, Mora MF, Kurfman EA, Noell AC, Willis PA.

Anal Chem. 2021 Jun 29. Online ahead of print.

Note: From the abstract: “For detection of any ionizable species, including organic compounds that do not participate in terrestrial biology (i.e., ‘unknown unknowns’), mass spectrometry (MS) is essential. Inorganic ions, or any dissolved charged species present, can be analyzed using capacitively coupled contactless conductivity detection (C4D). Additionally, for the trace analysis of compounds of key interest to astrobiology (particularly, amino acids), laser-induced fluorescence (LIF) detection holds unique promise, due to the fact that it has the highest demonstrated sensitivity of any form of detection. Here, we demonstrate a fully automated, portable capillary electrophoresis analyzer that is capable of all these modes of detection. The prototype system developed here addresses the three most significant challenges for doing electrophoretic separations: precise sample injection, HV isolation, and automation of all operational steps. These key challenges were successfully addressed with the use of custom-designed rotor-stator valves with optimized operational sequences incorporating gas purging steps, rinses, and HV application.”

Journal Impact Factor: 6.785

Funding: “The research described in this paper was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. Financial support for this project was provided by JPL internal research programs. Emily Kurfman was funded by the NIH Graduate Training Program in Dynamic Aspects of Chemical Biology Grant T32GM008545 from the National Institutes of General Medical Sciences. The authors are grateful to Jed Harrison from University of Alberta and Anthony Ricco from NASA Ames Research Center for hardware design discussions.”

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Other papers of interest:

 

1

Chakraborty N, Zamarioli A, Gautam A, Campbell R, Mendenhall SK, Childress PJ, Dimitrov G, Sowe B, Tucker A, Zhao L, Hammamieh R, Kacena MA.

Comput Struct Biotechnol J. 2021 Jun 8;19:3507-20.

Note: ISS results. This article may be obtained online without charge.

 

2

Xu P, Chen H, Hu J, Cai W.

Commun Biol. 2021 Jul 2;4(1):835.

Note: Chinese satellite SJ-10 results. From the abstract: “Here, using the offspring of the seedlings grown in microgravity environment in the SJ-10 [Shijian 10] satellite for 11 days and returned to Earth, we systematically studied the potential effects of spaceflight on DNA methylation, transcriptome, and phenotype in the offspring.” This article may be obtained online without charge.

3

Yarmanova EN.

Hum Physiol. 2021 May;47:328-34.

Note: ISS results.

 

4

Degan P, Cortese K, Pulliero A, Bruno S, Gagliani MC, Congiu M, Izzotti A.

Int J Mol Sci. 2021 Jul;22(13):6951.

Note: A random positioning machine was used in this study. This article is part of Special Issue “Recent Advances in Microgravity and Cell Adherence” (https://www.mdpi.com/journal/ijms/special_issues/Microgravity_Cell). The Special Issue also includes an article from previous Current Awareness List #948 https://doi.org/10.3390/ijms22094550. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

5

Gao Y, Han H, Du J, He Q, Jia Y, Yan J, Dai H, Cui B, Yang J, Wei X, Yang L, Wang R, Long R, Ren Q, Yang X, Lu J.

Sci China Life Sci. 2021 Jun 24. Online ahead of print.

Note: Hindlimb unloading study.

 

6

ElGindi M, Ibrahim IH, Sapudom J, Garcia-Sabate A, Teo JCM.

Int J Mol Sci. 2021 Jun;22(12):6331.

Note: A random positioning machine was used in this study. From the abstract: “In this work, a microvessel for commercial cell culture plates was designed. Four 3D printable (polycarbonate (PC), polylactic acid (PLA) and resin) and castable (polydimethylsiloxane (PDMS)) materials were assessed for biocompatibility with adherent and suspension cell types.” This article is part of Special Issue “Molecular Mechanobiology in Space and on Earth” (https://www.mdpi.com/journal/ijms/special_issues/Molecular_Mechanobiology). The Special Issue also includes an article from previous Current Awareness List #928 https://doi.org/10.3390/ijms21238908 and Thiel et al. listed below. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

 

7

Thiel CS, Vahlensieck C, Bradley T, Tauber S, Lehmann M, Ullrich O.

Int J Mol Sci. 2021 Jul;22(13):6752.

Note: ISS and sounding rocket results. From the introduction: “To gain insights into the underlying gravity-dependent mechanisms, we applied metabolomics analyses to two experiments performed on different platforms: a suborbital ballistic rocket flight and an ISS microgravity experiment.” This article is part of Special Issue “Molecular Mechanobiology in Space and on Earth” (https://www.mdpi.com/journal/ijms/special_issues/Molecular_Mechanobiology). The Special Issue also includes an article from previous Current Awareness List #928 https://doi.org/10.3390/ijms21238908 and ElGindi et al. listed above. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

8

Grimm D.

Int J Mol Sci. 2021 Jul;22(13):6697.

Note: This article is an introductory article to Special Issue “Microgravity and Space Medicine” (https://www.mdpi.com/journal/ijms/special_issues/microgravity). The Special Issue also includes articles from previous Current Awareness Lists #902 https://doi.org/10.3390/ijms21103638, #910 https://doi.org/10.3390/ijms21145054, #917 https://doi.org/10.3390/ijms21186762, #920 https://doi.org/10.3390/ijms21197345, #924 https://doi.org/10.3390/ijms21218205, #930 https://doi.org/10.3390/ijms21249596, #934 https://doi.org/10.3390/ijms22020862, #940 https://doi.org/10.3390/ijms22042132 and https://doi.org/10.3390/ijms22052333, #944 https://doi.org/10.3390/ijms22063252 and https://doi.org/10.3390/ijms22073577, #948 https://doi.org/10.3390/ijms22094585. This article may be obtained online without charge.

 

9

Bacci G, Mengoni A, Emiliani G, Chiellini C, Cipriani EG, Bianconi G, Canganella F, Fani R.

Microbiome. 2021 Jun 30;9(1):152.

Note: Mars500 space simulation results. From the abstract: “Here, we report the characterization of the salivary microbiota from 88 samples taken during and after Mars500 mission for a total of 720 days.” This article may be obtained online without charge.

10

Ding Y, Cui Y, Yang X, Wang X, Tian G, Peng J, Wu B, Tang L, Cui CP, Zhang L.

J Bone Miner Metab. 2021 Jul 1. Online ahead of print.

Note: Hindlimb unloading study.

 

11

Mladenova V, Mladenov E, Scholz M, Stuschke M, Iliakis G.

Strong shift to ATR-dependent regulation of the G₂-checkpoint after exposure to high-LET radiation.

Life (Basel). 2021 Jun;11(6):560.

Note: This article is part of Special Issue “Radiobiology in Space” (https://www.mdpi.com/journal/life/special_issues/radiobio_space). The Special Issue also includes articles from previous Current Awareness Lists #914 https://doi.org/10.3390/life10090161, #917 https://doi.org/10.3390/life10090187, #925 https://doi.org/10.3390/life10110274, #927 https://doi.org/10.3390/life10110298, #930 https://doi.org/10.3390/life10120341, #934 https://doi.org/10.3390/life11010054, #936 https://doi.org/10.3390/life11020115. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

12

Pacelli C, Alessia C, Siong LM, Lorenzo A, Moeller R, Fujimori A, Igor S, Silvano O.

J Fungi (Basel). 2021 Jul;7(7):495.

Note: This article is part of Special Issue “Ecology and Evolution of Black Fungi” (https://www.mdpi.com/journal/jof/special_issues/black_fungi). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

13

De Martino E, Salomoni SE, Hodges PW, Hides J, Lindsay K, Debuse D, Winnard A, Elliott JM, Hoggarth M, Beard D, Cook JA, Ekman R, Hinterwaldner L, Scott J, Weber T, Caplan N.

J Appl Physiol (1985). 2021 Jul 1. Online ahead of print.

Note: Head-down tilt bed rest study.

14

Fomina EV, Lysova NY, Savinkina AO, Zhedyaev RY, Senatorova NA, Kukoba TB.

Hum Physiol. 2021 May;47:320-7.

Note: From the abstract: “The time of stimulation of support receptors in locomotor training was analyzed individually for 13 cosmonauts for each day of a long-term space flight.”

 

15

Hettinger ZR, Hamagata K, Confides AL, Lawrence MM, Miller BF, Butterfield TA, Dupont-Versteegden EE.

J Gerontol A Biol Sci Med Sci. 2021 Jun 28;glab186. Online ahead of print.

Note: Hindlimb unloading study.

 

16

Nosikova IN, Ryabova AM, Dmitrieva LE, Zakirova AZ, Kitov VV, Tomilovskaya ES, Kozlovskaya IB.

Hum Physiol. 2021 May;47:282-8.

Note: Dry immersion study.

 

17

Tomilovskaya E, Amirova L, Nosikova I, Rukavishnikov I, Chernogorov R, Lebedeva S, Saveko A, Ermakov I, Ponomarev I, Zelenskaya I, Shigueva T, Shishkin N, Kitov V, Riabova A, Brykov V, Abu Sheli N, Vassilieva G, Orlov O.

Front Physiol. 2021 Jun 14;12:661959.

Note: Dry immersion study. This article may be obtained online without charge.

18

Alexander P, Vsevolod L, Elena B, Oleg G, Daria K, Natalia M, Pavel M.

J Exp Biol. 2021 Jun 28;jeb.242138. Online ahead of print.

Note: Hindlimb unloading study.