Status Report

NASA Spaceline Current Awareness List #955 25 June 2021 (Space Life Science Research Results)

By SpaceRef Editor
June 25, 2021
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Roma PG, Schneiderman JS, Schorn JM, Whiting SE, Landon LB, Williams TJ.
Assessment of spaceflight medical conditions and treatments potential impacts on behavioral health and performance.
Life Sci Space Res. 2021 Aug;30:72-81.
PI: P. G. Roma
Note: ISS results. From the introduction: “…the primary goals of the present study were to systematically document (1) the BHP-relevant symptoms for each of the 100 EMCL medical conditions, (2) the BHP-relevant effects of the 105 spaceflight medical treatments in the current International Space Station (ISS) On-Orbit Medication List, and (3) the likelihood of potential BHP impacts from spaceflight medical treatments. To our knowledge, this is the first systematic assessment of spaceflight medical conditions’ and treatments’ potential impacts on behavioral health and performance risk.”
Journal Impact Factor: 2.453
Funding: “We thank Dr. Erik Antonsen for helpful discussions and guidance on use of the Exploration Medical Conditions List, Dr. Tina Bayuse of the NASA Johnson Space Center Pharmacy for graciously providing the ISS On-Orbit Medication List documentation, Dr. Natacha Chough of NASA Spaceflight Medical Operations for graciously providing the NASA Flight Surgeon Quick Reference Guide, and the NASA Space and Clinical Operations Division for their cooperation and support of the project. We also thank Dr. Vi Nguyen for contributing to the assessments of BHP-relevant effects of prescription medications, and Diana Arias for superb project management support. PGR, JSS, JMS, SEW, and LBL are supported by KBR’s Human Health and Performance Contract NNJ15HK11B through the National Aeronautics and Space Administration. TJW is supported by the NASA Human Research Program. This project was supported by NASA Human Research Program Directed Project Assessment of Spaceflight Medical Conditions and Treatments Potential Impacts on Behavioral Health and Performance (PI: PG Roma).”
Wong CP, Iwaniec UT, Turner RT.
Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the International Space Station.
npj Microgravity. 2021 Jun 18;7(1):23.
PI: R. T. Turner
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 3.380
Funding: “This work was supported by NASA (80NSSC19K0430 and NNX15AL15G).”
Boerma M, Davis CM, Jackson IL, Schaue D, Williams JP.
All for one, though not one for all: Team players in normal tissue radiobiology.
Int J Radiat Biol. 2021 Jun 15;1-61. Online ahead of print.
PIs: C. M. Davis, K. O’Banion
Note: From the abstract: “As part of the special issue on ‘Women in Science’, this review offers a perspective on past and ongoing work in the field of normal (non-cancer) tissue radiation biology, highlighting the work of many of the leading contributors to this field of research.”
Journal Impact Factor: 2.368
Funding: “Dr. Boerma’s work was supported by National Institute of General Medical Sciences (NIGMS) P20 GM109005; National Institute of Allergy and Infectious Diseases (NIAID) U01 AI148308 and U01 AI133561. Dr. Davis’ work was supported by National Aeronautics and Space Administration (NASA) 80NSSC18K1080. Dr. Jackson’s work was supported by Biomedical Advanced Research and Development Authority (BARDA) HHSO10020150009I, HHSO1003300IT, HHSO10033003T, and HHSO10033004T; NIAID R44AI138865, and U19 AI150574. Dr. Schaue’s work was supported by the National Cancer Institute (NCI) R01 CA226875, R01 CA238998, and R21 CA228542; NIAID U01 AI148322. Dr. Williams’ work was supported by NCI R01 CA220467, R01 HL127001; NASA 80NSSC21K0542.”
McIntire LK, McKinley RA, Goodyear C, McIntire JP, Brown RD.
Cervical transcutaneous vagal nerve stimulation (ctVNS) improves human cognitive performance under sleep deprivation stress.
Commun Biol. 2021 Jun 10;4(1):634.
PI: R. A. McKinley
Note: From the abstract: “The objective of this research was to evaluate the efficacy of cervical transcutaneous vagal nerve stimulation (ctVNS) to mitigate the negative effects of fatigue on cognition and mood.” This article may be obtained online without charge.
Journal Impact Factor: 4.165
Funding: “The authors would like to thank NASA for their funding and support of this project.”
Other papers of interest:
Han Y, Zeger L, Tripathi R, Egli M, Ille F, Lockowandt C, Florin G, Atic E, Redwan IN, Fredriksson R, Kozlova EN.
Molecular genetic analysis of neural stem cells after space flight and simulated microgravity on Earth.
Biotechnol Bioeng. 2021 Jun 14. Online ahead of print.
Note: MASER sounding rocket study. A random positioning machine was used for the simulation studies. From the abstract: “Understanding how stem cells adapt to space flight conditions is fundamental for human space missions and extraterrestrial settlement. We analyzed gene expression in boundary cap neural crest stem cells (BCs), which are attractive for regenerative medicine by their ability to promote proliferation and survival of cocultured and co-implanted cells. BCs were launched to space (space exposed cells) (SEC), onboard sounding rocket MASER 14 as free-floating neurospheres or in a bioprinted scaffold.”
Lazzari ZT, Aria KM, Menger R.
Neurosurgery and spinal adaptations in spaceflight: A literature review.
Clin Neurol Neurosurg. 2021 Aug;207:106755. Review.
Note: From the abstract: “Our aim was to review and summarize available data regarding changes in spinal health with exposure to spaceflight, especially focusing on effects of microgravity. …Articles included in this review were identified via search engine using MEDLINE, PubMed, Cochrane Review, Google Scholar, and references within other relevant articles. Search criteria included ‘spine and spaceflight’, ‘vertebral column and spaceflight’, ‘vertebral disc and spaceflight’, and ‘muscle atrophy and spaceflight’, with results limited to articles written in English from 1961 to 2020. References of selected articles were included as appropriate.”
Pandya M, Ma W, Lyu H, Luan X, Diekwisch TGH.
Propagation of dental and respiratory cells and organs in microgravity.
J Vis Exp. 2021 May 25;(171):e62690.
Note: Rotary bioreactor systems (RCCSs) are used to simulate microgravity. From the abstract: “In the present study we have used RCCSs to co-culture cervical loop cells and dental pulp cells to become ameloblasts, to characterize periodontal progenitor/scaffold interactions, and to determine the effect of inflammation on lung alveoli.”
Cerri M, Hitrec T, Luppi M, Amici R.
Be cool to be far: Exploiting hibernation for space exploration.
Neurosci Biobehav Rev. 2021 Sept;128:218-32. Review.
Note: From the abstract: “In mammals, torpor/hibernation is a state that is characterized by an active reduction in metabolic rate followed by a progressive decrease in body temperature. Torpor was successfully mimicked in non-hibernators by inhibiting the activity of neurons within the brainstem region of the Raphe Pallidus, or by activating the adenosine A1 receptors in the brain. This state, called synthetic torpor, may be exploited for many medical applications, and for space exploration, providing many benefits for biological adaptation to the space environment, among which an enhanced protection from cosmic rays.”
Fuentes A, Hyde D, Johnson I, Haston CK.
Acute radiation-induced hematopoietic depletion does not alter the onset or severity of pneumonitis in mice.
Radiat Res. 2021 Jun 15. Online ahead of print.
Nishiyama Y, Morita A, Wang B, Sakai T, Ramadhani D, Satoh H, Tanaka K, Sasatani M, Ochi S, Tominaga M, Ikushima H, Ueno J, Nenoi M, Aoki S.
Evaluation of sodium orthovanadate as a radioprotective agent under total-body irradiation and partial-body irradiation conditions in mice.
Int J Radiat Biol. 2021 Jun 14;1-32. Online ahead of print.
Zhao L, Tian J, Borasi G, Mi D, Sun Y.
Improved asymptotic expansions in high- and low-dose ranges for generalized multi-hit model of radiation-induced cell survival.
Radiat Res. 2021 Jun 18. Online ahead of print.
Zhou J, Wu J, Zheng S, Chen X, Zhou D, Shentu X.
Integrated transcriptomic and proteomic analysis reveals up-regulation of apoptosis and small heat shock proteins in lens of rats under low temperature.
Front Physiol. 2021 Jun 17;12:683056.
Note: This article may be obtained online without charge.
Rice D, Martinelli GP, Jiang W, Holstein GR, Rajguru SM.
Pulsed infrared stimulation of vertical semicircular canals evokes cardiovascular changes in the rat.
Front Neurol. 2021 May 28;12:680044.
Note: From the abstract: “The present study determined whether unilateral activation of the posterior (PC) or anterior (AC) semicircular canal is sufficient to elicit changes in BP and/or HR. The study employed frequency-modulated pulsed infrared radiation (IR: 1,863 nm) directed via optical fibers to PC or AC of adult male Long-Evans rats.” This article may be obtained online without charge.
Alyami HS, Ibrahim MA, Alyami MH, Dahmash EZ, Almeanazel OT, Algahtani TS, Alanazi F, Alshora DH.
Formulation of sublingual promethazine hydrochloride tablets for rapid relief of motion sickness.
Saudi Pharm J. 2021 May;29(5):478-86.
Note: This article may be obtained online without charge.
Zhou Q, Meng X, Huang G, Yi H, Zheng J, Zhang K, Xu W.
MEK1/2 inhibition synergistically enhances the preventive effects of normobaric oxygen on spinal cord injury in decompression sickness rats.
Front Physiol. 2021 Jun 1;12:674430.
Note: This article may be obtained online without charge.
Beckner ME, Conkright WR, Eagle SR, Martin BJ, Sinnott AM, LaGoy AD, Proessl F, Lovalekar M, Jabloner LR, Roma PG, Basner M, Ferrarelli F, Germain A, Flanagan SD, Connaboy C, Nindl BC.
Impact of simulated military operational stress on executive function relative to trait resilience, aerobic fitness, and neuroendocrine biomarkers.
Physiol Behav. 2021 Jul 1;236:113413.
Note: From the abstract: “This study demonstrates H-FIT and H-RES may buffer the impact of [simulated military operational stress] SMOS on vigilance. SMOS negatively impacted circulating neuroendocrine biomarkers. While BDNF returned to baseline concentrations by the end of the 5 d protocol, NPY, IGF-I, and α-klotho may require a longer recovery period. These data suggest that the military may benefit by training and/or selection processes targeting at augmenting trait resilience and aerobic fitness for increased readiness.”
Funding: “This study was funded by the Department of Defense (Award # W81XWH-17–2–0070). PGR is supported in part by KBR’s Human Health and Performance Contract NNJ15HK11B through the National Aeronautics and Space Administration.”

SpaceRef staff editor.