Status Report

NASA Spaceline Current Awareness List #949 14 May 2021 (Space Life Science Research Results)

By SpaceRef Editor
May 14, 2021
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Belobrajdic B, Melone K, Diaz-Artiles A.
Planetary extravehicular activity (EVA) risk mitigation strategies for long-duration space missions.
npj Microgravity. 2021 May 12;7(1):16. Review.
PI: D. Selva
Note: From the introduction: “The goal of this research effort is to identify the key risks associated with planetary EVAs and to identify suitable mitigation strategies, specifically for planetary surface exploration. Through an extensive review of ongoing research that includes academia, government, and industry, this paper will pinpoint some of the key risks associated with EVAs, with emphasis on those for planetary surface exploration. In this context, we divided EVA risk mitigation strategies into two main categories: (1) spacesuit design and (2) CONOPS.” This article may be obtained online without charge.
Journal Impact Factor: 3.380
Funding: “This work was supported by the NASA Innovative Advanced Concepts (NIAC) program (grant number 80NSSC19K0969) and by the NASA Human Research Program (grant number 80NSSC19K0656).”
Barker R, Costes SV, Miller J, Gebre SG, Lombardino J, Gilroy S.
Rad-Bio-App: A discovery environment for biologists to explore spaceflight-related radiation exposures.
npj Microgravity. 2021 May 11;7(1):15.
PI: S. Gilroy
Note: From the abstract: “In addition to microgravity, spaceflight simultaneously exposes biology to a suite of other stimuli. For example, in space, organisms experience ionizing radiation environments that significantly differ in both quality and quantity from those normally experienced on Earth. However, data on radiation exposure during space missions is often complex to access and to understand, limiting progress towards defining how radiation affects organisms against the unique background of spaceflight. To help address this challenge, we have developed the Rad-Bio-App. This web-accessible database imports radiation metadata from experiments archived in NASA’s GeneLab data repository, and then allows the user to explore these experiments both in the context of their radiation exposure and through their other metadata and results.” GeneLab is available at: This article may be obtained online without charge.
Journal Impact Factor: 3.380
Funding: “The authors would like to thank Drs. Ryan Rios and Kerry Lee of the Space Radiation Analysis Group, NASA-Johnson Space Center, for preliminary analysis of the radiation dose data from the US Laboratory on the ISS and Dr. Eloise Pariset, Jonas Brown, Ruby Kleijwegt and Ben Schlenker for helpful discussions. This work is supported by NASA 80NSSC18K0132 and 86NM0018D000 to S.G. and R.B. and by the GeneLab Project at NASA Ames Research Center, through NASA’s Space Biology Program in the Division of Biological and Physical Sciences (BPS) of the Science Mission Directorate.”
Other papers of interest:
Kamada M, Miyamoto K, Oka M, Uheda E, Yamazaki C, Shimazu T, Sano H, Kasahara H, Suzuki T, Higashibata A, Ueda J.
DNA microarray analysis of gene expression of etiolated maize seedlings grown under microgravity conditions in space: Relevance to the International Space Station experiment “Auxin Transport.”
Biol Sci Space. 2021;35:1-14.
Note: ISS results. This article may be obtained online without charge.
Okada R, Fujita SI, Suzuki R, Hayashi T, Tsubouchi H, Kato C, Sadaki S, Kanai M, Fuseya S, Inoue Y, Jeon H, Hamada M, Kuno A, Ishii A, Tamaoka A, Tanihata J, Ito N, Shiba D, Shirakawa M, Muratani M, Kudo T, Takahashi S.
Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment.
Sci Rep. 2021 Apr 28;11(1):9168.
Note: ISS results. This article may be obtained online without charge.
Takács E, Barkaszi I, Czigler I, Pató LG, Altbäcker A, McIntyre J, Cheron G, Balázs L.
Persistent deterioration of visuospatial performance in spaceflight.
Sci Rep. 2021 May 5;11(1):9590.
Note: ISS results. From article: “Five male astronauts with a mean age of 54.2 (SD = 2.6) participated in this experiment. Each astronaut took part in an approximately half-year long space mission aboard the ISS. This study was conducted during four missions (expeditions 20/21, 26/27, 30/31, 34/35). Tasks were performed on 9 occasions, 3 times before, 2 times during and 4 times after flight. Data were collected at regular time intervals.” This article may be obtained online without charge.
Komorowski M, Thierry S, Stark C, Sykes M, Hinkelbein J.
On the challenges of anesthesia and surgery during interplanetary spaceflight.
Anesthesiology. 2021 May 3. Online ahead of print.
Note: From the abstract: “Two months after landing on Mars, an astronaut suffers from a fall during an extravehicular activity, resulting in a fractured femur. Because it is impossible to return home, the remaining crew must manage the injury. …Experts have estimated that the most significant risks for space exploration missions are trauma, hemorrhagic shock, and infections. To some extent, the likelihood of medical events can be estimated from analog ground populations, both military and civilian, and data gathered during human spaceflight experience.”
Jemison M, Olabisi R.
Biomaterials for human space exploration: A review of their untapped potential.
Acta Biomater. 2021 May 4;S1742-7061(21)00270-1. Review. Online ahead of print.
Note: From the abstract: “The space environment permits the fabrication of novel biomaterials that cannot be produced on Earth, but benefit Earth. Similarly, designing a biomaterial to address a space-based challenge may lead to novel biomaterials that will ultimately benefit Earth. This review describes several persistent challenges to human space exploration, a variety of biomaterials that might mitigate those challenges, and considers a special category of space biomaterial.” M. Jemison is a former NASA astronaut. This article may be obtained online without charge.
Mosca C, Fagliarone C, Napoli A, Rabbow E, Rettberg P, Billi D.
Revival of anhydrobiotic cyanobacterium biofilms exposed to space vacuum and prolonged dryness: Implications for future missions beyond low Earth orbit.
Astrobiology. 2021 May;21(5):541-50.
Note: ISS results.
Amirova LE, Plehuna A, Rukavishnikov IV, Saveko AA, Peipsi A, Tomilovskaya ES.
Sharp changes in muscle tone in humans under simulated microgravity.
Front Physiol. 2021 May 6;12:661922.
Note: Dry Immersion was the simulation method used in this study. From the abstract: “To perform measurements of changes in muscle tone, we used a MyotonPRO device. The list of muscles that we assessed includes: trunk – mm. deltoideus posterior, trapezius, erector spinae; leg – mm. biceps femoris, rectus femoris, tibialis anterior, soleus, gastrocnemius; foot – m. flexor digitorum brevis, tendo Achillis, aponeurosis plantaris.” This article may be obtained online without charge.
Chen X, Li C, Liu H.
Enhanced recombinant protein production under special environmental stress.
Front Microbiol. 2021 Apr 15;12:630814. Review.
Note: From the abstract: “In this review, we summarize some extreme environmental factors used for the improvement of heterologous protein expression, including low temperature, hypoxia, microgravity and high osmolality. The applications of these strategies are elaborated with examples of well-documented studies. We also demonstrated the confirmed or hypothetical mechanisms of environment stress affecting the host behaviors. In addition, multi-omics techniques driving the stress-responsive research for construction of efficient microbial cell factories are also prospected at the end.” This article may be obtained online without charge.
Hebbar PA, Bhattacharya K, Prabhakar G, Pashilkar AA, Biswas P.
Correlation between physiological and performance-based metrics to estimate pilots’ cognitive workload.
Front Psychol. 2021 Apr 20;12:555446.
Note: This article may be obtained online without charge.
Kourtidou-Papadeli C, Frantzidis CA, Gilou S, Plomariti CE, Nday CM, Karnaras D, Bakas L, Bamidis PD, Vernikos J.
Gravity threshold and dose response relationships: Health benefits using a short arm human centrifuge.
Front Physiol. 2021 May 11;12:644661.
Note: The short arm human centrifuge was used in this study.
Yilmaz K, Burnley M, Böcker J, Müller K, Jones AM, Rittweger J.
Influence of simulated hypogravity on oxygen uptake during treadmill running.
Physiol Rep. 2021 May;9(9):e14787.
Note: From the abstract: “Prolonged exposure to microgravity during spaceflights leads to severe deterioration in the physical performance of astronauts. To understand the effectiveness of existing in-flight daily countermeasures and to plan exercise onboard the International Space Station, we compared supine treadmill running to traditional upright treadmill running on Earth.” This article may be obtained online without charge.
Puukila S, Tharmalingam S, Al-Khayyat W, Peterson J, Hooker AM, Muise S, Boreham DR, Dixon DL.
Transcriptomic response in the spleen after whole-body low-dose x-ray irradiation.
Radiat Res. 2021 May 6. Online ahead of print.
Yamashita SI, Kyuuma M, Inoue K, Hata Y, Kawada R, Yamabi M, Fujii Y, Sakagami J, Fukuda T, Furukawa K, Tsukamoto S, Kanki T.
Mitophagy reporter mouse analysis reveals increased mitophagy activity in disuse-induced muscle atrophy.
J Cell Physiol. 2021 May 2. Online ahead of print.

SpaceRef staff editor.