NASA Spaceline Current Awareness List #948 7 May 2021 (Space Life Science Research Results)

Papers deriving from NASA support:

 

1

Macias BR, Ferguson CR, Patel N, Gibson C, Samuels BC, Laurie SS, Lee SMC, Ploutz-Snyder R, Kramer L, Mader TH, Brunstetter T, Alferova IV, Hargens AR, Ebert DJ, Dulchavsky SA, Stenger MB.

JAMA Ophthalmol. 2021 Apr 29;e210931. Online ahead of print.

PIs: B.R. Macias, S.A. Dulchavsky, M.B. Stenger

Note: ISS results. From the article: “In support of our hypothesis, this study documents the late development of optic disc edema in 1 crew member and progressive development of choroidal folds and optic disc edema in another crew member throughout the duration of 1 year in low Earth orbit aboard the International Space Station. As spaceflight missions increase in duration, quantitative analyses of ocular structural and functional changes are important to monitor astronaut health and the efficacy of potential SANS countermeasures.”

Journal Impact Factor: 6.198

Funding: “This work was supported by the National Aeronautics and Space Administration Human Research Program as part of the Fluid Shifts (NNJ11ZSA002NA) and Ocular Health studies.”

 

2

Schuerger AC, Amaradasa BS, Dufault NS, Hummerick ME, Richards JT, Khodadad CL, Smith TM, Massa GD.

Astrobiology. 2021 Apr 29. Online ahead of print.

Note: ISS results.

Journal Impact Factor: 4.091

Funding: “The authors would like to thank the National Aeronautics and Space Administration for providing the Zinnia hybridatissues from the VEG-01C flight experiment for this study. The VEG-01C validation test flight was funded by NASA’s Space Biology program. The flight experiment would not have been possible without help from the VEG and Veggie teams at KSC and SNC-ORBITEC, the ISS program, the Payload Operations and Integration Center and Marshall Space Flight Center, and the tireless efforts of the astronauts on the ISS. We also wish to thank K. Venkateswaran at the Jet Propulsion Laboratory, Pasadena, California, for graciously providing cultures of the ISS-F3 and ISS-F4 strains of Fusarium oxysporum for these studies; and C.S. Cockell at the University of Edinburgh, Scotland—and a second anonymous reviewer—for their helpful suggestions during the review process.”

3

Simpson AC, Urbaniak C, Singh NK, Wood JM, Debieu M, O’Hara NB, Mason CE, Venkateswaran K.

Microbiol Resour Announc. 2021 Apr 29;10(17):e00214-21.

PI: C. Jaing

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 0.486

Funding: “Part of the research described was carried out at the Jet Propulsion Laboratory of the California Institute of Technology under a contract with NASA. This research was funded by a 2014 Space Biology NNH14ZTT002N award (grant 80NSSC18K0113) to Crystal Jaing and K.V., which also partially funded postdoctoral fellowships for C.U. and J.M.W. Additionally, A.C.S. was supported by grant 80NM0018D0004, funded to K.V. We thank astronauts Colonel Jack Fischer, Colonel Mark Vande Hei, Norishige Kanai, and Alexander Gerst for collecting samples aboard the ISS, the implementation team (Fathi Karouia) at NASA Ames Research Center for coordinating this effort, and Crystal Jaing (Lawrence Livermore National Laboratory), principal investigator of the team. …The Jet Propulsion Laboratory supercomputing facility staff is acknowledged, notably, Narendra J. Patel (Jimmy) and Edward Villanueva, for continuous support in providing the best possible infrastructure for BIG-DATA analysis.”

 

4

Lan M, Phillips SD, Archambault-Leger V, Chepko AB, Lu R, Anderson AP, Masterova KS, Fellows AM, Halter RJ, Buckey JC.

Physiol Rep. 2021 Apr;9(8):e14782.

PI: J.C. Buckey

Note: From the article: “The cause of reduced IJV flow in space is not well understood, but understanding it is important for preventing in-flight vein thromboses. To explore possible causes, we used a novel numerical model of the cranial circulation. The model was created using MATLAB® Simscape Fluids™ (MathWorks®, Natick, MA). The model simulates changes in body fluid distribution and pressures in various body positions (supine, prone, head down tilt), different gravity conditions (0-g, 1-g, etc.), different body sizes (neck, chest, waist circumference), and the presence of an external pressure device (lower body negative pressure (LBNP), lower body positive pressure (LBPP)) used on the lower extremities.” This article may be obtained online without charge.

Journal Impact Factor: 1.535

Funding: “The development of the numerical models was supported by grant CA03401 from the National Space Biomedical Research Institute through NCC 9–58 and by NASA EPSCoR Cooperative Agreement NNX13AD35A.”

5

Rubinstein L, Paul AM, Houseman C, Abegaz M, Tabares Ruiz S, O’Neil N, Kunis G, Ofir R, Cohen J, Ronca AE, Globus RK, Tahimic CGT.

Cells. 2021 Apr 19;10(4):940.

PIs: L. Rubinstein, R.K. Globus, A.M. Paul, NASA Postdoctoral Program Fellowship

Note: Hindlimb unloading study.

Journal Impact Factor: 3.748

Funding: “This work was supported by an Ames Research Innovation Award (ARIA) to R.K.G., L.R. and A.M.P. were supported by a fellowship from the NASA Space Biology Postdoctoral Program (NPP).”

6

Sater SH, Sass AM, Seiner A, Natividad GC, Shrestha D, Fu AQ, Oshinski JN, Ethier CR, Martin BA.

J R Soc Interface. 2021 Apr;18(177):20200920.

PIs: C.R. Ethier, B.A. Martin

Note: Head-down tilt study.

Journal Impact Factor: 3.748

Funding: “This study was funded by NASA grant nos 80NSSC20K0920, NNX16AT06G and 80NSSC19K1298; NASA Idaho Space Grant Consortium grant no. NNX10AM75H; National Institute of Neurological Disorders and Stroke grant no. 1R01NS11128301; the Georgia Research Alliance and the NASA Human Research Program.”

7

Zwart SR, Mulavara AP, Williams TJ, George K, Smith SM.

Neurosci Biobehav Rev. 2021 Apr 26;S0149-7634(21)00185-8. Review.

PI: S.M. Smith

Note: From the abstract: “Here we review the nutritional perspective of how these spaceflight hazards affect the astronaut’s brain, behavior, performance, and sensorimotor function. We also assess potential nutrient/nutritional countermeasures that could prevent or mitigate spaceflight risks and ensure that crewmembers remain healthy and perform well during their missions. Just as history has taught us the importance of nutrition in terrestrial exploration, we must understand the role of nutrition in the development and mitigation of spaceflight risks before humans can successfully explore beyond low-Earth orbit.”

Journal Impact Factor: 8.330

Funding: “Funding was provided by the NASA Human Research Program’s Human Factors and Behavior and Performance, the Human Health Countermeasures, and Space Radiation Elements for this effort.”

8

Whittle RS, Diaz-Artiles A.

J Appl Physiol (1985). 2021 Apr 29. Online ahead of print.

PI: A. Diaz-Artiles

Journal Impact Factor: 3.044

Funding: “80NSSC20K1521/NASA Human Research Program.”

 

 

Please Note: The following articles belong to the Special Issue “Overcoming the Challenges of Space Environment” edited by M. Boerma and I. Koturbash. The articles are available at https://www.tandfonline.com/toc/lesc21/39. Additional articles will be forthcoming and may be found in the link to the Special Issue.

9

Boerma M, Koturbash I.

J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):109-12. Editorial.

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.552

Funding: No funding cited. M. Boerma is PI on the 80NSSC19K0437 “Gamma-tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects” project.

10

Willey JS, Britten RA, Blaber E, Tahimic CGT, Chancellor J, Sanford LD, Kubik AJ, Delp MD, Mao XW.

J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):129-79.

PIs: J.S. Willey, R.A. Britten, M.D. Delp, X.W. Mao, C.L. Limoli/R.A. Britten/NSCOR, S. Rutkove

Note: Hindlimb unloading study.

Journal Impact Factor: 2.552

Funding: “This project was supported by Willey – NASA Space Biology grant no. NNX15AB50G, NIH/NIAMS 1R21AR072806-01, and the Translational Research Institute for Space Health through NASA NNX16AO69A for award EO005. Britten – NASA grant nos. NNX16AC40G, NNX15AI22G, and NNX14AE73G. Mortreux – NASA grant nos. NNX16AL36G and 80NSSC19K1598. Delp – NASA grant nos. NNX16AC28G, NNX15AE86G, 80NSSC19K1322, and 80NSSC19K1599. Mao-NASA Space Biology grant no. NNX15AB41G, NASA 80NSSC18K0310, 80NSSC20K0986 and LLU Department of Basic Sciences.”

 

11

Chancellor J, Nowadly C, Williams J, Aunon-Chancellor S, Chesal M, Looper J, Newhauser W.

J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):113-28.

PI: J. Chancellor

Note: Hindlimb unloading study.

Journal Impact Factor: 2.552

Funding: “The National Institute of Health R01 CA220467 R01 HL127001JCC acknowledges support by the Translational Research Institute for Space Health (TRISH) through NASA NNX16AO69A. JCC and MEC acknowledges support from LaSPACE/NASA Grant Number 80NSSC20M0110. JPW acknowledges support from the National Institute of Health through grants R01 CA220467 and R01 HL127001.”

12

Davis CM, Allen AR, Bowles DE.

J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):180-218.

PIs: C.M. Davis, A.R. Allen, D.E. Bowles

Journal Impact Factor: 2.552

Funding: “This work was supported by NASA research grant 80NSSC18K1080 (CMD), Translational Research Institute through NASA cooperative agreement NNX16AO69A (ARA, DEB) and NASA research grant NNX16AK20G (DEB).”

13

Dissmore T, DeMarco AG, Jayatilake M, Girgis M, Bansal S, Li Y, Mehta K, Sridharan V, Gill K, Bansal S, Tyburski JB, Cheema AK.

J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):219-33.

PI: M. Boerma, M. Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 2.552

Funding: “This study was supported by a grant from the National Space Biomedical Research Institute [RE03701 through NCC 9-58] and NASA [80NSSC17K0425 and 80NSSC19K0437] to Dr. Cheema. The authors would like to acknowledge the Metabolomics Shared Resource in Georgetown University (Washington, DC, USA) which is partially supported by NIH/NCI/CCSG grant P30-CA051008.”

 

14

Girgis M, Li Y, Jayatilake M, Gill K, Wang S, Makambi K, Sridharan V, Cheema AK.

J Environ Sci Health C Toxicol Carcinog. 2021 Apr 27;39(2):234-49.

PI: M. Boerma, M. Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 2.552

Funding: “This study was supported by the National Space Biomedical Research Institute [RE03701 through NCC 9–58] and 1U01AI133561-01 funding from NIH/NIAID to AKC and National Institute of Allergy and Infectious Diseases. The authors would like to acknowledge the Metabolomics Shared Resource in Georgetown University (Washington, DC, USA) which is partially supported by NIH/NCI/CCSG grant P30-CA051008.”

_______________________________________________________

 

 

Other papers of interest:

 

1

Kesserwani H.

Cureus. 2021 Mar 25;13(3):e14103. Review.

Note: From the abstract: “Recent data from astronauts who have returned to Earth from a long-duration space flight have unequivocally distinguished spaceflight-associated neuro-ocular syndrome (SANS) from idiopathic intracranial hypertension (IIH) and pseudotumor cerebri (PTC). We review the semiology and pathogenesis of these three entities, noting that optic disc edema is what unites them, and this where the similarities between SANS and IIH/PTC end. We distinguish between PTC and IIH and between SANS and IIH/PTC and review the medical and surgical therapy of IIH/PTC.” This article may be obtained online without charge.

 

2

Walsh L, Hafner L, Straube U, Ulanowski A, Fogtman A, Durante M, Weerts G, Schneider U.

Radiat Environ Biophys. 2021 Apr 30. Online ahead of print.

3

Genah S, Monici M, Morbidelli L.

Int J Mol Sci. 2021 Apr 27;22(9):4585. Review.

Note: This article may be obtained online without charge.

 

4

Simon Á, Smarandache A, Iancu V, Pascu ML.

Molecules. 2021 Apr 12;26(8):2221. Review.

Note: This article may be obtained online without charge.

 

5

Ho CNQ, Tran MT, Doan CC, Hoang SN, Tran DH, Le LT.

Int J Mol Sci. 2021 Apr 27;22(9):4550.

Note: A 3D clinostat was used in this study. This article may be obtained online without charge.

6

Restier-Verlet J, El-Nachef L, Ferlazzo ML, Al-Choboq J, Granzotto A, Bouchet A, Foray N.

Int J Mol Sci. 2021 Apr 3;22(7)3739. Review.

Note: From the abstract: “This review summarizes the specificities of space radiobiology and opens the debate as regards refinements of current radiation protection concepts that will be useful for the better estimation of risks.” This article may be obtained online without charge.

7

Useinova AN, Kaliberdenko V, Sapegin ID, Kulanthaivel S, Shterenshis MV, Dmitriyevskaya MI, Balasundaram K.

Cent Nerv Syst Agents Med Chem. 2021 Apr 27. Online ahead of print.

8

Simões MF, Antunes A.

Pathogens. 2021 Apr 9;10(4):450. Review.

Note: This article may be obtained online without charge.

 

9

Peyroteo MMA, Belinha J, Natal Jorge RM.

Biomech Model Mechanobiol. 2021 Apr 26. Online ahead of print.

10

Bourdillon N, Jeanneret F, Nilchian M, Albertoni P, Ha P, Millet GP.

Front Neurosci. 2021 Apr 8;15:642548.

Note: This article may be obtained online without charge.