NASA Spaceline Current Awareness List ##947 30 April 2021 (Space Life Science Research Results)

Papers deriving from NASA support:

 

1

Smith K, Mercuri J.

Aerosp Med Hum Perform. 2021 May 1;92(5):342-52.

Note: From the article: “While the etiology of IVD degeneration and herniation is well understood within the clinical environment on Earth, limited research has been done to elucidate the effects of microgravity and cosmic radiation on these IVD pathologies. Therefore, the objective of this paper is to review current research including human, animal, and cell culture studies to further our understanding of how space impacts astronaut IVD health and to chart future directions for mechanistic studies.”

Journal Impact Factor: 0.889

Funding: “Research support for the Laboratory of Orthopaedic Tissue Regeneration and Orthobiologics has been provided in part by a research grant from the National Aeronautics and Space Administration South Carolina Space Grant Consortium, Research and Education Awards Program (REAP). The authors would also like to acknowledge the generous support from the John Witherspoon Gilpin, M.D., ‘82 Endowment.”

 

2

Padgen MR, Parra MP, Ricco AJ, Matin AC.

Life Sci Space Res (Amst). 2021 May;29:85-6.

Note: Escherichia coli Antimicrobial Satellite (EcAMSat) results. This article is a response to the comment by C. Wang (https://doi.org/10.1016/j.lssr.2021.03.007), which is included in the “Other papers of interest” section within this list. Wang‘s comment is on CA List article #873 (https://doi.org/10.1016/j.lssr.2019.10.007).

Journal Impact Factor: 2.453

Funding: No funding cited. A.C. Matin is the PI on the original article in CA List #873.

 

3

Krishnan B, Chandramouli N, Krystyn ZB, Alikhani L, Wang J, Sowa A, Groen K, Perry B, Dickstein DL, Baulch JE, Limoli CL, Britten RA.

Int J Mol Sci. 2021 Apr 1;22(7):3668.

PIs: C.L. Limoli/J.E. Baulch/R.A. Britten/NSCOR

Note: This article, available online without charge, belongs to the Special Issue “Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment” (https://www.mdpi.com/journal/ijms/special_issues/OSaD_space). The Special Issue also includes an article from Current Awareness List #944 https://doi.org/10.3390/ijms22063070. From the introduction: “The current study was designed to extend our understanding of the impact of chronic low dose and low dose rate neutron irradiation on HSP using two approaches. The first aspect of our study established low frequency stimulation (LFS) of LTD synaptic plasticity in the input L2-3 layer of the prelimbic (PrL) cortex of the mPFC in littermates of the C57Bl/6 mice used for LTP assessment. The second part of our study used fluorescence assisted single synaptosome LTP (FASS-LTP) analysis to perform a cross-species validation of HSP (i.e., LTP) changes in the HPC of rats that were concurrently exposed to chronic low dose and dose rate neutron irradiation with the C57Bl/6 mice.”

Journal Impact Factor: 4.556

Funding: “This work was supported by R21AG059223 (BK) and NASA NSCOR NNX15AI22G (CLL, JEB, RAB).”

 

4

Shuryak I, Brenner DJ, Blattnig SR, Shukitt-Hale B, Rabin BM.

Sci Rep. 2021 Apr 23;11(1):8845.

PIs: D.J. Brenner, B.M. Rabin

Note: From the abstract: “Here we considered two general mechanisms of ionizing radiation-induced damage: targeted effects (TE), caused by traversal of cells by ionizing tracks, and non-targeted effects (NTE), caused by responses of other cells to signals released by traversed cells. We compared the performances of 18 dose response model variants based on these concepts, fitted by robust nonlinear regression to a large published data set on novel object recognition testing in rats exposed to multiple space-relevant radiation types (H, C, O, Si, Ti and Fe ions), covering wide ranges of linear energy transfer (LET) (0.22–181 keV/μm) and dose (0.001–2 Gy).” This article may be obtained online without charge.

Journal Impact Factor: 3.998

Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) grant NNX16AR81A to DJB and NASA Grant NNX16AE06G to BMR and BSH.”

 

5

Chin S, Kwon T, Khan BR, Sparks JA, Mallery EL, Szymanski DB, Blancaflor EB.

Plant Cell. 2021 Apr 20;koab115. Online ahead of print.

PI: E.B. Blancaflor

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.618

Funding: “This work was supported by the National Aeronautics and Space Administration (NASA grants 80NSSC19K0129 and 80NSSC18K1462) and the Noble Research Institute to E.B.B. and by the National Science Foundation (NSF MCB Grant No.1715544) to D.B.S.”

 

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Other papers of interest:

 

1

Cockell CS, Santomartino R, Finster K, Waajen AC, Nicholson N, Loudon CM, Eades LJ, Moeller R, Rettberg P, Fuchs FM, Van Houdt R, Leys N, Coninx I, Hatton J, Parmitano L, Krause J, Koehler A, Caplin N, Zuijderduijn L, Mariani A, Pellari S, Carubia F, Luciani G, Balsamo M, Zolesi V, Ochoa J, Sen P, Watt JAJ, Doswald-Winkler J, Herová M, Rattenbacher B, Wadsworth J, Everroad RC, Demets R.

Front Microbiol. 2021 Apr 1;12:641387.

Note: ISS results. This article may be obtained online without charge.

 

2

Meskers AJH, Houben MMJ, Pennings HJM, Clément G, Groen E.

J Vestib Res. 2021 Apr 16. Online ahead of print.

Note: Parabolic flight results.

 

3

Matula EE, Nabity JA.

Life Sci Space Res (Amst). 2021 May;29:73-84.

Note: From the abstract: “The findings presented here imply that a sufficient volume of C. vulgaris, with nutrient supplementation or biomass harvesting, could support the respiratory requirements of a long duration human mission with a dynamic cabin environment and these data can be used in future dynamic models.”

 

4

Wang B, Ye T, Li X, Bian P, Liu Y, Wang G.

Life Sci Space Res (Amst). 2021 May;29:22-9.

Note: From the abstract: “These data shed light on the possible survival strategy of desert algae to near space environments. Our results indicated that Mars-like near space conditions represent an extreme environment for desert algae in terms of temperature, pressure, and radiations. The survival strategy of Chlorella in response to near space will help gain insights into the possibility of extremophile colonization on the surface of Mars and in similar extraterrestrial habitats.”

 

5

Wang C.

Life Sci Space Res (Amst). 2021 May;29:72.

Note: This article is a comment on the original article by Padgen et al., from Current Awareness List #873, which is available at https://doi.org/10.1016/j.lssr.2019.10.007. The reply by Padgen et al. to this comment is included in the “Papers deriving from NASA support” section within this list and is available at https://doi.org/10.1016/j.lssr.2021.03.006.

 

6

Zhang S, Wang K, Zhu R, Jiang C, Niu W.

Aerosp Med Hum Perform. 2021 May 1;92(5):312-8.

Note: From the abstract: “A finite element model of the L4L5 lumbar segment was developed with eight loading schemes representing different interventions. The loading schemes included no intervention, wearing a penguin suit, sleeping in a fetal position, wearing a penguin suit combined with sleeping in the fetal position, reclining for 4 or 16 h/d, and maintaining upright posture for 4 or 16 h/d.”

 

7

Kordyum E, Hasenstein KH.

Life Sci Space Res (Amst). 2021 May;29:1-7. Review. Online ahead of print.

8

Lv J, Jiang N, Wang H, Huang H, Bao Y, Chen Y, Liu X.

Life Sci Space Res (Amst). 2021 May;29:63-71.

Note: Hindlimb unloading study. From the abstract: “The weightless environment encountered in space flight can cause cognitive changes, affecting mission execution and endanger mission safety. Ground simulations provide the means to evaluate these effects and the resulting risks. In this study, rats were used as model animals and subjected to simulated weightlessness by suspending them from their tails. Tail-suspension and operant task learning experiments were conducted to study the effects of simulated weightlessness on the complex operant conditioning abilities of the subject’s acquisition, maintenance, and signal discrimination skills.”

 

9

Cheok LJ, Ying Goh BL, Soh FW, Boon Chuan BT.

Aerosp Med Hum Perform. 2021 May 1;92(5):289-93.

10

Gupta V, Tyagi A, Bhatnagar A, Singh S, Gaidhani SN, Srikanth N.

Int J Radiat Biol. 2021 Apr 19;1-17. Online ahead of print.

11

Ogoh S, Sato K, de Abreu S, Denise P, Normand H.

Exp Physiol. 2021 Apr 18. Online ahead of print.

Note: Head-down bed rest study. 

 

12

Recenti M, Ricciardi C, Aubonnet R, Picone I, Jacob D, Svansson HÁ R, Agnarsdóttir S, Karlsson GH, Baeringsdóttir V, Petersen H, Gargiulo P.

Front Bioeng Biotechnol. 2021 Apr 1;9:635661.

Note: This article may be obtained online without charge.

13

Stewart MA, Pingali S, Newman DG.

Aerosp Med Hum Perform. 2021 May 1;92(5):319-25.

Note: From the abstract: “This study shows that there appears to be a difference between the OKCR at low and high altitude. Pilots at higher altitude seem to exhibit a smaller head tilt for the same aircraft bank angle. More research is required to fully understand why there is a decrease in the OKCR at high altitude, as well as the actual consequences of the decreased reflex on pilot orientation.”

 

14

Ackerman KE, Popp KL, Bouxsein ML.

Br J Sports Med. 2021 Apr 21;bjsports-2021-104164. Editorial. Online ahead of print.

Note: This editorial is commenting on an article from Current Awareness List #938, Gabel L, Liphardt AM, Hulme PA, Heer M, Zwart SR, Sibonga JD, Smith SM, Boyd S. Pre-flight exercise and bone metabolism predict unloading-induced bone loss due to spaceflight. Br J Sports Med. 2021 Feb 17;bjsports-2020-103602. The Gabel et al. article is available online without charge at http://dx.doi.org/10.1136/bjsports-2020-103602.