Status Report

NASA Spaceline Current Awareness List ##946 23 April 2021 (Space Life Science Research Results)

By SpaceRef Editor
April 23, 2021
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Califar B, Zupanska A, Callaham JA, Bamsey MT, Graham T, Paul A-L, Ferl RJ.
Shared metabolic remodeling processes characterize the transcriptome of Arabidopsis thaliana within various suborbital flight environments.
Gravit Space Res. 2021 Jan 28;9(1):13-29.
PI: R.J. Ferl
Note: From the abstract: “The data presented herein highlight the potential for various suborbital platforms to contribute insights into biological responses to spaceflight, and further suggest that in-flight fixation during suborbital experiments will enhance insights into responses during each phase of flight.” This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This work was made possible by programmatic support from the University of Florida, Florida Space Institute, NASA Flight Opportunities and NASA Space Biology. Specific funding was provided by NASA Space Biology grant NNX15AB12G, NASA Flight Opportunities grant 80NSSC20K0113, and Florida Space Grant Consortium grant UCFOI-0000262765.”
Marshall-Goebel K, Macias BR, Laurie SS, Lee SMC, Ebert DJ, Kemp DT, Miller AE, Greenwald SH, Martin DS, Young M, Hargens AR, Levine BD, Stenger MB.
Mechanical countermeasures to headward fluid shifts.
J Appl Physiol (1985). 2021 Apr 15. Online ahead of print.
PI: K. Marshall-Goebel
Note: From the article: “In the study, we characterized the ability of acute application of mechanical countermeasures to reduce a posture-induced fluid shift; however, some physiological changes that occur during spaceflight that have been hypothesized to be related to the headward fluid shift, such as the development of ocular changes associated with SANS, occurs over weeks to months.”
Journal Impact Factor: 3.044
Funding: No funding cited. K. Marshall-Goebel, B.R. Macias, S.S. Laurie, S.M.C. Lee, D.J. Ebert, S.H. Greenwald, D.S. Martin, M. Young, and M.B. Stenger are affiliated with NASA Johnson Space Center.
Smith CM, Zwart SR, Douglas GL, Heer M.
Human adaptation to spaceflight: The role of food and nutrition. Second edition.
Houston, TX: NASA Lyndon B. Johnson Space Center, 2021. 255 p. NP-2021-03-003-JSC.
PI: C.M. Smith
Note: Chapters include: Nutritional Requirements for Space Explorers; Space Food Systems; Energy; Fluid; Bone; Muscle; Cardiovascular; Brain; Ocular; Immune; Oxidative Stress; Supplements, Foods, and Pharmaceuticals; and Conducting Space Research. From the preface: “This book marks our third effort to review available literature regarding the role of nutrition in astronaut health. In 2009, we reviewed the existing knowledge and history of human nutrition for spaceflight, with a key goal of identifying additional data that would be required before NASA could confidently reduce the risk of an inadequate food system or inadequate nutrition to as low as possible in support of human expeditions to the Moon or Mars… This previous review is available for free download, most recently at …In 2014, we published a second volume of the book, which was not so much a second edition, but rather a view of space nutrition from a different perspective. [It is] also available at the link mentioned… The current version is an expanded, updated version of that second book, providing both a systems approach overall, but also including details of nutrients and their roles within each system. As such, this book is divided into chapters based on physiological systems (e.g., bone, muscle, ocular); highlighted in each chapter are the nutrients associated with that particular system. We provide updated information on space food systems and constraints of the same, and provide dietary intake data from International Space Station (ISS) astronauts.”
Funding: No funding cited. C.M. Smith, S.R. Zwart, and G.L. Douglas are affiliated with NASA Johnson Space Center.
Rienecker KDA, Paladini MS, Grue K, Krukowski K, Rosi S.
Microglia: Ally and enemy in deep space.
Neurosci Biobehav Rev. 2021 Apr 16;126:509-14. Review.
PI: S. Rosi
Note: From the abstract: “In 2024 the first female astronaut will land on the Moon, advancing our preparations for human missions to Mars. While on Earth we are protected from space radiation by our planet’s magnetic field, on such deep space voyages astronauts will be exposed to high-energy particles from solar flares and galactic cosmic rays (GCR). This exposure carries risks to the central nervous system (CNS) that could jeopardize the mission and astronaut health.” This article may be obtained online without charge.
Journal Impact Factor: 8.330
Funding: “This work was supported by the National Institutes of Health: NIH/ National Institute on Aging Grant R01AG056770 (to S.R.); NIH/National Cancer Institute Grants R01 CA213441 and R01 CA246722 (to S. R.), National Aeronautics and Space Administration (NASA) grants NNX14AC94G and 80NSSC19K1581 (to S.R.).”
Lagatuz M, Vyas RJ, Predovic M, Lim S, Jacobs N, Martinho M, Valizadegan H, Kao D, Oza N, Theriot CA, Zanello SB, Taibbi G, Vizzeri G, Dupont M, Grant MB, Lindner DJ, Reinecker HC, Pinhas A, Chui TY, Rosen RB, Moldovan N, Vickerman MB, Radhakrishnan K, Parsons-Wingerter P.
Vascular patterning as integrative readout of complex molecular and physiological signaling by VESsel GENeration Analysis.
J Vasc Res. 2021 Apr 9;1-24. Review. Online ahead of print.
PI: P. Parsons-Wingerter
Note: This article may be obtained online without charge.
Journal Impact Factor: 1.725
Funding: “The research was supported by the US National Institutes of Health Awards R01HL110170 (MAB with PPW), R01EY027301 (TCY), DK-068181, DK-033506, AI093588, and DK-043351 (HCR); Department of Translational Hematology and Oncology Research, Cleveland Clinic Foundation (DJL); Marrus Family Foundation, New York Eye and Ear Infirmary Foundation (RBR), Indiana Institute for Medical Research and Richard L. Roudebush VA Medical Center (NM); and the National Aeronautics and Space Administration (NASA) support from the Vascularized Tissue Centennial Challenge (PPW, ML, and DK), Space Radiation Program (PPW and ML), NASA awards from STMD Game Changing Development (PPW, HV, NO, and DK), Ames Center Innovation Fund (PPW, DK, HV, and NO), and Human Research Program by NNJ12ZSA002N (PPW, GV, GT, and SBZ) and 80NSSC19K1699 (SBZ, CAT, and PPW).”
Holden S, Perez R, Hall R, Fallgren CM, Ponnaiya B, Garty G, Brenner DJ, Weil MM, Raber J.
Effects of acute and chronic exposure to a mixed field of neutrons and photons and single or fractionated simulated galactic cosmic ray exposure on behavioral and cognitive performance in mice.
Radiat Res. 2021 Apr 15. Online ahead of print.
PIs: M. Weil/J. Raber/NSCOR
Note: From the article: “In the current study, we assessed the effects of acute and chronic irradiation to a mixed field of neutrons and photons and single or fractionated simulated galactic cosmic ray exposure on behavioral and cognitive performance in mice. In addition, we assessed the effects of an aspirin-containing diet in the presence and absence of chronic exposure to a mixed field of neutrons and photons.”
Journal Impact Factor: 2.657
Funding: “This work was supported by NASA NSCOR grant no. NNX15AK13G. The Columbia IND Neutron Facility (CINF) is partially funded by the National Institute of Allergy and Infectious Diseases (NIAID), grant no. U19 AI067773.”
Nelson CB, Alturki TM, Luxton JJ, Taylor LE, Maranon DG, Muraki K, Murnane JP, Bailey SM.
Telomeric double strand breaks in G1 human cells facilitate formation of 5′ C-rich overhangs and recruitment of TERRA.
Front Genet. 2021 Mar 25;12:644803.
PI: S.M. Bailey
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.258
Funding: “The authors gratefully acknowledge funding from NASA (NNX14AB02G and 80NSSC19K0434).”
Yang DS, Saeedi A, Davtyan A, Fathi M, Sherman MB, Safari MS, Klindziuk A, Barton MC, Varadarajan N, Kolomeisky AB, Vekilov PG.
Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils.
Proc Natl Acad Sci USA. 2021 Mar 9;118(10):e2015618118.
PI: P.G. Vekilov
Note: From the abstract: “Here, we combine immunofluorescence three-dimensional confocal microscopy of human breast cancer cells with light scattering and transmission electron microscopy of solutions of the purified protein and molecular simulations to illuminate the mechanisms of phase transformations across multiple length scales, from cellular to molecular.”
Journal Impact Factor: 9.412
Funding: “This work was supported by the NIH (Award No. 1R21AI126215-01), the NSF (Award Nos. DMR-1710354 and DMR-1705464), Congressionally Directed Medical Research Programs (Award No. CA160591), Cancer Prevention and Research Institute of Texas (Award No. RP180466), Melanoma Research Alliance (Award No. 509800), and NASA (Award No. NNX14AD68G). Additional support was provided by the Center for Theoretical Biological Physics at Rice University sponsored by NSF (Grant PHY-1427654) and the Sealy Center for Structural Biology and Molecular Biophysics at the University of Texas Medical Branch.”
Wostyn P, Gibson CR, Mader TH.
The glymphatic pathway in the optic nerve: Did astronauts already reveal signs of its existence?
npj Microgravity. 2021 Apr 19;7(1):14.
Note: This article, available online without charge, is in reference to an article from Current Awareness List #919, which is available at
Journal Impact Factor: 3.380
Funding: No funding cited. C.R. Gibson is affiliated with NASA Johnson Space Center Space Medicine Operations Division.
Davila AF.
Life on Mars: Independent genesis or common ancestor?
Astrobiology. 2021 Apr 13. Online ahead of print.
Journal Impact Factor: 4.280
Funding: “Writing of this article was supported with funding from the NASA Internal Scientist Funding Model (ISFM).”
Other papers of interest:
Ong J, Lee AG, Moss HE.
Head-down tilt bed rest studies as a terrestrial analog for spaceflight associated neuro-ocular syndrome.
Front Neurol. 2021 Mar 26;12:648958. Review.
Note: Head-down tilt bed rest study. From the abstract: “In this paper, we review the HDTBR as an analog for SANS pathogenesis; the clinical and imaging overlap between SANS and HDTBR studies; and potential SANS countermeasures that have been or could be tested with HDTBR.” This article may be obtained online without charge.
Kume A, Kamachi H, Onoda Y, Hanba YT, Hiwatashi Y, Karahara I, Fujita T.
How plants grow under gravity conditions besides 1 g: Perspectives from hypergravity and space experiments that employ bryophytes as a model organism.
Plant Mol Biol. 2021 Apr 14. Review. Online ahead of print.
Note: ISS results. From the abstract: “In this review, we summarize our latest findings regarding P. patens growth response to hypergravity, with reference to our on-going ‘Space moss’ project. In our ground-based hypergravity experiments, we analyzed the morphological and physiological changes and found unexpected increments of chloroplast size and photosynthesis rate, which might underlie the enhancement of growth and increase in the number of gametophores and rhizoids. We further discussed our approaches at the cellular level and compare the gravity resistance in mosses and that in angiosperms. Finally, we highlight the advantages and perspectives from the space experiments and conclude that research with bryophytes is beneficial to comprehensively and precisely understand gravitational responses in plants.”
Wang Q, Dong L, Wang M, Chen S, Li S, Chen Y, He W, Zhang H, Zhang Y, Pires Dias AC, Yang S, Liu X.
Dammarane sapogenins improving simulated weightlessness-induced depressive-like behaviors and cognitive dysfunction in rats.
Front Psychiatry. 2021 Mar 26;12:638328.
Note: Hindlimb suspension and isolation study.
Zaharieva E, Sasatani M, Matsumoto R, Kamiya K.
Formation of DNA damage foci in human and mouse primary fibroblasts chronically exposed to gamma radiation at 0.1 mGy/min.
Radiat Res. 2021 Apr 15. Online ahead of print.
Fischer D, Klerman EB, Phillips AJK.
Measuring sleep regularity: Theoretical properties and practical usage of existing metrics.
Sleep. 2021 Apr 17:zsab103. Online ahead of print.
Hinkel-Lipsker JW, Stoehr NM, Lachica IJ, Rogers SM.
Gait adaptations to physical fatigue during the negotiation of variable and unexpected obstacles.
Hum Factors. 2021 Apr 14;187208211007588. Online ahead of print.
Vallee N, Dugrenot E, Desruelle AV, Tardivel C, Martin JC, Guernec A, Boussuges A, Rives S, Risso JJ, Guerrero F.
Evidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness.
Sci Rep. 2021 Apr 15;11(1):8317.
Note: This article may be obtained online without charge.
Zhang W, Cao Y, Chen S, Li F, Chen X, Liu Y.
Integrated metabolomics and network pharmacology approach to exploring the potential mechanism of Tianxiang Capsule for treating motion sickness.
J Ethnopharmacol. 2021 Jul 15;275:114107.

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