Status Report

NASA Spaceline Current Awareness List ##942 26 March 2021 (Space Life Science Research Results)

By SpaceRef Editor
March 26, 2021
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Basner M, Dinges DF, Howard K, Moore TM, Gur RC, Mühl C, Stahn AC.
Continuous and intermittent artificial gravity as a countermeasure to the cognitive effects of 60 days of head-down tilt bed rest.
Front Physiol. 2021 Mar 17;12:643854.
PI: A.C. Stahn
Note: Head-down tilt bed rest study. This article may be obtained online without charge.
Journal Impact Factor: 2.067
Funding: “This study was supported by NASA through 80NSSC18K0765 and NNJ14ZSA001N.”
Udho EB, Huebner SM, Albrecht DM, Matkowskyj KA, Clipson L, Hedican CA, Koth R, Snow SM, Eberhardt EL, Miller D, Van Doorn R, Gjyzeli G, Spengler EK, Storts DR, Thamm DH, Edmondson EF, Weil MM, Halberg RB, Bacher JW.
Tumor aggressiveness is independent of radiation quality in murine hepatocellular carcinoma and mammary tumor models.
Int J Radiat Biol. 2021 Mar 15;1-35. Online ahead of print.
Journal Impact Factor: 2.368
Funding: “This work was supported by NASA grant NNX15AK13G.”
McNulty MJ, Xiong YM, Yates K, Karuppanan K, Hilzinger JM, Berliner AJ, Delzio J, Arkin AP, Lane NE, Nandi S, McDonald KA.
Molecular pharming to support human life on the Moon, Mars, and beyond.
Crit Rev Biotechnol. 2021 Mar 9;1-16. Online ahead of print.
PI: K.A. McDonald
Journal Impact Factor: 8.108
Funding: “This material is based upon work supported by NASA under grant or cooperative agreement award number NNX17AJ31G. This work was also supported by a NASA Space Technology Research Fellowship (NASA grant number 80NSSC18K1157). KAM and SN would also like to acknowledge support by the Translational Research Institute through NASA NNX16AO69A.”
Other papers of interest:
Qiang J, Kang J, Liu Z.
[Analysis and enlightenment of human research results on ISS.]
Space Med Med Eng. 2021;(1):89-94. Chinese.
Note: ISS results. From the abstract: “The latest results of the human research program on ISS from October 2015 to October 2019 were summarized and analyzed including researches in cardiovascular system, brain, perception, cognition, psychology and the Twins Study, so as to provide references for the future space station missions of China.”
Ai J, Yang J, Zhu S, Chen X.
[Research progress in effects of weightlessness/simulated weightlessness on ocular structure and visual function.]
Space Med Med Eng. 2021;(1):75-9. Chinese.
Note: Head-down bed rest study. From the abstract: “In this paper, the effects of simulated weightlessness on the eye structure and visual function of animals, as well as the influence of head down bed rest and orbital flight on the eye structure and visual function of humans were summarized.”
Peng Y, Fei J, Guo Y, Zhao H, Yang Z.
[Effect of simulated weightlessness by head down bed rest on efficiency of pre-oxygenation in human.]
Space Med Med Eng. 2021;(1):7-11. Chinese.
Note: Head-down bed rest study. From the abstract: “Objective: To explore the influence of simulated weightlessness by head down bed rest (HDBR) on efficiency of pre-oxygenation in human, and to provide a basis for better assessment of the risk of decompression sickness in astronauts during extravehicular activity (EVA).”
Zhang H, Liu HY, Zhang CQ, Liu ZZ, Wang W.
Simulation of the mechanical behavior of osteons using artificial gravity devices in microgravity.
Comput Methods Biomech Biomed Engin. 2021 Mar 16;1-10. Online ahead of print.
Note: From the abstract: “Aviation medical research shows that disuse osteoporosis will occur after long-term space flight. Even with countermeasures such as exercise and drug treatments, this outcome cannot be avoided in flight. In recent years, the application of artificial gravity devices that change the mechanical microenvironment of bone in microgravity have shown promise in mitigating the risk of disuse osteoporosis. Considering the existence of osteocytes, a fluid-solid coupling finite element model for osteons with two-stage pore structure (Haversian canal, lacunar-canalicular system) was established.”
Jiang Y, Wang Y, Zhang X, Shi Y, Xu Z, Qin H, Li Y.
[Research on change process of individual emotions in the whole cycle of long-term head-down tilt bed rest.]
Space Med Med Eng. 2021;(1):18-24. Chinese.
Note: Head-down tilt bed rest study. From the abstract: “Objective: To track and evaluate the individual emotional changes in whole cycle under the condition of long-term head-down tilt bed rest (HDBR).”
Liu H, Ru N, Bai Y, Zhou Y, Wu Y, Xu H, Ma J, Su X.
[Simulated weightlessness may result in cerebral artery calcification in rats by altering OPG/RANKL/RANK system.]
Space Med Med Eng. 2021;(1):1-6. Chinese.
Note: Hindlimb unloading study. From the abstract: “Objective: To explore the effects of 4-week and 8-week simulated weightlessness by hindlimb unloading(HU) on cerebral artery calcification in rats and its underlying mechanisms.”
Huang C, Chen H, Song B, Qu L.
[Research progress on mutual regulation of redox homeostasis and clock genes and its application prospect in space medicine.]
Space Med Med Eng. 2021;(1):80-8. Chinese.
Note: From the abstract: “In this paper, the transcriptional oscillation of clock genes and non-transcriptional oscillation of redox were reviewed, the regulation relationship between them and the influence of microgravity on them were summarized.”
Zhivodernikov IV, Ratushnyy AY, Buravkova LB.
Secretory activity of mesenchymal stromal cells with different degree of commitment under conditions of simulated microgravity.
Bull Exp Biol Med. 2021 Feb;170(4):560-4.
Note: From the abstract: “We studied the effect of microgravity modeling during 10 days on paracrine activity of osteogenically committed and intact MSC. Cell response to simulated microgravity depended on the degree of commitment. The response of osteogenically committed MSC was less pronounced and manifested in increased production of sclerostin. In intact MSC, an increase in IL-8 and VEGF secretion and a decrease in osteoprotegerin level were detected. These changes can underlie the shift of bone homeostasis towards bone resorption.”
Bonnevie ED, Ashinsky BG, Dekky B, Volk SW, Smith HE, Mauck RL.
Cell morphology and mechanosensing can be decoupled in fibrous microenvironments and identified using artificial neural networks.
Sci Rep. 2021 Mar 15;11(1):5950.
Note: This article may be obtained online without charge.
Bansod YD, Kebbach M, Kluess D, Bader R, van Rienen U.
Finite element analysis of bone remodelling with piezoelectric effects using an open-source framework.
Biomech Model Mechanobiol. 2021 Mar 19. Online ahead of print.
Note: From the abstract: “The simulation results showed that the electrically stimulated bone surface enhanced bone deposition and these are in good agreement with previous findings from the literature. Moreover, mechanical stimuli due to daily physical activities could be supported by therapeutic electrical stimulation to reduce bone loss in case of physical impairment or osteoporosis.”
Yang J, Zhou S, Lv H, Wei M, Fang Y, Shang P.
Static magnetic field of 0.2  0.4 T promotes the recovery of hindlimb unloading-induced bone loss in mice.
Int J Radiat Biol. 2021 Mar 15;1-29. Online ahead of print.
Note: Hindlimb unloading study.
Li Y, Wang H, Chen S, Liu X, Li Y, Qu L, Wang Q.
[Study on learning and memory impairment in mice induced by chronic sleep interruption based on object recognition task.]
Space Med Med Eng. 2021;(1):25-30. Chinese.
Wilson MD, Ballard T, Strickland L, Amy Boeing A, Cham B, Griffin MA, Jorritsma K.
Understanding fatigue in a naval submarine: Applying biomathematical models and workload measurement in an intensive longitudinal design.
Appl Ergon. 2021 Jul;94:103412.
Kappert KDR, Voskuilen L, Smeele LE, Balm AJM, Jasperse B, Nederveen AJ, van der Heijden F.
Personalized biomechanical tongue models based on diffusion-weighted MRI and validated using optical tracking of range of motion.
Biomech Model Mechanobiol. 2021 Mar 7. Online ahead of print.
Mikelsaar M, Mändar R.
Commentary: Gut microbiome and space travelers’ health: State of the art and possible pro/prebiotic strategies for long-term space missions.
Front Physiol. 2021 Mar 23;12:350.
Note: This article, available online without charge, is a commentary on an article by Turroni et al., from Current Awareness List #915 available at From the abstract of this Commentary: “The paper of Turroni et al. (2020) has raised the important issue of maintaining the health and well-being of space travelers by supporting a well-functioning system of the host-microbiome in an extreme environment.” The Commentary article also belongs to the Special Topic Issue “Aerospace Health and Safety: Today and the Future,” available at to see all available articles. The Special Topic Issue also includes articles from previous Current Awareness Lists #873, #893, #897, #907, #910, #911, #918, #936, and #940

SpaceRef staff editor.