Status Report

NASA Spaceline Current Awareness List #940 12 March 2021 (Space Life Science Research Results)

By SpaceRef Editor
March 12, 2021
Filed under , , ,
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Barrila J, Sarker SF, Hansmeier N, Yang S, Buss K, Briones N, Park J, Davis RR, Forsyth RJ, Ott CM, Sato K, Kosnik C, Yang A, Shimoda C, Rayl N, Ly D, Landenberger A, Wilson SD, Yamazaki N, Steel J, Montano C, Halden RU, Cannon T, Castro-Wallace SL, Nickerson CA.
Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium.
npj Microgravity. 2021 Mar 9;7(1):9.
PI: C.A. Nickerson
Note: Space Shuttle results. From the abstract: “Here we report our results from the STL-IMMUNE study flown aboard Space Shuttle mission STS-131, which investigated multi-omic responses (transcriptomic, proteomic) of human intestinal epithelial cells to infection with Salmonella Typhimurium when both host and pathogen were simultaneously exposed to spaceflight.” This article may be obtained online without charge.
Journal Impact Factor: 3.380
Funding: “This work was funded by NASA grants NNX09AH40G (C.A.N., C.M.O., J.B.) and 80NSSC18K1478 (C.A.N., C.M.O., and J.B.; includes NASA PECASE funding to J.B.).”
Feiveson A, George K, Shavers M, Moreno-Villanueva M, Zhang Y, Babiak-Vazquez A, Crucian B, Semones E, Wu H.
Predicting chromosome damage in astronauts participating in International Space Station missions.
Sci Rep. 2021 Mar 5;11(1):5293.
PI: H. Wu
Note: ISS results. From the abstract: “Here, in a study of 43 crew-missions, we investigated whether individual radiosensitivity, as determined by the ex vivo dose–response of the pre-flight chromosome aberration rate (CAR), contributes to the prediction of the post-flight CAR incurred from the radiation exposure during missions.” This article may be obtained online without charge.
Journal Impact Factor: 3.998
Funding: “We would like to thank the NASA Human Research Program for endorsing the study. We would also like to thank Drs. Ianik Plante and Shaowen Hu of NASA Johnson Space Center (JSC) for their suggestions, and Dr. Francis Cucinotta of the University of Nevada at Las Vegas for directing the biodosimetry program while at JSC.” B. Crucian and H. Wu are affiliated with NASA Johnson Space Center.
Gamboa A, Branscum AJ, Olson DA, Sattgast LH, Iwaniec UT, Turner RT.
Effects of spaceflight on cancellous and cortical bone in proximal femur in growing rats.
Bone Rep. 2021 Feb 14;14:100755.
PI: R.T. Turner
Note: Space Shuttle results. From the abstract: “To test the generalizability of our initial observation, we evaluated archived proximal femora from two additional spaceflight missions: a 10-day mission (STS-57) with 7.5-week-old male Fisher 344 rats, and a 14-day mission (STS-62) with 12-week-old ovariectomized (ovx) female Fisher 344 rats.” This article may be obtained online without charge.
Journal Impact Factor: 3.4
Funding: “This work was supported by NASA (80NSSC19K0430 and NNX15AL15G).”
Laranjeiro R, Harinath G, Pollard AK, Gaffney CJ, Deane CS, Vanapalli SA, Etheridge T, Szewczyk NJ, Driscoll M.
Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans.
iScience. 2021 Jan 29;24(2):102105.
PI: S.A. Vanapalli
Note: ISS results. From the abstract: “Here, we exploited the unique experimental advantages of the nematode Caenorhabditis elegans to explore how spaceflight affects adult neurons in vivo. We found that animals that lived 5 days of adulthood on the International Space Station exhibited hyperbranching in PVD and touch receptor neurons. We also found that, in the presence of a neuronal proteotoxic stress, spaceflight promotes a remarkable accumulation of neuronal-derived waste in the surrounding tissues, suggesting an impaired transcellular degradation of debris released from neurons. Our data reveal that spaceflight can significantly affect adult neuronal morphology and clearance of neuronal trash, highlighting the need to carefully assess the risks of long-duration spaceflight on the nervous system and to develop adequate countermeasures for safe space exploration.” This article may be obtained online without charge.
Journal Impact Factor: 4.447
Funding: “We thank NASA’s Cold Stowage team (payload loading), the Biotechnology Space Support Center (BIOTESC; control of payload operations), and the crew of Expedition 57 (Alexander Gerst, Serena Auñón-Chancellor, and Sergey Prokopyev; payload handling). R.L., G.H., and M.D. thank Cousin Tina Lara for accommodations. We thank Sander van den Heuvel (Utrecht University) for permission to use the C. elegans microscopy image in the graphical abstract and Beata Edyta Mierzwa ( for permission to use the Molecular Muscle Experiment mission logo in the Graphical Abstract. We thank the UK Space Agency, the European Space Agency (ESA), the Japan Aerospace Exploration Agency (JAXA), and the National Aeronautics and Space Administration (NASA) for their support of the Molecular Muscle Experiment. This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC United Kingdom) (Grant Nos. BB/N015894/1) and the European Space Agency (ESA) (designations Molecular Muscle Experiment and ESA-14-ISLRA_Prop-0029). S.A.V. acknowledges support from the National Aeronautics and Space Administration (NASA) (Grant No. NNX15AL16G).”
Lee MD, O’Rourke A, Lorenzi H, Bebout BM, Dupont CL, Everroad RC.
Reference-guided metagenomics reveals genome-level evidence of potential microbial transmission from the ISS environment to an astronaut’s microbiome.
iScience. 2021 Feb 19;24(2):102114.
PIs: M.D. Lee, A. O’Rourke, H. Lorenzi
Note: ISS results. From the abstract: “This work highlights the value in generating genomic libraries of microbes from built-environments such as the ISS and demonstrates one way such data can be integrated with metagenomics to facilitate the tracking and monitoring of astronaut microbiomes and health.” This article may be obtained online without charge.
Journal Impact Factor: 4.447
Funding: “Funding for this work was provided to M.D.L. by NASA Space Biology (NNH16ZTT001N-MOBE), A.O.’R. by NASA Space Biology (80NSSC17K0035), and H.L. by NASA Human Research Program (NNX12AB02G). Isolates recovered from the ISS by NASA were provided to authors M.D.L. and A.O.’R as part of their respective grants noted above.”
Vroom MM, Rodriguez-Ocasio Y, Lynch JB, Ruby EG, Foster JS.
Modeled microgravity alters lipopolysaccharide and outer membrane vesicle production of the beneficial symbiont Vibrio fischeri.
npj Microgravity. 2021 Mar 8;7(1):8.
PI: J.S. Foster
Note: High aspect ratio rotating vessels (HARVs) were used. This article may be obtained online without charge.
Journal Impact Factor: 3.380
Funding: “This work was supported in part by the NASA Space Biology program (80NSSC18K1465) and Florida Space Institute Space Research Initiative awarded to J.S.F. MMV was supported in part by a Dissertation Improvement Fellowship and a NASA Florida Space Grant Consortium Scholarship award from the NASA Florida Space Grant Consortium. Y.R.O. was supported by a National Science Foundation STEP award (DUE 1161177). J.B.L. was supported by National Institutes of Health grant F32 GM119238.”
Azadan RJ, Agha NH, Kunz HE, Baker FL, Mylabathula PL, Ledoux TA, O’Connor DP, Pedlar CR, Simpson RJ.
The effects of normoxic endurance exercise on erythropoietin (EPO) production and the impact of selective β1 and non-selective β1 + β2 adrenergic receptor blockade.
Eur J Appl Physiol. 2021 Mar 1. Online ahead of print.
Journal Impact Factor: 2.580
Funding: “This work was supported by National Institute of Health (NIH) Grant R21 CA197527-01A1 to R.J. Simpson and American College of Sports Medicine (ACSM) National Aeronautics and Space Administration (NASA) Foundational Research Grant to N. Agha.”
Reed J, Kirkman LA, Kafsack BF, Mason CE, Deitsch KW.
Telomere length dynamics in response to DNA damage in malaria parasites.
iScience. 2021 Jan 20;24(2):102082.
PI: C.E. Mason
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.447
Funding: “The Department of Microbiology and Immunology at Weill Medical College of Cornell University acknowledges the support of the William Randolph Hearst Foundation. This work was supported by the National Institutes of Health (AI 52390 to K.W.D., AI 99327 to K.W.D. and L.A.K., AI76635 to L.A.K., AI141965 to B.F.K.). K.W.D. is a Stavros S. Niarchos Scholar and a recipient of a William Randolf Hearst Endowed Faculty Fellowship. L.A.K. received support from the William Randolph Hearst Foundation as a Clinical Scholar in Microbiology and Infectious Diseases. We would also like to thank funding from the Bert L. & N. Kuggie Vallee Foundation to C.E.M., the WorldQuant Foundation to C.E.M., The Pershing Square Sohn Cancer Research Alliance to C.E.M., NASA (NNX14AH50G) to C.E.M., the National Institutes of Health (R01ES021006, 1R21AI129851, 1R01MH117406) to C.E.M., TRISH (NNX16AO69A:0107, NNX16AO69A:0061) to C.E.M., The Bill and Melinda Gates Foundation (OPP1151054) to C.E.M., and the Leukemia and Lymphoma Society (LLS) grants (LLS 9238-16, LLS-MCL-982) to C.E.M.”
McFadden MJ, McIntyre ABR, Mourelatos H, Abell NS, Gokhale NS, Ipas H, Xhemalçe B, Mason CE, Horner SM.
Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine.
Cell Rep. 2021 Mar 2;34(9):108798.
PI: C.E. Mason
Note: This article may be obtained online without charge.
Journal Impact Factor: 8.109
Funding: “This work was supported by Burroughs Wellcome Fund (S.M.H.) and National Institutes of Health grants R01AI125416, R21AI129851 (S.M.H. and C.E.M.), R01MH117406 (C.E.M.), T32-CA009111 (M.J.M.), and R01- GM127802 (B.X.). Other funding sources include National Science and Engineering Research Council of Canada (A.B.R.M., PGS-D funding); American Heart Association (N.S.G., Pre-doctoral Fellowship, 17PRE33670017); National Institute of General Medical Sciences of the National Institutes of Health Medical Scientist Training Program grant to the Weill Cornell/Rockefeller/ Sloan Kettering Tri-Institutional MD-PhD Program (H.M., T32GM007739); Bert L. and N. Kuggie Vallee Foundation; WorldQuant Foundation; Pershing Square Sohn Cancer Research Alliance; and NASA (NNX14AH50G).”
Garikipati VNS, Arakelyan A, Blakely EA, Chang PY, Truongcao MM, Cimini M, Malaredy V, Bajpai A, Addya S, Bisserier M, Brojakowska A, Eskandari A, Khlgatian MK, Hadri L, Fish KM, Kishore R, Goukassian DA.
Long-term effects of very low dose particle radiation on gene expression in the heart: Degenerative disease risks.
Cells. 2021 Feb 13;10(2):387.
PIs: E.A. Blakely, D.A. Goukassian
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.366
Funding: “This research was funded by NASA grant no. 80NSSC19K1078 (formerly 80NSSC17K0112) to D.A.G. and by NASA grant no. NNJ11HA94I to E.B. and P.C, under contract DEAC02-05CH11231 with the US Department of Energy. Additional support was provided in part by NASA grant no. 80NSSC19K1079 (formerly 80NSSC18K0921) to D.A.G. and by NIH National Heart, Lung, and Blood Institute (NHLBI) grant nos. HL091983, HL143892, and HL134608t to R.K.”
Other papers of interest:
Manian V, Orozco J, Gangapuram H, Janwa H, Agrinsoni C.
Network analysis of gene transcriptions of Arabidopsis thaliana in spaceflight microgravity.
Genes (Basel). 2021 Feb 25;12(3):337.
Note: ISS results. From the abstract: “The transcriptomic datasets of the plant model organism Arabidopsis thaliana grown in the International Space Station provided by GeneLab have been mined to isolate the impact of spaceflight microgravity on gene expressions related to root growth.” This article may be obtained online without charge.
Meerman M, Bracco Gartner TCL, Buikema JW, Wu SM, Siddiqi S, Bouten CVC, Grande-Allen KJ, Suyker WJL, Hjortnaes J.
Myocardial disease and long-distance space travel: Solving the radiation problem.
Front Cardiovasc Med. 2021;8:631985. Review.
Note: This article may be obtained online without charge.
Orlovska I, Podolich O, Kukharenko O, Zaets I, Reva O, Khirunenko L, Zmejkoski D, Rogalsky S, Barh D, Tiwari S, Kumavath R, Góes-Neto A, Azevedo V, Brenig B, Ghosh P, de Vera JP, Kozyrovska N.
Bacterial cellulose retains robustness but its synthesis declines after exposure to a Mars-like environment simulated outside the International Space Station.
Astrobiology. 2021 Feb 26 Online ahead of print.
Note: From the abstract: “The pristine cellulose-based pellicle membranes from a kombucha microbial community (KMC) were exposed outside the International Space Station.”
Wise PM, Neviani P, Riwaldt S, Corydon TJ, Wehland M, Braun M, Krüger M, Infanger M, Grimm D.
Changes in exosome release in thyroid cancer cells after prolonged exposure to real microgravity in space.
Int J Mol Sci. 2021 Feb 21;22(4):2132.
Note: ISS results. The article belongs to the Special Issue “Microgravity and Space Medicine,” available at From the abstract: “Here, we studied supernatants harvested from the CellBox-1 experiment, which featured human thyroid cancer cells flown to the International Space Station during the SpaceX CRS-3 cargo mission.” This article may be obtained online without charge.
Xue X, Ali YF, Luo W, Liu C, Zhou G, Liu N-A.
Biological effects of space hypomagnetic environment on circadian rhythm.
Front Physiol. 2021 Mar 9;12(254).
Note: This article may be obtained online without charge.
Sun Y, Kuang Y, Zuo Z.
The emerging role of macrophages in immune system dysfunction under real and simulated microgravity conditions.
Int J Mol Sci. 2021 Feb 26;22(5):2333. Review.
Note: Review includes brief results from several spaceflight missions and various simulation methods. From the abstract: “The purpose of this review is to summarize recent advances on the dysfunction of macrophages arisen from microgravity and to discuss the mechanisms of these abnormal responses.” This article may be obtained online without charge.
Opsomer L, Crevecoeur F, Thonnard JL, McIntyre J, Lefèvre P.
Distinct adaptation patterns between grip dynamics and arm kinematics when the body is upside-down.
J Neurophysiol. 2021 Mar 3. Online ahead of print.
Milojevic T, Kish A, Yamagishi A.
Editorial: Astrobiology at the interface: Interactions between biospheres, geospheres, hydrospheres and atmospheres under planetary conditions.
Front Microbiol. 2021;12:629961. Editorial.
Note: This article may be obtained online without charge.
Verseux C, Heinicke C, Ramalho TP, Determann J, Duckhorn M, Smagin M, Avila M.
A low-pressure, N2/CO2 atmosphere is suitable for cyanobacterium-based life-support systems on Mars.
Front Microbiol. 2021;12:611798.
Note: This article may be obtained online without charge.
Knecht RS, Bucher CH, Van Linthout S, Tschöpe C, Schmidt-Bleek K, Duda GN.
Mechanobiological principles influence the immune response in regeneration: Implications for bone healing.
Front Bioeng Biotechnol. 2021;9:614508. Review.
Note: This article may be obtained online without charge.
Wiegmann S, Felsenberg D, Armbrecht G, Dietzel R.
Longitudinal changes in muscle power compared to muscle strength and mass.
J Musculoskelet Neuronal Interact. 2021 Mar 1;21(1):13-25.
Note: This article may be obtained online without charge.
Barnard SGR, McCarron R, Mancuso M, De Stefano I, Pazzaglia S, Pawliczek D, Dalke C, Ainsbury EA.
Radiation-induced DNA damage and repair in lens epithelial cells of both Ptch1(+/-) and Ercc2(+/-) mutated mice.
Radiat Res. 2021 Mar 2. Online ahead of print.
Chen K, Wu R, Mo B, Yan X, Shen D, Chen M.
Comparison between liraglutide alone and liraglutide in combination with insulin on osteoporotic rats and their effect on bone mineral density.
J Musculoskelet Neuronal Interact. 2021 Mar 1;21(1):142-8.
Note: This article may be obtained online without charge.
Marucci M, Di Flumeri G, Borghini G, Sciaraffa N, Scandola M, Pavone EF, Babiloni F, Betti V, Aricò P.
The impact of multisensory integration and perceptual load in virtual reality settings on performance, workload and presence.
Sci Rep. 2021 Mar 1;11(1):4831.
Note: This article may be obtained online without charge.
Qiao H, Zhang J, Zhang L, Li Y, Loft S.
Exploring the peak-end effects in air traffic controllers’ mental workload ratings.
Hum Factors. 2021 Mar 3:18720821994355. Online ahead of print.

SpaceRef staff editor.