Status Report

NASA Spaceline Current Awareness List #939 5 March 2021 (Space Life Science Research Results)

By SpaceRef Editor
March 5, 2021
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Papers deriving from NASA support:
Pramanik A, Gao Y, Patibandla S, Mitra D, McCandless MG, Fassero LA, Gates K, Tandon R, Ray PC.
Aptamer conjugated gold nanostar-based distance-dependent nanoparticle surface energy transfer spectroscopy for ultrasensitive detection and inactivation of corona virus.
J Phys Chem Lett. 2021 Mar 4;12(8):2166-2171. Online ahead of print.
PI: R. Tandon
Journal Impact Factor: 6.710
Funding: “P.C.R. is supported by NSF-RAPID Grant No. DMR-2030439 and NSF-PREM Grant No. DMR-1826886. P.C.R. acknowledges NIH-NIMHD Grant No. 1U54MD015929-01 for cell culture, bioimaging, and biological assay facilities. R.T. is supported by NASA award (80NSSC19K1603) and COVID-19 funds from his institute.”
Ellwood RA, Hewitt JE, Torregrossa R, Philp AM, Hardee JP, Hughes S, van de Klashorst D, Gharahdaghi N, Anupom T, Slade L, Deane CS, Cooke M, Etheridge T, Piasecki M, Antebi A, Lynch GS, Philp A, Vanapalli SA, Whiteman M, Szewczyk NJ.
Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model.
Proc Natl Acad Sci USA. 2021 Mar 2;118(9):e2018342118.
PI: S.A. Vanapalli
Journal Impact Factor: 9.412
Funding: “R.A.E. was supported by the University of Nottingham School of Medicine. J.E.H. was supported by the Fulbright U.S. Student Program and the Germanistic Society of America. C.S.D. was supported by Medical Research Council (MRC) Grant MR/T026014/1. S.A.V. was supported by NASA Grant NNX15AL16G. This work was partially supported by Biotechnology and Biological Sciences Research Council Grant BB/N015894/1, MRC Grant MR/S002626/1 (to M.W.), United Mitochondrial Disease Foundation Grant PI-19-0985 (to M.W. and T.E.), the Brian Ridge Scholarship (R.T.), and the University of Exeter Diamond Jubilee Scholarship (L.S.). This research was also supported by MRC Versus Arthritis Centre for Musculoskeletal Ageing Research Grants MR/P021220/1 and MR/R502364/1 and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre. A.M.P. was supported by a Graham Painton Foundation Fellowship from University of New South Wales Sydney. J.P.H. was supported by a McKenzie Research Fellowship from The University of Melbourne. This work was supported by National Health and Medical Research Council Grant GNT1124474 (to G.S.L.). A.P. was supported by the Al and Val Rosenstrauss Fellowship from the Rebecca L. Cooper Medical Research Foundation. N.J.S. was supported by the Osteopathic Heritage Foundation.”
Shuryak I, Brenner DJ.
Quantitative modeling of multigenerational effects of chronic ionizing radiation using targeted and nontargeted effects.
Sci Rep. 2021 Feb 26;11(1):4776.
PI: D.J. Brenner
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.998
Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) Grant NNX16AR81A.”
Malone SK, Peleckis AJ, Grunin L, Yu G, Jang S, Weimer J, Lee I, Rickels MR, Goel N.
Characterizing glycemic control and sleep in adults with long-standing type 1 diabetes and hypoglycemia unawareness initiating hybrid closed loop insulin delivery.
J Diabetes Res. 2021 Feb 12;2021:6611064.
PI: N. Goel
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.965
Funding: “The authors would like to acknowledge support from the Human Metabolism Resource of the Institute for Diabetes, Obesity & Metabolism at the University of Pennsylvania. This work was supported by the National Institutes of Health (R01DK117488 (NG), R01DK091331 (MRR), K99NR017416 (SKM), and UL1TR001878 (University of Pennsylvania Center for Human Phenomic Science)). Other support was provided by the National Aeronautics and Space Administration (NASA) (NNX14AN49G and 80NSSC20K0243 (NG)) and from the Pennsylvania Department of Health (SAP 4100079750 (IL)).”
Smith MG, Wusk GC, Nasrini J, Baskin P, Dinges DF, Roma PG, Basner M.
Effects of six weeks of chronic sleep restriction with weekend recovery on cognitive performance and wellbeing in high-performing adults.
Sleep. 2021 Feb 25;zsab051. Online ahead of print.
PIs: P.G. Roma, M. Basner
Journal Impact Factor: 4.805
Funding: “MGS, JN, MB, and DFD are supported by NASA through NNX14AH98G and by the National Space Biomedical Research Institute (NSBRI) through grant NBPF00012 (NASA NCC 9-58). GCW is supported by the NASA Space Technology Research Fellowship program of the Space Technology Mission Directorate. PGR and PB are supported by KBR’s Human Health and Performance Contract NNJ15HK11B through the National Aeronautics and Space Administration. This project was supported by NASA Human Research Program Directed Projects Identification and Validation of HFBP Exploration Measures in HERA for Transport and HFBP Exploration Measures in HERA for Mars (PI: PG Roma).”
Day JA, Diener C, Otwell AE, Tams KE, Bebout B, Detweiler AM, Lee MD, Scott MT, Ta W, Ha M, Carreon SA, Tong K, Ali AA, Gibbons SM, Baliga NS.
Lettuce (Lactuca sativa) productivity influenced by microbial inocula under nitrogen-limited conditions in aquaponics.
PLoS One. 2021 Feb 23;16(2):e0247534.
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.740
Funding: “This research was possible due to the support and resources provided by Ray Williams and the Black Farmers Collective, Jeff King and the Microsoft Giving Campaign, Fred Hutchinson Cancer Research Center, Seattle Youth Employment Program, CrowdRise donors, the National Science Foundation (NSF MSB-1237267, MCB-1616955, MCB-1518261, DB-1262637, DB-1565166, MCB-1330912), a Washington Research Foundation Distinguished Investigator Award (supporting CD and SMG), and a Scientific Innovation Fund grant from the NASA Office of the Chief Scientist to Brad M. Bebout.”
Vangay P, Burgin J, Johnston A, Beck KL, Berrios DC, Blumberg K, Canon S, Chain P, Chandonia JM, Christianson D, Costes SV, Damerow J, Duncan WD, Dundore-Arias JP, Fagnan K, Galazka JM, Gibbons SM, Hays D, Hervey J, Hu B, Hurwitz BL, Jaiswal P, Joachimiak MP, Kinkel L, Ladau J, Martin SL, McCue LA, Miller K, Mouncey N, Mungall C, Pafilis E, Reddy TBK, Richardson L, Roux S, Shaffer JP, Sundaramurthi JC, Thompson LR, Timme RE, Zheng J, Wood-Charlson EM, Eloe-Fadrosh EA.
Microbiome metadata standards: Report of the National Microbiome Data Collaborative’s workshop and follow-on activities.
mSystems. 2021 Feb 23;6(1):e01194-20. 
Note: This article may be obtained online without charge.
Journal Impact Factor: 6.28
Funding: “The NMDC is supported by the Genomic Science Program in the United States Department of Energy, Office of Science, Office of Biological and Environmental Research (BER) under contract numbers DE-AC02-05CH11231 (LBNL), 89233218CNA000001 (LANL), DE-AC05-00OR22725 (ORNL), and DE-AC05-76RL01830 (PNNL). S.V.C., D.C.B., and J.M.G. were funded by the Space Biology Program (Science Mission Directorate, Biological and Physical Sciences Division) of the National Aeronautics and Space Administration. J.H. was supported by internal Basic Research programs (Work Units 4888 and 1L73) at the U.S. Naval Research Laboratory. A.J. was supported by the Intramural Research Program of the National Library of Medicine, National Institutes of Health. The work of J.P.S. was supported by NIH-SD-IRACDA (5K12GM068524-17). S.M.G. was supported by a Washington Research Foundation Distinguished Investigator Award.”
Miry O, Zhang XL, Vose LR, Gopaul KR, Subah G, Moncaster JA, Wojnarowicz MW, Fisher AM, Tagge CA, Goldstein LE, Stanton PK.
Life-long brain compensatory responses to galactic cosmic radiation exposure.
Sci Rep. 2021 Feb 22;11(1):4292. 
PIs: L.E. Goldstein, P.K. Stanton 
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.998
Funding: “This work was supported by NASA grants NNX13AB66G (P.K.S.) and NNX11AR05G (L.E.G.). We wish to thank Dr. Eleanor Blakely for invaluable assistance in dose selection and beam physics, Dr. Adam Rusek, Dr. Michael Sivertz and Dr. Chiara La Tessa for equally invaluable technical assistance in performance of these experiments, and the entire NASA Space Radiation Laboratory and Animal Facility at Brookhaven National Laboratory for their extraordinary work in enabling space radiation biology research at the highest level in the world.”
Basner M, Stahn AC, Nasrini J, Dinges DF, Moore TM, Gur RC, Mühl C, Macias BR, Laurie SS.
Effects of head-down tilt bed rest plus elevated CO2 on cognitive performance.
J Appl Physiol (1985). 2021 Feb 25. Online ahead of print.
PI: M. Basner 
Note: Head-down tilt bed rest study.
Journal Impact Factor: 3.044
Funding: “This study was supported by NASA through grants 80NSSC18K0765 and NNJ14ZSA001N.”
Other papers of interest:
Acres JM, Youngapelian MJ, Nadeau J.
The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis.
npj Microgravity. 2021 Feb 22;7(1):7. Review.
Note: From the article: “This review begins by summarizing the technologies available for simulating microgravity, with some recent analysis of the fluid mechanics of spaceflight analog devices. The possible effects of the different types of vessels on microorganisms apart from their simulation of weightlessness are discussed, as well as other complications that may arise from attempting to compare groundbased with ISS-based microbial gene expression studies.” This article may be obtained online without charge.
Mohammadyari P, Gadda G, Taibi A.
Modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth.
Sci Rep. 2021 Feb 25;11(1):4672.
Note: Head-down tilt bed rest study. From the abstract: “In this study we modelled the human haemodynamics with focus on head and neck exposed to different hydrostatic pressures in supine, upright (head-up tilt), head-down tilt position, and microgravity environment by using a well-developed 1D-0D haemodynamic model. The model consists of two parts that simulates the arterial (1D) and brainvenous (0D) vascular tree.” This article may be obtained online without charge.
Chen Y, Xu C, Zhong C, Lyu Z, Liu J, Chen Z, Dun H, Xin B, Xie Q.
Temporal characteristics of the oropharyngeal and nasal microbiota structure in crewmembers stayed 180 days in the controlled ecological life support system.
Front Microbiol. 2021 Feb 3;11:617696.
Note: The Chinese Controlled Ecological Life Support System (CELSS) was used in this study. This article may be obtained online without charge.
Hamilton MCK, Neumann S, Szantho G, Rydon L, Lawton CB, Hart E, Manghat NE, Turner MS.
The design and use of a simple device for the MRI assessment of changes in cardiovascular function by lower-body negative-pressure-simulated reduction of central blood volume.
Clin Radiol. 2021 Feb 23;S0009-9260(21)00077-5. Online ahead of print.
Domogauer JD, de Toledo SM, Howell RW, Azzam EI.
Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity.
Cell Commun Signal. 2021 Feb 26;19(1):30.
Note: This article may be obtained online without charge.
Wada T.
Computational model of motion sickness describing the effects of learning exogenous motion dynamics.
Front Syst Neurosci. 2021 Feb 9;15:634604.
Note: This article may be obtained online without charge.
Brauns K, Friedl-Werner A, Maggioni MA, Gunga HC, Stahn AC.
Head-down tilt position, but not the duration of bed rest affects resting state electrocortical activity.
Front Physiol. 2021 Feb 24.
Note: Head-down tilt bed rest study. This article may be obtained online without charge.
Culliton K, Louati H, Laneuville O, Ramsay T, Trudel G.
Six degrees head-down tilt bed rest caused low-grade hemolysis: A prospective randomized clinical trial.
npj Microgravity. 2021 Feb 15;7(1):4.
Note: Head-down tilt bed rest study. This article may be obtained online without charge.
De Pascale S, Arena C, Aronne G, De Micco V, Pannico A, Paradiso R, Rouphael Y.
Biology and crop production in Space environments: challenges and opportunities.
Life Sci Space Res. 2021 Mar 2. Online ahead of print.
Inns TB, McCormick D, Greig CA, Atherton PJ, Phillips BE, Piasecki M.
Factors associated with electrical stimulation-induced performance fatigability are dependent upon stimulation location.
Exp Physiol. 2021 Feb 26. Online ahead of print.
Dong L, Song Y, Zhang Y, Zhao W, Wang C, Lin H, Al-Ani MK, Liu W, Xue R, Yang L.
Mechanical stretch induces osteogenesis through the alternative activation of macrophages.
J Cell Physiol. 2021 Feb 26. Online ahead of print.

SpaceRef staff editor.