NASA Spaceline Current Awareness List #938 26 February 2021 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm . Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Papers deriving from NASA support:
1
Gabel L, Liphardt AM, Hulme PA, Heer M, Zwart SR, Sibonga JD, Smith SM, Boyd S.
Pre-flight exercise and bone metabolism predict unloading-induced bone loss due to spaceflight.
Br J Sports Med. 2021 Feb 17;bjsports-2020-103602. Online ahead of print.
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 12.68
Funding: “The biomarker data were shared from the Biochemistry Profile project, which was funded by the NASA Human Research Program’s Human Health Countermeasures Element.” J.D. Sibonga and S.M. Smith are affiliated with NASA Johnson Space Center.
2
Greene KA, Withers SS, Lenchik L, Tooze JA, Weaver AA.
Trunk skeletal muscle changes on CT with long-duration spaceflight.
Ann Biomed Eng. 2021 Feb 18. Online ahead of print.
PI: A.A. Weaver
Note: ISS results.
Journal Impact Factor: 3.324
Funding: “Funding was provided by the NASA Human Research Program (NNX16AP89G). Katelyn Greene is supported by a NIH/NIA Predoctoral Fellowship (F31 AG069414), and Dr. Ashley Weaver is supported by a NIH/NIA Career Development Award (K25 AG058804).”
3
Roy-O’Reilly M, Mulavara A, Williams T.
A review of alterations to the brain during spaceflight and the potential relevance to crew in long-duration space exploration.
NPJ Microgravity. 2021 Feb 16;7(1):5. Review.
Note: From the article: “This review summarizes the current findings of neuroimaging-evaluated changes to the brain after spaceflight, and includes comparison to data from spaceflight analog studies. We have also reviewed the evidence indicating that mission duration is a key factor in spaceflight-associated brain alterations, and have highlighted potential sources of CNS-related risk to crew performance during spaceflight.” This article may be obtained online without charge.
Journal Impact Factor: 0.994
Funding: “Published in cooperation with the Biodesign Institute at Arizona State University, with the support of NASA.” T. Williams is affiliated with NASA Johnson Space Center.
4
Roberts DR, Collins HR, Lee JK, Taylor JA, Turner M, Zaharchuk G, Wintermark M, Antonucci MU, Mulder ER, Gerlach DA, Asemani D, McGregor HR, Seidler RD.
Altered cerebral perfusion in response to chronic mild hypercapnia and head-down tilt bed rest as an analog for spaceflight.
Neuroradiology. 2021 Feb 15. Online ahead of print.
PI: D.R. Roberts
Note: Head-down tilt bed rest study.
Journal Impact Factor: 2.238
Funding: “This study was funded by the National Aeronautics and Space 539 Administration (NASA), grant # NNX13AJ92G.”
5
Rosahl SC, Covarrubias C, Wu JH, Urquieta E.
Staying cool in space: A review of therapeutic hypothermia and potential application for space medicine.
Ther Hypothermia Temp Manag. 2021 Feb 22. Online ahead of print.
Journal Impact Factor: 1.333
Funding: “E.U. and J.H.W. were supported by the Translational Research Institute for Space Health through NASA NNX16AO69A. None of the authors has a financial or proprietary interest in any material or method mentioned.”
6
Song Y, Min J, Yu Y, Wang H, Yang Y, Zhang H, Gao W.
Wireless battery-free wearable sweat sensor powered by human motion.
Sci Adv. 2020 Sep 30;6(40):eaay9842.
PI: W. Gao
Note: This article may be obtained online without charge.
Journal Impact Factor: 13.116
Funding: “This work was supported by the California Institute of Technology Startup Grant and the Translational Research Institute through NASA NNX16AO69A. We gratefully acknowledge critical support and infrastructure provided for this work by the Kavli Nanoscience Institute at Caltech.”
7
Padgen MR, Liddell LC, Bhardwaj SR, Gentry D, Marina D, Parra M, Boone T, Tan M, Ellingson L, Rademacher A, Benton J, Schooley A, Friedericks C, Hanel RP, Ricco AJ, Bhattacharya S, Maria SRS.
BioSentinel: A biofluidic nanosatellite monitoring microbial growth and activity in deep space.
Astrobiology. 2021 Feb 18. Online ahead of print.
Journal Impact Factor: 4.280
Funding: “This work was supported by NASA’s Advanced Exploration Systems (AES) Program Office.” M.R. Padgen, L.C. Liddell, S.R. Bhardwaj, D. Gentry, D. Marina, M. Parra, T. Boone, M. Tan, L. Ellingson, A. Rademacher, J. Benton, A. Schooley, C. Friedericks, R.P. Hanel, A.J. Ricco, S. Bhattacharya, and S.R.S. Maria are affiliated with NASA Ames Research Center.
8
Sapoval N, Mahmoud M, Jochum M, Liu Y, Elworth RAL, Wang Q, Albin D, Ogilvie H, Lee MD, Villapol S, Hernandez K, Maljkovic Berry I, Foox J, Beheshti A, Ternus K, Aagaard K, Posada D, Mason C, Sedlazeck FJ, Treangen TJ.
Hidden genomic diversity of SARS-CoV-2: Implications for qRT-PCR diagnostics and transmission.
Genome Res. 2021 Feb 18;gr.268961.120. Online ahead of print.
PI: A. Beheshti
Note: Update of: Hidden genomic diversity of SARS-CoV-2: implications for qRT-PCR diagnostics and transmission. Sapoval N, Mahmoud M, Jochum MD, Liu Y, Elworth RAL, Wang Q, Albin D, Ogilvie H, Lee MD, Villapol S, Hernandez KM, Berry IM, Foox J, Beheshti A, Ternus K, Aagaard KM, Posada D, Mason CE, Sedlazeck F, Treangen TJ. bioRxiv. 2020 Jul 2:2020.07.02.184481. doi: 10.1101/2020.07.02.184481. Preprint. PMID: 32637955. This article was previously in CA #907 as a preprint in the bioRxiv preprint server. This article may be obtained online without charge.
Journal Impact Factor: 11.093
Funding: “N.S. and Y.L. are supported by the Department of Computer Science, Rice University. Q.W., D.A., T.J.T, and R.A.L.E. are supported by startup funds from Rice University. M.J. is supported under NIH award No. R01HD091731 from the NICHD. F.J.S. acknowledges funding and part of the data was produced by Baylor College of Medicine under NIAID (U19AI144297-01). A.B. is supported by supplemental funds for COVID-19 research from Translational Research Institute through NASA Cooperative Agreement NNX16AO69A (T-0404) and further funding was provided by KBR, Inc. D.P. is supported by the European Research Council (ERC-617457-PHYLOCANCER), Spanish Ministry of Economy and Competitiveness, and Xunta de Galicia.”
_____________________________________________________
Other papers of interest:
1
Dong J, Wang H, Li G, Wang K, Tan Y, Zhang L, Wang Y, Hu Z, Cao X, Shi F, Zhang S.
The combined effects of simulated microgravity and X-ray radiation on MC3T3-E1 cells and rat femurs.
NPJ Microgravity. 2021 Feb 15;7(1):3.
Note: A clinostat was used. This article may be obtained online without charge.
2
Gibbons TD, Ainslie PN, Thomas KN, Wilson LC, Akerman AP, Donnelly J, Campbell HA, Cotter JD.
Influence of the mode of heating on cerebral blood flow, non-invasive intracranial pressure and thermal tolerance in humans.
J Physiol. 2021 Feb 14. Online ahead of print.
3
Ilieva V, Steel B, Pratscher J, Olsson-Francis K, Macey MC.
Assembly of bacterial genome sequences from metagenomes of spacecraft assembly cleanrooms.
Microbiol Resour Announc. 2021 Feb 18;10(7):e01439-20.
Note: This article may be obtained online without charge.
4
Bashir AK, Wink L, Duller S, Schwendner P, Cockell C, Rettberg P, Mahnert A, Beblo-Vranesevic K, Bohmeier M, Rabbow E, Gaboyer F, Westall F, Walter N, Cabezas P, Garcia-Descalzo L, Gomez F, Malki M, Amils R, Ehrenfreund P, Monaghan E, Vannier P, Marteinsson V, Erlacher A, Tanski G, Strauss J, Bashir M, Riedo A, Moissl-Eichinger C.
Taxonomic and functional analyses of intact microbial communities thriving in extreme, astrobiology-relevant, anoxic sites.
Microbiome. 2021 Feb 18;9(1):50.
Note: This article may be obtained online without charge.
5
Stoye E.
Daily briefing: ESA is recruiting the first astronauts with disabilities.
Nature. 2021 Feb 17. Online ahead of print.
6
Carrasco-Leon A, Ezponda T, Meydan C, Valcárcel LV, Ordoñez R, Kulis M, Garate L, Miranda E, Segura V, Guruceaga E, Vilas-Zornoza A, Alignani D, Pascual M, Amundarain A, Castro-Labrador L, Martín-Uriz PS, El-Omri H, Taha RY, Calasanz MJ, Planes FJ, Paiva B, Mason CE, San Miguel JF, Martin-Subero JI, Melnick A, Prosper F, Agirre X.
Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma.
Leukemia. 2021 Feb 17. Online ahead of print.
7
Small E, Juul N, Pomeranz D, Burns P, Phillips C, Cheffers M, Lipman GS.
Predictive capacity of pulmonary function tests for acute mountain sickness.
High Alt Med Biol. 2021 Feb 18. Online ahead of print.
8
Holloway PM, Willaime-Morawek S, Siow R, Barber M, Owens RM, Sharma AD, Rowan W, Hill E, Zagnoni M.
Advances in microfluidic in vitro systems for neurological disease modeling.
J Neurosci Res. 2021 Feb 13. Online ahead of print. Review.
9
Walbeek TJ, Harrison EM, Gorman MR, Glickman GL.
Naturalistic intensities of light at night: A review of the potent effects of very dim light on circadian responses and considerations for translational research.
Front Neurol. 2021 Feb 1;12:625334. Review.
Note: This article may be obtained online without charge.
10
Shamim-Uzzaman QA, Bae CJ, Ehsan Z, Setty AR, Devine M, Dhankikar S, Donskoy I, Fields B, Hearn H, Hwang D, Jain V, Kelley D, Kirsch DB, Martin W, Troester M, Trotti LM, Won CH, Epstein LJ.
The use of telemedicine for the diagnosis and treatment of sleep disorders: An American Academy of Sleep Medicine update.
J Clin Sleep Med. 2021 Feb 18. Online ahead of print.
11
Łabuz J, Sztatelman O, Jagiełło-Flasińska D, Hermanowicz P, Bażant A, Banaś AK, Bartnicki F, Giza A, Kozłowska A, Lasok H, Sitkiewicz E, Krzeszowiec W, Gabryś H, Strzałka W.
Phototropin interactions with SUMO proteins.
Plant Cell Physiol. 2021 Feb 17;pcab027. Online ahead of print.
12
Lustig A, Margi R, Orlov A, Orlova D, Azaria L, Gefen A.
The mechanobiology theory of the development of medical device-related pressure ulcers revealed through a cell-scale computational modeling framework.
Biomech Model Mechanobiol. 2021 Feb 19;1-10. Online ahead of print. Review.
Note: This article may be obtained online without charge.
13
Li J, Fredericks M, Cannell M, Wang K, Sako D, Maguire MC, Grenha R, Liharska K, Krishnan L, Bloom T, Belcheva EP, Martinez PA, Castonguay R, Keates S, Alexander MJ, Choi H, Grinberg AV, Pearsall RS, Oh P, Kumar R, Suragani RN.
ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders.
J Clin Invest. 2021 Feb 15;131(4):e138634.
