Status Report

NASA Spaceline Current Awareness List #936 12 February 2021 (Space Life Science Research Results)

By SpaceRef Editor
February 12, 2021
Filed under , , ,

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,


Papers deriving from NASA support:



Boothby TC.

Water content influences the vitrified properties of CAHS proteins.

Mol Cell. 2021 Feb 4;81(3):411-3.

PI: T.C. Boothby

Note: This comment refers to the article: Arakawa K, Numata K. Reconsidering the “glass transition” hypothesis that intrinsically unstructured CAHS proteins contribute to desiccation tolerance of tardigrades. Mol Cell. 2021 Feb 4;81(3):411-3. This letter may be obtained online without charge.

Journal Impact Factor: 15.584

Funding: “This publication was made possible by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Grant # 2P20GM103432 as well as NASA (80NSSC20K0283) and DARPA (W911NF2020137) awards to TCB.”



Michalettou TD, Michalopoulos I, Costes SV, Hellweg CE, Hada M, Georgakilas AG.

A meta-analysis of the effects of high-LET ionizing radiations in human gene expression.

Life (Basel). 2021 Feb 3;11(2):115.

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.51

Funding: “This research received no external funding.” S.V. Costes is affiliated with NASA Ames Research Center.




Other papers of interest:



Bogomolov VV, Polyakov AV, Kovachevich IV, Alferova IV, Repenkova LG, Turchaninova VF.

Medical support of manned long-duration missions (one year or longer) on the Mir orbital space station.

Hum Physiol. 2020 Dec;46(7):766-70.

Note: Mir orbital space station results.



Kotovskaya AR, Fomina GA, Salnikov VA.

Investigations of leg veins in cosmonauts after repeated 6-month missions to the RS of the ISS.

Hum Physiol. 2020 Dec;46(7):776-9.

Note: ISS results.



Mikheeva I, Mikhailova G, Shtanchaev R, Arkhipov V, Pavlik L.

Influence of a 30-day spaceflight on the structure of motoneurons of the trochlear nerve nucleus in mice.

Brain Res. 2021 Feb 1;147331. Online ahead of print.

Note: Bion-M1 biosatellite results.



Stepanova SI, Koroleva MV, Nesterov VF, Supolkina NS, Galichiy VA, Karpova OI.

Assessment of the work–rest schedule of the Russian members of the International Space Station crews 40/41–53/54 using the flight monitoring data.

Hum Physiol. 2020 Dec;46(7):760-5.

Note: ISS results.



Ryumin OO, Voitenko AM.

Interplanetary mission: Crew commander assignment and psychological training.

Hum Physiol. 2020 Dec;46(7):731-5.



Supolkina NS, Yusupova AK, Shved DM, Chekalina AI, Sarantsev SV, Gushin VI, Feichtinger EL.

Crew–mission control communicative behaviour in Sirius-17 experiment.

Hum Physiol. 2020 Dec;46(7):771-5.

Note: Results from Russian SIRIUS-17 analog 17-day confinement experiment.



Botzheim L, Laczko J, Torricelli D, Mravcsik M, Pons JL, Barroso FO.

Effect of gravity and kinematic constraints on muscle synergies in arm cycling.

J Neurophysiol. 2021 Feb 3. Online ahead of print.



Green MJ, Aylott JW, Williams P, Ghaemmaghami AM, Williams PM.

Immunity in space: Prokaryote adaptations and immune response in microgravity.

Life (Basel). 2021 Feb 2;11(2):112. Review.

Note: A Rotary Cell Culture System was used. This article may be obtained online without charge.



Shenkman BS, Kozlovskaya IB.

Physiological basis of low-frequency electromyostimulation, a promising countermeasure against sarcopenia and hypogravity-induced muscle atrophy.

Hum Physiol. 2020 Dec;46(7):780-6.



Ilyin EA, Larina IM, Nosovsky AM.

Levels of protein and the main protein fractions in human blood during a year-long exposure to hypobaric hypoxia, hypokinesia, and isolation.

Hum Physiol. 2020 Dec;46(7):811-6.



Solbiati S, Martin-Yebra A, Vaïda P, Caiani EG.

Evaluation of cardiac circadian rhythm deconditioning induced by 5-to-60 days of head-down bed rest.

Front Physiol. 2021 Jan 13;11:612188.

Note: Head-down bed rest study. This article may be obtained online without charge.



Zhao H, Shi Y, Qiu C, Zhao J, Gong Y, Nie C, Wu B, Yang Y, Wang F, Luo L.

Effects of simulated microgravity on ultrastructure and apoptosis of choroidal vascular endothelial cells.

Front Physiol. 2021 Jan 18;11:577325.

Note: This article describes results obtained under parabolic flight microgravity conditions. This article may be obtained online without charge.



Aprile P, Kelly DJ.

Hydrostatic pressure regulates the volume, aggregation and chondrogenic differentiation of bone marrow derived stromal cells.

Front Bioeng Biotechnol. 2021 Jan 15;8:619914.

Note: This article may be obtained online without charge.



de Coulon E, Dellenbach C, Rohr S.

Advancing mechanobiology by performing whole-cell patch clamp recording on mechanosensitive cells subjected simultaneously to dynamic stretch events.

iScience. 2021 Jan 7;24(2):102041.

Note: This article may be obtained online without charge.



Howsmon DP, Sacks MS.

On valve interstitial cell signaling: The link between multiscale mechanics and mechanobiology.

Cardiovasc Eng Technol. 2021 Feb 1. Online ahead of print.



Kutko OV, Rykova MP, Antropova EN, Kalinin SA, Shulgina SM, Sadova AA, Orlova KD, Kiseleva DD, Smarov VA, Vassilieva GY, Ponomarev SA.

Effect of 21-day dry immersion on the production of cytokines involved in the regulation of bone metabolism by T cells.

Hum Physiol. 2020 Dec;46(7):787-91.



Man’ko OM, Smoleevskii AE, Tomilovskaya ES, Kozlovskaya IB.

Effect of five-day dry immersion on eye hydrodynamics.

Hum Physiol. 2020 Dec;46(7):792-7.



Orlov OI, Panasiuk MI, Shurshakov VA.

Radiation factor in lunar missions.

Hum Physiol. 2020 Dec;46(7):709-21. Review.



Shafirkin AV, Grigoriev YG, Ushakov IB.

More precise determination of the relative biological effectiveness of fast neutrons and accelerated multi-charged ions at low doses for estimation of the risk of injury of brain and lens neurons.

Hum Physiol. 2020 Dec;46(7):722-30.



Zhang M, Yan S, Xu X, Yu T, Guo Z, Ma M, Zhang Y, Gu Z, Feng Y, Du C, Wan M, Hu K, Han X, Gu N.

Three-dimensional cell-culture platform based on hydrogel with tunable microenvironmental properties to improve insulin-secreting function of MIN6 cells.

Biomaterials. 2021 Jan 21;270:120687. Online ahead of print.



Dingle YL, Bonzanni M, Liaudanskaya V, Nieland TJF, Kaplan DL.

Integrated functional neuronal network analysis of 3D silk-collagen scaffold-based mouse cortical culture.

STAR Protoc. 2021 Jan 25;2(1):100292.

Note: This article may be obtained online without charge.



Okawara H, Arai Y, Matsuno H, Marcián P, Borák L, Aoki K, Wakabayashi N.

Effect of load-induced local mechanical strain on peri-implant bone cell activity related to bone resorption and formation in mice: An analysis of histology and strain distributions.

J Mech Behav Biomed Mater. 2021 Jan 30;116:104370. Online ahead of print.



Mullen T, Twist C, Daniels M, Dobbin N, Highton J.

Influence of contextual factors, technical performance, and movement demands on the subjective task load associated with professional rugby league match-play.

Int J Sports Physiol Perform. 2021 Jan 31;1-9. Online ahead of print.

Note: The NASA Task Load Index was used.


SpaceRef staff editor.