Status Report

NASA Spaceline Current Awareness List #934 29 January 2021 (Space Life Science Research Results)

By SpaceRef Editor
January 29, 2021
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Editor,


Note: A special List of NASA-funded articles published during the gap between December 2013 and May 2014 has been added to the Lists in the 2014 tab on the NASA Task Book website at


Papers deriving from NASA support:



Reschke MF, Kozlovskaya IB, Lysova N, Kitov  V, Rukavishnikov I, Kofman IS, Tomilovskaya ES, Rosenberg MJ, Osetsky N, Fomina E, Grishin A, Wood SJ.

[Joint Russian-USA field test: Implications for deconditioned crew following long duration spaceflight].

Aviakosm Ekolog Med. 2020;54(6):94-100. Russian.

PI: M.F. Reschke

Note: ISS results.

Journal Impact Factor: 0.25

Funding: PI reports funding under NASA grant “Recovery of Functional Performance Following Long Duration Space Flight (Field Test).”



Stahl-Rommel S, Jain M, Nguyen HN, Arnold RR, Aunon-Chancellor SM, Sharp GM, Castro CL, John KK, Juul S, Turner DJ, Stoddart D, Paten B, Akeson M, Burton AS, Castro-Wallace SL.

Real-time culture-independent microbial profiling onboard the International Space Station using nanopore sequencing.

Genes (Basel). 2021 Jan 16;12(1):106. 

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 3.759

Funding: “This work was supported by the Johnson Space Center’s Office of the Chief Technologist, the ISS Vehicle Program Office, and NASAs Advanced Exploration System Life Support Systems (AES-LSS) Project.”



Villacampa A, Ciska M, Manzano A, Vandenbrink JP, Kiss JZ, Herranz R, Medina FJ.

From spaceflight to Mars g-levels: Adaptive response of A. thaliana seedlings in a reduced gravity environment is enhanced by red-light photostimulation.

Int J Mol Sci. 2021 Jan 18;22(2):899.

PI: J.Z. Kiss

Note: ISS results. GeneLab: The original sequencing data described in this study have been deposited at NASA’s GeneLab repository as the GLDS-314 dataset (DOI: 10.26030/z5yf-jx91,, [40]). This article may be obtained online without charge.

Journal Impact Factor: 4.556

Funding: “This research was funded by the Agencia Estatal de Investigación of the Spanish Ministry of Science an Innovation, Grants #ESP2015-64323-R and #RTI2018-099309-B-I00 (co-funded by EUERDF) to F.J.M., by pre-doctoral fellowships to A.M. and A.V. from the Spanish National Program for Young Researchers Training (MINECO, Ref. #BES-2013-063933, #BES-2016-077976) and the Seedling Growth Project for ISS experimentation #LSRA2009-0932/ 1177, a shared project of ESA-ELIPS Program and NASA, to F.J.M. and J.Z.K. In addition, J.Z.K. is funded by Grants NNX12A065G and 80NSSC17K0546. This research is related to the Space Omics TT funded by the ESA contract 4000131202/20/NL/PG to R.H.”



Mantri AV, Allaway HCM, Brezicha JE, Hogan HA, Bloomfield SA.

Oral estradiol impact on mitigating unloading-induced bone loss in ovary-intact rats.

Aerosp Med Hum Perform. 2021 Feb 1;92(2):65-74.

PI: S.A. Bloomfield

Note: Hindlimb unloading study.

Journal Impact Factor: 0.889

Funding: “This study was supported by the National Biomedical Research Institute, the Huffines Institute for Sports Medicine and Human Performance, and the American College of Sports Medicine.”



Shuryak I, Brenner DJ. 

Review of quantitative mechanistic models of radiation-induced non-targeted effects (NTE).

Radiat Prot Dosimetry. 2020 Nov;192(2):235-52.

PI: D.J. Brenner

Journal Impact Factor: 0.773

Funding: “This research was supported by the National Institute of Allergy and Infectious Diseases (NIAID) grant U19-AI067773 to the Center for High-Throughput Minimally Invasive Radiation Biodosimetry, and by the National Aeronautics and Space Administration (NASA) grant NNX16AR81A.”



Gregory KB, Soriano-Smith RN, Lamp ACM, Hilditch CJ, Rempe MJ, Flynn-Evans EE, Belenky GL.

Flight crew alertness and sleep relative to timing of in-flight rest periods in long-haul flights.

Aerosp Med Hum Perform. 2021 Feb 1;92(2):83-91.

Journal Impact Factor: 0.889

Funding: No funding cited. K.B. Fregory and E.E. Flynn-Evans are affiliated with NASA Ames Research Center.



Yuen K, Strang AR, Flynn-Evans EE, Barrantes Perez JH, Berneking M, Bhui R, Cheng JY, Dombrowsky J, Ganguly G, Rishi MA, Rosen C, Upender R, Sullivan SS.

Child and teen sleep and pandemic-era school. 

J Clin Sleep Med. 2021 Jan 12. Online ahead of print.

Journal Impact Factor: 3.038

Funding: E.E. Flynn-Evans is affiliated with NASA Ames Research Center.



Hupfeld KE, McGregor HR, Reuter-Lorenz PA, Seidler RD. 

Microgravity effects on the human brain and behavior: Dysfunction and adaptive plasticity.

Neurosci Biobehav Rev. 2021 Mar;122:176-89. Review. Epub 2021 Jan 14.

PI: R.D. Seidler

Note: From the abstract: “Here, we introduce a new conceptual framework to synthesize spaceflight effects on the brain, Spaceflight Perturbation Adaptation Coupled with Dysfunction (SPACeD). We review the literature implicating neurobehavioral dysfunction and adaptation in response to spaceflight and microgravity analogues, and we consider pre-, during-, and post-flight factors that may interact with these processes.”

Journal Impact Factor: 8.33

Funding: “During completion of this work KH was supported by training grant T32-NS082128 from the National Institute of Neurological Disorders and Stroke (NINDS), as well as a National Science Foundation (NSF) Graduate Research Fellowship under grants DGE-1315138 and DGE-1842473. HM was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) postdoctoral fellowship. RS was supported by NASA grants 80NSSC17K0021, 80NSSC18K0783, and 80NSSC17K0461.”



Doarn CR, Polk JD, Grigoriev A, Comtois JM, Shimada K, Weerts G, Dervay JP, Taddeo TA, Sargsyan A.

A framework for multinational medical support for the International Space Station: A model for exploration.

Aerosp Med Hum Perform. 2021 Feb 1;92(2):129-34.

Journal Impact Factor: 0.889

Funding: No funding cited. J.D. Polk is affiliated with NASA Headquarters; J.P. Dervay, T.A. Taddeo, and A. Sargsyan are affiliated with NASA Johnson Space Center.




Other papers of interest:



Góes-Neto A, Kukharenko O, Orlovska I, Podolich O, Imchen M, Kumavath R, Kato RB, de Carvalho DS, Tiwari S, Brenig B, Azevedo V, Reva O, de Vera JP, Kozyrovska N, Barh D.

Shotgun metagenomic analysis of Kombucha Mutualistic Community exposed to Mars-like environment outside the International Space Station.

Environ Microbiol. 2021 Jan 21. Online ahead of print.

Note: ISS results.



Kawano F, Ohira T, Goto K, Ohira Y. 

[Role(s) of gravitational loading on the growth and development of neuromuscular properties].

Aviakosm Ekolog Med. 2020;54(6):73-9. Review. Russian.

Note: Spaceflight and hindlimb unloading study results are discussed.



Kornilova LN. 

[Orientation in space, vestibular function and ocular tracking in the changed gravitational environment].

Aviakosm Ekolog Med. 2020;54(6):50-7. Review. Russian.

Note: Mir and ISS results. Dry immersion was used for ground studies.



Kozlovskaya IB, Lapin BA, Miller NV, Badakva AM. 

[Russian vestibular investigations with primates in flights of the biosatellites].

Aviakosm Ekolog Med. 2020;54(6):101-9. Russian.

Note: Bion results.



Weber B, Riecke C, Stulp F. 

Sensorimotor impairment and haptic support in microgravity.

Exp Brain Res. 2021 Jan 19. Online ahead of print.

Note: ISS results. This article may be obtained online without charge.



Grigoriev AI, Lapin BA, Kozlovskaya IB, Ilyin ЕА. 

[Biosatellites Bion 6-11: Investigations with primates].

Aviakosm Ekolog Med. 2020;54(6):101-9. Russian.

Note: Bion 6 results.



Puspitasari A, Cerri M, Takahashi A, Yoshida Y, Hanamura K, Tinganelli W.

Hibernation as a tool for radiation protection in space exploration.

Life (Basel). 2021 Jan 14;11(1):54.

Note: This article may be obtained online without charge.



Vinogradova OL, Tomilovskaya ES, Kozlovskaya IB. 

[Gravitational factor as a base of the evolutionary adaptation of animal organisms to activities in the Earth conditions].

Aviakosm Ekolog Med. 2020;54(6):5-26. Review. Russian.

Note: Bed rest, dry immersion, and hindlimb unloading studies are reviewed.



Monti N, Masiello MG, Proietti S, Catizone A, Ricci G, Harrath AH, Alwasel SH, Cucina A, Bizzarri M.

Survival pathways are differently affected by microgravity in normal and cancerous breast cells.

Int J Mol Sci. 2021 Jan 16;22(2):862.

Note: A random positioning machine was used. This article may be obtained online without charge.



Liang L, Li H, Cao T, Qu L, Zhang L, Fan GC, Greer PA, Li J, Jones DL, Peng T.

Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways.

J Biol Chem. 2020 Dec 4;295(49):16840-51.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Sriharan S, Kay G, Lee JCY, Pollock RD, Russomano T. 

Cardiopulmonary resuscitation in hypogravity simulation.

Aerosp Med Hum Perform. 2021 Feb 1;92(2):106-12.

Note: A body suspension device was used for unloading.



Sun L, Li D, Yuan Y, Wang D. 

Intestinal long non-coding RNAs in response to simulated microgravity stress in Caenorhabditis elegans. 

Sci Rep. 2021 Jan 21;11(1):1997.

Note: A Rotary Cell Culture System was used. This article may be obtained online without charge.



Mohanadass CA, Church LE. 

Response to “Measuring the optic nerve sheath diameter with ultrasound in acute middle cerebral artery stroke patients”: For application to Long-Duration Spaceflight (LDSF).

J Stroke Cerebrovasc Dis. 2021 Jan 19. Online ahead of print.

Note: The authors comment on the article: Güzeldağ S, Yılmaz G, Tuna M, Altuntaş M, Özdemir M. Measuring the optic nerve sheath diameter with ultrasound in acute middle cerebral artery stroke patients. J Stroke Cerebrovasc Dis. 2021 Feb;30(2):105523. A reply from the original authors can be found at



Croft RJ, Kölegård R, Tribukait A, Taylor NAS, Eiken O. 

Effects of acceleration-induced reductions in retinal and cerebral oxygenation on human performance.

Aerosp Med Hum Perform. 2021 Feb 1;92(2):75-82.

Note: A human centrifuge was used. 



Peris-Moreno D, Cussonneau L, Combaret L, Polge C, Taillandier D.

Ubiquitin ligases at the heart of skeletal muscle atrophy control.

Molecules. 2021 Jan 14;26(2):407. Review.

Note: This article may be obtained online without charge.



Shenkman BS, Mirzoev TM, Kozlovskaya IB. 

[Tonic activity and gravitational control of the postural muscle].

Aviakosm Ekolog Med. 2020;54(6):58-72. Review. Russian.



Zeng N, D’Souza RF, Macrae CL, Figueiredo VC, Pileggi CA, Markworth JF, Merry TL, Cameron-Smith D, Mitchell CJ.

Daily protein supplementation attenuates immobilization-induced blunting of postabsorptive muscle mTORC1 activation in middle age men.

Am J Physiol Cell Physiol. 2021 Jan 20. Online ahead of prnt.



Bing L, Jie Z, Jianxiong M, Weibo C, Ce Z, Wuzeng W, Shuai L, Guomin L, Guosheng X, Yang Z, Jun L, Yinsong W, Xinlong M.

Crosstalk between histone and DNA methylation mediates bone loss in hind limb unloading.

J Bone Miner Res. 2021 Jan 19. Online ahead of print.

Note: Hindlimb unloading study.



Pierantoni M, Le Cann S, Sotiriou V, Ahmed S, Bodey AJ, Jerjen I, Nowlan NC, Isaksson H.

Muscular loading affects the 3D structure of both the mineralized rudiment and growth plate at early stages of bone formation.

Bone. 2021 Apr;145:115849. Epub 2021 Jan 14.

Note: This article may be obtained online without charge.



David E, Wolfson M, Fraifeld VE. 

Background radiation impacts human longevity and cancer mortality: Reconsidering the linear no-threshold paradigm.

Biogerontology. 2021 Jan 22. Online ahead of print.



Jagetia GC. 

Antioxidant activity of curcumin protects against the radiation-induced micronuclei formation in cultured human peripheral blood lymphocytes exposed to various doses of γ-radiation.

Int J Radiat Biol. 2021 Jan 19. Online ahead of print.



Kokhan VS, Mariasina S, Pikalov VA, Abaimov DA, Somasundaram SG, Kirkland CE, Aliev G.

Neurokinin-1 receptor antagonist reverses functional CNS alteration caused by combined γ-rays and carbon nuclei irradiation.

CNS Neurol Disord Drug Targets. 2021 Jan 21. Online ahead of print.



Kunze S, Cecil A, Prehn C, Möller G, Ohlmann A, Wildner G, Thurau S, Unger K, Rößler U, Hölter SM, Tapio S, Wagner F, Beyerlein A, Theis F, Zitzelsberger H, Kulka U, Adamski J, Graw J, Dalke C.

Posterior subcapsular cataracts are a late effect after acute exposure to 0.5 Gy ionizing radiation in mice.

Int J Radiat Biol. 2021 Jan 19. Online ahead of print.



Little MP, Azizova TV, Hamada N. 

Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: A review of the epidemiology.

Int J Radiat Biol. 2021 Jan 20. Online ahead of print.



Pawliczek D, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Graw J, Dalke C.

Ionising radiation causes vision impairment in neonatal B6C3F1 mice.

Exp Eye Res. 2021 Mar;204:108432. Epub 2021 Jan 14.



Khurana VG, Jithoo R, Barnett M. 

Aerospace implications of key neurological conditions.

Aerosp Med Hum Perform. 2021 Feb 1;92(2):113-9. Review.



Qi RR, Xiao SF, Su Y, Mao YQ, Pan LL, Li CH, Lu YL, Wang JQ, Cai YL.

Sea voyage training and motion sickness effects on working ability and life quality after landing.

Aerosp Med Hum Perform. 2021 Feb 1;92(2):92-8.



Gerasimenko Y, Edgerton VR, Harkema S, Kozlovskaya I. 

[Gravity dependent mechanisms of sensorimotor regulation оf posture and locomotion].

Aviakosm Ekolog Med. 2020;54(6):27-42. Review. Russian.



Sayenko DG, Tomilovskaya ES. 

[Ideas of I.B. Kozlovskaya about the influence of microgravity on the posture control system].

Aviakosm Ekolog Med. 2020;54(6):43-9. Russian.



Boulanger N, Buisseret F, Dehouck V, Dierick F, White O. 

Adiabatic invariants drive rhythmic human motion in variable gravity.

Phys Rev E. 2020 Dec;102(6-1):062403.



Levik YS. 

[Space researches and new concepts in the physiology of movements].

Aviakosm Ekolog Med. 2020;54(6):80-91. Russian.



Fang X, Liu B, Shao Q, Huang X, Li J, Luan S, He K. 

AtPiezo plays an important role in root cap mechanotransduction.

Int J Mol Sci. 2021 Jan 5;22(1):467.

Note: This article may be obtained online without charge.



Mosaddad SA, Salari Y, Amookhteh S, Soufdoost RS, Seifalian A, Bonakdar S, Safaeinejad F, Moghaddam MM, Tebyanian H.

Response to mechanical cues by interplay of YAP/TAZ transcription factors and key mechanical checkpoints of the cell: A comprehensive review.

Cell Physiol Biochem. 2021 Jan 22;55(1):33-60. Review.

Note: This article may be obtained online without charge.



Biganeh J, Ashtarinezhad A, Behzadipour D, Khanjani N, Tavakoli Nik A, Hosseinabadi MB.

Investigating the relationship between job stress, workload and oxidative stress in nurses.

Int J Occup Saf Ergon. 2021 Jan 19. Online ahead of print.

Note: The NASA Task Load Index was used.



Hertzum M. 

Reference values and subscale patterns for the Task Load Index (TLX): A meta-analytic review.

Ergonomics. 2021 Jan 19. Online ahead of print.

Note: Reference values for the NASA Task Load Index are provided.

SpaceRef staff editor.