Status Report

NASA Spaceline Current Awareness List #932 15 January 2021 (Space Life Science Research Results)

By SpaceRef Editor
January 15, 2021
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Koutnik AP, Favre ME, Noboa K, Sanchez-Gonzalez MA, Moss SE, Goubran B, Ari C, Poff AM, Rogers CQ, DeBlasi JM, Samy B, Moussa M, Serrador JM, D’Agostino DP.

Human adaptations to multiday saturation on NASA NEEMO.

Front Physiol. 2021 Jan 12;11:1778.

PI: M. Schubert

Note: The NASA Extreme Environment Mission Operation (NEEMO) is a space-flight analog mission conducted within Florida International University’s Aquarius Undersea Research Laboratory (AURL). This article may be obtained online without charge.

Journal Impact Factor: 3.367

Funding: “This study was supported by Ketone Technologies LLC and NASA Human Research Program Grant (NNX10AO19G).”



LaPelusa M, Donoviel D, Branzini SE, Carlson PE Jr, Culler S, Cheema AK, Kaddurah-Daouk R, Kelly D, de Cremoux I, Knight R, Krajmalnik-Brown R, Mayo SL, Mazmanian SK, Mayer EA, Petrosino JF, Garrison K. 

Microbiome for Mars: Surveying Microbiome Connections to Healthcare with Implications for Long-Duration Human Spaceflight, virtual workshop, July 13, 2020.

Microbiome. 2021 Jan 4;9(1):2.

Note: This report summarizes each speaker’s presentation in the order presented at the Microbiome for Mars workshop, July 13, 2020. Video presentations are available at This article may be obtained online without charge.

Journal Impact Factor: 11.607

Funding: “Support for the conference was provided by the Translational Research Institute for Space Health (TRISH) through NASA Cooperative Agreement NNX16AO69A. Additional support was provided by Caltech.”



Vernice NA, Meydan C, Afshinnekoo E, Mason CE.

Long-term spaceflight and the cardiovascular system.

Precis Clin Med. 2020 Dec;3(4):284-91.

PI: C.E. Mason

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “This work was funded by NASA (Grant Nos. NNX14AH50G and NNX17AB26G) and the National Institutes of Health (Grant No. R25EB020393).”



Hord JM, Garcia MM, Farris KR, Guzzoni V, Lee Y, Lawler MS, Lawler JM.

Nox2 signaling and muscle fiber remodeling are attenuated by losartan administration during skeletal muscle unloading.

Physiol Rep. 2021 Jan;9(1):e14606.

PI: J.M. Lawler

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.13

Funding: “This work was supported by grants from NASA (NNX13AE45G) (J.M.L.), the Space Physiology Predoctoral Research Grant from NASA/ACSM (J.M.H.), the Sydney and J.L. Huffines Institute at Texas A&M University (J.M.H., J.M.L.), and the Strategic Research Award (J.M.H.) from the College of Health and Education at Texas A&M University.”



Little-Letsinger SE, Turner ND, Ford JR, Suva LJ, Bloomfield SA.

Omega-3 fatty acid modulation of serum and osteocyte tumor necrosis factor alpha in adult mice exposed to ionizing radiation.

J Appl Physiol (1985). 2021 Jan 7. Online ahead of print.

PIs: S.A. Bloomfield, N.D. Turner

Journal Impact Factor: 3.044

Funding: “National Aeronautics and Space Administration awarded to ND Turner (NNX15AD64G) for the parent protocol and to SA Bloomfield (NNX17AC91G); Sydney & J.L. Huffines Institute for Sports Medicine and Human Performance and the College of Education and Human Development awards to SE Little-Letsinger, Texas A&M University.”



Ma L, Gonzalez-Junca A, Zheng Y, Ouyang H, Illa-Bochaca I, Horst KC, Krings G, Wang Y, Fernandez-Garcia I, Chou W, Barcellos-Hoff MH.

Inflammation mediates the development of aggressive breast cancer following radiotherapy.

Clin Cancer Res. 2021 Jan 5. Online ahead of print.

PI: M.H. Barcellos-Hoff; M.H. Barcellos-Hoff/NSCOR

Journal Impact Factor: 10.107

Funding: “This research was supported by NASA Specialized Center for Research in Radiation Health Effects, NNX09AM52G, and NNX13AF06G at New York University School of Medicine and NIH R01CA190980 at UCSF to M.H. Barcellos-Hoff.”



Marcinkowski MA, Bell ST, Roma PG.

The nature of conflict for teams in isolated, confined, and extreme environments.

Acta Astronaut. 2021 Jan 8. Article in press.

PIs: S.T. Bell, P. Roma

Journal Impact Factor: 2.83

Funding: “This research is based, in part, on a master’s thesis completed by MAM at DePaul University under the direction of STB. MAM and STB were supported in part by National Aeronautics and Space Administration (NASA) grant NNX16AQ48G (PI: S.T. Bell). STB and PGR were supported by KBR’s Human Health and Performance Contract NNJ15HK11B through the National Aeronautics and Space Administration. This project was supported by NASA Human Research Program Directed Projects Identification and Validation of HFBP Exploration Measures in HERA for Transport and HFBP Exploration Measures in HERA for Mars (PI: P.G. Roma).”



Ozubko JD, Sirianni LA, Ahmad FN, MacLeod CM, Addante RJ.

Recallable but not recognizable: The influence of semantic priming in recall paradigms.

Cogn Affect Behav Neurosci. 2021 Jan 6. Online ahead of print.

Journal Impact Factor: 2.206

Funding: “Experiments 1, 2, 3, and 5 were supported by a Natural Sciences and Engineering Research Council of Canada Discovery Grant (A7459) to CMM. Experiment 4 was supported by grants to RJA from the National Institute of Health (grant 1 L30 NS112849-01), the National Institute of Neurological Disorders and Stroke, the CSUSB Office of Academic Research Mini-Grants Program, the CSUSB Office of Student Research Faculty Assigned Time Grant Program, the CSUSB Office of Sponsored Programs Faculty Summer Research Fellowship, the CSUSB Faculty Senate Assigned Time for Exceptional Service to Students, and the CSUSB OSR Faculty-Student Research Grant to RJA & LAS. LAS was supported in part by KBR’s Human Health and Performance Contract NNJ15HK11B through the National Aeronautics and Space Administration, as well as by the CSUSB Student Success Initiative’s Innovative Scholars Fund & Culminating Project Fellowships.”



Hammond TG, Allen PL, Wells HW, Russick JM, Nislow C, Giaever G, Birdsall HH.

Moonshot: Affordable, simple, flight hardware for the Artemis-1 mission and beyond.

Front Space Technol. 2020 Nov 11;1:5.

PI: T.G. Hammond

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “NASA Grant 80NSSC19K0706 under solicitation NNH18ZTT001N-EM1 to the Institute for Medical Research supported these studies.”




Other papers of interest:



Satoh K, Yamazaki T, Furukawa S, Mukai C, Makimura K.

Identification of fungi isolated from astronaut nasal and pharyngeal smears and saliva under operations nomenclature, Myco.

Microbiol Immunol. 2021 Jan 4. Online ahead of print.

Note: ISS results.



Then SM.

Spaceflight altered the gene and protein expression of the membrane transporter proteins in Jurkat cells.

Asia Pac J Mol Med Med. 2020;9(1):1.

Note: ISS results. This article may be obtained online without charge.



Shao D, Ye L, Zhu B, Li Q, Yang H, Shi J, Huang Q, Zhao W.

Mechanisms of the effect of simulated microgravity on the cytotoxicity of NK cells following the DNA methylation of NKG2D and the expression of DAP10.

Microgravity Sci Technol. 2021 Feb;33(1):6.

Note: A rotating wall vessel was used.



Limper U, Tank J, Ahnert T, Maegele M, Grottke O, Hein M, Jordan J.

The thrombotic risk of spaceflight: Has a serious problem been overlooked for more than half of a century?

Eur Heart J. 2021 Jan;42(1):97-100.



Xie LH, Gwathmey JK, Zhao Z.

Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators.

Pflugers Arch. 2021 Jan 4. Online ahead of print. Review.



Zhu L, Nie L, Xie S, Li M, Zhu C, Qiu X, Kuang J, Liu C, Lu C, Li W, Meng E, Zhang D, Zhu L.

Attenuation of antiviral immune response caused by perturbation of TRIM25-mediated RIG-I activation under simulated microgravity.

Cell Rep. 2021 Jan 5;34(1):108600.

Note: A Rotary Cell Culture System was used. This article may be obtained online without charge.



Phadtare N, Phad O.

Space food and beverage.

Food Ag Spectr J. 2020 Dec 29;1(04):42-8. Review.

Note: This article may be obtained online without charge.



Sato C, Miyakoshi N, Kasukawa Y, Nozaka K, Tsuchie H, Nagahata I, Yuasa Y, Abe K, Saito H, Shoji R, Shimada Y.

Teriparatide and exercise improve bone, skeletal muscle, and fat parameters in ovariectomized and tail-suspended rats.

J Bone Miner Metab. 2021 Jan 3. Online ahead of print.

Note: Hindlimb unloading study.



Brech GC, Machado-Lima A, Bastos MF, de Jesus Bonifácio W, Peterson MD, Takayama L, Pereira RMR, D’Andréa Greve JM, Alonso AC.

Vitamin D supplementation associated with 12-weeks multimodal training in older women with low bone mineral density: A randomized double-blind placebo-controlled trial.

Exp Gerontol. 2021 Jan 6. Online ahead of print.



Hua R, Zhang J, Riquelme MA, Jiang JX.

Connexin gap junctions and hemichannels link oxidative stress to skeletal physiology and pathology.

Curr Osteoporos Rep. 2021 Jan 6. Online ahead of print. Review.



Kong L, Wang Y, Wang H, Pan Q, Zuo R, Bai S, Zhang X, Lee WY, Kang Q, Li G.

Conditioned media from endothelial progenitor cells cultured in simulated microgravity promote angiogenesis and bone fracture healing.

Stem Cell Res Ther. 2021 Jan 8;12(1):47.

Note: A 3-D clinostat was used. This article may be obtained online without charge.



Li X, Kordsmeier J, Xiong J.

New advances in osteocyte mechanotransduction.

Curr Osteoporos Rep. 2021 Jan 9. Online ahead of print. Review.



Płódowska M, Lopez-Riego M, Akuwudike P, Sobota D, Filipek M, Kłosowski M, Kaźmierczak U, Brzozowska B, Baliga A, Lisowska H, Braziewicz J, Olko P, Lundholm L, Wojcik A.

Small is beautiful: Low activity alpha and gamma sources for small-scale radiation protection research experiments.

Int J Radiat Biol. 2021 Jan 11. Online ahead of print.

Note: This article may be obtained online without charge.



Ren H, Yang G, Liu L, Jin C, Chen S, Ai F, Chen Y, Zhao M, Shakir Y, Zhao S, Ma H, Wang R, Deng Y.

The sequence preference of gamma radiation mutagenesis using a novel in vitro model.

Acta Astronaut. 2021 Jan 7. Article in press.



Sorokina SS, Malkov AE, Shubina LV, Zaichkina SI, Pikalov VA.

Low dose of carbon ion irradiation induces early delayed cognitive impairments in mice.

Radiat Environ Biophys. 2021 Jan 3. Online ahead of print.



Maffert A, Aupy B.

Optokinetic stimulation efficiency for sea sickness treatment.

Int Marit Health. 2020;71(4):249-52.

Note: This article may be obtained online without charge.



Hughes AM, Sonesh SC, Mason RE, Gregory ME, Marttos A, Schulman CI, Salas E.

Trauma, teams, and telemedicine: Evaluating telemedicine and teamwork in a mass casualty simulation.

Mil Med. 2020 Nov 13. Online ahead of print.



McManus M, Harris LR.

When gravity is not where it should be: How perceived orientation affects visual self-motion processing.

PLoS One. 2021 Jan 6;16(1):e0243381.

Note: This article may be obtained online without charge.



Nakano M, Furuichi T, Sokabe M, Iida H, Tatsumi H.

The gravistimulation-induced very slow Ca2+ increase in Arabidopsis seedlings requires MCA1, a Ca2+-permeable mechanosensitive channel.

Sci Rep. 2021 Jan 8;11(1):227.

Note: This article may be obtained online without charge.



Nedukha O, Kordyum E, Vorobyova T.

Sensitivity of plant plasma membrane to simulated microgravity.

Microgravity Sci Technol. 2021 Feb;33(1):10.

Note: A clinostat was used.



Wang M, Li P, Ma Y, Nie X, Grebe M, Men S.

Membrane sterol composition in Arabidopsis thaliana affects root elongation via auxin biosynthesis.

Int J Mol Sci. 2021 Jan 4;22(1):437.

Note: This article may be obtained online without charge.



Zhang M, Zhang Y, Jiang Z, Lv X, Guo C.

Low-illumination image enhancement in the space environment based on the DC-WGAN algorithm.

Sensors (Basel). 2021 Jan 4;21(1):286.

Note: From the abstract: “Owing to insufficient illumination of the space station, the image information collected by the intelligent robot will be degraded, and it will not be able to accurately identify the tools required for the robot’s on-orbit maintenance. This situation increases the difficulty of the robot’s maintenance in a low-illumination environment. We proposes a novel enhancement method for images under low-illumination, namely, a deep learning algorithm based on the combination of deep convolutional and Wasserstein generative adversarial networks (DC-WGAN) in CIELAB color space.” This article may be obtained online without charge.



Galoyan T, Betts K, Abramian H, Reddy P, Izzetoglu K, Shewokis PA.

Examining mental workload in a spatial navigation transfer game via functional near infrared spectroscopy.

Brain Sci. 2021 Jan 4;11(1):E45.

Note: The NASA Task Load Index was used. This article may be obtained online without charge.



Zehnder EC, Law BHY, Schmölzer GM.

Assessment of healthcare provider workload in neonatal resuscitation.

Front Pediatr. 2020 Dec 22;8:598475.

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

SpaceRef staff editor.