Status Report

NASA Spaceline Current Awareness List #927 4 December 2020 (Space Life Science Research Results)

By SpaceRef Editor
December 4, 2020
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website athttps://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, [email protected].

 

Papers deriving from NASA support:

 

1

Mhatre S, Wood JM, Sielaff AC, Mora M, Duller S, Singh NK, Karouia F, Moissl-Eichinger C, Venkateswaran K.

Assessing the risk of transfer of microorganisms at the International Space Station due to cargo delivery by commercial resupply vehicles.

Front Microbiol. 2020 Nov 6;11:566412.

https://pubmed.ncbi.nlm.nih.gov/33240227

PI: K. Venkateswaran

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.235

Funding: “The research described in this manuscript was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV, which also funded postdoctoral fellowship for AS, SM, NS, and JW. FK was supported through the KBRwyle/FILMSS subcontract with the Department of Pharmaceutical Chemistry at the University of California, San Francisco, # NNA14AB82C, at NASA Ames Research Center.”

 

2

Ray K, Williams S, Morrical S, Garbino A, Hong M, Sanders R.

Pulmonary fluid shifts occur as a result of scuba diving at NASA’s Neutral Buoyancy Lab.

Undersea Hyperb Med. 2020;47(4):531-7.

https://pubmed.ncbi.nlm.nih.gov/33227828

Journal Impact Factor: 0.748

Funding: No funding cited. A. Garbino, M. Hong, and R. Sanders are affiliated with NASA Johnson Space Center.

 

3

Thompson M, Woods K, Newberg J, Oxford JT, Uzer G.

Low-intensity vibration restores nuclear YAP levels and acute YAP nuclear shuttling in mesenchymal stem cells subjected to simulated microgravity.

npj Microgravity. 2020 Dec 1;6(1):35.

https://www.nature.com/articles/s41526-020-00125-5

Note: A clinostat was used. This article may be obtained online without charge.

Journal Impact Factor: 3.380

Funding: “This study was supported by NASA ISGC NNX15AI04H, NIH grants R01AG059923, 5P2CHD086843–03, P20GM109095, P20GM103408, and NSF grants 1929188 & 2025505.”

 

4

Lindner JR.

Limb perfusion imaging in peripheral artery disease.

JACC Cardiovasc Imaging. 2020 Nov 13. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33221233 

PI: B.D. Levine

Note: The article is an editorial comment on: Chou TH, Alvelo JL, Janse S, Papademetris X, Sumpio BE, Mena-Hurtado C, Sinusas AJ, Stacy MR. Prognostic value of radiotracer-based perfusion imaging in critical limb ischemia patients undergoing lower extremity revascularization. JACC Cardiovasc Imaging. 2020 Nov 12. Epub ahead of print. https://pubmed.ncbi.nlm.nih.gov/33221224.

Journal Impact Factor: 12.74

Funding: “Dr. Lindner has been supported by grants R01-HL078610, R01-HL130046, and P51-OD011092 from the National Institutes of Health; grant 18–18HCFBP_2–0009 from NASA; and grants from Boston Scientific and Lantheus Medical Imaging.”

 

5

Speacht TL, Lang CH, Donahue HJ.

Soluble RANKL exaggerates hindlimb suspension-induced osteopenia but not muscle protein balance.

J Orthop Res. 2020 Nov 22. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33222219

PI: H.J. Donahue

Note: Hindlimb unloading study.

Journal Impact Factor: 2.728

Funding: “This study was supported by the National Space Biomedical Research Institute (grant MA02802); the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grant AR068132) and the National Institute on Alcohol Abuse and Alcoholism (grant AA11290).”

 

6

Wolak RJ, Johnson JC.

Social dynamics in an isolated, confined, and extreme workplace.

Int J Biometeorol. 2020 Nov 23. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33230641

PI: L. DeChurch

Note: The article is part of a special issue on Indoor Biometeorology. This article may be obtained online without charge.

Journal Impact Factor: 2.680

Funding: “This research was supported by the National Science Foundation grants BNS-9011351 and OPP-9610231. In addition, a portion of this work was sponsored by grants from the National Aeronautics and Space Administration grant NAG-5-4571 and grant NNX15AM26G.”

 

7

Ma W, Balta VA, West R, Newlin KN, Miljanić O, Sullivan DJ, Vekilov PG, Rimer JD.

A second mechanism employed by artemisinins to suppress Plasmodium falciparum hinges on inhibition of hematin crystallization.

J Biol Chem. 2020 Nov 25. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33239360

PI: P.G. Vekilov

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.238

Funding: “National Science Foundation (Award No. DMR-1710354) and the National Institutes of Health (Award No. 1R21AI126215-01). D.J.S. acknowledges support from the Johns Hopkins Malaria Research Institute and The Bloomberg Family Foundation. J.D.R. and O.Š.M. acknowledge support from The Welch Foundation (Award Nos. E-1794 and E-1768, respectively). P.G.V. received additional support from NASA (Award Nos. NNX14AD68G and NNX14AE79G).”

 

8

Kim KJ, Bekdash OS, Norcross JR, Conkin J, Garbino A, Fricker J, Young M, Abercromby AFJ.

The partial pressure of inspired carbon dioxide exposure levels in the extravehicular mobility unit.

Aerosp Med Hum Perform. 2020 Dec 1;91(12):923-31.

https://pubmed.ncbi.nlm.nih.gov/33243335

Journal Impact Factor: 0.889

Funding: No funding cited. The authors are affiliated with NASA Johnson Space Center.

 

9

Schwertz H, Roth LA, Woodard D.

Propellant off-gassing and implications for triage and rescue.

Aerosp Med Hum Perform. 2020 Dec 1;91(12):956-61.

https://pubmed.ncbi.nlm.nih.gov/33243339

Journal Impact Factor: 0.889

Funding: No funding cited. D. Woodard is affiliated with NASA Kennedy Space Center.

 

Please Note: The following citations are part of a special collection of articles, “The Biology of Spaceflight,” published in Cell Press journals and available at https://www.cell.com/c/the-biology-of-spaceflight. From Cell Press: “As humankind reaches for the stars to journey to the next frontier in space, research on spaceflight biology is critical for understanding how living systems, including human health, may be affected by spaceflight and space exploration. This special collection on the biology of spaceflight, published in Cell and other Cell Press journals, includes research articles, short communications, and a review article that cover studies with model systems and astronaut samples. The work, which was done in collaboration between NASA and other space agencies around the world, uncovers the impact of known hazards of spaceflight, such as radiation and microgravity, and discusses the standards for multi-omics from space and the preparations needed for Mars and other missions in the next two decades.” The 19 articles cited below have been published; another 9 are awaiting final review and will be cited in future SPACELINE Current Awareness Lists. The articles are available online without charge. An additional non-NASA-affiliated article appears at #2 in the ‘Other papers of interest’ section.

 

10

Afshinnekoo E, Scott RT, MacKay MJ, Pariset E, Cekanaviciute E, Barker R, Gilroy S, Hassane D, Smith SM, Zwart SR, Nelman-Gonzalez M, Crucian BE, Ponomarev SA, Orlov OI, Shiba D, Muratani M, Yamamoto M, Richards SE, Vaishampayan PA, Meydan C, Foox J, Myrrhe J, Istasse E, Singh N, Venkateswaran K, Keune JA, Ray HE, Basner M, Miller J, Vitaterna MH, Taylor DM, Wallace D, Rubins K, Bailey SM, Grabham P, Costes SV, Mason CE, Beheshti A. 

Fundamental biological features of spaceflight: Advancing the field to enable deep-space exploration.

Cell. 2020 Nov 25;183(5):1162-84. Review.

https://pubmed.ncbi.nlm.nih.gov/33242416

PIs: S.M. Bailey; C.E. Mason; A. Beheshti; S.V. Costes; E. Cekanaviciute; P. Grabham; E. Pariset, TRISH Postdoctoral Fellowship Program. NASA Twins Study PIs: S.M. Bailey, M. Basner, A.P. Feinberg, S.M.C. Lee, C.E. Mason, E. Mignot, B.K. Rana, S.M. Smith, M.P. Snyder, F.W. Turek, A.R. Hargens

Note: From the Introduction: “In this review, we outline the fundamental biological features associated with spaceflight that are related to human health risks and aerospace medicine. These features can serve as a guide for future fundamental and applied spaceflight biology research, including personalized medical therapies for astronauts and countermeasure development. We also list open-access spaceflight biological data and biospecimen resources available for request by the scientific community.” The article is featured on the cover of the journal at: https://www.cell.com/cell/issue?pii=S0092-8674(19)X0025-2. GeneLab is available at: https://genelab.nasa.gov/.

Journal Impact Factor: 38.637

Funding: “Support was provided by NASA: NNX14AH51G (all Twins Study principal investigators [PIs]); NNX14AB02G and 80NSSC19K0434 (S.M.B.); NNX14AH50G, NNX17AB26G, and 19_HCBPSR_2-0067. Support was also provided by the NIH (R01CA249054, R01AI151059, and R01MH117406 to C.E.M.). A.B. was supported by NASA grant 16-ROSBFP_GL-0005: NNH16ZTT001N-FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (Award Number: 80NSSC19K0883) and the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404). S.P. and O.O. were supported by the program of fundamental research (themes 64.1; 65.1) of the IBMP. S.V.C. and E.C. are funded by NASA Human Research Program grants NNJ16HP24I (S.V.C.) and 80JSC018N001 (E.C.) and E.P. by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A. P.G. is funded by Human Research Program grant 80NSSC18K1492.”

 

11

Bezdan D, Grigorev K, Meydan C, Pelissier Vatter FA, Cioffi M, Rao V, MacKay M, Nakahira K, Burnham P, Afshinnekoo E, Westover C, Butler D, Moszary C, Donahoe T, Foox J, Mishra T, Lucotti S, Rana BK, Melnick AM, Zhang H, Matei I, Kelsen D, Yu K, Lyden DC, Taylor L, Bailey SM, Snyder MP, Garrett-Bakelman FE, Ossowski S, De Vlaminck I, Mason CE.

Cell-free DNA (cfDNA) and exosome profiling from a year-long human spaceflight reveals circulating biomarkers.

iScience. 2020 Nov 25. [Article in Press]

https://www.cell.com/iscience/fulltext/S2589-0042(20)31041-5

PIs: S.M. Bailey, C.E. Mason, M.P. Snyder. NASA Twins Study PIs:  S.M. Bailey, M. Basner, A.P. Feinberg, S.M.C. Lee, C.E. Mason, E. Mignot, B.K. Rana, S.M. Smith, M.P. Snyder, F.W. Turek, A.R. Hargens

Note: ISS results.

Journal Impact Factor: 4.447

Funding: “We would like to thank the Epigenomics Core Facility and the Scientific Computing Unit (SCU) at Weill Cornell Medicine, as well as the Starr Cancer Consortium (I9-A9-071) and funding from the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L and N Kuggie Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH51G (all Twins Study principal investigators); NNX14AB02G (S.M.B.); and NNX17AB26G (C.E.M.), NNX14AH52G), the National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006, R01AI151059, 1R21AI129851, 1R01MH117406), TRISH (NNX16AO69A:0107, NNX16AO69A:0061, NIH/NCATS KL2-TR-002385), the Bill and Melinda Gates Foundation (OPP1151054), the Leukemia and Lymphoma Society (LLS) grants (LLS 9238-16, LLS-MCL-982).”

 

12

da Silveira WA, Fazelinia H, Rosenthal SB, Laiakis EC, Kim MS, Meydan C, Kidane Y, Rathi KS, Smith SM, Stear B, Ying Y, Zhang Y, Foox J, Zanello S, Crucian B, Wang D, Nugent A, Costa HA, Zwart SR, Schrepfer S, Elworth RAL, Sapoval N, Treangen T, MacKay M, Gokhale NS, Horner SM, Singh LN, Wallace DC, Willey JS, Schisler JC, Meller R, McDonald JT, Fisch KM, Hardiman G, Taylor D, Mason CE, Costes SV, Beheshti A.

Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact.

Cell. 2020 Nov 25;183(5):1185-201.e20.

https://pubmed.ncbi.nlm.nih.gov/33242417

PIs: J.S. Willey, S.M. Smith, B.E. Crucian, C.E. Mason

Note: ISS results. The article is featured on the cover of the journal at: https://www.cell.com/cell/issue?pii=S0092-8674(19)X0025-2. GeneLab is available at: https://genelab.nasa.gov/.

Journal Impact Factor: 38.637

Funding: “Research funding was provided by the GeneLab Project at NASA Ames Research Center, through NASA’s Space Biology Program in the Division of Space Life and Physical Sciences Research and Applications. … J.S.W. was supported by NASA NNX15AB50G. Metabolomics work by E.C.L. was supported by award number P30 CA051008 (P.I. Louis Weiner) from the National Cancer Institute. G.H. acknowledges support from NIH U54MD010706, U01DA045300, and QUB startup funds. W.A.d.S. and G.H. acknowledge support from NASA SC Space Grant/EPSCoR. N.S.G. was supported by the American Heart Association (17PRE33670017). … The human physiology data reported were supported by the Human Health Countermeasures Element of the NASA Human Research Program, and funding provided to S.M.S., S.R.Z., and B.E.C. We would like to thank the XSEDE Supercomputing Resources, STARRI13-0052, the Vallee and WorldQuant Foundation, the Pershing Square Foundation, NASA (NNX15AB50G, NNX17AB26G, 19-19OMNI_2-0109), the National Institutes of Health (R01MH117406, R01CA249054), TRISH (NNX16AO69A:0107, NNX16AO69A:0061), and the LLS 9238-16, Mak, (LLSMCL7001-18).”

 

13

Gertz ML, Chin CR, Tomoiaga D, MacKay M, Chang C, Butler D, Afshinnekoo E, Bezdan D, Schmidt MA, Mozsary C, Melnick A, Garrett-Bakelman F, Crucian B, Lee SMC, Zwart SR, Smith SM, Meydan C, Mason CE. 

Multi-omic, single-cell, and biochemical profiles of astronauts guide pharmacological strategies for returning to gravity.

Cell Rep. 2020 Nov 20. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242408

PI: C.E. Mason

Journal Impact Factor: 8.109

Funding: “We would like to thank the Epigenomics Core Facility at Weill Cornell Medicine, the Starr Cancer Consortium (I9-A9-071), and the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, the Bert L. and N. Kuggie Vallee Foundation, the WorldQuant Foundation, the Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, NNX17AB26G), the National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006, 1R21AI129851, 1R01MH117406, 1F31CA254302-01), TRISH (NNX16AO69A:0107, NNX16AO69A:0061), the Bill and Melinda Gates Foundation (OPP1151054), and the Leukemia and Lymphoma Society (LLS) (LLS 9238-16, Mak; LLS-MCL-982, Chen-Kiang).”

 

14

Lai Polo S-H, Saravia-Butler AM, Boyko V, Dinh MT, Chen Y-C, Fogle H, Reinsch SS, Ray S, Chakravarty K, Marcu O, Chen RB, Costes SV, Galazka JM.

RNAseq analysis of rodent spaceflight experiments is confounded by sample collection techniques.

iScience. 2020 Nov 25. [Article in Press]

https://www.cell.com/iscience/fulltext/S2589-0042(20)30930-5

Note: ISS and Space Shuttle results. GeneLab is available at: https://genelab.nasa.gov/.

Journal Impact Factor: 4.447

Funding: “This work was funded by the NASA Space Biology program within the NASA Science Mission Directorate’s (SMD) Biological and Physical Sciences (BPS) Division.”

 

15

Luxton JJ, McKenna MJ, Lewis A, Taylor LE, George KA, Dixit SM, Moniz M, Benegas W, Mackay MJ, Mozsary C, Butler D, Bezdan D, Meydan C, Crucian BE, Zwart SR, Smith SM, Mason CE, Bailey SM. 

Telomere length dynamics and DNA damage responses associated with long-duration spaceflight.

Cell Rep. 2020 Nov 20. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242406

PIs: S.M. Bailey, C.E. Mason, S.M. Smith. NASA Twins Study PIs: S.M. Bailey, M. Basner, A.P. Feinberg, S.M.C. Lee, C.E. Mason, E. Mignot, B.K. Rana, S.M. Smith, M.P. Snyder, F.W. Turek, A.R. Hargens

Note: ISS results.

Journal Impact Factor: 8.109

Funding: “The study was supported by NASA: NNX14AH51G (all Twins Study principal investigators [PIs]); NNX14AB01G and 80NSSC19K0434 (S.M.B.); and NNX17AB26G (C.E.M.). The Biochemical Profile and Nutritional Status Assessment projects were supported by the Human Health Countermeasures Element of the NASA Human Research Program (S.M.S.).

 

16

Luxton JJ, McKenna MJ, Taylor LE, George KA, Zwart SR, Crucian BE, Drel VR, Garrett-Bakelman FE, Mackay MJ, Butler D, Foox J, Grigorev K, Bezdan D, Meydan C, Smith SM, Sharma K, Mason CE, Bailey SM. 

Temporal telomere and DNA damage responses in the space radiation environment.

Cell Rep. 2020 Nov 20. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242411

PIs: S.M. Bailey, C.E. Mason, S.M. Smith. NASA Twins Study PIs: S.M. Bailey, M. Basner, A.P. Feinberg, S.M.C. Lee, C.E. Mason, E. Mignot, B.K. Rana, S.M. Smith, M.P. Snyder, F.W. Turek, A.R. Hargens

Note: ISS results.

Journal Impact Factor: 8.109

Funding: “This study was supported by NASA: NNX14AH51G (all Twins Study principal investigators [PIs]), NNX14AB01G and 80NSSC19K0434 (to S.M.B.), and NNX17AB26G (to C.E.M.). The Biochemical Profile and Nutritional Status Assessment projects were supported by the Human Health Countermeasures Element of the NASA Human Research Program (to S.M.S.). Additional support was provided by the NIH (UH3DK114920) and DOD (CDMRPPR181598) (to K.S.).”

 

17

Malkani S, Chin CR, Cekanaviciute E, Mortreux M, Okinula H, Tarbier M, Schreurs AS, Shirazi-Fard Y, Tahimic CGT, Rodriguez DN, Sexton BS, Butler D, Verma A, Bezdan D, Durmaz C, MacKay M, Melnick A, Meydan C, Li S, Garrett-Bakelman F, Fromm B, Afshinnekoo E, Langhorst BW, Dimalanta ET, Cheng-Campbell M, Blaber E, Schisler JC, Vanderburg C, Friedländer MR, McDonald JT, Costes SV, Rutkove S, Grabham P, Mason CE, Beheshti A.

Circulating miRNA spaceflight signature reveals targets for countermeasure development.

Cell Rep. 2020 Nov 21. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242410

PIs: C.E. Mason, A. Beheshti

Note: ISS results.

Journal Impact Factor: 8.109

Funding: “C.E.M. would like to thank the Epigenomics Core Facility at Weill Cornell Medicine, the Scientific Computing Unit (SCU), XSEDE Supercomputing Resources, STARR I13-0052, the Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, NNX17AB26G, 19-19OMNI_2-0109), and the National Institutes for Health (R01MH117406, R01CA249054, TRISH [NNX16AO69A:0107, NNX16AO69A:0061], LLS 9238-16, Mak, LLS-MCL7001-18). This work was also supported by NASA grant 16-ROSBFP_GL-0005: NNH16ZTT001N-FG Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research (award 80NSSC19K0883) and The Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404) awarded to A.B. ISS-related mouse tissue research reported in this publication was supported by the International Space Station U.S. National Laboratory under award UA-2019-018 given to A.B.”

 

18

Manzano A, Villacampa A, Sáez-Vásquez J, Kiss JZ, Medina FJ, Herranz R.

The importance of Earth reference controls in spaceflight-omics research: Characterization of nucleolin mutants from the Seedling Growth experiments.

iScience. 2020 Nov 20;23(11):101686.

https://pubmed.ncbi.nlm.nih.gov/33163940

PI: J.Z. Kiss

Note: From the Introduction: “In this article, in a series of ground studies to complement space experiments, we have exposed A. thaliana (ecotype Columbia) WT, nuc1-2 and nuc2-2 seedlings to two different illumination regimes at the beginning of the plant development (6 days from germination).” The article is featured on the cover of the journal at: https://www.cell.com/iscience/issue?pii=S2589-0042(20)X0011-3. This citation previously appeared in SPACELINE Current Awareness List #925, 20 November 2020.

Journal Impact Factor: 4.447

Funding: “This work was supported by the Agencia Estatal de Investigación of the Spanish Ministry of Science and Innovation, Grants #ESP2015-64323-R and #RTI2018-099309-B-I00 (co-funded by EU-ERDF) to F.J.M., by predoctoral fellowships to A.M. and A.V. from the Spanish National Program for Young Researchers Training (MINECO, Ref. BES-2013-063933, BES-2016-077976), and the Seedling Growth Project to the ISS LSRA2009-0932/1177, a shared project of ESA-ELIPS Program and NASA. J.Z.K. is funded by Grants NNX12A065G and 80NSSC17K0546. These results are related to the Space Omics TT funded by the European Space Agency contract ESA 4000131202/20/NL/PG to R.H.”

 

19

Nwanaji-Enwerem JC, Nwanaji-Enwerem U, Van Der Laan L, Galazka JM, Redeker NS, Cardenas A.

A longitudinal epigenetic aging and leukocyte analysis of simulated space travel: The Mars-500 Mission.

Cell Rep. 2020 Nov 10:108406. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242403

Note: Bed rest study.

Journal Impact Factor: 8.109

Funding: “This work was supported by the National Institutes of Health (R03AG067064 and R01ES031259).” J.M. Galazka is affiliated with NASA Ames Research Center.

 

20

Pariset E, Bertucci A, Petay M, Malkani S, Lopez Macha A, Paulino Lima IG, Gomez Gonzalez V, Tin AS, Tang J, Plante I, Cekanaviciute E, Vazquez M, Costes SV.

DNA damage baseline predicts resilience to space radiation and radiotherapy.

Cell Rep. 2020 Nov 21:108434. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242409

PIs: S.V. Costes; E. Pariset, TRISH Postdoctoral Fellowship Program

Journal Impact Factor: 8.109

Funding: “For finger prick data, we thank the hundreds of donors who provided blood to Exogen Biotechnology, Inc., and funding via the crowdfunding platform Indiegogo and a Lawrence Berkeley National Laboratory Innovation grant (DEAC02-05CH11231). For the cancer study, we thank patients who provided blood draws, as well as the radiation oncologist, physicists, and nurses from the PTRC at the LLU Medical Center and a NIH/NIAID/Columbia University pilot grant (S U19 AI067773-10). For the cosmic radiation study, we thank NASA Human Research Project grant NNJ16HP24I (to S.V.C.) and the Translational Research Institute for Space Health through NASA NNX16AO69A (to E.P.).”

 

21

Paul AM, Cheng-Campbell M, Blaber EA, Anand S, Bhattacharya S, Zwart SR, Crucian BE, Smith SM, Meller R, Grabham P, Beheshti A.

Beyond low-Earth orbit: Characterizing immune and microRNA differentials following simulated deep spaceflight conditions in mice.

iScience. 2020 Nov 25. [Article in Press]

https://www.cell.com/iscience/fulltext/S2589-0042(20)30944-5

PIs: A. Beheshti; S.M. Smith; A.M. Paul, NASA Postdoctoral Program Fellowship

Note: Hindlimb unloading study. GeneLab is available at: https://genelab.nasa.gov/.

Journal Impact Factor: 4.447

Funding: “This work is supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404) awarded to A.B. and by the Universities Space Research Association (USRA) and NASA Space Biology Program postdoctoral fellowship to A.M.P. The astronaut data were provided by the Nutritional Status Assessment, Dietary Intake Can Predict and Protect Against Changes in BoneMetabolism During Space Flight and Recovery (Pro K), and the Biochemical Profile projects (PI: Smith and Zwart), which were supported by the NASA Human Research Program’s Human Health Countermeasure Element.”

 

22

Rutter L, Barker R, Bezdan D, Cope H, Costes SV, Degoricija L, Fisch KM, Gabitto MI, Gebre S, Giacomello S, Gilroy S, Green SJ, Mason CE, Reinsch SS, Szewczyk NJ, Taylor DM, Galazka JM, Herranz R, Muratani M. 

A new era for space life science: International standards for space omics processing.

Patterns. 2020 Nov 25. [Article in Press]

https://www.cell.com/patterns/fulltext/S2666-3899(20)30196-3

PIs: S. Gilroy, S. Vanapalli

Note: GeneLab is available at: https://genelab.nasa.gov/.

Journal Impact Factor: Not available for this journal

Funding: “European (D.B., H.C., N.J.S., R.H., and S. Giacomello) contribution is supported by ESA Topical Team “Space Omics: Towards an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments” grant 4000131202/20/NL/PG/pt to R.H. S. Giacomello is supported by Formas grant 2017-01066_3. H.C. is supported by the Horizon Centre for Doctoral Training at the University of Nottingham (UKRI grant no. EP/S023305/1) and by the NASA GeneLab Animal Analysis Working Group. N.J.S. is supported by the National Aeronautics and Space Administration (NNX15AL16G). NASA GeneLab members (J.M.G., S.V.C., S.S.R., L.D., S. Gebre) are supported by the NASA Space Biology program within the NASA Science Mission Directorate’s (SMD) Biological and Physical Sciences (BPS) Division. R.B. and S. Gilroy are supported by NASA (80NSSC19K0132). L.R. and M.M. represent the Omics Subgroup of Japan Society for the Promotion of Science (JSPS) KAKENHI funding group Living in Space and are supported by JP15K21745, JP15H05940, and JP20H03234. L.R. is supported by JSPS postdoctoral fellowship P20382. D.T. is supported by the Department of Biomedical and Health Informatics and The Children’s Hospital of Philadelphia Research Institute. K.F. is supported by the UC San Diego Department of Medicine and National Institutes of Health, grant UL1TR001442 of CTSA (Clinical and Translational Science Awards). C.E.M. is funded from the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, and the National Institutes of Health (R01MH117406). S.V.C., J.M.G., and S.S.R. are supported by the GeneLab Project at NASA Ames Research Center, through NASA’s BPS division in the SMD…”

 

23

Scott RT, Grigorev K, Mackintosh G, Gebre SG, Mason CE, Del Alto ME, Costes SV.

Advancing the integration of biosciences data sharing to further enable space exploration.

Cell Rep. 2020 Nov 19. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242404

Note: GeneLab is available at: https://genelab.nasa.gov/.

Journal Impact Factor: 8.109

Funding: No funding cited. Most of the authors are affiliated with NASA Ames Research Center.

 

24

Szewczak L.

An extraordinary astronaut.

Cell. 2020 Nov 23. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242423

Note: The authors converses with retired astronaut Scott Kelly and Chris Mason, a NASA-funded researcher.

Journal Impact Factor: 38.637

Funding: No funding cited. S. Kelly was affiliated with NASA Johnson Space Center.

 

25

Trinchant NM, MacKay MJ, Chin C, Afshinnekoo E, Foox J, Meydan C, Butler D, Mozsary C, Vernice NA, Darby C, Schatz MC, Bailey SM, Melnick AM, Guzman M, Bolton K, Braunstein LZ, Garrett-Bakelman F, Levine RL, Hassane D, Mason CE. 

Clonal hematopoiesis before, during, and after human spaceflight.

Cell Rep. 2020 Nov 20:108458. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242405

PI: C.E. Mason

Note: ISS results.

Journal Impact Factor: 8.109

Funding: “The study was supported by NASA/TRISH grants (NNX14AH51G, NNX17AB26G, NNX16AO69A:0107, NNX16AO69A:0061), as well as the Bert L and N Kuggie Vallee Foundation, Igor Tulchinsky and the WorldQuant Foundation, and The Pershing Square Sohn Cancer Research Alliance (Mason).”

 

26

Walls S, Diop S, Birse R, Elmen L, Gan Z, Kalvakuri S, Pineda S, Reddy C, Taylor E, Trinh B, Vogler G, Zarndt R, McCulloch A, Lee P, Bhattacharya S, Bodmer R, Ocorr K.

Prolonged exposure to microgravity reduces cardiac contractility and initiates remodeling in Drosophila.

Cell Rep. 2020 Nov 23. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242407

PI: R. Bodmer

Note: ISS results. GeneLab is available at: https://genelab.nasa.gov/.

Journal Impact Factor: 8.109

Funding: “This work was supported in part by the following grants: K.O., NASA NNX13AN38G, AHA SDG 0835243N, NIH HL132241, and NIA AG061598; R.B., NASA NNX13AN38G, NIA AG058075, and NIH HL05432 and HL149992; and S.B., NASA NNX13AN38G and A.M., R01 HL137100.”

 

27

Willis CRG, Szewczyk NJ, Costes SV, Udranszky IA, Reinsch SS, Etheridge T, Conley CA.

Comparative transcriptomics identifies neuronal and metabolic adaptations to hypergravity and microgravity in Caenorhabditis elegans.

iScience. 2020 Nov 25. [Article in Press]

https://www.cell.com/iscience/fulltext/S2589-0042(20)30931-7

Note: ISS results; centrifugation was used for hypergravity studies. GeneLab is available at: https://genelab.nasa.gov/.

Journal Impact Factor: 4.447

Funding: “C.R.G.W. is supported by the Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership (BB/J014400/1; BB/M009122/1). This work was partially supported by funding from the Biotechnology and Biological Sciences Research Council (BB/N015894/1). This research was also supported by the MRC-Versus Arthritis Centre for Musculoskeletal Aging Research (MR/P021220/1; MR/R502364/1) and National Institute for Health Research Nottingham Biomedical Research Centre.” S.V. Costes, I.A. Udranszky, S.S. Reinsch, and C.A. Conley are affiliated with NASA Ames Research Center.

 

28

Wuu Y-R, Hu B, Okunola H, Paul AM, Blaber EA, Cheng-Campbell M, Beheshti A, Grabham P.

LET-dependent low dose and synergistic inhibition of human angiogenesis by charged particles: Validation of miRNAs that drive inhibition.

iScience. 2020 Nov 25. [Article in Press]

https://www.cell.com/iscience/fulltext/S2589-0042(20)30968-8

PIs: P. Grabham, A. Beheshti

Note: GeneLab is available at: https://genelab.nasa.gov/.

Journal Impact Factor: 4.447

Funding: “This work was supported by NASA grants; NNX11AR03G, and NNX14AR22G awarded to P.G. and the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404) awarded to A.B.”

______________________________________________________

 

 

Other papers of interest:

 

1

Zakharova NM, Tarahovsky YS, Komelina NP, Fadeeva IS, Kovtun AL.

Long-term pharmacological torpor of rats with feedback-controlled drug administration.

Life Sci Space Res. 2021 Feb;28:18-21. Epub 2020 Nov 26.

http://www.sciencedirect.com/science/article/pii/S2214552420300857

 

2

Madrigal P, Gabel A, Villacampa A, Manzano A, Deane CS, Bezdan D, Carnero-Diaz E, Medina FJ, Hardiman G, Grosse I, Szewczyk N, Weging S, Giacomello S, Harridge SDR, Morris-Paterson T, Cahill T, da Silveira WA, Herranz R. 

Revamping space-omics in Europe.

Cell Syst. 2020 Nov 9. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242401

Note: This article is part of the Cell Press “The Biology of Spaceflight” special collection.

 

3

Hughson RL, Irving E.

Spaceflight not an eye-popping experience for astronauts.

J Physiol. 2020 Nov 26. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242219

 

4

Wostyn P, De Winne F, Stern C, Mader TH, Gibson CR, De Deyn PP.

Potential involvement of the “ocular glymphatic system” in optic disc edema in astronauts.

Aerosp Med Hum Perform. 2020 Dec 1;91(12):975-7.

https://pubmed.ncbi.nlm.nih.gov/33243343

 

5

Figueiredo VC, D’Souza RF, Van Pelt DW, Lawrence MM, Zeng N, Markworth JF, Poppitt SD, Miller BF, Mitchell CJ, McCarthy JJ, Dupont-Versteegden EE, Cameron-Smith D.

Ribosome biogenesis and degradation regulate translational capacity during muscle disuse and reloading.

J Cachexia Sarcopenia Muscle. 2020 Nov 24. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33231914

Note: A brace was used for knee immobilization. This article may be obtained online without charge.

 

6

Yoshihara T, Naito H.

Protective effects of acute exercise preconditioning on disuse-induced muscular atrophy in aged muscle: A narrative literature review.

J Physiol Sci. 2020 Nov 27;70(1):55. Review.

https://pubmed.ncbi.nlm.nih.gov/33246401

Note: This article may be obtained online without charge.

 

7

Ait Oumghar I, Barkaoui A, Chabrand P.

Toward a mathematical modeling of diseases’ impact on bone remodeling: Technical review.

Front Bioeng Biotechnol. 2020 Nov 2;8:584198. Review.

https://pubmed.ncbi.nlm.nih.gov/33224935

Note: This article may be obtained online without charge.

 

8

Poorani R, Bhatt AN, Das UN.

Modulation of pro-inflammatory and pro-resolution mediators by γ-linolenic acid: An important element in radioprotection against ionizing radiation.

Arch Med Sci. 2020;16(6):1448-56.

https://pubmed.ncbi.nlm.nih.gov/33224346

Note: This article may be obtained online without charge.

 

9

Sakata D, Belov O, Bordage MC, Emfietzoglou D, Guatelli S, Inaniwa T, Ivanchenko V, Karamitros M, Kyriakou I, Lampe N, Petrovic I, Ristic-Fira A, Shin WG, Incerti S.

Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA.

Sci Rep. 2020 Nov 27;10(1):20788.

https://pubmed.ncbi.nlm.nih.gov/33247225

Note: This article may be obtained online without charge.

 

10

Wang B, Yasuda H.

Relative biological effectiveness of high LET particles on the reproductive system and fetal development.

Life (Basel). 2020 Nov 20;10(11):298. Review.

https://pubmed.ncbi.nlm.nih.gov/33233778

Note: This article may be obtained online without charge.

 

11

Chang CH, Stoffregen TA, Cheng KB, Lei MK, Li CC.

Effects of physical driving experience on body movement and motion sickness among passengers in a virtual vehicle.

Exp Brain Res. 2020 Nov 26. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33242143

 

12

Wu J, Yan M, Zhang D, Zhou D, Yamaguchi N, Ito T.

Histone demethylases coordinate the antagonistic interaction between abscisic acid and brassinosteroid signaling in Arabidopsis.

Front Plant Sci. 2020 Nov 25;11:1862.

https://www.frontiersin.org/article/10.3389/fpls.2020.596835

Note: This article may be obtained online without charge.

 

13

Macharoen K, Du M, Jung S, McDonald KA, Nandi S.

Production of recombinant butyrylcholinesterase from transgenic rice cell suspension cultures in a pilot-scale bioreactor.

Biotechnol Bioeng. 2020 Nov 26. [Epub ahead of print]

https://pubmed.ncbi.nlm.nih.gov/33241854

 

14

Wang Z, Lu Y, Fu S.

A multidimensional method for pilot workload assessment and diagnosis.

Aerosp Med Hum Perform. 2020 Dec 1;91(12):932-9.

https://pubmed.ncbi.nlm.nih.gov/33243336

Note: The NASA Task Load Index was used.

 

SpaceRef staff editor.