Status Report

NASA Spaceline Current Awareness List #926 27 November 2020 (Space Life Science Research Results)

By SpaceRef Editor
November 27, 2020
Filed under , , ,

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



Hoffmann F, Rabineau J, Mehrkens D, Gerlach DA, Moestl S, Johannes BW, Caiani EG, Migeotte PF, Jordan J, Tank J.

Cardiac adaptations to 60 day head-down-tilt bed rest deconditioning. Findings from the AGBRESA study.

ESC Heart Fail. 2020 Nov 15. [Epub ahead of print]

Note: Bed rest study (AGBRESA is the Artificial Gravity Bed Rest—European Space Agency). A short-arm human centrifuge was used. This article may be obtained online without charge.

Journal Impact Factor: 3.902

Funding: “This work was supported by NASA, ESA, the Belgian Federal Scientific Policy Office (PRODEX PEA 4000110826), and programmatic funding of the German Aerospace Center (DLR). F.H. received funding from the German Aerospace Center (DLR) and the German Federal Ministry of Economy and Technology (BMWi; 50WB1816). J.R. was supported by the Fonds de la Recherche Scientifique (Mandat Aspirant F.R. S.–FNRS FC 29801).”



Lee SMC, Laurie SS, Macias BR, Zwart SR, Smith SM, Stenger MB.

Reply to Greaves et al.

J Appl Physiol (1985). 2020 Nov 1;129(5):1113.

PI: S.M.C. Lee

Note: The authors reply to #4 in the ‘Other papers of interest’ section. This article may be obtained online without charge.

Journal Impact Factor: 3.044

Funding: From the original study: “This research was supported by NASA’s Human Research Program.”



Lafita-Navarro MC, Venkateswaran N, Kilgore JA, Kanji S, Han J, Barnes S, Williams NS, Buszczak M, Burma S, Conacci-Sorrell M.

Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells.

PLoS Genet. 2020 Nov 17;16(11):e1009117.

PI: S. Burma

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.174

Funding: This research was supported by Cancer Prevention and Research Institute of Texas RR150059 and RP150596, American Cancer Society IRG-17-174-13, Welch I-1914, NCI R01CA245548, University of Texas Southwestern Circle of Friends Early Investigator Award to M.C-S, the NIH (R01GM125812) to M.B, and NIH grant CA197796, NNX16AD78G to SB, 1S10OD021684-01 award to Dr. Kate Luby-Phelps.”



Aunins TR, Erickson KE, Chatterjee A.

Transcriptome-based design of antisense inhibitors potentiates carbapenem efficacy in CRE Escherichia coli.

Proc Natl Acad Sci U S A. 2020 Nov 16. [Epub ahead of print]

PI: A. Chatterjee

Journal Impact Factor: 9.350

Funding: “This work was funded by University of Colorado Dean’s Graduate research grants (to T.R.A. and K.E.E.), the University of Colorado Graduate Assistance in Areas of National Need Fellowship (to T.R.A.), the W. M. Keck Foundation, Defense Advanced Research Projects Agency Young Faculty Award D17AP00024 (to A.C.), National Aeronautics and Space Administration Cooperative Agreement Notice–Translational Research Institute for Space Health Grant NNX16A069A (to A.C.), and Lab Venture Challenge Award (to A.C.).”



Khossravi EA, Hargens AR.

Visual disturbances during prolonged space missions.

Curr Opin Ophthalmol. 2020 Nov 12. [Epub ahead of print] Review.

PI: A.R. Hargens

Note: From the abstract: “This article reviews symptoms, likely causes, and potential solutions, such as lower body negative pressure, to counteract space-associated neuroocular syndrome (SANS).”

Journal Impact Factor: 2.983

Funding: “Supported by NASA grants NNX13AJ12G “Fluid Distribution before, during and after Prolonged Space Flight,” 80NSSC19K0301 “Venous Congestion and Directed Countermeasures,” and 80NSSC19K0409 “Self-Generated LBNP for Deep-Space Missions.””



Parihar VK, Angulo MC, Allen BD, Syage A, Usmani MT, Passerat de la Chapelle E, Amin AN, Flores L, Lin X, Giedzinski E, Limoli CL.

Sex-specific cognitive deficits following space radiation exposure.

Front Behav Neurosci. 2020 Sep 16;14:535885.

PIs: C.L. Limoli/V.K. Parihar/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.512

Funding: “This work was supported by NASA Grant NNX15AI22G (VP, CL).”



Preston RJ, Rühm W, Azzam EI, Boice JD Jr, Bouffler S, Held KD, Little MP, Shore RE, Shuryak I, Weil MM.

Adverse outcome pathways, key events and radiation risk assessment.

Int J Radiat Biol. 2020 Nov 19. [Epub ahead of print] Review.

PI: E.I. Azzam

Journal Impact Factor: 2.368

Funding: “Financial support for the preparation of NCRP Report No. 186 was provided by a Grant from the Centers for Disease Control and Prevention (CDC)….The contribution of MPL was supported by the Intramural Research Program of the National Institutes of Health, the National Cancer Institute, Division of Cancer Epidemiology and Genetics. The Contribution of EIA was supported by the US Department of Energy Low Dose Research program, the National Aeronautics and Space Administration and the National Institutes of Health.”



Gottlieb JF, Goel N, Chen S, Young MA.

Meta-analysis of sleep deprivation in the acute treatment of bipolar depression.

Acta Psychiatr Scand. 2020 Nov 15. [Epub ahead of print] Review.

PI: N. Goel

Journal Impact Factor: 5.362

Funding: “Partial support for this meta-analysis was provided by National Aeronautics and Space Administration (NASA) NNX14AN49G and grant 80NSSC20K0243 (to N.G.), and National Institutes of Health grant NIH R01DK117488 (to N.G.). J.F.G., S.C. and M.Y. received no funding support for this paper.”




Other papers of interest:



Catizone A, Morabito C, Cammarota M, Schiraldi C, Corano Scheri K, Ferranti F, Mariggiò MA, Ricci G.

Microgravity-induced cell-to-cell junctional contacts are counteracted by antioxidant compounds in TCam-2 seminoma cells.

Appl Sci. 2020 Nov 23;10(22):8289.

Note: A random positioning machine was used. This article belongs to the Special Issue “Advances in Space Biology: Cell Behavior in Microgravity” available at This article may be obtained online without charge.



Liu J, Yuan M, Wang L, Li Y, Bart  B, Du S, Zhao X, Qu L, Li Z, Chen Z, Wu Y, Yang X, Li Z, Aubert A, Li Y.

[Hemodynamic responses induced by 75° and 60° head-up tilt].

Space Med Med Eng. 2020;2020(5):377-83. Chinese.

Note: Head-up tilt was used.



Liu R, Xue G, Yuan M, Wang J, Wang J, Cheng J, Yuan M.

[Expression and bioinformatics analysis of miR-1224-5p in RAW264.7 macrophages infected by space mutation E.coli under simulated weightlessness].

Space Med Med Eng. 2020;2020(5):384-9. Chinese.

Note: A clinostat was used.



Greaves DK, Robertson AD, Patterson CA, Au JS, Hughson RL.

Evidence for increased cardiovascular risk to crew during long duration space missions.

J Appl Physiol (1985). 2020 Nov 1;129(5):1111-2.

Note: The authors comment on: Lee SMC, Ribeiro LC, Martin DS, Zwart SR, Feiveson AH, Laurie SS, Macias BR, Crucian BE, Krieger S, Weber D, Grune T, Platts SH, Smith SM, Stenger MB. Arterial structure and function during and after long-duration spaceflight. J Appl Physiol (1985). 2020 Jul 1;129(1):108-23. The original article appeared in SPACELINE Current Awareness List #904, 19 June 2020. A reply from Lee, et al. may be found in the NASA section of this list. This article may be obtained online without charge.



Robertson AD, Papadhima I, Edgell H.

Sex differences in the autonomic and cerebrovascular responses to upright tilt.

Auton Neurosci. 2020 Dec 1;229:102742.

Note: Supine rest and 70° upright tilt were used.



Klassen SA, Shoemaker JK.

Action potential subpopulations within human muscle sympathetic nerve activity: Discharge properties and governing mechanisms.

Auton Neurosci. 2021 Jan 1;230:102743. Review. Epub 2020 Nov 5.



Tomida K, Nakae H.

Efficacy of belt electrode skeletal muscle electrical stimulation on muscle flexibility of lower limbs: A randomized controlled pilot trial.

Medicine (Baltimore). 2020 Nov 20;99(47):e23156.

Note: This article may be obtained online without charge.



Huai Y, Zhang W, Chen Z, Zhao F, Wang W, Dang K, Xue K, Gao Y, Jiang S, Miao Z, Li M, Hao Q, Chen C, Qian A.

A comprehensive analysis of microRNAs in human osteoporosis.

Front Endocrinol (Lausanne). 2020 Oct 21;11:516213.

Note: This article may be obtained online without charge.



Komatsu DE, Duque E, Hadjiargyrou M.

MicroRNAs and fracture healing: Pre-clinical studies.

Bone. 2020 Nov 17. [Epub ahead of print] Review.



Riffault M, Johnson GP, Owen MM, Javaheri B, Pitsillides AA, Hoey DA.

Loss of adenylyl cyclase 6 in leptin receptor-expressing stromal cells attenuates loading-induced endosteal bone formation.

JBMR Plus. 2020 Nov 20;4(11):e10408.

Note: Mechanical loading of the tibia was used. This article may be obtained online without charge.



Steppe L, Liedert A, Ignatius A, Haffner-Luntzer M.

Influence of low-magnitude high-frequency vibration on bone cells and bone regeneration.

Front Bioeng Biotechnol. 2020 Oct 21;8:595139. Review.

Note: This article may be obtained online without charge.



Wood A, Karipidis K.

Radiofrequency fields and calcium movements into and out of cells.

Radiat Res. 2020 Nov 18. [Epub ahead of print]



Bruguera MB, Fink A, Schröder V, Bermudez SL, Dessy E, van den Berg FP, Lawson G, Dangoisse C, Possnig C, Albertsen N, Pattyn N, Ewald R.

Assessment of the effects of isolation, confinement and hypoxia on spaceflight piloting performance for future space missions – The SIMSKILL experiment in Antarctica.

Acta Astronaut. 2021 Feb;179:471-83. Epub 2020 Nov 20.

Note: From the abstract: “…the SIMSKILL Experiment aims to investigate how spacecraft piloting performance decays over time by deploying a Soyuz flight simulator on the Antarctic research stations Halley VI and Concordia, which feature similar living conditions as those of a space mission, leading eventually to muscular atrophy, loss of cognitive capacities, and reduction of psycho-motor skills.”



Wang X, Wang Y, Yang X, Gao S, Su Y.

[Effects of head-down bed rest, calorie restriction and claustrophobic environment on individuals’ cognitive control and emotional state].

Space Med Med Eng. 2020;2020(5):457-63. Review. Chinese.

Note: Head-down tilt bed rest studies are reviewed.



Zhang W, Liu H, Li Z, Liu H.

[Effect of strawberry gardening on autonomic nervous response and emotion of people long-term staying indoor].

Space Med Med Eng. 2020;2020(5):409-15. Chinese.



Reem NT, Chambers L, Zhang N, Abdullah SF, Chen Y, Feng G, Gao S, Soto-Burgos J, Pogorelko G, Bassham DC, Anderson CT, Walley JW, Zabotina OA.

Post-synthetic reduction of pectin methylesterification causes morphological abnormalities and alterations to stress response in Arabidopsis thaliana.

Plants (Basel). 2020 Nov 12;9(11):E1558.

Note: This article may be obtained online without charge.



Tsugawa S, Kanda N, Nakamura M, Goh T, Ohtani M, Demura T.

Spatio-temporal kinematic analysis of shoot gravitropism in Arabidopsis thaliana.

Plant Biotechnol. 2020 Nov 17. [Article in Press]

Note: This article may be obtained online without charge.



Watanabe S, Takahashi N, Kanno Y, Suzuki H, Aoi Y, Takeda-Kamiya N, Toyooka K, Kasahara H, Hayashi KI, Umeda M, Seo M.

The Arabidopsis NRT1/PTR FAMILY protein NPF7.3/NRT1.5 is an indole-3-butyric acid transporter involved in root gravitropism.

Proc Natl Acad Sci U S A. 2020 Nov 20. [Epub ahead of print]

Note: This article may be obtained online without charge.



Arai T, Fricker J.

Electro-oxidation of urine and constituent analysis of resulting wastewater and generated gases for water recovery in space.

Acta Astronaut. 2021 Feb;179:415-24. Epub 2020 Nov 19.



Gao J, Tang Y, Wu Z, Liu X, Xu Z, Ai W.

[Selection of substrates and their effects on lettuce growth in CELSS].

Space Med Med Eng. 2020;2020(5):440-8. Chinese.



Trouillefou CM, Law-Kam Cio Y-S, Jolicoeur M, Said B, Galarneau A, Achiche S, Beltrame G.

An autonomous plant growing miniaturized incubator for a Cubesat.

Acta Astronaut. 2021 Feb;179:439-49. Epub 2020 Nov 20.



Sawers RG.

Setting the stage: Genes controlling mechanosensation and Ca2+-signalling in E. coli.

J Bacteriol. 2020 Nov 16. [Epub ahead of print]

Note: This article may be obtained online without charge.



Ma L, Yuan J, Yin H, Zhang W, Xu K.

[Application of Drosophila in space biology researches].

Space Med Med Eng. 2020;2020(5):449-56. Chinese.



Geng H, Zhou Y, Zhang Y, Liu J, Niu J, Shi J.

[Review on study of team workload for multi-person synergy in complex system].

Space Med Med Eng. 2020;2020(5):464-70. Review. Chinese.



Ponnambalam CT, Donmez B.

Searching for street parking: Effects on driver vehicle control, workload, physiology, and glances.

Front Psychol. 2020 Oct 20;11:574262.

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

SpaceRef staff editor.