NASA Spaceline Current Awareness List #925 20 November 2020 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Nikitaki Z, Pariset E, Sudar D, Costes SV, Georgakilas AG.
In situ detection of complex DNA damage using microscopy: A rough road ahead.
Cancers (Basel). 2020 Nov 6;12(11):E3288. Review.
https://pubmed.ncbi.nlm.nih.
PI: E. Pariset, TRISH Postdoctoral Fellowship Program
Note: This article may be obtained online without charge.
Journal impact Factor: 6.126
Funding: “Funding: This research is co-financed by Greece and the European Union (European Social Fund- ESF) through the Operational Program “Human Resources Development, Education and Lifelong Learning” in the context of the project “Reinforcement of Postdoctoral Researchers—2nd Cycle” (MIS-5033021), implemented by the State Scholarships Foundation (IKY). E.P. is funded by the Translational Research Institute for Space Health through NASA NNX16AO69A.”
2
Stepanov VG, Fox GE.
Expansion segments in bacterial and archaeal 5S ribosomal RNAs.
RNA. 2020 Nov 12. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.320
Funding: “This work was supported in part by NASA Exobiology Grant NNX14AK36G and NASA Contract 80NSSC18K1139 under the Center for Origin of Life, Georgia Institute of Technology to GEF.”
3
Paul AM, Mhatre SD, Cekanaviciute E, Schreurs A-S, Tahimic CGT, Globus RK, Anand S, Crucian BE, Bhattacharya S.
Neutrophil-to-lymphocyte ratio: A biomarker to monitor the immune status of astronauts.
Front Immunol. 2020 Nov 2;11:2833.
https://www.frontiersin.org/
PIs: S. Govind; A. Paul, NASA Postdoctoral Program Fellowship
Note: Hindlimb unloading study. A high-aspect rotating wall vessel (HARV) was used. This article may be obtained online without charge.
Journal Impact Factor: 5.085
Funding: “This work was supported in part by Universities Space Research Association (USRA) and NASA’s Space Biology Program postdoctoral fellowship (to AMP) and NASA’s Space Biology Grant #NNX15AB42G (to SB).”
4
Jin W, Zhang W, Mitra D, McCandless MG, Sharma P, Tandon R, Zhang F, Linhardt RJ.
The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica.
Int J Biol Macromol. 2020 Nov 15;163:1649-58.
https://pubmed.ncbi.nlm.nih.
PI: R. Tandon
Note: This article may be obtained online without charge.
Journal Impact Factor: 5.162
Funding: “This study was supported by the Zhejiang Provincial Natural Science Foundation of China (No. LY19D060006), the National Natural Science Foundation of China (No. 41906095) and China Scholarship Council (W.J.). R.T. received funding from National Aeronautics and Space Administration (80NSSC19K1603) and the University of Mississippi Medical Center. The National Institutes of Health Grants DK111958, CA231074, NS088496 and AG062344 to R.J.L.”
5
Tandon R, Sharp JS, Zhang F, Pomin VH, Ashpole NM, Mitra D, McCandless MG, Jin W, Liu H, Sharma P, Linhardt RJ.
Effective inhibition of SARS-CoV-2 entry by heparin and enoxaparin derivatives.
J Virol. 2020 Nov 10. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
PI: R. Tandon
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.501
Funding: “Partial funding for this work was provided by University of Mississippi Medical Center. H.L and J.S.S. acknowledge funding from the National Institute of General Medical Sciences (R01GM127267). N.M.A. acknowledges funding from the National Institute of General Medical Sciences (P30GM122733). R.T. acknowledges funding from NASA (80NSSC19K1603).”
6
Blackwell AA, Schell BD, Osterlund Oltmanns JR, Whishaw IQ, Ton ST, Adamczyk NS, Kartje GL, Britten RA, Wallace DG.
Skilled movement and posture deficits in rat string-pulling behavior following low dose space radiation (28Si) exposure.
Behav Brain Res. 2020 Nov 9. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
PI: R.A. Britten
Journal Impact Factor: 2.977
Funding: “Office of Academic Affiliations VA Advanced Fellowship in Polytrauma/Traumatic Brain Injury Rehabilitation; Department of Veterans Affairs. This work was funded in part by NASA grant support NNX14AE73 and NNX16AC40G.”
7
Penninckx S, Pariset E, Acuna AU, Lucas S, Costes SV.
Considering cell proliferation to optimize detection of radiation-induced 53BP1-positive foci in 15 mouse strainsex vivo.
Radiat Res. 2020 Nov 12. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
PIs: S.V. Costes; E. Pariset, TRISH Postdoctoral Fellowship Program
Journal Impact Factor: 2.779
Funding: “This work was supported by the National Aeronautics and Space Administration (grant no. NNJ16HP24I to SVC, principal investigator) and by the Low Dose Scientific Focus Area, Office of Biological and Environmental Research, U.S. Department of Energy (contract no. DE AC02-05CH11231). EP is funded by the NASA Human Research Program (no. NNJ16HP24I) and the Translational Research Institute for Space Health through NASA Cooperative Agreement No. NNX16AO69A. SP is funded by the Walloon Region (PROTHERWAL, grant no. 7289).”
8
Takahashi A, Yamanouchi S, Takeuchi K, Takahashi S, Tashiro M, Hidema J, Higashitani A, Adachi T, Zhang S, Guirguis FNL, Yoshida Y, Nagamatsu A, Hada M, Takeuchi K, Takahashi T, Sekitomi Y.
Combined environment simulator for low-dose-rate radiation and partial gravity of Moon and Mars.
Life (Basel). 2020 Nov 6;10(11):E274.
https://pubmed.ncbi.nlm.nih.
PI: M. Hada
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.991
Funding: “This research was funded by the Institute of Space and Astronautical Science, JAXA Front Loading Study, MEXT Grant-in-Aid for Scientific Research on Innovative Areas, Japan “Living in Space” (grant nos. JP15H05945, JP15H05935, and JP15K21745) and NASA Space Biology Program (grant no. 80NSSC19K0133).”
9
Manzano A, Villacampa A, Sáez-Vásquez J, Kiss JZ, Medina FJ, Herranz R.
The importance of Earth reference controls in spaceflight-omics research: Characterization of nucleolin mutants from the Seedling Growth experiments.
iScience. 2020 Nov 20;23(11):101686.
https://pubmed.ncbi.nlm.nih.
PI: J.Z. Kiss
Note: From the Introduction: “In this article, in a series of ground studies to complement space experiments, we have exposed A. thaliana (ecotype Columbia) WT, nuc1-2 and nuc2-2 seedlings to two different illumination regimes at the beginning of the plant development (6 days from germination).” This article may be obtained online without charge.
Journal Impact Factor: 4.447
Funding: “This work was supported by the Agencia Estatal de Investigación of the Spanish Ministry of Science and Innovation, Grants #ESP2015-64323-R and #RTI2018-099309-B-I00 (co-funded by EU-ERDF) to F.J.M., by predoctoral fellowships to A.M. and A.V. from the Spanish National Program for Young Researchers Training (MINECO, Ref. BES-2013-063933, BES-2016-077976), and the Seedling Growth Project to the ISS LSRA2009-0932/1177, a shared project of ESA-ELIPS Program and NASA. J.Z.K. is funded by Grants NNX12A065G and 80NSSC17K0546. These results are related to the Space Omics TT funded by the European Space Agency contract ESA 4000131202/20/NL/PG to R.H.”
______________________________
Other papers of interest:
1
Pardon LP, Cheng H, Chettry P, Patel NB.
Optic nerve head morphological changes over 12 hours in seated and head-down tilt postures.
Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):21.
https://pubmed.ncbi.nlm.nih.
Note: Head-down tilt study. This article may be obtained online without charge.
2
D’Ambra MN.
Commentary: Using aerospace engineering analyses to explore functional tricuspid regurgitation.
Semin Thorac Cardiovasc Surg. 2020 Nov 11. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
3
Brzeszczyńska J, Brzeszczyński F, Hamilton DF, McGregor R, Simpson A.
Role of microRNA in muscle regeneration and diseases related to muscle dysfunction in atrophy, cachexia, osteoporosis, and osteoarthritis.
Bone Joint Res. 2020 Nov;9(11):798-807. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
4
Kobayashi H, Nakamura S, Sato Y, Kobayashi T, Miyamoto K, Oya A, Matsumoto M, Nakamura M, Kanaji A, Miyamoto T.
ALDH2 mutation promotes skeletal muscle atrophy in mice via accumulation of oxidative stress.
Bone. 2020 Nov 11. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
5
Liang S, Ling S, Du R, Li Y, Liu C, Shi J, Gao J, Sun W, Li J, Zhong G, Liu Z, Zhao D, Sun H, Li Y, Yuan X, Qu H, Jin X, Li D, Shi D, Li Y.
The coupling of reduced type H vessels with unloading-induced bone loss and the protection role of Panax quinquefolium saponin in the male mice.
Bone. 2021 Feb;143:115712. Epub 2020 Oct 24.
https://pubmed.ncbi.nlm.nih.
Note: Hindlimb unloading study.
6
Liedert A, Nemitz C, Haffner-Luntzer M, Schick F, Jakob F, Ignatius A.
Effects of estrogen receptor and Wnt signaling activation on mechanically induced bone formation in a mouse model of postmenopausal bone loss.
Int J Mol Sci. 2020 Nov 5;21(21):8301.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
7
Chauhan V, Vuong NQ, Bahia S, Nazemof N, Kumarathasan P.
In vitro exposure of human lens epithelial cells to X-rays at varied dose-rates initiates protein level changes relevant to cataractogenesis.
Int J Radiat Biol. 2020 Nov 9. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
8
Ostheim P, Majewski M, Gluzman-Poltorak Z, Vainstein V, Basile LA, Lamkowski A, Schüle S, Kaatsch HL, Haimerl M, Stroszczynski C, Port M, Abend M.
Predicting the radiation sensitivity of male and female rhesus macaques using gene expression.
Radiat Res. 2020 Nov 12. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
9
Straube U.
Operational radiation protection for human space flight: The flight surgeon’s perspective.
Ann ICRP. 2020 Nov 10. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
10
Sun W, Bergemeier AP, Liao Y, Wu S, Tong L.
CIRP sensitizes cancer cell responses to ionizing radiation.
Radiat Res. 2020 Nov 12. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
11
Fujimoto C, Kawahara T, Yagi M, Murofushi T.
Association between vestibular dysfunction and findings of horizontal head-shaking and vibration-induced nystagmus.
J Vestib Res. 2020 Nov 3. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
12
Chomienne L, Blouin J, Bringoux L.
Online corrective responses following target jump in altered gravitoinertial force field point to nested feedforward and feedback control.
J Neurophysiol. 2020 Nov 11. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
13
Wedtgrube A, Bockisch CJ, Straumann D, Tarnutzer AA.
Prolonged static whole-body roll-tilt and optokinetic stimulation significantly bias the subjective postural vertical in healthy human subjects.
Front Neurol. 2020 Oct 15;11:595975.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
14
Reneau A.
Moon First and Mars Second: A Practical Approach to Human Space Exploration.
Cham, Switzerland: Springer, 2021. 104 p.
https://link.springer.com/
Note: From the Preface: “This book will investigate the rationale for international space agencies as well as private companies to return to the lunar surface through international, public-private partnerships and even entrepreneurial initiatives.”
15
Wassermann B, Rybakova D, Adam E, Zachow C, Bernhard M, Müller M, Mancinelli R, Berg G.
Studying seed microbiomes.
Methods Mol Biol. 2021;2232:1-21. Epub 2020 Nov 8.
https://pubmed.ncbi.nlm.nih.
16
Xu F, Xue S, Deng L, Zhang S, Li Y, Zhao X.
The piperazine compound ASP activates an auxin response in Arabidopsis thaliana.
BMC Genomics. 2020 Nov 11;21(1):788.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
17
Harry E, Sinsky C, Dyrbye LN, Makowski MS, Trockel M, Tutty M, Carlasare LE, West CP, Shanafelt TD.
Physician task load and the risk of burnout among US physicians in a national survey.
Jt Comm J Qual Patient Saf. 2020 Oct 4. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used.
18
Klapczynski C, Sallée C, Tardieu A, Peschot C, Boutot M, Mohand N, Lacorre A, Margueritte F, Gauthier T.
Training for next generation surgeons: A pilot study of robot-assisted hysterectomy managed by resident using dual console.
Arch Gynecol Obstet. 2020 Nov 12. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used.
19
Tomilovskaya ES, Rukavishnikov IV, Amirova LE, Shigueva TA, Saveko АА, Kitov VV, Vasilieva GY, Ponomarev SA, Smirnova ТА, Кozlovskaya IB, Orlov OI.
[21-day dry immersion: Design and primary results].
Aviakosm Ekolog Med. 2020;54(4):5-14. Russian.
https://www.elibrary.ru/item.
Note: This issue of Aviakosmicheskaya i Ekologicheskaya Meditsina (Aerospace and Environmental Medicine) is dedicated to a 21-day dry immersion study sponsored by the Russian Institute for Biomedical Problems (IBMP). This article describes the design and primary results. The following articles report on particular aspects of the study.
20
Amirova LE, Saveko AA, Rukavishnikov IV, Nistorescu A, Dinculescu A, Valeanu V, Kozlovskaya IB, Vizitiu C, Tomilovskaya ES, Orlov OI.
[Effects of 21-day support unloading on characteristics of transverse stiffness of human muscles. Estimation of efficiency of new myotonometric approaches].
Aviakosm Ekolog Med. 2020;54(4):15-22. Russian.
https://www.elibrary.ru/item.
21
Kukoba TB, Babich DR, Fomina EV, Orlov OI.
[Changes in the muscle strength-velocity qualities under the modeled spaceflight effects in the conditions of 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):23-7. Russian.
https://www.elibrary.ru/item.
22
Fedyai SO, Tomilovskaya ES, Rukavishnikov IV, Lebedeva SA, Guschin VI.
[Motor activity dynamics in test-subjects during 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):28-32. Russian.
https://www.elibrary.ru/item.
23
Lysova NY, Kitov VV, Tomilovskaya ES, Fomina EV.
[Locomotion with a supplementary motor task after the exposure to 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):33-6. Russian.
https://www.elibrary.ru/item.
24
Orlova ЕА, Vinogradova OL, Popov DV, Borovik AS.
[Effect of the fitness level on aerobic capacity of pectorial girdle muscles and precision of complex coordination movements under loads of varying power].
Aviakosm Ekolog Med. 2020;54(4):37-43. Russian.
https://www.elibrary.ru/item.
25
Glukhikh DО, Naumov IA, Kornilova LN, Telitsyn NG, Tomilovskaya ES.
[Eye tracking function, visual-manual tracking and vestibular function under the conditions of 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):44-51. Russian.
https://www.elibrary.ru/item.
26
Shishkin NV, Ermakov IY, Amirova LE, Abu Sheli NMА, Tomilovskaya ES.
[Vertical stability with open and closed eyes before and after 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):52-7. Russian.
https://www.elibrary.ru/item.
27
Lyakhovetskii VA, Sosnina IS, Zelenskiy КА, Karpinskaya VJ, Tomilovskaya ES.
[Effect of 21-day dry immersion on the sensorimotor evaluation of the Ponzo and Muller-Lyer illusions during grasping].
Aviakosm Ekolog Med. 2020;54(4):58-63. Russian.
https://www.elibrary.ru/item.
28
Skedina МА, Kovaleva АА, Potapov MG.
[Metabolic and electrical activities of the brain during 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):64-72. Russian.
https://www.elibrary.ru/item.
29
Poliakov AV, Niyazov AR, Fedyai SO, Rukavishnikov IV, Kirichenko VV, Pozdniakov SV, Nosovsky AM, Zaripov RN.
[Analysis of the human pain sensitivity during 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):73-8. Russian.
https://www.elibrary.ru/item.
30
Zaripov RN, Suvorov AV.
[External respiration in healthy humans in the conditions of 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):79-83. Russian.
https://www.elibrary.ru/item.
31
Lysova NY, Babich DR, Rezvanova SK, Timme EA, Fomina EV.
[Changes in physical performance of the subjects in the condition of 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):84-7. Russian.
https://www.elibrary.ru/item.
32
Markin AA, Zhuravleva OA, Kuzichkin DS, Vostrikova LV, Zabolotskaya IV, Tomilovskaya ES, Loginov VI, Stepanova GP.
[Investigation of metabolic reactions in human subjects in dynamics of 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):88-92. Russian.
https://www.elibrary.ru/item.
33
Larina IM, Pastushkova LK, Goncharova AG, Vasilieva GY, Kashirina DN, Koloteva MI, Taguirova SK, Kononikhin AS, Brzhozovsky AG.
[Direction of the processes related to the significantly changing proteins in the blood proteome during 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):93-100. Russian.
https://www.elibrary.ru/item.
34
Kuzichkin DS, Markin AA, Zhuravleva OA, Krivitsina ZA, Vostrikova LV, Zabolotskaya IV, Loginov VI, Tikhonova GА.
[Investigation of the plasma component in the blood aggregate state control system of test-subjects in the 21-day dry immersion study].
Aviakosm Ekolog Med. 2020;54(4):101-4. Russian.
https://www.elibrary.ru/item.
35
Poliakov AV, Niyazov AR, Ogurtsov PP, Guimadiev RR, Fedyai SO, Pozdniakov SV, Nosovsky AM.
[Analysis of several biochemical parameters and microRNA dynamics for use as markers of metabolic shifts in the human liver under the condition of 21-day dry immersion].
Aviakosm Ekolog Med. 2020;54(4):105-11. Russian.
https://www.elibrary.ru/item.
36
Ilyin VK, Rykova MP, Antropova EN, Solovieva ZO, Skedina MA, Kovaleva АА.
[The study of physiological and microbiological features of the human periodontium in the experiment dry immersion].
Aviakosm Ekolog Med. 2020;54(4):112-7. Russian.
