Status Report

NASA Spaceline Current Awareness List #922 30 October 2020 (Space Life Science Research Results)

By SpaceRef Editor
October 30, 2020
Filed under , , ,

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,


Papers deriving from NASA support:



Morrison MD, Nicholson WL.

Comparisons of transcriptome profiles from Bacillus subtilis cells grown in space versus High Aspect Ratio Vessel (HARV) clinostats reveal a low degree of concordance.

Astrobiology. 2020 Oct 19. [Epub ahead of print]

PI: W.L. Nicholson

Note: ISS results; a HARV clinostat was used for ground studies.

Journal Impact Factor: 4.280

Funding: “This work was supported by grants NNX14AT38G and NNX17AD51G from NASA Research Opportunities in Space Biology.”



McGregor HR, Lee JK, Mulder ER, De Dios YE, Beltran NE, Kofman IS, Bloomberg JJ, Mulavara AP, Seidler RD.

Brain connectivity and behavioral changes in a spaceflight analog environment with elevated CO2.

Neuroimage. 2021 Jan 15;225:117450. Epub 2020 Oct 16.

PI: R.D. Seidler

Note: Head-down tilt bed rest study. This article may be obtained online without charge.

Journal Impact Factor: 5.902

Funding: “This study was supported by NASA grant #80NSSC17K0021. HRM was supported by a NSERC postdoctoral fellowship and a NASA Human Research Program grant augmentation.”



Dillon GA, Lichter ZS, Alexander LM, Vianna LC, Wang J, Fadel PJ, Greaney JL.

Reproducibility of the neurocardiovascular responses to common laboratory-based sympathoexcitatory stimuli in young adults.

J Appl Physiol (1985). 2020 Sep 17. [Epub ahead of print]

Journal Impact Factor: 3.044

Funding: “TL1 TR002016 and NASA Pennsylvania Space Grant Consortium (GAD); NIH R01 HL093238 472 (LMA); NIH K99 HL133414 (JLG). PJF is supported by NIH PO1 HL137630-01A1.”



Lindner JR.

Contrast echocardiography: Current status and future directions.

Heart. 2020 Oct 19. [Epub ahead of print] Review.

PI: J.R. Lindner

Journal Impact Factor: 5.213

Funding: “JRL is supported by grants R01-HL078610, R01-HL130046 and P51-OD011092 from the National Institutes of Health, Bethesda, Maryland, USA, and grant 14-14NSBRI1-0025 from NASA.”



Berrios DC, Galazka J, Grigorev K, Gebre S, Costes SV.

NASA GeneLab: Interfaces for the exploration of space omics data.

Nucleic Acids Res. 2020 Oct 20. [Epub ahead of print]

Note: GeneLab is available at: This article may be obtained online without charge.

Journal Impact Factor: 11.501

Funding: “Space Biology Program (Science Mission Directorate, Biological and Physical Sciences Division) of the National Aeronautics and Space Administration.”



Cochrane C, Ba D, Klerman EB, St Hilaire MA.

An ensemble mixed effects model of sleep loss and performance.

J Theor Biol. 2021 Jan 21;509:110497. Epub 2020 Sep 20.

PIs: E.B. Klerman, D. Schreckenghost

Journal Impact Factor: 2.327

Funding: “Funding for this project was provided by: NIH (KL2TR002370, F32DK107146, T32HL007901, K24HL105664, R01HL114088, R01GM105018, R01HL128538, P01AG009975, R21HD086392, U01AG12642, and M01RR02635), US AFOSR (F49620-95-1-0388 and F49620-00-1-0266), NASA (NAS 9-19435), and NSBRI (HFP02802, HFP04201, HDP0006).”



Lyons KD, Slaughenhaupt RM, Mupparaju SH, Lim JS, Anderson AA, Stankovic AS, Cowan DR, Fellows AM, Binsted KA, Buckey JC.

Autonomous psychological support for isolation and confinement.

Aerosp Med Hum Perform. 2020 Nov;91(11):876-85.

PIs: J.C. Buckey, J.A. Cartreine, R. Rose, K.A. Binsted

Note: Virtual reality of nature scenes and the Expedition Application for Peak Psychological Performance (Expedition-APPP), an interactive media-based set of self-directed tools that address conflict resolution, stress management, and depression treatment were evaluated in the isolated and confined environments (ICE) of the Hawai’i Space Exploration Analog and Simulation (HI-SEAS) missions HI-SEAS III, HI-SEAS IV, and HI-SEAS V.

Journal Impact Factor: 0.889

Funding: “This effort was supported by the National Space Biomedical Research Institute project NBPF03801 (P.I. Jay Buckey) through NCC 9-58. The development of the Expedition-APPP programs was also supported by the National Space Biomedical Research Institute through NCC 9-58. The development of portions of the Expedition-APPP programs was also supported by the National Space Biomedical Research Institute through NCC 9-58 through projects NBPF01603 and NBPF00404 (P.I. James Cartreine, Ph.D.) and NBPF1605 (P.I. Raphael Rose, Ph.D.) with the assistance of The Troupe Modern Media. HI-SEAS research was supported in part by NASA Grants NNX13AM78G and NNX15AN05G. Ryan Slaughenhaupt received support from the Mark C. Hansen Undergraduate Research, Scholarship, and Creativity Fund through Dartmouth’s undergraduate advising and research.”



Basner M, Moore TM, Hermosillo E, Nasrini J, Dinges DF, Gur RC, Johannes B.

Cognition test battery performance is associated with simulated 6df spacecraft docking performance.

Aerosp Med Hum Perform. 2020 Nov;91(11):861-7.

PIs: M. Basner, D.F. Dinges, R.C. Gur

Note: Study participants, with demographic characteristics similar to astronauts, performed the Cognition test battery as well as a simulated 6 degrees-of-freedom (6df) spacecraft docking task.

Journal Impact Factor: 0.889

Funding: “The research was supported by NASA through grants NNX14AM81G, NNX14AH27G, and NNX14AH98G, by the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58 and by ESA through grant AO-13-Concordia-13.”



Tran FH, Spears SL, Ahn KJ, Eisch AJ, Yun S.

Does chronic systemic injection of the DREADD agonists clozapine-N-oxide or compound 21 change behavior relevant to locomotion, exploration, anxiety, and depression in male non-DREADD-expressing mice?

Neurosci Lett. 2020 Oct 17. [Epub ahead of print]

PI: A.J. Eisch

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.274

Funding: “This work was supported by the University of Pennsylvania McCabe Fund Pilot Award (SY), a 2019 International Brain Research Organization travel grant (SY), the 2019 Brain & Behavior Research Foundation NARSAD Young Investigator Grant (SY), University of Pennsylvania Undergraduate Research Foundation grant (SY), the National Aeronautics and Space Administration (AJE, 80NSSC17K0060), the Children’s Hospital of Philadelphia Department of Anesthesiology and Critical Care Development Funds (AJE), and the University of Pennsylvania Office of the Vice Provost for Research (SLS).”



Case JC, Gibert J, Booth J, SunSpiral V, Kramer-Bottiglio R.

Spinal helical actuation patterns for locomotion in soft robots.

IEEE Robot Autom Lett. 2020 Jul;5(3):3814-21.

Journal Impact Factor: 3.6

Funding: “10.13039/100000104-National Aeronautics and Space Administration; Early Career Faculty Program; NASA Space Technology Research Fellowship; NRC Research Associateship; 10.13039/100000161-National Institute of Standards and Technology.”




Other papers of interest:



Popova NK, Kulikov AV, Naumenko VS.

Spaceflight and brain plasticity: Spaceflight effects on regional expression of neurotransmitter systems and neurotrophic factors encoding genes.

Neurosci Biobehav Rev. 2020 Oct 18. [Epub ahead of print] Review.

Note: Space Shuttle STS 90 and ISS results are discussed.



Hanifin JP, Dauchy RT, Blask DE, Hill SM, Brainard GC.

Relevance of electrical light on circadian, neuroendocrine, and neurobehavioral regulation in laboratory animal facilities.

ILAR J. 2020 Oct 19;60(2):150-8.

Note: This article may be obtained online without charge.



Meigal AY, Gerasimova-Meigal LI, Saenko IV.

Physiological reactions of patients with Parkinsonism to simulated microgravity using “dry” immersion: A pilot study.

Hum Physiol. 2020 Sep 1;46(5):579-86. Review.

Note: Dry immersion was used.



Kargarpour Z, Nasirzade J, Panahipour L, Miron RJ, Gruber R.

Relative centrifugal force (RCF; G-Force) affects the distribution of TGF-β in PRF membranes produced using horizontal centrifugation.

Int J Mol Sci. 2020 Oct 15;21(20):E7629.

Note: Centrifugation was used. This article may be obtained online without charge.



Wang J, Wang J, Li X, Hou W, Cao J, Feng J.

Endothelial dysfunction in a cell culture model exposed to various intermittent hypoxia modes.

High Alt Med Biol. 2020 Oct 21. [Epub ahead of print]



Arquilla K, Leary S, Webb AK, Anderson AP.

Wearable 3-lead electrocardiogram placement model for fleet sizing of medical devices.

Aerosp Med Hum Perform. 2020 Nov;91(11):868-75.



Rabineau J, Hossein A, Landreani F, Haut B, Mulder E, Luchitskaya E, Tank J, Caiani EG, van de Borne P, Migeotte PF.

Cardiovascular adaptation to simulated microgravity and countermeasure efficacy assessed by ballistocardiography and seismocardiography.

Sci Rep. 2020 Oct 19;10(1):17694.

Note: Head-down tilt bed rest study. This article may be obtained online without charge.



Martin Paez Y, Judie LI, Subramanian PS.

Spaceflight associated neuro-ocular syndrome (SANS): A systematic review and future directions.

Eye Brain. 2020 Oct 19;12:105-17. Review.–peer-reviewed-article-EB

Note: This article may be obtained online without charge.



Brent MB, Lodberg A, Bromer FD, van der Eerden BCJ, Eijken M, Brüel A, Thomsen JS.

Activin type IIA decoy receptor and intermittent parathyroid hormone in combination overturns the bone loss in disuse-osteopenic mice.

Bone. 2021 Jan;142:115692. Epub 2020 Oct 15.

Note: Botulinum toxin A was used to immobilize mouse hindlimbs.



Brent MB, Lodberg A, Thomsen JS, Brüel A.

Rodent model of disuse-induced bone loss by hind limb injection with botulinum toxin A.

MethodsX. 2020 Oct 3;7:101079.

Note: Botulinum toxin A was used to immobilize mouse hindlimbs. This article may be obtained online without charge.




Chicheva MM, Mal’tsev AV, Kokhan VS, Bachurin SO.

The effect of ionizing radiation on cognitive functions in mouse models of Alzheimer’s disease.

Dokl Biol Sci. 2020 Sep;494(1):225-7.



Kim J, Oh H, Kim W, Choi S, Son W, Lee S.

A deep motion sickness predictor induced by visual stimuli in virtual reality.

IEEE Trans Neural Netw Learn Syst. 2020 Oct 20. [Epub ahead of print]



Figtree WVC, Schubert MC, Rinaudo CN, Migliaccio AA.

The instantaneous training demand drives vestibulo-ocular reflex adaptation.

Exp Brain Res. 2020 Oct 18. [Epub ahead of print]



Rinaudo CN, Schubert MC, Figtree WVC, Cremer PD, Migliaccio AA.

Human vestibulo-ocular reflex adaptation reduces when training demand variability increases.

J Assoc Res Otolaryngol. 2020 Oct 22. [Epub ahead of print]



Satar B, Akin Ocal FC, Karacayli C, Coban VK.

Routine vestibular tests may point out vestibular subtype of seasickness only.

Aerosp Med Hum Perform. 2020 Nov;91(11):852-60.



Stone JE, McGlashan EM, Facer-Childs ER, Cain SW, Phillips AJK.

Accuracy of the GENEActiv device for measuring light exposure in sleep and circadian research.

Clocks Sleep. 2020 Jun;2(2):143-52.

Note: This article may be obtained online without charge.



Tekieh T, Lockley SW, Robinson PA, McCloskey S, Zobaer MS, Postnova S.

Modeling melanopsin-mediated effects of light on circadian phase, melatonin suppression, and subjective sleepiness.

J Pineal Res. 2020 Oct;69(3):e12681.



DeLucia PR, Greenlee ET.

Tactile vigilance is stressful and demanding.

Hum Factors. 2020 Oct 22. [Epub ahead of print]



Aebi MR, Bourdillon N, Noser P, Millet GP, Bron D.

Cognitive impairment during combined normobaric vs. hypobaric and normoxic vs. hypoxic acute exposure.

Aerosp Med Hum Perform. 2020 Nov;91(11):845-51.



Uchida K, Baker SE, Wiggins CC, Senefeld JW, Shepherd JRA, Trenerry MR, Buchholtz ZA, Clifton HR, Holmes DR, Joyner MJ, Curry TB.

A novel method to measure transient impairments in cognitive function during acute bouts of hypoxia.

Aerosp Med Hum Perform. 2020 Nov;91(11):839-44.



Alleyne CW.

Space and global health.

In: Murthy P, Ansehl A, eds. Technology and Global Public Health. Cham: Springer International, 2020. p. 3-6.



He Y, Makarczyk MJ, Lin H.

Role of mitochondria in mediating chondrocyte response to mechanical stimuli.

Life Sci. 2020 Dec 15;263:118602. Epub 2020 Oct 18.



Brown LA, Peick J, Pickett MT, Fanara T, Gilchrist SC, Smiley A, Roberson L.

Aquatic invertebrate protein sources for long-duration space travel.

Life Sci Space Res. 2020 Oct 24. [Article in Press]



Anton NE, Rendina MA, Hennings JM, Stambro R, Stanton-Maxey KJ, Stefanidis D.

Association of medical students’ stress and coping skills with simulation performance.

Simul Healthc. 2020 Oct 20. [Epub ahead of print]

Note: The NASA Task Load Index was used.



Arabacӏ A, Önler E.

The effect of noise levels in the operating room on the stress levels and workload of the operating room team.

J Perianesth Nurs. 2020 Oct 16. [Epub ahead of print]

Note: The NASA Task Load Index was used.



Yang L, Wang T, Weidner TK, Madura JA 2nd, Morrow MM, Hallbeck MS.

Intraoperative musculoskeletal discomfort and risk for surgeons during open and laparoscopic surgery.

Surg Endosc. 2020 Oct 20. [Epub ahead of print]

Note: ӏThe NASA Task Load Index was used.

SpaceRef staff editor.