Status Report

NASA Spaceline Current Awareness List #919 9 October 2020 (Space Life Science Research Results)

By SpaceRef Editor
October 9, 2020
Filed under , , ,

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:


Mao XW, Nishiyama NC, Byrum SD, Stanbouly S, Jones T, Holley J, Sridharan V, Boerma M, Tackett AJ, Willey JS, Pecaut MJ, Delp MD.

Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model.

FASEB J. 2020 Sep 26. [Epub ahead of print]

PIs: X.W. Mao, M.D. Delp

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.966

Funding: “This study was supported by NASA Space Biology grants NNX15AB41G and NNX16AC28G, Centers of Biomedical Research Excellence (COBRE) grant P20GM121293 and Loma Linda University Department of Basic Sciences.”



Rohr JJ, Sater S, Sass AM, Marshall-Goebel K, Ploutz-Snyder RJ, Ethier CR, Stenger MB, Martin BA, Macias BR.

Quantitative magnetic resonance image assessment of the optic nerve and surrounding sheath after spaceflight.

npj Microgravity. 2020 Oct 8;6(1):30.

PIs: C.R. Ethier, B.R. Macias

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 3.380

Funding: “This study was funded by NASA Idaho Space Grant Consortium grant NNX10AM75H, NASA grant NNX16AT06G, National Institute of Neurological Disorders, and Stroke grant 1R01NS11128301, the Georgia Research Alliance, and the NASA Human Research Program.”



Lawley JS, Babu G, Janssen S, Petersen LG, Hearon CM Jr, Dias KA, Sarma S, Williams MA, Whitworth LA, Levine BD.

Daily generation of a footward fluid shift attenuates ocular changes associated with head-down tilt bedrest.

J Appl Physiol (1985). 2020 Sep 17. [Epub ahead of print]

PI: B.D. Levine

Note: Head-down tilt bed rest study.

Journal Impact Factor: 3.044

Funding: “This work was supported by the National Space Biomedical Research Institute (NSBRI) grant CA 00005 through NASA cooperative agreement NCC 9-58-49.”



Rahman M, Edwards H, Birze N, Gabrilska R, Rumbaugh KP, Blawzdziewicz J, Szewczyk NJ, Driscoll M, Vanapalli SA.

NemaLife chip: A micropillar-based microfluidic culture device optimized for aging studies in crawling C. elegans.

Sci Rep. 2020 Oct 1;10(1):16190.

PI: S.A. Vanapalli

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.998

Funding: “This work was partially supported by funding from NIH (Grant Nos. R21 AG050503, R01 AG051995-01A1, R01AG051995), NASA (Grant No. NNX15AL16G), NSF CAREER (Grant No. 1150836) and BBSRC (Grant No. N015894). In addition, this research was also supported by the MRC Versus Arthritis Centre for Musculoskeletal Ageing Research [Grant Numbers MR/P021220/1 and MR/R502364/1] and National Institute for Health Research Nottingham Biomedical Research Centre.”



Zea L, Santa Maria SR, Ricco AJ.

CubeSats for microbiology and astrobiology research.

In: Cappelletti C, Battistini S, Malphrus B, eds. CubeSate Handbook: From Mission Design to Operations. 1st ed. Cambridge, MA: Academic Press, 2021. p. 147-62.

PI: L. Zea

Note: From the Introduction: “This chapter surveys and summarizes progress to date with “microbiology CubeSats” from the science, engineering, and programmatic points of view. In addition to their science payloads, key satellite “bus” subsystems, for example, power and communication, and their ground control systems are described. Operational parameters such as orbital information are also detailed. Special focus is given to the payload hardware design, development, and operation. Finally, the first biology experiment to be conducted in heliocentric orbit beyond Earth’s magnetosphere since the final Apollo mission in 1972 is described and discussed: BioSentinel is a CubeSat scheduled for launch as soon as 2021.” The microbiology CubeSats discussed are GeneSat-1 (2006), PharmaSat (2009), O/OREOS (2010), SporeSat-1 (2014), and EcAMSat (2017).

Journal Impact Factor: Not applicable to this publication

Funding: “This material is based upon work supported by the National Aeronautics and Space Administration through the Office of Biological and Physical Research (OBPR), the Exploration Systems Mission Directorate (ESMD), the Space Life and Physical Sciences Research and Applications (SLPSRA) division within the Human Exploration and Operations Mission Directorate (HEOMD), the Science Mission Directorate’s (SMD’s) Astrobiology Small Payloads Program, and HEOMD’s Advanced Exploration Systems Division….LZ was supported by the National Aeronautics and Space Administration under Grant No. 80NSSC18K1468 and BioServe Space Technologies.”



Pariset E, Penninckx S, Kerbaul CD, Guiet E, Macha AL, Cekanaviciute E, Snijders AM, Mao JH, Paris F, Costes SV.

53BP1 repair kinetics for prediction of in vivo radiation susceptibility in 15 mouse strains.

Radiat Res. 2020 Sep 29. [Epub ahead of print]

PIs: S.V. Costes; E. Pariset, TRISH Postdoctoral Fellowship Program

Journal Impact Factor: 2.779

Funding: “This work was supported by the National Aeronautics and Space Administration [grant no. NNJ16HP24I to SVC, Principal Investigator (PI)] and by the Low Dose Scientific Focus Area, Office of Biological and Environmental Research, U.S. Department of Energy [contract no. DE AC02-05CH11231 to G. H. Karpen (PI) and SVC, J-HM and AMS (co-PIs)]. EP is funded by the NASA Human Research Program (no. NNJ16HP24I) and the Translational Research Institute for Space Health (NASA Cooperative Agreement no. NNX16AO69A). SP is funded by the Walloon Region (PROTHERWAL, grant no. 7289). The study was founded by the project MIRRO from Région Pays de la Loire (France) and EG was funded by la Ligue Nationale Contre le Cancer.”



Prins TJ, Saldate JJ, Berke GS, Hoffman LF.

On the legacy of genetically altered mouse models to explore vestibular function: Distribution of vestibular hair cell phenotypes in the otoferlin-null mouse.

Ann Otol Rhinol Laryngol. 2019 Jun;128(6 Suppl):125S-133S.

PI: L.F. Hoffman

Journal Impact Factor: 1.284

Funding: “The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: National Aeronautics and Space Administration (NASA) NNX13AL99G.”



Su SH, Keith MA, Masson PH.

Gravity signaling in flowering plant roots.

Plants (Basel). 2020 Oct;9(10):1290. Review.

PI: P.H. Masson

Note: This article, available online without charge, belongs to the Special Issue “Mechanical Signaling in Plants” ( Two gravity-related articles were in previous Current Awareness lists. Additional articles may be found in the link to the special issue.

Journal Impact Factor: 2.762

Funding: “This report was made possible by grants from the National Aeronautics and Space Administration (Grants # NNX14AT23G, 80NSSC18K1481 and 80NSSC19K1483), the National Science Foundation (Grant # 1951182-IOS), HATCH awards from the University of Wisconsin-Madison College of Agriculture and Life Sciences (grant # WIS01860 and WIS03064), and a Fall Competition Award from the University of Wisconsin-Madison Vice Chancellor for Research and Graduate Education Office (grant # MSN226688).”



Manzano A, Creus E, Tomás A, Valbuena MA, Villacampa A, Ciska M, Edelmann RE, Kiss JZ, Medina FJ, Herranz R.

The FixBox: Hardware to provide on-orbit fixation capabilities to the EMCS on the ISS.

Microgravity Sci Technol. 2020 Oct 6. [Article in Press]

PI: J.Z. Kiss

Journal Impact Factor: 1.845

Funding: “This work was supported by the Agencia Estatal de Investigación of the Spanish Ministry of Science an Innovation, Grants #ESP2015–64323-R and #RTI2018–099309-B-I00 (co-funded by EUERDFEUERDF), awarded to FJM, and by pre-doctoral fellowships to (AM), (MV) and (AV) from the Spanish National Program for Young Researchers Training (MINECO, Ref. BES-2013-063933, BES-2016-077976). This research was supported also by grants (NNX12A0656 and 80NSSC17K0546) from NASA to JZK. The Seedling Growth Project spaceflights and activities to the ISS were funded by ILSRA2009–0932/1177 of ESA-ELIPS Program. The FixBox has been built under a contract to SENER Aeroespacial SA by ESA (400010569 7/12/NL/FC) to support the SG project.”




Other papers of interest:



Kawaguchi Y, Shibuya M, Kinoshita I, Yatabe J, Narumi I, Shibata H, Hayashi R, Fujiwara D, Murano Y, Hashimoto H, Imai E, Kodaira S, Uchihori Y, Nakagawa K, Mita H, Yokobori SI, Yamagishi A. 

DNA damage and survival time course of deinococcal cell pellets during 3 years of exposure to outer space.

Front Microbiol. 2020 Aug 26;11:2050.

Note: ISS results. This article may be obtained online without charge.



Baevsky RM, Funtova II, Luchitskaya ES.

Role of the right and left parts of the heart in mechanisms of body adaptation to the conditions of long term space flight according to longitudinal ballistocardiography.

Acta Astronaut. 2020 Oct 6. [Article in Press]

Note: ISS results.



Bakshi A, DiZio P, Lackner JR.

The effect of hypergravity on upright balance and voluntary sway.

J Neurophysiol. 2020 Sep 30. [Epub ahead of print]

Note: Parabolic flight results.



Bakshi A, DiZio P, Lackner JR.

Multiple roles of active stiffness in upright balance and multi-directional sway.

J Neurophysiol. 2020 Sep 30. [Epub ahead of print]



Hariom SK, Ravi A, Mohan GR, Pochiraju HD, Chattopadhyay S, Nelson EJR.

Animal physiology across the gravity continuum.

Acta Astronaut. 2021 Jan 1;178:522-35. Review. Epub 2020 Sep 25.

Note: From the Introduction: “In this review, we summarize the effects of extreme gravity conditions, both microgravity and hypergravity on the physiology of animal models studied thus far.”



de Maistre S, Gaillard S, Martin JC, Richard S, Boussuges A, Rives S, Desruelle AV, Blatteau JE, Tardivel C, Risso JJ, Vallée N.

Cecal metabolome fingerprint in a rat model of decompression sickness with neurological disorders.

Sci Rep. 2020 Sep 29;10(1):15996.

Note: This article may be obtained online without charge.



Yin M, Ye B, Jin Y, Liu L, Zhang Y, Li P, Wang Y, Li Y, Han Y, Shen W, Zhao Z.

Changes in Vibrio natriegens growth under simulated microgravity.

Front Microbiol. 2020 Aug 28;11:2040.

Note: A High Aspect Ratio Vessel (HARV) was used. This article may be obtained online without charge.



Liang L, Li H, Cao T, Qu L, Zhang L, Fan GC, Greer PA, Li J, Jones DL, Peng T.

Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways.

J Biol Chem. 2020 Sep 28. [Epub ahead of print]

Note: Hindlimb unloading study. This article may be obtained online without charge.



Liu H, Guo J, Li Y, Zhang Y, Wang J, Gao J, Deng Y, Li Y.

Investigation on intestinal proteins and drug metabolizing enzymes in simulated microgravity rats by a proteomics method.

Molecules. 2020 Sep 24;25(19):E4391.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Zanca D, Gori M, Melacci S, Rufa A.

Gravitational models explain shifts on human visual attention.

Sci Rep. 2020 Oct 1;10(1):16335.

Note: From the Introduction: “In the proposed framework, the encoding of the oculomotor command needs a simple neuronal hardware, with the very mild assumption of units that perform sum operation, without the need of backward flows, leading to a plausible and straightforward biological implementation…we provide a mathematical formulation in which conspicuous features are modeled as masses that compete to attract visual attention. We derive laws that regulate attentional shifts through a gravitational model. The resulting shifts will be a consequence of gravitational attractions, together with a mechanism of inhibition of return (IOR), part of the visual foraging behavior, that allows the model to explore the whole scene.” This article may be obtained online without charge.



Metzger CE, Anand N. S, Phan PH, Bloomfield SA.

Hindlimb unloading causes regional loading-dependent changes in osteocyte inflammatory cytokines that are modulated by exogenous irisin treatment.

npj Microgravity. 2020 Oct 7;6(1):28.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Roux JP, Boutroy S, Bouxsein ML, Chapurlat R, Wegrzyn J.

Local and global microarchitecture is associated with different features of bone biomechanics.

Bone Rep. 2020 Dec;13:100716. Epub 2020 Sep 15.

Note: This article may be obtained online without charge.



Vahidi G, Rux C, Sherk VD, Heveran CM.

Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment.

Bone. 2020 Sep 25. [Epub ahead of print] Review.



El-Maraghi EF, Abdel-Fattah KI, Soliman SM, El-Sayed WM.

Taurine abates the liver damage induced by γ-irradiation in rats through anti-inflammatory and anti-apoptotic pathways.

Int J Radiat Biol. 2020 Sep 29. [Epub ahead of print]



Gupta N, Kainthola A, Tiwari M, Agrawala PK.

Gut microbiota response to ionizing radiation and its modulation by HDAC inhibitor TSA.

Int J Radiat Biol. 2020 Oct 1. [Epub ahead of print]



Leavitt RJ, Acharya MM, Baulch JE, Limoli CL.

Extracellular vesicle-derived miR-124 resolves radiation-induced brain injury.

Cancer Res. 2020 Aug 19;80(19):4266-77. [Epub ahead of print]



Ostheim P, Haupt J, Schüle S, Herodin F, Valente M, Drouet M, Majewski M, Port M, Abend M.

Differentiating total- or partial-body irradiation in baboons using mRNA expression patterns: A proof of concept.

Radiat Res. 2020 Sep 29. [Epub ahead of print]



Wang Y, Sun Y, Zhang Z, Li Z, Zhang H, Liao Y, Tang C, Cai P.

Enhancement in the ATP level and antioxidant capacity of Caenorhabditis elegans under continuous exposure to extremely low-frequency electromagnetic field for multiple generations.

Int J Radiat Biol. 2020 Sep 29. [Epub ahead of print]



Balestrucci P, Maffei V, Lacquaniti F, Moscatelli A.

The effects of visual parabolic motion on the subjective vertical and on interception.

Neuroscience. 2020 Sep 30. [Epub ahead of print]



Li Y, Yuan W, Li L, Miao R, Dai H, Zhang J, Xu W.

Light-dark modulates root hydrotropism associated with gravitropism by involving amyloplast response in Arabidopsis.

Cell Rep. 2020 Sep 29;32(13):108198.

Note: This article may be obtained online without charge.



Wang CK, Han PL, Zhao YW, Ji XL, Yu JQ, You CX, Hu DG, Hao YJ.

Auxin regulates anthocyanin biosynthesis through the auxin repressor protein MdIAA26.

Biochem Biophys Res Commun. 2020 Sep 25. [Epub ahead of print]



Fili T, Gòdia F, González-Cinca R.

Trade-off analysis of phase separation techniques for advanced life support systems in space.

Acta Astronaut. 2021 Jan;178:571-83. Epub 2020 Oct 2.

Note: From the abstract: “We present a review of these techniques [phase separation approaches] and a trade-off analysis for their application in life support systems and, in particular, in the MELiSSA (Micro Ecological Life Support System Alternative) photosynthesis bioreactor.”



Schlegel AM, Haswell ES.

Charged pore-lining residues are required for normal channel kinetics in the eukaryotic mechanosensitive ion channel MSL1.

Channels (Austin). 2020 Dec;14(1):310-25. Epub 2020 Sep 29.

Note: This article may be obtained online without charge.



Zhang X, Kim TH, Thauland TJ, Li H, Majedi FS, Ly C, Gu Z, Butte MJ, Rowat AC, Li S.

Unraveling the mechanobiology of immune cells.

Curr Opin Biotechnol. 2020 Sep 29;66:236-45. Review.

Note: This article may be obtained online without charge.

SpaceRef staff editor.