Status Report

NASA Spaceline Current Awareness List #918 2 October 2020 (Space Life Science Research Results)

By SpaceRef Editor
October 2, 2020
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:



Bharadwaj AR, Singh NK, Wood JM, Debieu M, O’Hara NB, Karouia F, Mason CE, Venkateswaran K.

Draft genome sequences of Lactobacillales isolated from the International Space Station.

Microbiol Resour Announc. 2020 Sep 24;9(39):e00942-20.

PI: K. Venkateswaran

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 0.88

Funding: “Government sponsorship is acknowledged. This research was funded by a 2012 Space Biology NNH12ZTT001N grant (no. 19-12829-26) under task order NNN13D111T awarded to K.V., which also funded a postdoctoral fellowship for J.M.W., and a subcontract to Biotia, Inc.”



Kitto RZ, Dhillon Y, Bevington J, Horne M, Giegé P, Drouard L, Heintz D, Villette C, Corre N, Arrivé M, Manefield MJ, Bowman R, Favier J-J, Osborne B, Welch C, McKay CP, Hammond MC. 

Synthetic biological circuit tested in spaceflight.

Life Sci Space Res. 2020 Sep 24. [Article in Press]

Note: ISS results. From the abstract: “An exogenously inducible biological circuit for protein production in Arabidopsis thaliana, pX7-AtPDSi, was flown to ISS and functionally investigated.”

Journal Impact Factor: 2.453

Funding: M. Horne, R. Bowman, and C.P. McKay are affiliated with NASA Ames Research Center.



Makedonas G, Mehta SK, Scheuring RA, Haddon R, Crucian BE.

SARS-CoV-2 pandemic impacts on NASA ground operations to protect ISS astronauts.

J Allergy Clin Immunol Pract. 2020 Sep 21. [Epub ahead of print]

Note: This article may be obtained online without charge.

PI: B.E. Crucian

Journal Impact Factor: 7.574

Funding: The PI reports that this work was done under the project: “Functional Immune Alterations, Latent Herpesvirus Reactivation, Physiological Stress, and Clinical Incidence Onboard the International Space Station.”




Zamkovaya T, Foster JS, de Crécy-Lagard V, Conesa A.

A network approach to elucidate and prioritize microbial dark matter in microbial communities.

ISME J. 2020 Sep 22. [Epub ahead of print]

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.180

Funding: “This study was funded in part by National Aeronautics and Space Administration through the University of Central Florida’s NASA Florida Space Grant Consortium and Space Florida (NX15AI10H). This work was also funded in part by the NASA Exobiology program (80NSSC20K0612) awarded to JSF and AC.”



Lee C, Rohr J, Sass A, Sater S, Zahid A, Macias B, Stenger MB, Samuels BC, Martin BA, Oshinski JN, Ethier CR.

In vivo estimation of optic nerve sheath stiffness using noninvasive MRI measurements and finite element modeling.

J Mech Behav Biomed Mater. 2020 Oct;110:103924.

PI: C.R. Ethier

Journal Impact Factor: 3.372

Funding: “This work was supported by NASA grant NNX16AT06G, NASA Idaho Space Grant Consortium grant NNX10AM75H, NASA Human Research Program, the Georgia Research Alliance, and the Unrestricted/Challenge Grant to UAB Research to Prevent Blindness.”



Rabin BM, Cahoon DS, Shukitt-Hale B.

Response to comments by Bevelacqua and Mortazavi.

Life Sci Space Res. 2020 Nov;27:111-2. Epub 2020 Sep 23.

PI: B.M. Rabin

Note: The authors reply to: Bevelacqua JJ, Mortazavi SMJ. Comments on “Effects of partial- or whole-body exposures to 56Fe particles on brain function and cognitive performance in rats.” Life Sci Space Res. 2020 Nov 27:105-6. Epub 2020 Aug 28., which originally appeared in SPACELINE Current Awareness List #914, 4 Sep 2020. 

Journal Impact Factor: 2.453

Funding: From the original article: “This research was supported by NASA Grant NNX16AE06G.”



Sadhukhan R, Majumdar D, Garg S, Landes RD, McHargue V, Pawar SA, Chowdhury P, Griffin RJ, Narayanasamy G, Boerma M, Dobretsov M, Hauer-Jensen M, Pathak R.

Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen.

Life Sci Space Res. 2020 Sep 29. [Article in Press]

Note: Hindlimb unloading study.

Journal Impact Factor: 2.453

Funding: “This study was supported by Arkansas Space Grant Consortium Grant NNX15AR71H (R.P.), an Institutional Development Award (IDeA) from the NIGMS of the National Institutes of Health under Grant Number P20 GM109005 (R.P. and M.H.-J), and Peer Reviewed Medical Research Program Expansion Award- W81XWH1910737 from Department of Defense (S.A.P.).”



Flynn-Evans EE, Kirkley C, Young M, Bathurst N, Gregory K, Vogelpohl V, End A, Hillenius S, Pecena Y, Marquez JJ.

Changes in performance and bio-mathematical model performance predictions during 45 days of sleep restriction in a simulated space mission.

Sci Rep. 2020 Sep 24;10(1):15594.

PI: E.E. Flynn-Evans

Note: The Human Exploration Research Analog (HERA) was used. This article may be obtained online without charge.

Journal Impact Factor: 4.011

Funding: “This work was supported by funding from NASA program NNJ15ZSA001N.”



Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT.

Nanopore sequencing at Mars, Europa, and microgravity conditions.

npj Microgravity. 2020 Sep 7;6:24.

PI: N. Bryan, Space Biology Postdoctoral Fellowship

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.380

Funding: “This work was supported by NASA award NNX15AF85G. N.C.B. was supported by NASA Postdoctoral Fellowship award 80NSSC17K0688.”



Warzecha M, Verma L, Johnston BF, Palmer JC, Florence AJ, Vekilov PG.

Olanzapine crystal symmetry originates in preformed centrosymmetric solute dimers.

Nat Chem. 2020 Oct;12(10):914-20.

PI: P.G. Vekilov

Journal Impact Factor: 23.193

Funding: “This work was supported by the National Science Foundation (award no. DMR-1710354), NASA (award nos. NNX14AD68G and NNX14AE79G) and The Welch Foundation (Grant E-1882). We acknowledge the CMAC National Facility, housed within the University of Strathclyde’s Technology and Innovation Centre, and funded with a UK Research Partnership Investment Fund (UKRPIF) capital award, SFC ref H13054, from the Higher Education Funding Council for England (HEFCE).”



Olenych S.

Time-lapse imaging of neural stem cells exposed to microgravity on the International Space Station.

Micros Today. 2020 Sep;28(5):26-9.

Note: While not peer-reviewed, the article provides information about Dr. Araceli Espinosa-Jeffrey’s NASA Space Biology-funded research with neural cell growth aboard the International Space Station. That research is NASA grant NNX15AB43G, “The Impact of Real Microgravity on the Proliferation of Human Neural Stem Cells and derived-Oligodendrocytes.” ISS results are discussed. This article may be obtained online without charge.




Other papers of interest:



Hides JA, Lambrecht G, Sexton CT, Pruett C, Petersen N, Jaekel P, Rosenberger A, Weerts G.

The effects of exposure to microgravity and reconditioning of the lumbar multifidus and anterolateral abdominal muscles; implications for people with LBP.

Spine J. 2020 Sep 20. [Epub ahead of print]

Note: ISS results.



Komiyama T.

Practicalities of dose management for Japanese astronauts staying at the International Space Station.

Ann ICRP. 2020 Sep 24. [Epub ahead of print]

Note: ISS results.



Przybyla C, Dutto G, Bernard M, Rollin B, Laurand X, Averseng J, Gasset E, Tadadjeu I, Dusseau L.

European sea bass (Dicentrarchus labrax) and meagre (Argyrosomus regius) fertilized egg resistance to a spacecraft launcher vibration qualifying test.

Aquacult Int. 2020 Sep 23. [Article in Press]



Lin JJ, Yan HF, Sun PM, Zhang T, Hu G, Zhao Y, Sun HW, Zhou JL, Cui Y.

[Study of thermal injury effects on human HaCaT cells under simulated microgravity environment].

Zhonghua Shao Shang Za Zhi. 2020 Sep 20;36(9):830-7. Chinese.

Note: A Rotary Cell Culture System was used.



Buchovec I, Gricajeva A, Kalėdienė L, Vitta P.

Antimicrobial photoinactivation approach based on natural agents for control of bacteria biofilms in spacecraft.

Int J Mol Sci. 2020 Sep 21;21(18):E6932. Review.

Note: This article may be obtained online without charge.



Gallo C, Ridolfi L, Scarsoglio S.

Cardiovascular deconditioning during long-term spaceflight through multiscale modeling.

npj Microgravity. 2020 Oct 1;6(1):27.

Note: This article may be obtained online without charge.



Navasiolava N, Yuan M, Murphy R, Robin A, Coupé M, Wang L, Alameddine A, Gauquelin-Koch G, Gharib C, Li Y, Custaud MA.

Vascular and microvascular dysfunction induced by microgravity and its analogs in humans: Mechanisms and countermeasures.

Front Physiol. 2020 Aug 20;11:952. Review.

Note: Methods of simulation discussed are head-down tilt and horizontal bed rest, dry immersion, sitting, leg suspension, and confinement. Some ISS results are mentioned. This article may be obtained online without charge.



Wang XP, Xing CY, Zhang JX, Zhou JH, Li YC, Yang HY, Zhang PF, Zhang W, Huang Y, Long JG, Gao F, Zhang X, Li J.

Time-restricted feeding alleviates cardiac dysfunction induced by simulated microgravity via restoring cardiac FGF21 signaling.

FASEB J. 2020 Sep 21. [Epub ahead of print]

Note: Hindlimb unloading study. This article may be obtained online without charge.



Lee J, Jang D, Jeong H, Kim KS, Yang S.

Impairment of synaptic plasticity and novel object recognition in the hypergravity-exposed rats.

Sci Rep. 2020 Sep 25;10(1):15813.

Note: Centrifugation was used. This article may be obtained online without charge.



Bai ZM, Wang ZP, Guo MH, Zhang LJ, Xu JL, Yu L, Li CR.

[Effects of electroacupuncture combined with passive stretch exercise on disused muscle atrophy and expression of skeletal troponin in mice].

Zhen Ci Yan Jiu. 2020 Sep 25;45(9):720-5. Chinese.

Note: Hindlimb immobilization was used.



Böl M, Iyer R, Garcés-Schröder M, Kohn S, Dietzel A.

Mechano-geometrical skeletal muscle fibre characterisation under cyclic and relaxation loading.

J Mech Behav Biomed Mater. 2020 Oct;110:104001.

Note: This article may be obtained online without charge.



Ogawa M, Belavý DL, Yoshiko A, Armbrecht G, Miokovic T, Felsenberg D, Akima H.

Effects of 8 weeks of bed rest with or without resistance exercise intervention on the volume of the muscle tissue and the adipose tissues of the thigh.

Physiol Rep. 2020 Sep;8(18):e14560.

Note: Bed rest study. This article may be obtained online without charge.



Karsenty G.

The central regulation of bone mass: Genetic evidence and molecular bases.

Handb Exp Pharmacol. 2020 Sep 23. [Epub ahead of print]



Wu CH, Ou CH, Yen IC, Lee SY.

4-Acetylantroquinonol B inhibits osteoclastogenesis by inhibiting the autophagy pathway in a simulated microgravity model.

Int J Mol Sci. 2020 Sep 22;21(18):E6971.

Note: A Rotary Cell Culture System was used. This article may be obtained online without charge.



Amani F, Allahbakhshian Farsani M, Gholami M, Aghamiri SMR, Bakhshandeh M, Hosein Mohamadi M.

The protective effect of oleuropein against radiation-induced cytotoxicity, apoptosis and genetic damage in cultured human lymphocytes.

Int J Radiat Biol. 2020 Sep 24. [Epub ahead of print]



Naito M, Hasebe N, Shikishima M, Amano Y, Haruyama J, Matias-Lopes JA, Kim KJ, Kodaira S.

Radiation dose and its protection in the moon from galactic cosmic rays and solar energetic particles: At the lunar surface and in a lava tube.

J Radiol Prot. 2020 Sep 23;40(4):947-61.

Note: This article may be obtained online without charge.



Sobel A, Duncan R.

Aerospace environmental health: Considerations and countermeasures to sustain crew health through vastly reduced transit time to/from Mars.

Front Public Health. 2020 Aug 19;8:327. Review.

Note: This article may be obtained online without charge.



Sovilj MP, Vuković B, Radolić V, Miklavčić I, Stanić D.

Potential benefit of retrospective use of neutron monitors in improving ionising radiation exposure assessment on international flights: Issues raised by neutron passive dosimeter measurements and EPCARD simulations during sudden changes in solar activity.

Arh Hig Rada Toksikol. 2020 Jun 29;71(2):152-7.

Note: This article may be obtained online without charge.



Winroth S, Scott C, Ishida H.

Structure and performance of benzoxazine composites for space radiation shielding.

Molecules. 2020 Sep 22;25(18):E4346.

Note: This article may be obtained online without charge.



Zhang S, Wimmer-Schweingruber RF, Yu J, Wang C, Fu Q, Zou Y, Sun Y, Wang C, Hou D, Böttcher SI, Burmeister S, Seimetz L, Schuster B, Knierim V, Shen G, Yuan B, Lohf H, Guo J, Xu Z, Freiherr von Forstner JL, Kulkarni SR, Xu H, Xue C, Li J, Zhang Z, Zhang H, Berger T, Matthiä D, Hellweg CE, Hou X, Cao J, Chang Z, Zhang B, Chen Y, Geng H, Quan Z.

First measurements of the radiation dose on the lunar surface.

Sci Adv. 2020 Sep;6(39):eaaz1334.

Note: This article may be obtained online without charge.



Zhong Y, Pouliot M, Downey AM, Mockbee C, Roychowdhury D, Wierzbicki W, Authier S.

Efficacy of delayed administration of sargramostim up to 120 hours post exposure in a nonhuman primate total body radiation model.

Int J Radiat Biol. 2020 Sep 22.

Note: This article may be obtained online without charge.



Komeili A, Otoo BS, Abusara Z, Sibole S, Federico S, Herzog W.

Chondrocyte deformations under mild dynamic loading conditions.

Ann Biomed Eng. 2020 Sep 21. [Epub ahead of print]



Marion S, Radenovic A.

Towards artificial mechanosensing.

Nat Mater. 2020 Oct;19(10):1043-4.



Chramiec A, Teles D, Yeager K, Marturano-Kruik A, Pak J, Chen T, Hao L, Wang M, Lock R, Tavakol DN, Lee MB, Kim J, Ronaldson-Bouchard K, Vunjak-Novakovic G.

Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety.

Lab Chip. 2020 Sep 21. [Epub ahead of print]



Cubo-Mateo N, Podhajsky S, Knickmann D, Slenzka K, Ghidini T, Gelinsky M.

Can 3D bioprinting be a key for exploratory missions and human settlements on the Moon and Mars?

Biofabrication. 2020 Sep 25;12(4):043001.



Wagner KT, Nash TR, Liu B, Vunjak-Novakovic G, Radisic M.

Extracellular vesicles in cardiac regeneration: Potential applications for tissues-on-a-chip.

Trends Biotechnol. 2020 Sep 18. [Epub ahead of print]



Kahya M, Lyons KE, Pahwa R, Akinwuntan AE, He J, Devos H.

Reliability and validity of pupillary response during dual-task balance in Parkinson’s disease.

Arch Phys Med Rehabil. 2020 Sep 17. [Epub ahead of print]

Note: The NASA Task Load Index was used.



Wu C, Cha J, Sulek J, Sundaram CP, Wachs J, Proctor RW, Yu D.

Sensor-based indicators of performance changes between sessions during robotic surgery training.

Appl Ergon. 2021 Jan;90:103251. Epub 2020 Sep 19.

Note: The NASA Task Load Index was used.

SpaceRef staff editor.