Status Report

NASA Spaceline Current Awareness List #916 18 September 2020 (Space Life Science Research Results)

By SpaceRef Editor
September 18, 2020
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,

Papers deriving from NASA support:


Kramer A, Venegas-Carro M, Mulder E, Lee JK, Moreno-Villanueva M, Bürkle A, Gruber M.

Cardiorespiratory and neuromuscular demand of daily centrifugation: Results from the 60-day AGBRESA bed rest study.

Front Physiol. 2020 Sep 11;11:1155.

Note: Bed rest study (AGBRESA is the Artificial Gravity Bed Rest—European Space Agency). A short-arm human centrifuge was used. This article may be obtained online without charge.

Journal Impact Factor: 3.367

Funding: “The part of the bed rest study described in this manuscript was funded by the German Aerospace Centre (DLR, Grant No. FKZ50WB1734). The whole bed rest study was funded by the German Aerospace Center, the European Space Agency (Contract No. 4000113871/15/NL/PG) and the National Aeronautics and Space Administration (Contract No. 80JSC018P0078).”



Urbaniak C, Wong S, Tighe S, Arumugam A, Liu B, Parker CW, Wood JM, Singh NK, Skorupa DJ, Peyton BM, Jenson R, Karouia F, Dragon J, Venkateswaran K.

Validating an automated nucleic acid extraction device for Omics in Space using whole cell microbial reference standards.

Front Microbiol. 2020 Aug 21;11:1909.

PIs: K. Venkateswaran; C. Urbaniak, NASA Postdoctoral Program Fellowship

Note: From the abstract: “The Omics in Space team has developed the μTitan (simulated micro(μ) gravity tested instrument for automated nucleic acid) system capable of automated, streamlined, nucleic acid extraction that is adapted for use under microgravity.” This article may be obtained online without charge.

Journal Impact Factor: 4.235

Funding: “This research was supported by the TRISH through Cooperative Agreement NNX16AO69A awarded to KV. W. M. Keck Foundation supported for DS and BP. The NASA postdoctoral fellowship supported part of CU time. Preliminary work of this research was supported by a NASA SBIR Contract (NNX17CP21P) awarded to SW.”



Semple C, Riveros D, Sung D-M, Nagy JA, Rutkove SB, Mortreux M.

Using electrical impedance myography as a biomarker of muscle deconditioning in rats exposed to micro- and partial-gravity analogs.

Front Physiol. 2020 Sep 15;11:1181.

PI: S.B. Rutkove

Note: From the abstract: “Here, we used EIM to assess muscle changes in animals exposed to two new models: hindlimb suspension using a pelvic harness (HLS) and a partial weight-bearing (PWB) model that mimics partial gravity (including Lunar and Martian gravities).” This article may be obtained online without charge.

Journal Impact Factor: 3.367

Funding: “This work was funded by the National Aeronautics and Space Administration (NASA: NNX16AL36G and 80NSSC19K1598).”



Spaeth AM, Goel N, Dinges DF.

Caloric and macronutrient intake and meal timing responses to repeated sleep restriction exposures separated by varying intervening recovery nights in healthy adults.

Nutrients. 2020 Sep 3;12(9):E2694.

PI: N. Goel

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.171

Funding: “This work was funded by NIH grants R01 NR004281 (DFD), F31 AG044102 (AMS) and R01 DK117488 (NG); the Department of the Navy, Office of Naval Research Award No. N00014-11-1-0361 (NG); Clinical and Translational Research Center (CTRC) grant UL1TR000003 (University of Pennsylvania); and National Aeronautics and Space Administration (NASA) grants NNX14AN49G and 80NSSC20K0243 (NG).”



Other papers of interest:



Suzuki T, Uruno A, Yumoto A, Taguchi K, Suzuki M, Harada N, Ryoke R, Naganuma E, Osanai N, Goto A, Suda H, Browne R, Otsuki A, Katsuoka F, Zorzi M, Yamazaki T, Saigusa D, Koshiba S, Nakamura T, Fukumoto S, Ikehata H, Nishikawa K, Suzuki N, Hirano I, Shimizu R, Oishi T, Motohashi H, Tsubouchi H, Okada R, Kudo T, Shimomura M, Kensler TW, Mizuno H, Shirakawa M, Takahashi S, Shiba D, Yamamoto M.

Nrf2 contributes to the weight gain of mice during space travel.

Commun Biol. 2020 Sep 8;3(1):496.

Note: ISS results. This article may be obtained online without charge.



Mohr SM, Bagriantsev SN, Gracheva EO.

Cellular, molecular, and physiological adaptations of hibernation: The solution to environmental challenges.

Annu Rev Cell Dev Biol. 2020 Sep 8. [Epub ahead of print]



Chi HN, Son HN, Chung DC, Huan LD, Diem TH, Long LT.

Simulated microgravity reduces proliferation and reorganizes the cytoskeleton of human umbilical cord mesenchymal stem cells.

Physiol Res. 2020 Sep 9. [Epub ahead of print]

Note: A clinostat was used. This article may be obtained online without charge.



Laventie BJ, Jenal U.

Surface sensing and adaptation in bacteria.

Annu Rev Microbiol. 2020 Sep 8;74:735-60. Review.



Miyatake S, Hino K, Natsui Y, Ebisu G, Fujita S.

Protein supplementation enhances the effects of intermittent loading on skeletal muscles by activating the mTORC1 signaling pathway in a rat model of disuse atrophy.

Nutrients. 2020 Sep 7;12(9):E2729.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Noonan AM, Mashouri P, Chen J, Power GA, Brown SHM.

Training induced changes to skeletal muscle passive properties are evident in both single fibers and fiber bundles in the rat hindlimb.

Front Physiol. 2020 Aug 12;11:907.

Note: Treadmill running was used. This article may be obtained online without charge.



Ghandhi SA, Sima C, Weber WM, Melo DR, Rudqvist N, Morton SR, Turner HC, Amundson SA.

Dose and dose-rate effects in a mouse model of internal exposure to 137Cs. Part 1: Global transcriptomic responses in blood.

Radiat Res. 2020 Sep 15. [Epub ahead of print]



Hafner L, Walsh L, Schneider U.

Cancer incidence risks above and below 1 Gy for radiation protection in space.

Life Sci Space Res. 2020 Sep 14. [Article in Press]



Tang J, Xiao Q, Gui Z, Li B, Zhang P.

Simulation of proton-induced DNA damage patterns using an improved clustering algorithm.

Radiat Res. 2020 Sep 15. [Epub ahead of print]



Tezari A, Paschalis P, Mavromichalaki H, Karaiskos P, Crosby N, Dierckxsens M.

Assessing radiation exposure inside the Earth’s atmosphere.

Radiat Prot Dosimetry. 2020 Sep 9. [Epub ahead of print]



Uchinomiya K, Yoshida K, Kondo M, Tomita M, Iwasaki T.

A mathematical model for stem cell competition to maintain a cell pool injured by radiation.

Radiat Res. 2020 Sep 16. [Epub ahead of print]



Roy K, Jana S, Ghosh SK, Mahanty B, Mallick Z, Sarkar S, Sinha C, Mandal D.

3D MOF assisted self-polarized ferroelectret: An effective auto-powered remote healthcare monitoring approach.

Langmuir. 2020 Sep 8. [Epub ahead of print]



Kazibwe Z, Soto-Burgos J, MacIntosh GC, Bassham DC.

TOR mediates the autophagy response to altered nucleotide homeostasis in a ribonuclease mutant.

J Exp Bot. 2020 Sep 9. [Epub ahead of print]



Li Y, Yuan W, Li L, Dai H, Dang X, Miao R, Baluška F, Kronzucker HJ, Lu C, Zhang J, Xu W.

Comparative analysis reveals gravity is involved in the MIZ1-regulated root hydrotropism.

J Exp Bot. 2020 Sep 9. [Epub ahead of print]



Schlegel AM, Haswell ES.

Analyzing plant mechanosensitive ion channels expressed in giant E. coli spheroplasts by single-channel patch-clamp electrophysiology.

Methods Cell Biol. 2020;160:61-82.



Poon C.

Factors implicating the validity and interpretation of mechanobiology studies in simulated microgravity environments.

Eng Rep. 2020 Sep 11. [Article in Press]

Note: From the abstract: “For the benefit of the growing space biology community, this article critically reviews a typical s-μg cell culture environment in terms of three key conditions: fluid-mediated mechanical stimuli, oxygen tension and biochemical.” Devices reviewed are Rotating Wall Vessels, 2D and 3D clinostats, random positioning machines, and magnetic levitation culture systems. This article may be obtained online without charge.



Seedhouse E.

Life Support Systems for Humans in Space.

Cham: Springer, 2020. 314 p.  

Note: Chapters in this textbook include: Life Support Systems Basics, Space Physiology and Psychology, Open-Loop vs. Closed-Loop Life Support Systems, Evolution and Development of Life Support Systems, International Space Station Life Support System, Extravehicular Activity, Countermeasures, Growing Food in Space, and Future Life Support Concepts.



Sadeghi Yarandi M, Ghasemi M, Ghanjal A.

The relationship between individual, physical and psychosocial risk factors with musculoskeletal disorders and related disabilities in flight security personnel.

Int J Occup Saf Ergon. 2020 Sep 7. [Epub ahead of print]

Note: The NASA Task Load Index was used.

SpaceRef staff editor.