NASA Spaceline Current Awareness List #913 28 August 2020 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Attias J, Grassi A, Bosutti A, Ganse B, Degens H, Drey M.
Head-down tilt bed rest with or without artificial gravity is not associated with motor unit remodeling.
Eur J Appl Physiol. 2020 Aug 14. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.580
Funding: “The authors would like to acknowledge the UK Space Agency (ST/S0001735/1), DLR (grant number 50WB1928), and the German Research Council (DFG, grant number GA 2420/1-1) in funding this project. In addition, the authors appreciate the support of the European Space Agency (ESA, 16-16ESA AGBR-0013, contract number 4000113871/15/NL/PG) and the National Aeronautics and Space Administration (NASA, contract number 80JSC018P0078).”
2
Bretl KN, Clark TK.
Improved feasibility of astronaut short-radius artificial gravity through a 50-day incremental, personalized, vestibular acclimation protocol.
npj Microgravity. 2020 Aug 26;6(1):22.
https://www.nature.com/
Note: A short-arm centrifuge was used. This article may be obtained online without charge.
Journal Impact Factor: 3.380
Funding: “This work was supported by a NASA Space Technology Research Fellowship, grant number 80NSSC17K0085.”
3
Emens JS, Berman AM, Thosar SS, Butler MP, Roberts SA, Clemons NA, Herzig MX, McHill AW, Morimoto M, Bowles NP, Shea SA.
Circadian rhythm in negative affect: Implications for mood disorders.
Psychiatry Res. 2020 Nov;293:113337. Epub 2020 Aug 4.
https://pubmed.ncbi.nlm.nih.
PI: S.S. Thosar, NSBRI Postdoctoral Fellowship Program
Journal impact Factor: 2.118
Funding: “This work was supported by the National Institutes of Health grants R01-HL125893, R01-HL142064, R01-HL140577, F32-HL131308, KL2-TR002370, and UL1-TR000128; NSBRI NCC 9-58; American Sleep Medicine Foundation; Ford Foundation; and the Oregon Institute of Occupational Health Sciences.”
4
Titone MK, McArthur BA, Ng TH, Burke TA, McLaughlin LE, MacMullen LE, Goel N, Alloy LB.
Sex and race influence objective and self-report sleep and circadian measures in emerging adults independently of risk for bipolar spectrum disorder.
Sci Rep. 2020 Aug 15;10(1):13731.
https://pubmed.ncbi.nlm.nih.
PI: N. Goel
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.998
Funding: “This research was supported by National Institutes of Health grants MH77908 and MH102310 to Lauren B. Alloy. Brae Anne McArthur was supported by a Banting Postdoctoral Fellowship from the Social Sciences and Humanities Research Council. Taylor A. Burke was supported by a National Science Foundation Graduate Student Research Fellowship. Namni Goel was supported in part by National Aeronautics and Space Administration (NASA) grants NNX14AN49G and 80NSSC20K0243 and National Institutes of Health grant R01DK117488.”
5
Yamazaki EM, Goel N.
Genetics of circadian and sleep measures in adults: Implications for sleep medicine.
Curr Sleep Med Rep. 2020 Mar 1;6(1):32-45.
https://link.springer.com/
PI: N. Goel
Journal Impact Factor: 1.137
Funding: “Preparation of this manuscript was supported in part by National Aeronautics and Space Administration grant NNX14AN49G and 80NSSC20K0243 (NG).”
6
Connaboy C, Sinnott AM, LaGoy A, Krajewski KT, Johnson CA, Pepping G-J, Simpson RJ, Bower JL, Alfano CA.
Cognitive performance during prolonged periods in isolated, confined, and extreme environments.
Acta Astronaut. 2020 Dec;177:545-51. Epub 2020 Aug 18.
http://www.sciencedirect.com/
PI: C.A. Alfano
Note: Results are from studies conducted at Antarctic stations.
Journal Impact Factor: 2.83
Funding: “This research was supported by a grant from the National Aeronautical Science Administration (NASA) to Drs. Alfano & Simpson (#NNX15AC13G).”
7
Tang YQ, Lee SA, Rahman M, Vanapalli SA, Lu H, Schafer WR.
Correction: Ankyrin is an intracellular tether for TMC mechanotransduction channels.
Neuron. 2020 Aug 19;107(4):759-61.
https://pubmed.ncbi.nlm.nih.
PI: S.A. Vanapalli
Note: The authors clarify labels on the western blots in Figures 2E, 4D, and 4G. The original article was cited in SPACELINE Current Awareness List #897, 1 May 2020 (https://www.ncbi.nlm.nih.gov/
Journal Impact Factor: 14.415
Funding: From the original article: “This work was funded by Medical Research Council grant MC-A023-5PB91 and Wellcome Trust grant WT103784MA to W.R.S., NIH grant 1R21DC015652 to H.L. and W.R.S., NIH grant R01NS096581 to H.L., and grants from NASA (NNX15AL16G) and the Cancer Prevention and Research Institute of Texas (RP160806) to S.A.V.”
______________________________
Other papers of interest:
1
Kawaguchi Y, Shibuya M, Kinoshita I, Yatabe J, Narumi I, Shibata H, Hayashi R, Fujiwara D, Murano Y, Hashimoto H, Imai E, Kodaira Si, Uchihori Y, Nakagawa K, Mita H, Yokobori S, Yamagishi A.
DNA damage and survival time course of Deinococcal cell pellets during 3 years of exposure to outer space.
Front Microbiol. 2020 Aug 26;11:2050.
https://www.frontiersin.org/
Note: ISS results. This article may be obtained online without charge.
2
Ogoh S, Washio T, Paton JFR, Fisher JP, Petersen LG.
Gravitational effects on intracranial pressures and blood flow regulation in young men: A potential shunting role for the external carotid artery.
J Appl Physiol (1985). 2020 Aug 20. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Head-down tilt study.
3
Kim TY.
Theoretical study on microgravity and hypogravity simulated by random positioning machine.
Acta Astronaut. 2020 Aug 23. [Article in Press]
http://www.sciencedirect.com/
Note: A random positioning machine was used.
4
Carniello V, Peterson BW, van der Mei HC, Busscher HJ.
Role of adhesion forces in mechanosensitive channel gating in Staphylococcus aureus adhering to surfaces.
npj Biofilms Microbiomes. 2020 Aug 21;6(1):31.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
5
Aebi MR, Bourdillon N, Bron D, Millet GP.
Minimal influence of hypobaria on heart rate variability in hypoxia and normoxia.
Front Physiol. 2020 Aug 21;11:1072.
https://www.frontiersin.org/
Note: This article may be obtained online without charge.
6
Kadoya Y, Miyati T, Kobayashi S, Ohno N, Gabata T.
Evaluation of gravity effect on inferior vena cava and abdominal aortic flow using multi-posture MRI.
Acta Radiol. 2020 Aug 16. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Upright and supine positions were used.
7
Lee J, Vernon SD, Jeys P, Ali W, Campos A, Unutmaz D, Yellman B, Bateman L.
Hemodynamics during the 10-minute NASA Lean Test: Evidence of circulatory decompensation in a subset of ME/CFS patients.
J Transl Med. 2020 Aug 15;18(1):314.
https://pubmed.ncbi.nlm.nih.
Note: The NASA Lean Test is used to assess orthostatic intolerance. This article may be obtained online without charge.
8
Baba S, Smith T, Hellmann J, Bhatnagar A, Carter K, Vanhoover A, Caruso J.
Space flight diet-induced deficiency and response to gravity-free resistive exercise.
Nutrients. 2020 Aug 11;12(8):E2400.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
9
Rocha LC, Jacob CDS, Barbosa GK, Pimentel Neto J, Krause Neto W, Gama EF, Ciena AP.
Remodeling of the skeletal muscle and postsynaptic component after short-term joint immobilization and aquatic training.
Histochem Cell Biol. 2020 Aug 14. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Joint immobilization was used.
10
Brent MB, Brüel A, Thomsen JS.
Animal models of disuse-induced bone loss: Study protocol for a systematic review.
Syst Rev. 2020 Aug 16;9(1):185. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
11
Karsenty G.
That feeling in your bones.
Cerebrum. 2020 Jul-Aug;2020:cer-05-20.
https://pubmed.ncbi.nlm.nih.
Note: Dr. Karsenty discusses his research on osteocalcin. A podcast associated with this article featuring the author is available at https://www.dana.org/videos-
12
Yong KW, Choi JR, Choi JY, Cowie AC.
Recent advances in mechanically loaded human mesenchymal stem cells for bone tissue engineering.
Int J Mol Sci. 2020 Aug 13;21(16):E5816. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
13
Evsen L, Li X, Zhang S, Razin S, Doetzlhofer A.
let-7 miRNAs inhibit CHD7 expression and control auditory-sensory progenitor cell behavior in the developing inner ear.
Development. 2020 Aug 14;147(15):dev183384.
https://pubmed.ncbi.nlm.nih.
14
Jörges B, López-Moliner J.
Determining mean and standard deviation of the strong gravity prior through simulations.
PLoS One. 2020 Aug 19;15(8):e0236732.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
15
Razzak RA, Bagust J, Docherty S.
Young and older adults differ in integration of sensory cues for vertical perception.
J Aging Res. 2020 Jul 31;2020:8284504.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
16
Mick S, Badets A, Oudeyer PY, Cattaert D, De Rugy A.
Biological plausibility of arm postures influences the controllability of robotic arm teleoperation.
Hum Factors. 2020 Aug 18. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
17
Malau-Aduli BS, Hays R, D’Souza K, Smith AM, Jones K, Turner R, Shires L, Smith J, Saad S, Richmond C, Celenza A, Sen Gupta T.
Examiners’ decision-making processes in observation-based clinical examinations.
Med Educ. 2020 Aug 18. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used.
Please note: Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets is a new book in Springer’s Space and Society series. From the abstract: “This book presents a collection of chapters, which address various contexts and challenges of the idea of human enhancement for the purposes of human space missions. The authors discuss pros and cons of mostly biological enhancement of human astronauts operating in hostile space environments, but also ethical and theological aspects are addressed. In contrast to the idea and program of human enhancement on Earth, human enhancement in space is considered a serious and necessary option. This book aims at scholars in the following fields: ethics and philosophy, space policy, public policy, as well as biologists and psychologists.” The monograph and individual chapters are listed below.
18
Szocik K, editor.
Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets.
Cham, Switzerland: Springer International, 2020. 291 p.
https://link.springer.com/
19
Rappaport MB, Corbally CJ.
Normalizing the paradigm on human enhancements for spaceflight.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International Publishing, 2020. p. 3-17.
https://link.springer.com/
20
Gouw AM.
CRISPR challenges and opportunities for space travel.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 19-34.
https://link.springer.com/
21
Kendal E.
Biological modification as prophylaxis: How extreme environments challenge the treatment/enhancement divide.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 35-46.
https://link.springer.com/
22
Abood S.
Crossing the posthuman Rubicon: When do enhancements change our definition of human?
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 47-70.
https://link.springer.com/
23
Braddock M.
Limitations for extraterrestrial colonisation and civilisation built and the potential for human enhancements.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 71-93.
https://link.springer.com/
24
Shelhamer M.
Human enhancements: New eyes and ears for Mars.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 95-103.
https://link.springer.com/
25
Newberg AB, Yaden DB.
Human enhancement from the overview effect in long-duration space flights.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 105-11.
https://link.springer.com/
26
Munévar G.
Science and ethics in the human-enhanced exploration of Mars.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 113-24.
https://link.springer.com/
27
Worden SP.
Interstellar missions and human enhancement.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 125-8.
https://link.springer.com/
28
Campa R.
Anti-aging medicine as a game changer for long-lasting space missions.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 129-48.
https://link.springer.com/
29
Norman Z, Reiss MJ.
Two planets, one species: Does a mission to Mars alter the balance in favour of human enhancement?
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 151-67.
https://link.springer.com/
30
Tachibana K.
Virtue ethics and the value of saving humanity.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 169-81.
https://link.springer.com/
31
Milligan T, Inaba S-I.
Ethical problems of life extension for space exploration.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 183-200.
https://link.springer.com/
32
Schwartz JSJ.
The accessible universe: On the choice to require bodily modification for space exploration.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 201-15.
https://link.springer.com/
33
Smith KC, Hylkema C.
Who’s afraid of little green men? Genetic enhancement for off-world settlements.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 217-37.
https://link.springer.com/
34
Peters T.
Evolving from earthlings into Martians?
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 239-51.
https://link.springer.com/
35
Szocik K.
Human enhancement and Mars settlement—Biological necessity or science-fiction? The special case of biomedical moral enhancement for future space missions.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 253-64.
https://link.springer.com/
36
Ćirković MM.
Anthropocentrism and the roots of resistance to both human bioenhancement and space colonization.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 265-78.
https://link.springer.com/
37
Oviedo L.
Religion as human enhancer: Prospects for deep spatial travel.
In: Szocik K, ed. Human Enhancements for Space Missions: Lunar, Martian, and Future Missions to the Outer Planets. Space and Society. Cham: Springer International, 2020. p. 279-88.
https://link.springer.com/
