Status Report

NASA Spaceline Current Awareness List #912 21 August 2020 2020 (Space Life Science Research Results)

By SpaceRef Editor
August 21, 2020
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor,



Papers deriving from NASA support:



English KL, Downs M, Goetchius E, Buxton R, Ryder JW, Ploutz-Snyder R, Guilliams ME, Scott JM, Ploutz-Snyder LL.

High intensity training during spaceflight: Results from the NASA Sprint Study.

npj Microgravity. 2020 Aug 18;6(1):21.

PI: L.L. Ploutz-Snyder

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.111

Funding: “This study was supported by research grants from the NASA Human Research Program and the National Space Biomedical Research Institute.”



Holmes ZC, Silverman JD, Dressman HK, Wei Z, Dallow EP, Armstrong SC, Seed PC, Rawls JF, David LA.

Short-chain fatty acid production by gut microbiota from children with obesity differs according to prebiotic choice and bacterial community composition.

MBio. 2020 Aug 11;11(4):e00914-20.

PI: L.A. David

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.747

Funding: “This study was supported in part by National Institutes of Health grants R24-DK110492 and 1R01DK116187, Translational Research Institute through Cooperative Agreement NNX16AO69A, the Damon Runyon Cancer Research Foundation, and the UNC CGIBD (NIDDK P30DK034987). This study used a high-performance computing facility partially supported by grant 2016-IDG-1013 (HARDAC : Reproducible HPC for Next-Generation Genomics) from the North Carolina Biotechnology Center.”



Kunz HE, Agha NH, Hussain M, LaVoy EC, Smith KA, Mylabathula P, Diak D, Baker FL, O’Connor DP, Bond RA, Katsanis E, Bollard CM, Simpson RJ.

The effects of β1 and β1+2 adrenergic receptor blockade on the exercise-induced mobilization and ex vivo expansion of virus-specific T cells: Implications for cellular therapy and the anti-viral immune effects of exercise.

Cell Stress Chaperones. 2020 Aug 10. [Epub ahead of print]

PI: R.J. Simpson

Journal Impact Factor: 2.892

Funding: “This work was supported by NASA Grants NNX12AB48G, NNX16AB29G, and NNX16AG02G to R.J.S., NIH Grant R21 CA197527-01A1 to R.J.S. and A.B.B., NIH grant R01 AI110007 to R.A.B., NIH grant P01 CA148600-01A1 to C.M.B., and an American College of Sports Medicine Foundation Doctoral Student Research grant awarded to H.K.”



Schreurs AS, Torres S, Truong T, Moyer EL, Kumar A, Tahimic CGT, Alwood JS, Globus RK.

Skeletal tissue regulation by catalase over-expression in mitochondria.

Am J Physiol Cell Physiol. 2020 Aug 12. [Epub ahead of print]

PIs: R.K. Globus; A-S. Schreurs, J.S. Alwood, and A. Kumar, NASA Postdoctoral Program Fellowships

Note: Hindlimb unloading study.

Journal Impact Factor: 3.485

Funding: “This research was supported by the National Space Biomedical Research Institute grant No. MA02501 under NASA cooperative agreement NCC 9-58 (R.K.G., J.S.A.),  a DOE-NASA Interagency Award No. DE-SC0001507, supported by the Office of Science (Biological and Environmental Research), U.S. Department of Energy (R.K.G.), and NASA Postdoctoral Program fellowships from NASA’s Space Biology Program (A-S. S. J.S.A., A.K), and a grant from the NASA Space Biology Program (NNH14ZTT001N) (R.K.G.).”



Demmig-Adams B, López-Pozo M, Stewart JJ, Adams WW 3rd.

Zeaxanthin and lutein: Photoprotectors, anti-inflammatories, and brain food.

Molecules. 2020 Aug 8;25(16):E3607. Review.

PI: B. Demmig-Adams

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.060

Funding: “This work was funded by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A and by the University of Colorado.”




Other papers of interest:



Bogomolov VV, Polyakov AV, Matsnev EI, Popova II, Kovachevich IV, Alferova IV, Repenkova LG, Sigaleva ЕE.

[Diagnostics and treatment of ENT diseases in Russian cosmonauts during missions to the orbital station Mir and ISS].

Aviakosm Ekolog Med. 2020;54(3):22-7. Russian.

Note: Mir and ISS results.



Gagnon MF, Lafleur C, Landry-Cuerrier M, Humphries MM, Kimmins S.

Torpor expression is associated with differential spermatogenesis in hibernating eastern chipmunks.

Am J Physiol Regul Integr Comp Physiol. 2020 Aug 12. [Epub ahead of print]



Khomenko MN, Bukhtiyarov IV, Malashchuk LS.

[Tolerance and adaptative/compensatory reactions of the human body to +Gz loads (head-to-pelvis direction) of high level, duration and onset rate].

Aviakosm Ekolog Med. 2020;54(3):54-62. Russian.

Note: The method used to apply increased gravity is not provided in the available abstract.



Mukhopadhyay S, Bagh S.

A microgravity responsive synthetic genetic device in Escherichia coli.

Biosens Bioelectron. 2020 Nov;167:112462. Epub 2020 Aug 1.

Note: A Rotating Wall Vessel bioreactor was used.



Scott JPR, Green DA, Weerts G, Cheuvront SN.

Body size and its implications upon resource utilization during human space exploration missions.

Sci Rep. 2020 Aug 14;10(1):13836.

Note: From the abstract: “The purpose of this theoretical study was to estimate the effects of body size and countermeasure (CM) exercise in an all-male crew composed of individuals drawn from a height range representative of current space agency requirements upon total energy expenditure (TEE), oxygen (O2) consumption, carbon dioxide (CO2) and metabolic heat (Hprod) production, and water requirements for hydration, during space exploration missions.” This article may be obtained online without charge.



Zhou H, Trudel G, Laneuville O.

Mechanical adaptation of synoviocytes A and B to immobilization and remobilization: A study in the rat knee flexion model.

J Mol Histol. 2020 Aug 10. [Epub ahead of print]

Note: Unilateral hindlimb knee immobilization in flexion was used.



Wang Y, Han B, Ding J, Qiu C, Wang W.

Endoplasmic reticulum stress mediates osteocyte death under oxygen-glucose deprivation in vitro.

Acta Histochem. 2020 Sep;122(6):151577.



Rcheulishvili N, Zhang Y, Papukashvili D, Deng YL.

Survey and evaluation of spacecraft-associated aluminum-degrading microbes and their rapid identification methods.

Astrobiology. 2020 Aug;20(8):925-34.



Navasiolava N, Yuan M, Murphy R, Robin A, Coupé M, Wang L, Alameddine A, Gauquelin-Koch G, Gharib C, Li Y, Custaud M-A.

Vascular and microvascular dysfunction induced by microgravity and its analogs in humans: Mechanisms and countermeasures.

Front Physiol. 2020 Aug 20;11:952. Review.

Note: Results from spaceflight studies and ground-based analogs such as bed rest, leg immobilization, and dry immersion are reviewed. This article may be obtained online without charge.



Zhang H, Chen J, Wang H, Lu X, Li K, Yang C, Wu F, Xu Z, Nie H, Ding B, Guo Z, Li Y, Wang J, Li Y, Dai Z.

Serum metabolomics associating with circulating microRNA profiles reveal the role of miR-383-5p in rat hippocampus under simulated microgravity.

Front Physiol. 2020 Aug 18;11:939.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Patel J, Parhi A, Al-Ghamdi S, Sonar CR, Mattinson DS, Tang J, Yang T, Sablani SS.

Stability of vitamin C, color, and garlic aroma of garlic mashed potatoes in polymer packages processed with microwave-assisted thermal sterilization technology.

J Food Sci. 2020 Aug 13. [Epub ahead of print]

Note: The study examined the use of polymer packages combined with microwave-assisted thermal sterilization (MATS) processing to provide safe, high quality, and nutritious shelf-stable food products for military use and space missions.



Bennett BT, Mohamed JS, Alway SE.

The effects of calcium-β-hydroxy-βmethylbutyrate on aging-associated apoptotic signaling and muscle mass and function in unloaded but nonatrophied extensor digitorum longus muscles of aged rats.

Oxid Med Cell Longev. 2020 Jul 24;2020:3938672.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Peters RM, Mildren RL, Hill AJ, Carpenter MG, Blouin JS, Inglis JT.

Lower-limb muscle responses evoked with noisy vibrotactile foot sole stimulation.

Physiol Rep. 2020 Aug;8(15):e14530.

Note: This article may be obtained online without charge.



Vilchinskaya NA, Paramonova II, Nemirovskaya TL, Lomonosova YN, Shenkman BS.

[Interleukin-6 expression in rat’s muscle soleus during functional unloading: Dynamics of the process and role of L-type calcium channels].

Aviakosm Ekolog Med. 2020;54(3):70-8. Russian.

Note: Hindlimb unloading study.



Estell EG, Le PT, Vegting Y, Kim H, Wrann C, Bouxsein ML, Nagano K, Baron R, Spiegelman BM, Rosen CJ.

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo.

Elife. 2020 Aug 11;9:e58172.

Note: This article may be obtained online without charge.



He B, Yin X, Hao D, Zhang X, Zhang Z, Zhang K, Yang X.

Blockade of IL-6 alleviates bone loss induced by modeled microgravity in mice.

Can J Physiol Pharmacol. 2020 Aug 13. [Epub ahead of print]

Note: Hindlimb unloading study.



Hou W, Zhang D, Feng X, Zhou Y.

Low magnitude high frequency vibration promotes chondrogenic differentiation of bone marrow stem cells with involvement of β-catenin signaling pathway.

Arch Oral Biol. 2020 Oct;118:104860. Epub 2020 Jul 31.



Jia R, Chen Y, Jia C, Hu B, Du Y.

Suppression of innate immune signaling molecule, MAVS, reduces radiation-induced bystander effect.

Int J Radiat Biol. 2020 Aug 10. [Epub ahead of print]



Kuznetsova EA, Sirota NP, Mitroshina IY, Pikalov VA, Smirnova EN, Rozanova OM, Glukhov SI, Sirota TV, Zaichkina SI.

DNA damage in blood leukocytes from mice irradiated with accelerated carbon ions with an energy of 450 MeV/nucleon.

Int J Radiat Biol. 2020 Aug 11. [Epub ahead of print]



Kalmanov AS, Shchastlivtseva DV, Kotrovskaya TI, Bubeev YA.

[EEG-reactions in human operators to a modified sleep-wake schedule and 21-day stay in isolation].

Aviakosm Ekolog Med. 2020;54(3):42-8.

Note: The study was conducted during a 21-day isolation mission.



Wang H, Liu J, Lu Z, Dai Y, Xie J, Xu S, Song Y, Xiao G, Gao F, Qu L, Cai X.

Implanted multichannel microelectrode array for simultaneous electrophysiological signal detection of hippocampal CA1 and DG neurons of simulated microgravity rats.

Biochem Biophys Res Commun. 2020 Aug 14. [Epub ahead of print]

Note: Hindlimb unloading study.



Curry C, Peterson N, Li R, Stoffregen TA.

Postural precursors of motion sickness in head-mounted displays: Drivers and passengers, women and men.

Ergonomics. 2020 Aug 11. [Epub ahead of print]



Fedyai SO, Shved DM, Gushchin VI, Kuznetsova PG, Polyakov AV, Nosovsky AM, Pozdnyakov SV, Niyazov AR.

[Dynamics of motor and verbal activity of test-subjects in 120-day isolation study SIRIUS-19].

Aviakosm Ekolog Med. 2020;54(3):36-41. Russian. 

Note: The research was conducted during the 4-month ground-based isolation mission, SIRIUS-19.



Gushchin VI, Shved DM, Yusupova AK, Supolkina NS, Chekalina AI, Savinkina AO, Lebedeva SA.

[Effect of modeled exploration mission factors on communication autonomy in an isolated multinational mixed-gender crew].

Aviakosm Ekolog Med. 2020;54(3):28-35. Russian.

Note: The research was conducted during the 4-month ground-based isolation mission, SIRIUS-19.



Bhutani S, Khan I, Nasser A, Saxena CS.

Thermal stress inside a disabled submarine.

Med J Armed Forces India. 2020 Jul;76(3):333-7.



Suhir E.

Astronaut’s performance vs. his/hers human-capacity-factor and state-of-health: Application of double-exponential-probability-distribution function.

Acta Astronaut. 2020 Aug 14. [Article in Press]



Inoue SI, Kaiserli E, Zhao X, Waksman T, Takemiya A, Okumura M, Takahashi H, Seki M, Shinozaki K, Endo Y, Sawasaki T, Kinoshita T, Zhang X, Christie JM, Shimazaki KI.

CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.

Plant J. 2020 Aug 11. [Epub ahead of print]



Ilyin VK, Usanova NA, Komissarova DV, Shef КА, Agureev AN, Kaspransky RR, Morozova YA, Sakharova AV, Nosovsky АМ.

[Combined use of fermentation beverages based on saccharomycets and probiotic and autoprobiotic preparations for normalyzing human microflora in isolation study SIRIUS-18/19].

Aviakosm Ekolog Med. 2020;54(3):49-53. Russian.

Note: The research was conducted during the 4-month ground-based isolation mission, SIRIUS-19.



Khizhnyak SV, Petrushkina SA, Chernov VЕ, Ushakova SA, Tikhomirov АА.

[Autochthonous microbial cenosis as a potential source of antagonistic strains for biological struggle against wheat Fusarium in biotechnical life support systems].

Aviakosm Ekolog Med. 2020;54(3):84-91. Russian.



Mukhamedieva LN, Tsarkov DS, Ozerov DS, Grigoriev GY, Lagutin AS, Nabiev SS, Vasiliev АА, Malashevich SV, Stavrovsky DB.

[Oxidative stress biomarkers in expirated air of healthy humans and promising techniques of their analysis during space flight].

Aviakosm Ekolog Med. 2020;54(3):5-21. Review. Russian.



Jaehnichen T.

The dynamics of economic action and the problems of its social embedding – Ethical challenges in view of the nascent commercial use of outer space.

HTS Teol Stud-Theol. 2020 Aug 13;76(1):a5996.

Note: From the abstract: “Although the commercial use of outer space does not seem to be a crucial point, it marks a new step of the dynamics of modern economics that has to be identified as an important ethical challenge. The article discusses aspects of ethics, law, religion and economy in a multidisciplinary way.” This article may be obtained online without charge.



Piechowski S, Pustowalow W, Arz M, Rittweger J, Mulder E, Wolf OT, Johannes B, Jordan J.

Virtual reality as training aid for manual spacecraft docking.

Acta Astronauti. 2020 Aug 20. [Article in Press]



Weibel DL.

The overview effect and the ultraview effect: How extreme experiences in/of outer space influence religious beliefs in astronauts.

Religions. 2020 Aug;11(8):418.

Note: From the abstract: “This paper, based mainly on astronauts’ first-person writings, historical documents, and my own ethnographic interviews with nine astronauts conducted between 2004 and 2020, explores how encountering the earth and other celestial objects in ways never before experienced by human beings has influenced some astronauts’ cosmological understandings.” This article may be obtained online without charge.



Innes RJ, Howard ZL, Thorpe A, Eidels A, Brown SD.

The effects of increased visual information on cognitive workload in a helicopter simulator.

Hum Factors. 2020 Aug 12. [Epub ahead of print]



Corazza F, Snijders D, Arpone M, Stritoni V, Martinolli F, Daverio M, Losi MG, Soldi L, Tesauri F, Da Dalt L, Bressan S.

Development and usability of PediAppRREST, a novel interactive tablet App to support the management of pediatric cardiac arrest: A pilot high-fidelity simulation-based study.

JMIR Mhealth Uhealth. 2020 Jul 26. [Epub ahead of print]

Note: The NASA Raw-Task Load Index was used. This article may be obtained online without charge.



Said S, Gozdzik M, Roche TR, Braun J, Rössler J, Kaserer A, Spahn DR, Nöthiger CB, Tscholl DW.

Validation of the Raw NASA Task Load Index Questionnaire to assess perceived workload in patient monitoring tasks: Pooled analysis using mixed models.

J Med Internet Res. 2020 Aug 11. [Epub ahead of print]

Note: The NASA Raw-Task Load Index was used. This article may be obtained online without charge.

SpaceRef staff editor.