NASA Spaceline Current Awareness List #908 24 July 2020 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/
Papers deriving from NASA support:
1
Wåhlin A, Holmlund P, Fellows AM, Malm J, Buckey JC, Eklund A.
Optic nerve length before and after spaceflight.
Ophthalmology. 2020 Jul 10. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 8.470
Funding: “This work was supported by the Swedish National Space Agency (grant 193-17), the County Council of Västerbotten, and grant NNX13AD35A to the New Hampshire NASA Experimental Program to Stimulate Competitive Research.”
2
Romsdahl J, Blachowicz A, Chiang YM, Venkateswaran K, Wang CCC.
Metabolomic analysis of Aspergillus niger isolated from the International Space Station reveals enhanced production levels of the antioxidant pyranonigrin A.
Front Microbiol. 2020 May 21;11:931.
https://pubmed.ncbi.nlm.nih.
PI: C.C.C. Wang
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 4.235
Funding: “This research was supported by the JPL Advanced Concept Development fund awarded to KV that funded a student fellowship for AB. Research at USC was supported by grant from NASA. This research was funded in part by NASA’s Space Biology grant number NNX15AB49G awarded to CW.”
3
Ahmed AS, Ramachandran V, O’Conor DK, Antonsen EL.
Immune dysfunction in spaceflight and diabetes mellitus – Translating space observations to terrestrial disease.
McGill J Med. 2019 Sep 7;17(1):127. Review.
http://mjm.mcgill.ca/article/
Note: Spaceflight results are reviewed. From the Introduction: “In this review, the effects of both spaceflight and diabetes mellitus (DM) on specific immune cells and signaling molecules are compared. While examining the unique conditions of spaceflight as a theoretical model for understanding immune dysfunction, we consider the putative crossover application to the study of immune alterations for DM populations.” This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: No funding cited. E.L. Antonsen is affiliated with NASA Johnson Space Center.
4
Barratt MR.
The Bert & Peggy DuPont Lecture: The human in space: A new physiology.
Trans Am Clin Climatol Assoc. 2020 Jul 18;131:201-34.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: No funding cited. M.R. Barratt is affiliated with NASA Johnson Space Center.
5
Owen PJ, Rantalainen T, Scheuring RA, Belavy DL.
Axial loading and posture cues in contraction of transversus abdominis and multifidus with exercise.
Sci Rep. 2020 Jul 14;10(1):11218.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.011
Funding: “This project was funded by GravityFit (Grant Number: RM32446), manufacturer of the exercise device used in testing.” R.A. Scheuring is affiliated with NASA Johnson Space Center.
6
de Wet WC, Slaba TC, Rahmanifard F, Wilson JK, Jordan AP, Townsend LW, Schwadron NA, Spence HE.
CRaTER observations and permissible mission duration for human operations in deep space.
Life Sci Space Res. 2020 Aug;26:149-62.
http://www.sciencedirect.com/
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.453
Funding: “This work was performed under the auspices of NASA grant number NG11PA03C.”
7
Kiffer F, Alexander T, Anderson J, Groves T, McElroy T, Wang J, Sridharan V, Bauer M, Boerma M, Allen A.
Late effects of 1H + 16O on short-term and object memory, hippocampal dendritic morphology and mutagenesis.
Front Behav Neurosci. 2020 Jun 26;14:96.
https://pubmed.ncbi.nlm.nih.
PIs: A. Allen; M. Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.362
Funding: “This work was supported by the National Space Biomedical Research Institute (NSBRI) Grant RE03701 through NASA cooperative agreement NCC 9-58, and by the Translational Research Institute through NASA cooperative agreement NNX16AO69A. This work was also supported by core facilities of the Center for Translational Neuroscience IDeA program award P30 GM110702 and by the Center for Translational Pediatric Research Genomics Core supported by P20 GM121293.”
8
Slaba TC, Plante I, Ponomarev A, Patel ZS, Hada M.
Determination of chromosome aberrations in human fibroblasts irradiated by mixed fields generated with shielding.
Radiat Res. 2020 Jul 16. [Article in Press]
https://meridian.allenpress.
PI: M. Hada
Journal Impact Factor: 2.779
Funding: “Funding for this work was provided by NASA Human Health and Performance Contract (HHPC) no. NNJ15HK11B. This work was supported by NASA Space Radiation Element (no. NNX16AR97G for MH) and TAMU Chancellor’s Research Initiative, Texas A&M University.”
9
Yadav M, Bhayana S, Liu J, Lu L, Huang J, Ma Y, Qamri Z, Mo X, Jacob DS, Parasa ST, Bhuiya N, Fadda P, Xu-Welliver M, Chakravarti A, Jacob NK.
Two-miRNA-based finger-stick assay for estimation of absorbed ionizing radiation dose.
Sci Transl Med. 2020 Jul 15;12(552):eaaw5831.
https://pubmed.ncbi.nlm.nih.
PI: N. Jacob
Note: This article may be obtained online without charge.
Journal Impact Factor: 17.161
Funding: “This study was supported, in part, by an Investigator-Initiated Research Award (IIRA) from United States Defense for Health Affairs through the Peer Reviewed Medical Research Program (award no. W81XWH-15-2-0054), National Aeronautics and Space Administration (NASA) (award no. 80NSSC18K1691), and Oakridge Associated Universities (ORAU)–Directed Research and Development fund to N.K.J. and, in part, with intramural funds from OSUCCC. Multiple shared resources used at the Institution were supported by National Cancer Institute (NCI) grant P30CA016058.”
10
Mehta RK, Nuamah J.
Relationship between acute physical fatigue and cognitive function during orthostatic challenge in men and women: A neuroergonomics investigation.
Hum Factors. 2020 Jul 17. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Journal Impact Factor: 2.649
Funding: “The work is supported by the NASA Michigan Space Grant Consortium.”
11
Kozlowski SWJ, Bell BS.
Advancing team learning: Process mechanisms, knowledge outcomes, and implications.
In: Argole L, Levine JM, eds. The Oxford Handbook of Group and Organizational Learning. New York: Oxford University Press, 2020. p. 195-232.
PI: S.W.J. Kozlowski
Journal Impact Factor: Not applicable to this publication
Funding: The PI reports funding through NASA grant NNX13AM77G.
12
Kozlowski SWJ, Bell BS.
Evidence-based principles and strategies for optimizing team functioning and performance in science teams.
In: Hall KL, Vogel AL, Croyle RT, eds. Strategies for Team Science Success: Handbook of Evidence-Based Principles for Cross-Disciplinary Science and Practical Lessons Learned from Health Researchers. Cham: Springer, 2019. p. 269-93.
https://link.springer.com/
PI: S.W.J. Kozlowski
Journal Impact Factor: Not applicable to this publication
Funding: “We gratefully acknowledge the U.S. Army Research Institute for the Behavioral and Social Sciences (ARI; W911NF-14-1-0026, S.W.J. Kozlowski & G.T. Chao, Principal Investigators), the National Aeronautics and Space Administration (NASA; NNX13AM77G, S.W.J. Kozlowski, Principal Investigator), and the National Science Foundation (NSF, 1533499, S.W.J. Kozlowski & G.T. Chao, Principal Investigators) for support that in part contributed to the composition of this chapter.”
13
Rosasco J, McCarroll ML, Gothard MD, Myers J, Hughes P, Schwartz A, George RL, Ahmed RA.
Medical decision-making in the physician hierarchy: A pilot pedagogical evaluation.
J Med Educ Curric Dev. 2020;7:2382120520925061. Epub 2020 Jul 2.
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “Financial support for this study was provided entirely by a subcontract grant with Zin Technologies, Inc.” J. Myers is affiliated with NASA Glenn Research Center.
______________________________
Other papers of interest:
1
Boada M, Perez-Poch A, Ballester M, García-Monclús S, González DV, García S, Barri PN, Veiga A.
Microgravity effects on frozen human sperm samples.
J Assist Reprod Genet. 2020 Jul 18. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: Parabolic flight results.
2
Wuest SL, Arnold J, Gander S, Zumbühl C, Jost C, Giger-Lange C, Cerretti G, Caliò M, Rattenbacher-Kiser K, Follonier C, Schälli O, Székely GS, Egli M, Ille F.
Microtubules and vimentin fiber stability during parabolic flights.
Microgravity Sci Technol. 2020 Jul 19. [Article in Press]
https://link.springer.com/
Note: Parabolic flight results. This article may be obtained online without charge.
3
Zhu H, Huang L, Yu CWF, Su H.
Thermal comfort under weightlessness: A physiological prediction.
Indoor Built Environ. 2020 Jul 12. [Article in Press]
https://journals.sagepub.com/
Note: Head-down tilt bed rest study.
4
Haftbaradaran Esfahani P, Knöll R.
Cell shape: Effects on gene expression and signaling.
Biophys Rev. 2020 Jul 15. [Epub ahead of print] Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
5
Guinet P, MacNamara JP, Berry M, Larcher F, Bareille M-P, Custaud M-A, Pavy-Le Traon A, Levine BD, Navasiolava N.
MNX (Medium Duration Nutrition and Resistance-Vibration Exercise) bed-rest: Effect of resistance vibration exercise alone or combined with whey protein supplementation on cardiovascular system in 21-day head-down bed rest.
Front Physiol. 2020 Jul 16;11:812.
https://www.frontiersin.org/
Note: Bed rest study. This article may be obtained online without charge.
6
Rikhi R, Samra G, Arustamyan M, Patel J, Zhou L, Bungo B, Moudgil R.
Radiation induced cardiovascular disease: An odyssey of bedside-bench-bedside approach.
Life Sci Space Res. 2020 Jul 22. [Article in Press]
http://www.sciencedirect.com/
7
Jorgenson KW, Phillips SM, Hornberger TA.
Identifying the structural adaptations that drive the mechanical load-induced growth of skeletal muscle: A scoping review.
Cells. 2020 Jul 9;9(7):E1658. Review.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
8
Eichholz KF, Woods I, Riffault M, Johnson GP, Corrigan M, Lowry MC, Shen N, Labour MN, Wynne K, O’Driscoll L, Hoey DA.
Human bone marrow stem/stromal cell osteogenesis is regulated via mechanically activated osteocyte-derived extracellular vesicles.
Stem Cells Transl Med. 2020 Jul 16. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
9
Lewis KJ, Yi X, Wright CS, Pemberton EZ, Bullock WA, Thompson WR, Robling AG.
The mTORC2 component rictor is required for load-induced bone formation in late-stage skeletal cells.
JBMR Plus. 2020 Jul;4(7):e10366.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
10
Naqvi SM, Panadero Pérez JA, Kumar V, Verbruggen ASK, McNamara LM.
A novel 3D osteoblast and osteocyte model revealing changes in mineralization and pro-osteoclastogenic paracrine signaling during estrogen deficiency.
Front Bioeng Biotechnol. 2020 Jun 10;8:601.
https://pubmed.ncbi.nlm.nih.
Note: This article may be obtained online without charge.
11
Andrews RN, Bloomer EG, Olson JD, Hanbury DB, Dugan GO, Whitlow CT, Cline JM.
Non-human primates receiving high-dose total-body irradiation are at risk of developing cerebrovascular injury years postirradiation.
Radiat Res. 2020 Jul 21. [Article in Press]
https://meridian.allenpress.
12
Das D, Li J, Cheng L, Franco S, Mahairaki V.
Human forebrain organoids from induced pluripotent stem cells: A novel approach to model repair of ionizing radiation-induced DNA damage in human neurons.
Radiat Res. 2020 Jun 4. [Article in Press]
https://meridian.allenpress.
13
Li X, McConnell KA, Che J, Ha CS, Lee SE, Kirby N, Shim EY.
DNA dosimeter measurement of relative biological effectiveness for 160 kVp and 6 MV X rays.
Radiat Res. 2020 Jun 9. [Article in Press]
https://meridian.allenpress.
14
Ritter GS, Nikolin VP, Popova NA, Proskurina AS, Kisaretova PE, Taranov OS, Dubatolova TD, Dolgova EV, Potter EA, Kirikovich SS, Efremov YR, Bayborodin SI, Romanenko MV, Meschaninova MI, Venyaminova AG, Kolchanov NA, Shurdov MA, Bogachev SS.
Characterization of biological peculiarities of the radioprotective activity of double-stranded RNA isolated from Saccharomyces сerevisiae.
Int J Radiat Biol. 2020 Jul 13. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
15
Tatum M.
Drugs in space: The pharmacy orbiting the Earth.
Pharm J. 2020 Jul 9.
Note: While not peer-reviewed, this article provides an interesting look at both pharmaceuticals for use by astronauts and development of pharmaceuticals in space based on research supported by the Translational Research Institute for Space Health (TRISH). A single copy of this article may be obtained online without charge.
16
van Loon JJWA.
Some challenges in gravity related research.
Front Space Technol. 2020 Jun 16;1:3.
https://www.frontiersin.org/
Note: The author introduces the Microgravity section of the new open-access journal Frontiers in Space Technologies, available at: https://www.frontiersin.org/
17
Zhang Y, Dong S, Wang K, Zhou Y, Sheng Q, Tan H.
Design, simulation and test of thermal control system of centrifuge for space utilization.
Microgravity Sci Technol. 2020 Jul 16. [Article in Press]
https://link.springer.com/
Note: This article may be obtained online without charge.
18
Huber AK, Patel N, Pagani CA, Marini S, Padmanabhan K, Matera DL, Said M, Hwang C, Hsu GC, Poli AA, Strong AL, Visser ND, Greenstein JA, Nelson R, Li S, Longaker MT, Tang Y, Weiss SJ, Baker BM, James AW, Levi B.
Immobilization after injury alters extracellular matrix and stem cell fate.
J Clin Invest. 2020 Jul 16. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
Note: A tubular brace was used for immobilization. This article may be obtained online without charge.
19
Devlin SP, Moacdieh NM, Wickens CD, Riggs SL.
Transitions between low and high levels of mental workload can improve multitasking performance.
IISE Trans Occup Ergon Hum Factors. 2020 Jun 12. [Epub ahead of print]
https://pubmed.ncbi.nlm.nih.
20
Nuamah JK, Seong Y, Jiang S, Park E, Mountjoy D.
Evaluating effectiveness of information visualizations using cognitive fit theory: A neuroergonomics approach.
Appl Ergon. 2020 Oct;88:103173. Epub 2020 Jun 11.
https://pubmed.ncbi.nlm.nih.
Note: The NASA Task Load Index was used.
